{"id":"https://openalex.org/W7225412490","doi":"https://doi.org/10.64898/2026.11.04.764247","title":"Dopamine synthesis capacity and tau pathology differentially modulate rest-to-task functional network dynamics","display_name":"Dopamine synthesis capacity and tau pathology differentially modulate rest-to-task functional network dynamics","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225412490","doi":"https://doi.org/10.64898/2026.11.04.764247"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.764247","doi":"https://doi.org/10.64898/2026.11.04.764247","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764247","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764247.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764247.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081255070","display_name":"Thomas Morin","orcid":"https://orcid.org/0000-0003-4120-0669","observed_orcids":["https://orcid.org/0000-0003-4120-0669"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M Morin","raw_affiliation_strings":["Massachusetts General Hospital;"],"raw_orcid":"https://orcid.org/0000-0003-4120-0669","affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077824717","display_name":"Hsiang-Yu Chen","orcid":"https://orcid.org/0000-0003-2531-536X","observed_orcids":["https://orcid.org/0000-0003-2531-536X"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsiang-Yu Chen","raw_affiliation_strings":["Brandeis University;"],"raw_orcid":"https://orcid.org/0000-0003-2531-536X","affiliations":[{"raw_affiliation_string":"Brandeis University;","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119494122","display_name":"Shaian Aghasoltan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaian Aghasoltan","raw_affiliation_strings":["Brandeis University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brandeis University;","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011348808","display_name":"Ming Hsu","orcid":"https://orcid.org/0000-0001-7195-3579","observed_orcids":["https://orcid.org/0000-0001-7195-3579"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming M Hsu","raw_affiliation_strings":["University of California, Berkeley"],"raw_orcid":"https://orcid.org/0000-0001-7195-3579","affiliations":[{"raw_affiliation_string":"University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061269385","display_name":"William J. Jagust","orcid":"https://orcid.org/0000-0002-4458-113X","observed_orcids":["https://orcid.org/0000-0002-4458-113X"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J Jagust","raw_affiliation_strings":["University of California, Berkeley"],"raw_orcid":"https://orcid.org/0000-0002-4458-113X","affiliations":[{"raw_affiliation_string":"University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064410653","display_name":"Anne S. Berry","orcid":"https://orcid.org/0000-0002-5086-3643","observed_orcids":["https://orcid.org/0000-0002-5086-3643"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne S Berry","raw_affiliation_strings":["Brandeis University;"],"raw_orcid":"https://orcid.org/0000-0002-5086-3643","affiliations":[{"raw_affiliation_string":"Brandeis University;","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064410653"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-synthesis-capacity","display_name":"dopamine synthesis capacity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.9359999895095825},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7649999856948853},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.902999997138977},{"id":"https://openalex.org/keywords/network-segregation","display_name":"network segregation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/network-stability","display_name":"network stability","score":0.902999997138977},{"id":"https://openalex.org/keywords/subsequent-memory","display_name":"subsequent memory","score":0.718999981880188},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ventral-striatum","display_name":"ventral striatum","score":0.8479999899864197},{"id":"https://openalex.org/keywords/18f-flortaucipir","display_name":"18F-flortaucipir","score":0.972000002861023},{"id":"https://openalex.org/keywords/11c-pittsburgh-compound-b","display_name":"11C-Pittsburgh compound B","score":0.8489999771118164},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7684999704360962},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6962000131607056},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6100000143051147},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5561000108718872},{"id":"https://openalex.org/C123757187","wikidata":"https://www.wikidata.org/wiki/Q9195957","display_name":"Network dynamics","level":2,"score":0.47589999437332153},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.43470001220703125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40700000524520874},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.38850000500679016},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.3619999885559082},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.35740000009536743},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C2983526489","wikidata":"https://www.wikidata.org/wiki/Q133500","display_name":"Associative learning","level":2,"score":0.32260000705718994},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.30219998955726624},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.3018999993801117},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.290800005197525},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28029999136924744},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C2779632907","wikidata":"https://www.wikidata.org/wiki/Q13444883","display_name":"Brain Structure and Function","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C101812284","wikidata":"https://www.wikidata.org/wiki/Q2450135","display_name":"Functional integration","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.2567000091075897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.764247","doi":"https://doi.org/10.64898/2026.11.04.764247","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764247","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764247.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.764247","doi":"https://doi.org/10.64898/2026.11.04.764247","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764247","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764247.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G7577060618","display_name":null,"funder_award_id":"BCS-0821855","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G7970753604","display_name":"MRI: Acquisition of a Siemens MAGNETOM Trio A Tim System","funder_award_id":"0821855","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000028254","display_name":null,"funder_award_id":"AG058748","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320310045","display_name":"BioClinica","ror":"https://ror.org/03t95yr58"},{"id":"https://openalex.org/F4320329568","display_name":"Grifols","ror":"https://ror.org/02ed64f32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320333592","display_name":"Avid Radiopharmaceuticals","ror":"https://ror.org/00szax507"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225412490.pdf","grobid_xml":"https://content.openalex.org/works/W7225412490.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1847168837","https://openalex.org/W1992381398","https://openalex.org/W2061662249","https://openalex.org/W2063017390","https://openalex.org/W2063418424","https://openalex.org/W2063435176","https://openalex.org/W2071951947","https://openalex.org/W2090495290","https://openalex.org/W2134174619","https://openalex.org/W2155925016","https://openalex.org/W2174753847","https://openalex.org/W2290598353","https://openalex.org/W2409112471","https://openalex.org/W2515282049","https://openalex.org/W2518624331","https://openalex.org/W2526529257","https://openalex.org/W2530046647","https://openalex.org/W2538764405","https://openalex.org/W2557390385","https://openalex.org/W2568463955","https://openalex.org/W2587755247","https://openalex.org/W2595643095","https://openalex.org/W2600090485","https://openalex.org/W2605370253","https://openalex.org/W2612528709","https://openalex.org/W2744354842","https://openalex.org/W2752480938","https://openalex.org/W2765181675","https://openalex.org/W2798089108","https://openalex.org/W2802442632","https://openalex.org/W2920611415","https://openalex.org/W2922301421","https://openalex.org/W2951583631","https://openalex.org/W2951617899","https://openalex.org/W2971637931","https://openalex.org/W2978074800","https://openalex.org/W3000313970","https://openalex.org/W3014686944","https://openalex.org/W3030476832","https://openalex.org/W3128043020","https://openalex.org/W3134233425","https://openalex.org/W3159931622","https://openalex.org/W3164613595","https://openalex.org/W3172751851","https://openalex.org/W3212303334","https://openalex.org/W4206601274","https://openalex.org/W4226101178","https://openalex.org/W4229052269","https://openalex.org/W4283832958","https://openalex.org/W4285707174","https://openalex.org/W4298127218","https://openalex.org/W4307494802","https://openalex.org/W4365514961","https://openalex.org/W4386157156","https://openalex.org/W4392089930","https://openalex.org/W4411067545","https://openalex.org/W4411449236","https://openalex.org/W4416055446","https://openalex.org/W7125519553"],"related_works":["https://openalex.org/W4386022299","https://openalex.org/W4206287204","https://openalex.org/W7125519553","https://openalex.org/W3112970757","https://openalex.org/W4380987027","https://openalex.org/W4295681301","https://openalex.org/W2150374285","https://openalex.org/W2944128766","https://openalex.org/W2803655157","https://openalex.org/W2547697407"],"abstract_inverted_index":{"Optimal":[0],"cognition":[1],"relies":[2],"on":[3,45,188],"large-scale":[4,177],"functional":[5],"brain":[6,32,46],"networks":[7,143],"which":[8],"balance":[9],"segregation":[10,100,127,175],"at":[11],"rest":[12],"with":[13,103,138,169],"selective":[14],"integration":[15],"during":[16,128],"task":[17],"performance.":[18],"In":[19,160],"aging,":[20],"these":[21],"network":[22,47,95,99,116,174,190],"dynamics":[23],"are":[24],"altered.":[25],"We":[26],"examined":[27],"two":[28],"prominent":[29],"features":[30],"of":[31,64,173,184,195],"aging:":[33],"dysregulated":[34],"dopamine":[35,65,133,185],"function":[36],"and":[37,51,58,61,86,97,118,121,155,186,198],"Alzheimer's":[38],"disease":[39],"(AD)-related":[40],"pathology":[41],"to":[42,108],"examine":[43],"impacts":[44],"dynamics.":[48],"Young":[49],"adults":[50,55,72,113,124,154],"cognitively":[52],"unimpaired":[53],"older":[54,112,123,153,162],"completed":[56],"resting-state":[57],"task-based":[59],"fMRI":[60],"PET":[62],"imaging":[63],"synthesis":[66,134],"capacity":[67,135],"([":[68,90],"18":[69,91],"F]fluoro-m-L-tyrosine).":[70],"Older":[71],"were":[73,101],"classified":[74],"as":[75],"\u03b2-amyloid":[76],"negative/positive":[77],"using":[78],"[":[79],"11":[80],"C]Pittsburgh":[81],"Compound-B":[82],"PET(PiB-":[83],"or":[84],"PiB+)":[85],"underwent":[87],"tau-PET":[88],"scanning":[89],"F]flortaucipir).":[92],"Greater":[93],"rest-to-task":[94,189],"stability":[96,117,140],"task-related":[98],"associated":[102,137,168],"better":[104],"subsequent":[105],"memory.":[106],"Compared":[107],"young":[109,145],"adults,":[110,146,163],"PiB+":[111,120,158,161],"showed":[114,125],"reduced":[115,126],"both":[119],"PiB-":[122],"rest.":[129],"Higher":[130],"ventral":[131],"striatal":[132],"was":[136,150,167],"greater":[139],"within":[141],"associative":[142],"in":[144,152,157,201],"but":[147],"this":[148],"relationship":[149],"attenuated":[151],"absent":[156],"participants.":[159],"higher":[164],"tau":[165,187],"burden":[166],"a":[170],"task-induced":[171],"collapse":[172],"across":[176],"networks.":[178],"These":[179],"findings":[180],"reveal":[181],"dissociable":[182],"influences":[183],"organization,":[191],"highlighting":[192],"the":[193],"value":[194],"integrating":[196],"neuromodulatory":[197],"pathological":[199],"markers":[200],"aging":[202],"research.":[203]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
