{"id":"https://openalex.org/W7225411148","doi":"https://doi.org/10.35378/gujs.1911521","title":"Phytochemical Profiling and Biological Activities of Mitragyna speciosa Leaf Extracts: Antioxidant and \u03b1-Glucosidase Inhibitory Activities","display_name":"Phytochemical Profiling and Biological Activities of Mitragyna speciosa Leaf Extracts: Antioxidant and \u03b1-Glucosidase Inhibitory Activities","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225411148","doi":"https://doi.org/10.35378/gujs.1911521"},"language":"en","primary_location":{"id":"doi:10.35378/gujs.1911521","doi":"https://doi.org/10.35378/gujs.1911521","is_oa":true,"landing_page_url":"https://doi.org/10.35378/gujs.1911521","pdf_url":"https://dergipark.org.tr/en/download/article-file/5823271","source":{"id":"https://openalex.org/S4210223673","display_name":"GAZI UNIVERSITY JOURNAL OF SCIENCE","issn_l":"1303-9709","issn":["1303-9709","2147-1762"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GAZI UNIVERSITY JOURNAL OF SCIENCE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/5823271","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035421345","display_name":"Teni Ernawati","orcid":"https://orcid.org/0000-0003-2235-8591","observed_orcids":["https://orcid.org/0000-0003-2235-8591"]},"institutions":[{"id":"https://openalex.org/I4387154144","display_name":"National Research and Innovation Agency","ror":"https://ror.org/02hmjzt55","country_code":"ID","type":"government","lineage":["https://openalex.org/I4387154144"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Teni Ernawati","raw_affiliation_strings":["National Research and Innovation Agency of Republic Indonesia (BRIN)"],"raw_orcid":"https://orcid.org/0000-0003-2235-8591","affiliations":[{"raw_affiliation_string":"National Research and Innovation Agency of Republic Indonesia (BRIN)","institution_ids":["https://openalex.org/I4387154144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060214928","display_name":"Fera Kurniadewi","orcid":"https://orcid.org/0000-0002-3541-8103","observed_orcids":["https://orcid.org/0000-0002-3541-8103"]},"institutions":[{"id":"https://openalex.org/I3133421993","display_name":"State University of Jakarta","ror":"https://ror.org/01hgg7b81","country_code":"ID","type":"education","lineage":["https://openalex.org/I3133421993"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Fera Kurniadewi","raw_affiliation_strings":["Universitas negeri Jakarta"],"raw_orcid":"https://orcid.org/0000-0002-3541-8103","affiliations":[{"raw_affiliation_string":"Universitas negeri Jakarta","institution_ids":["https://openalex.org/I3133421993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160996152","display_name":"Elvernita June","orcid":"https://orcid.org/0009-0009-0040-0702","observed_orcids":["https://orcid.org/0009-0009-0040-0702"]},"institutions":[{"id":"https://openalex.org/I3133421993","display_name":"State University of Jakarta","ror":"https://ror.org/01hgg7b81","country_code":"ID","type":"education","lineage":["https://openalex.org/I3133421993"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Elvernita June","raw_affiliation_strings":["Universitas negeri Jakarta"],"raw_orcid":"https://orcid.org/0009-0009-0040-0702","affiliations":[{"raw_affiliation_string":"Universitas negeri Jakarta","institution_ids":["https://openalex.org/I3133421993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161054023","display_name":"Mahardhika Kurniaputra","orcid":"https://orcid.org/0009-0005-9777-142X","observed_orcids":["https://orcid.org/0009-0005-9777-142X"]},"institutions":[{"id":"https://openalex.org/I3133421993","display_name":"State University of Jakarta","ror":"https://ror.org/01hgg7b81","country_code":"ID","type":"education","lineage":["https://openalex.org/I3133421993"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mahardhika Kurniaputra","raw_affiliation_strings":["Universitas negeri Jakarta"],"raw_orcid":"https://orcid.org/0009-0005-9777-142X","affiliations":[{"raw_affiliation_string":"Universitas negeri Jakarta","institution_ids":["https://openalex.org/I3133421993"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101840257","display_name":"Minarti Minarti","orcid":"https://orcid.org/0000-0003-0331-7444","observed_orcids":["https://orcid.org/0000-0003-0331-7444","https://orcid.org/0000-0002-9104-824X"]},"institutions":[{"id":"https://openalex.org/I3133421993","display_name":"State University of Jakarta","ror":"https://ror.org/01hgg7b81","country_code":"ID","type":"education","lineage":["https://openalex.org/I3133421993"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Minarti Minarti","raw_affiliation_strings":["Universitas negeri Jakarta"],"raw_orcid":"https://orcid.org/0000-0002-9104-824X","affiliations":[{"raw_affiliation_string":"Universitas negeri Jakarta","institution_ids":["https://openalex.org/I3133421993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109416046","display_name":"Francis Xavier","orcid":"https://orcid.org/0009-0001-3025-2749","observed_orcids":["https://orcid.org/0009-0001-3025-2749"]},"institutions":[{"id":"https://openalex.org/I3129280579","display_name":"Pancasila University","ror":"https://ror.org/0062tve42","country_code":"ID","type":"education","lineage":["https://openalex.org/I3129280579"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Francis Xavier","raw_affiliation_strings":["Universitas Pancasila"],"raw_orcid":"https://orcid.org/0009-0001-3025-2749","affiliations":[{"raw_affiliation_string":"Universitas Pancasila","institution_ids":["https://openalex.org/I3129280579"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035421345"],"corresponding_institution_ids":["https://openalex.org/I4387154144"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"Advanced Online Publication","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1404000073671341,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kratom","display_name":"Mitragyna speciosa","score":1.0},{"id":"https://openalex.org/keywords/kopi-luwak","display_name":"kopi luwak","score":0.6990000009536743},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.6700000166893005},{"id":"https://openalex.org/keywords/phytochemical-profiling","display_name":"phytochemical profiling","score":0.9309999942779541},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":0.9869999885559082},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7179999947547913},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.996999979019165},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anticancer-potential","display_name":"anticancer potential","score":0.7279999852180481},{"id":"https://openalex.org/keywords/yohimbine","display_name":"yohimbine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/estrogen-receptor-binding","display_name":"estrogen receptor binding","score":0.8299999833106995},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2781031786","wikidata":"https://www.wikidata.org/wiki/Q287582","display_name":"ABTS","level":4,"score":0.8079000115394592},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.7817000150680542},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7738000154495239},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.7401999831199646},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.737500011920929},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.7324000000953674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6948999762535095},{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.5741999745368958},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5627999901771545},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.4878999888896942},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.39969998598098755},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.3515999913215637},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.3343000113964081},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3231000006198883},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3050000071525574},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C2776292868","wikidata":"https://www.wikidata.org/wiki/Q424525","display_name":"Flavones","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.2879999876022339},{"id":"https://openalex.org/C2777728882","wikidata":"https://www.wikidata.org/wiki/Q407142","display_name":"Phenols","level":2,"score":0.2599000036716461}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.35378/gujs.1911521","doi":"https://doi.org/10.35378/gujs.1911521","is_oa":true,"landing_page_url":"https://doi.org/10.35378/gujs.1911521","pdf_url":"https://dergipark.org.tr/en/download/article-file/5823271","source":{"id":"https://openalex.org/S4210223673","display_name":"GAZI UNIVERSITY JOURNAL OF SCIENCE","issn_l":"1303-9709","issn":["1303-9709","2147-1762"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GAZI UNIVERSITY JOURNAL OF SCIENCE","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.35378/gujs.1911521","doi":"https://doi.org/10.35378/gujs.1911521","is_oa":true,"landing_page_url":"https://doi.org/10.35378/gujs.1911521","pdf_url":"https://dergipark.org.tr/en/download/article-file/5823271","source":{"id":"https://openalex.org/S4210223673","display_name":"GAZI UNIVERSITY JOURNAL OF SCIENCE","issn_l":"1303-9709","issn":["1303-9709","2147-1762"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","poland-20","russia-white-list-3","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GAZI UNIVERSITY JOURNAL OF SCIENCE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319804","display_name":"Badan Riset dan Inovasi Nasional","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225411148.pdf","grobid_xml":"https://content.openalex.org/works/W7225411148.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1990064402","https://openalex.org/W2048553024","https://openalex.org/W2129176513","https://openalex.org/W2162189097","https://openalex.org/W2168149223","https://openalex.org/W2774743973","https://openalex.org/W2791517164","https://openalex.org/W2885261856","https://openalex.org/W2888689266","https://openalex.org/W2963381019","https://openalex.org/W3011830770","https://openalex.org/W3089772362","https://openalex.org/W3110622041","https://openalex.org/W3110772142","https://openalex.org/W3184075740","https://openalex.org/W4210714819","https://openalex.org/W4221111611","https://openalex.org/W4232382114","https://openalex.org/W4284959808","https://openalex.org/W4288424219","https://openalex.org/W4306399525","https://openalex.org/W4306925924","https://openalex.org/W4311263987","https://openalex.org/W4312172624","https://openalex.org/W4316254301","https://openalex.org/W4365455828","https://openalex.org/W4377116112","https://openalex.org/W4378375306","https://openalex.org/W4385802398","https://openalex.org/W4386574533","https://openalex.org/W4390848494","https://openalex.org/W4393130153","https://openalex.org/W4393130179","https://openalex.org/W4402730353","https://openalex.org/W4409537862"],"related_works":["https://openalex.org/W4352980980","https://openalex.org/W7115972777","https://openalex.org/W4407241104","https://openalex.org/W2162189097","https://openalex.org/W2992574716","https://openalex.org/W7161132008","https://openalex.org/W4323772094","https://openalex.org/W7165389334","https://openalex.org/W4394783872","https://openalex.org/W4237667564"],"abstract_inverted_index":{"Mitragyna":[0],"speciosa,":[1],"a":[2],"medicinal":[3],"plant":[4],"native":[5],"to":[6,220],"Southeast":[7],"Asia,":[8],"has":[9],"long":[10],"been":[11],"used":[12],"in":[13,28,31,122,229],"traditional":[14],"medicine":[15],"and":[16,30,45,49,56,58,68,80,110,125,138,144,155,170,210],"is":[17],"ethnopharmacologically":[18],"associated":[19,167],"with":[20,127,168],"maintaining":[21],"physical":[22],"stamina.":[23],"This":[24],"study":[25],"evaluated":[26],"the":[27,93,177,221],"vitro":[29],"silico":[32],"biological":[33],"activities":[34],"of":[35,131,148,218],"M.":[36],"speciosa":[37],"leaves,":[38],"focusing":[39],"on":[40],"antioxidant":[41,52,165],"potential,":[42],"\u03b1-glucosidase":[43,59,179],"inhibition,":[44],"anticancer":[46],"potential.":[47],"Phenolic":[48],"flavonoid":[50,95,171],"contents,":[51],"capacities":[53],"(DPPH,":[54],"FRAP,":[55],"ABTS),":[57],"inhibitory":[60,180],"activity":[61,119,166,181],"were":[62],"assessed.":[63],"The":[64,87,173],"methanol":[65,69],"extract":[66],"(ME)":[67],"fraction":[70,90,175],"(MF)":[71],"showed":[72],"comparable":[73],"total":[74],"phenolic":[75,169,208],"contents":[76],"(18.20":[77],"\u00b1":[78,82,98,106,113,133,136,140,150,153,157,185,198],"1.02":[79],"18.60":[81],"2.31":[83],"mg":[84,100,108,115],"GAE/g,":[85],"respectively).":[86],"ethyl":[88],"acetate":[89],"(EF)":[91],"had":[92],"highest":[94],"content":[96],"(146.16":[97],"6.82":[99],"QE/g),":[101],"followed":[102],"by":[103],"ME":[104],"(129.90":[105],"4.96":[107],"QE/g)":[109],"MF":[111],"(102.56":[112],"5.85":[114],"QE/g).":[116],"Strong":[117],"radical-scavenging":[118],"was":[120,190],"observed":[121],"ME,":[123],"MF,":[124],"EF,":[126],"DPPH":[128],"IC\u2085\u2080":[129,146],"values":[130,147],"10.62":[132],"0.38,":[134],"11.06":[135],"0.37,":[137],"14.04":[139],"1.30":[141],"\u00b5g/mL,":[142,159],"respectively,":[143],"ABTS":[145],"1.23":[149],"0.04,":[151,154],"3.91":[152],"5.19":[156],"1.92":[158],"respectively.":[160],"These":[161],"results":[162],"indicate":[163],"substantial":[164],"content.":[172],"hexane":[174],"exhibited":[176],"strongest":[178],"(IC\u2085\u2080":[182,195],"=":[183,196],"55.64":[184],"1.14":[186],"\u00b5g/mL),":[187],"although":[188],"it":[189],"less":[191],"potent":[192],"than":[193],"quercetin":[194],"1.25":[197],"0.17":[199],"\u00b5g/mL).":[200],"LC-HRMS":[201],"profiling":[202],"identified":[203],"12":[204],"metabolites,":[205],"including":[206],"alkaloids,":[207],"compounds,":[209],"flavonoids.":[211],"Molecular":[212],"docking":[213],"suggested":[214],"moderate":[215],"binding":[216],"affinity":[217],"yohimbine":[219],"estrogen":[222],"receptor":[223],"(3ERT),":[224],"warranting":[225],"further":[226],"mechanistic":[227],"investigation":[228],"cancer":[230],"cell":[231],"models.":[232]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}