{"id":"https://openalex.org/W7225412934","doi":"https://doi.org/10.3389/fmicb.2026.1986940","title":"From gut education to central infiltration: microbiota-driven immune trafficking along the gut-brain axis","display_name":"From gut education to central infiltration: microbiota-driven immune trafficking along the gut-brain axis","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225412934","doi":"https://doi.org/10.3389/fmicb.2026.1986940"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1986940","doi":"https://doi.org/10.3389/fmicb.2026.1986940","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1986940","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1986940/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1986940/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055357094","display_name":"Carolina E. Prado","orcid":"https://orcid.org/0000-0001-7015-9058","observed_orcids":["https://orcid.org/0000-0001-7015-9058"]},"institutions":[{"id":"https://openalex.org/I3124150290","display_name":"Universidad San Sebasti\u00e1n","ror":"https://ror.org/04jrwm652","country_code":"CL","type":"education","lineage":["https://openalex.org/I3124150290"]},{"id":"https://openalex.org/I4210108487","display_name":"Fundaci\u00f3n Ciencia and Vida","ror":"https://ror.org/01p6hjg61","country_code":"CL","type":"nonprofit","lineage":["https://openalex.org/I4210108487"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Carolina Prado","raw_affiliation_strings":["Facultad de Medicina, Universidad San Sebasti\u00e1n","Laboratorio de Neuroinmunolog\u00eda, Centro Cient\u00edfico y Tecnol\u00f3gico de Excelencia Ciencia & Vida, Fundaci\u00f3n Ciencia & Vida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Medicina, Universidad San Sebasti\u00e1n","institution_ids":["https://openalex.org/I3124150290"]},{"raw_affiliation_string":"Laboratorio de Neuroinmunolog\u00eda, Centro Cient\u00edfico y Tecnol\u00f3gico de Excelencia Ciencia & Vida, Fundaci\u00f3n Ciencia & Vida","institution_ids":["https://openalex.org/I4210108487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161069793","display_name":"Daniel Hevia-Maga\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113179","display_name":"Finis Terrae University","ror":"https://ror.org/0225snd59","country_code":"CL","type":"education","lineage":["https://openalex.org/I4210113179"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Daniel Hevia-Maga\u00f1a","raw_affiliation_strings":["Escuela de Odontolog\u00eda, Facultad de Medicina y Salud, Universidad Finis Terrae, Providencia","Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Salud de la, Facultad de Medicina y Salud, Universidad Finis Terrae"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Odontolog\u00eda, Facultad de Medicina y Salud, Universidad Finis Terrae, Providencia","institution_ids":["https://openalex.org/I4210113179"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Salud de la, Facultad de Medicina y Salud, Universidad Finis Terrae","institution_ids":["https://openalex.org/I4210113179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055357094"],"corresponding_institution_ids":["https://openalex.org/I3124150290","https://openalex.org/I4210108487"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.7803000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.1527000069618225,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6610000133514404},{"id":"https://openalex.org/keywords/immune-cell-trafficking","display_name":"immune cell trafficking","score":0.6700000166893005},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5960000157356262},{"id":"https://openalex.org/keywords/gut-associated-lymphoid-tissue","display_name":"gut-associated lymphoid tissue","score":0.7950000166893005},{"id":"https://openalex.org/keywords/commensal-colonization","display_name":"commensal colonization","score":0.6449999809265137},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9120000004768372},{"id":"https://openalex.org/keywords/mucosal-barrier-disruption","display_name":"mucosal barrier disruption","score":0.6930000185966492},{"id":"https://openalex.org/keywords/pathobionts","display_name":"pathobionts","score":0.7630000114440918},{"id":"https://openalex.org/keywords/immune-privilege","display_name":"immune privilege","score":0.492000013589859},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.5960000157356262},{"id":"https://openalex.org/keywords/immune-cell-homing","display_name":"immune cell homing","score":0.5770000219345093},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8202999830245972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7382000088691711},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5490999817848206},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5187000036239624},{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.5049999952316284},{"id":"https://openalex.org/C2781185574","wikidata":"https://www.wikidata.org/wiki/Q3404271","display_name":"Immune privilege","level":3,"score":0.49889999628067017},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4593000113964081},{"id":"https://openalex.org/C2778719978","wikidata":"https://www.wikidata.org/wiki/Q6931261","display_name":"Mucosal immunology","level":4,"score":0.44780001044273376},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4336000084877014},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4307999908924103},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.4146000146865845},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.4049000144004822},{"id":"https://openalex.org/C201934248","wikidata":"https://www.wikidata.org/wiki/Q2492999","display_name":"Neuroimmunology","level":3,"score":0.4036000072956085},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4016999900341034},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.39419999718666077},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3935000002384186},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.373199999332428},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.3621000051498413},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.35260000824928284},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.3465999960899353},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3447999954223633},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.33410000801086426},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C2910341952","wikidata":"https://www.wikidata.org/wiki/Q570425","display_name":"Leukocyte Trafficking","level":4,"score":0.2623000144958496},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.2547999918460846},{"id":"https://openalex.org/C12387725","wikidata":"https://www.wikidata.org/wiki/Q937024","display_name":"Phenocopy","level":4,"score":0.2540999948978424}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmicb.2026.1986940","doi":"https://doi.org/10.3389/fmicb.2026.1986940","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1986940","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1986940/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:58d4e5eca48048689c773f1c6baffcda","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/58d4e5eca48048689c773f1c6baffcda","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1986940","doi":"https://doi.org/10.3389/fmicb.2026.1986940","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1986940","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1986940/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4345195815","display_name":"ROLE OF MICROBIOTA IN THE TRAFFICKING OF INTESTINAL IMMUNE CELLS INTO THE CNS IN HOMEOSTASIS AND DISEASE","funder_award_id":"1250646","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G8723814092","display_name":"CENTRO CIENTIFICO TECNOLOGICO DE EXCELENCIA CIENCIA & VIDA (CIENCIA & VIDA)","funder_award_id":"FB210008","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"}],"funders":[{"id":"https://openalex.org/F4320331146","display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","ror":"https://ror.org/05btm5233"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225412934.pdf","grobid_xml":"https://content.openalex.org/works/W7225412934.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1941562583","https://openalex.org/W1972691065","https://openalex.org/W1981266729","https://openalex.org/W2003342633","https://openalex.org/W2035421462","https://openalex.org/W2048469790","https://openalex.org/W2060185417","https://openalex.org/W2077059405","https://openalex.org/W2078653493","https://openalex.org/W2109113634","https://openalex.org/W2116286418","https://openalex.org/W2116959117","https://openalex.org/W2151626967","https://openalex.org/W2152529866","https://openalex.org/W2152730481","https://openalex.org/W2156372979","https://openalex.org/W2317145780","https://openalex.org/W2332044667","https://openalex.org/W2460079419","https://openalex.org/W2508310112","https://openalex.org/W2552808209","https://openalex.org/W2604241462","https://openalex.org/W2620042743","https://openalex.org/W2740887538","https://openalex.org/W2746835184","https://openalex.org/W2761210275","https://openalex.org/W2887737208","https://openalex.org/W2979366073","https://openalex.org/W2980067756","https://openalex.org/W3030972254","https://openalex.org/W3096212954","https://openalex.org/W3101876475","https://openalex.org/W3118771939","https://openalex.org/W3125753820","https://openalex.org/W3162058804","https://openalex.org/W3162691867","https://openalex.org/W3189796186","https://openalex.org/W4200050535","https://openalex.org/W4210878489","https://openalex.org/W4297264322","https://openalex.org/W4379056278","https://openalex.org/W4388824477","https://openalex.org/W4390604086","https://openalex.org/W4392965757","https://openalex.org/W4403925072","https://openalex.org/W4407831426","https://openalex.org/W4409327816","https://openalex.org/W4410034576","https://openalex.org/W4410817471","https://openalex.org/W4411050271","https://openalex.org/W4412806701","https://openalex.org/W4417447533","https://openalex.org/W7125973762"],"related_works":["https://openalex.org/W2996563996","https://openalex.org/W7203942085","https://openalex.org/W7202260294","https://openalex.org/W1761622267","https://openalex.org/W957361424","https://openalex.org/W4405000375","https://openalex.org/W2572551054","https://openalex.org/W3127151710","https://openalex.org/W6948057024","https://openalex.org/W2805575149"],"abstract_inverted_index":{"The":[0],"classical":[1],"paradigm":[2],"of":[3,118,142],"central":[4,119,166,200,215],"nervous":[5],"system":[6],"(CNS)":[7],"immune":[8,32,55,74,89,175],"privilege":[9],"has":[10,25],"evolved":[11],"toward":[12],"recognizing":[13],"a":[14,30,39,48,103],"dynamic,":[15],"multi-organ":[16],"neuroimmune":[17],"axis.":[18],"In":[19,106],"recent":[20],"years,":[21],"the":[22,43,58,93,100,115,171],"gastrointestinal":[23,44],"tract":[24],"been":[26],"widely":[27],"recognized":[28],"as":[29,38,47],"major":[31],"reservoir,":[33],"where":[34,124],"rather":[35],"than":[36],"functioning":[37],"localized":[40],"physical":[41],"barrier,":[42],"mucosa":[45,94],"acts":[46],"vital":[49],"educational":[50],"center":[51],"that":[52,164],"instructs":[53],"systemic":[54],"responses.":[56],"Within":[57],"gut-associated":[59],"lymphoid":[60],"tissue,":[61],"dietary":[62],"inputs,":[63],"microbial":[64],"metabolites,":[65],"and":[66,72,80,122,134,147,183,205,230],"commensal":[67],"colonization":[68],"imprint":[69],"intestinal":[70,212],"adaptive":[71],"innate":[73],"cells":[75,90,158,176],"with":[76,99],"distinct":[77],"functional":[78],"phenotypes":[79],"migratory":[81],"signatures.":[82],"Through":[83],"coordinated":[84],"molecular":[85],"mechanisms,":[86],"these":[87,173],"gut-educated":[88,194],"egress":[91],"from":[92],"to":[95,179,199,202,214],"reach":[96],"distant":[97],"sites,":[98],"CNS":[101],"representing":[102],"critical":[104],"destination.":[105],"experimental":[107],"models,":[108,228],"under":[109],"homeostatic":[110],"conditions,":[111],"gut-derived":[112],"signals":[113],"direct":[114],"physiological":[116],"seeding":[117],"border":[120],"zones":[121],"parenchyma,":[123],"specialized":[125],"populations":[126,195],"maintain":[127],"baseline":[128],"tissue":[129],"surveillance,":[130],"reinforce":[131],"barrier":[132,149],"integrity,":[133],"calibrate":[135],"neurodevelopmental":[136],"behaviors.":[137],"Conversely,":[138],"pathobiont":[139],"expansion,":[140],"loss":[141],"short-chain":[143],"fatty":[144],"acid-producing":[145],"commensals,":[146],"mucosal":[148],"disruption":[150],"predominantly":[151],"promote":[152],"pathogenic":[153],"gut":[154,174],"priming,":[155],"transforming":[156],"gut-resident":[157],"into":[159],"autoreactive":[160],"or":[161],"pro-inflammatory":[162],"effectors":[163],"breach":[165],"neurovascular":[167],"borders.":[168],"Once":[169],"inside":[170],"CNS,":[172],"can":[177],"contribute":[178],"neurodegeneration,":[180],"ischemic":[181],"injury,":[182],"neuroinflammatory":[184,243],"pathology.":[185,244],"However,":[186],"this":[187,210],"migration":[188],"is":[189],"not":[190],"always":[191],"destructive;":[192],"specific":[193],"are":[196],"simultaneously":[197],"deployed":[198],"boundaries":[201],"execute":[203],"anti-inflammatory":[204],"counter-regulatory":[206],"protection.":[207],"By":[208],"tracing":[209],"microbiota-driven":[211],"priming":[213],"infiltration,":[216],"we":[217],"highlight":[218],"shared":[219],"homing":[220],"mechanisms":[221],"identified":[222],"mainly":[223],"in":[224,237,241],"preclinical":[225],"models":[226],"(mouse":[227],"germ-free":[229],"photoconvertible":[231],"animals),":[232],"while":[233],"outlining":[234],"translational":[235],"challenges":[236],"establishing":[238],"their":[239],"role":[240],"human":[242]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}