{"id":"https://openalex.org/W7225409645","doi":"https://doi.org/10.64898/2026.11.03.26367178","title":"Multi-Modal Wearable and Biological Data Integration Reveals Physiological Signatures of Weight Variation in Overweight and Obese Adults: An AI4Food Machine Learning Study","display_name":"Multi-Modal Wearable and Biological Data Integration Reveals Physiological Signatures of Weight Variation in Overweight and Obese Adults: An AI4Food Machine Learning Study","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225409645","doi":"https://doi.org/10.64898/2026.11.03.26367178"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.03.26367178","doi":"https://doi.org/10.64898/2026.11.03.26367178","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.26367178","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.03.26367178.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.03.26367178.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161105136","display_name":"Hicham Attioui","orcid":"https://orcid.org/0009-0005-3471-4479","observed_orcids":["https://orcid.org/0009-0005-3471-4479"]},"institutions":[{"id":"https://openalex.org/I4210119819","display_name":"Universit\u00e9 Mohammed VI des Sciences et de la Sant\u00e9","ror":"https://ror.org/01tezat55","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210119819"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hicham Attioui","raw_affiliation_strings":["Universite Mohammed VI des Sciences et de la Sante;"],"raw_orcid":"https://orcid.org/0009-0005-3471-4479","affiliations":[{"raw_affiliation_string":"Universite Mohammed VI des Sciences et de la Sante;","institution_ids":["https://openalex.org/I4210119819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058003700","display_name":"Blanca Lacruz-Pleguezuelos","orcid":"https://orcid.org/0000-0003-3786-7233","observed_orcids":["https://orcid.org/0000-0003-3786-7233"]},"institutions":[{"id":"https://openalex.org/I105140100","display_name":"Madrid Institute for Advanced Studies","ror":"https://ror.org/027pk6j83","country_code":"ES","type":"education","lineage":["https://openalex.org/I105140100"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Blanca Lacruz-Pleguezuelos","raw_affiliation_strings":["Computational Biology Group. IMDEA Nutrition Institute, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3786-7233","affiliations":[{"raw_affiliation_string":"Computational Biology Group. IMDEA Nutrition Institute, Madrid, Spain","institution_ids":["https://openalex.org/I105140100"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001919002","display_name":"Enrique Carrillo de Santa Pau","orcid":"https://orcid.org/0000-0002-2310-2267","observed_orcids":["https://orcid.org/0000-0002-2310-2267"]},"institutions":[{"id":"https://openalex.org/I105140100","display_name":"Madrid Institute for Advanced Studies","ror":"https://ror.org/027pk6j83","country_code":"ES","type":"education","lineage":["https://openalex.org/I105140100"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Enrique Carrillo de Santa Pau","raw_affiliation_strings":["Computational Biology Group. IMDEA Nutrition Institute, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2310-2267","affiliations":[{"raw_affiliation_string":"Computational Biology Group. IMDEA Nutrition Institute, Madrid, Spain","institution_ids":["https://openalex.org/I105140100"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001919002"],"corresponding_institution_ids":["https://openalex.org/I105140100"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.2087000012397766,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10010","display_name":"Obesity, Physical Activity, Diet","score":0.2087000012397766,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12279","display_name":"Body Composition Measurement Techniques","score":0.0722000002861023,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.06549999862909317,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/weight-variation","display_name":"weight variation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.7039999961853027},{"id":"https://openalex.org/keywords/wearable-sensors","display_name":"wearable sensors","score":0.7099999785423279},{"id":"https://openalex.org/keywords/glucose-monitoring","display_name":"glucose monitoring","score":0.45899999141693115},{"id":"https://openalex.org/keywords/skin-temperature","display_name":"skin temperature","score":0.7979999780654907},{"id":"https://openalex.org/keywords/thermoregulation","display_name":"thermoregulation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sleep","display_name":"sleep","score":0.6209999918937683},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9769999980926514},{"id":"https://openalex.org/keywords/metabolic-phenotypes","display_name":"metabolic phenotypes","score":0.7260000109672546},{"id":"https://openalex.org/keywords/personalized-nutrition","display_name":"personalized nutrition","score":0.9620000123977661},{"id":"https://openalex.org/keywords/food-diary","display_name":"food diary","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.6371999979019165},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6101999878883362},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.5565000176429749},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5266000032424927},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.48919999599456787},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4345000088214874},{"id":"https://openalex.org/C98108635","wikidata":"https://www.wikidata.org/wiki/Q6497275","display_name":"Phenomics","level":5,"score":0.4036000072956085},{"id":"https://openalex.org/C150594956","wikidata":"https://www.wikidata.org/wiki/Q1334829","display_name":"Wearable computer","level":2,"score":0.38760000467300415},{"id":"https://openalex.org/C54290928","wikidata":"https://www.wikidata.org/wiki/Q4845080","display_name":"Wearable technology","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.3321000039577484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3278000056743622},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3269999921321869},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2786000072956085},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.2782000005245209},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2759000062942505},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C2777334680","wikidata":"https://www.wikidata.org/wiki/Q1607611","display_name":"Nocturnal","level":2,"score":0.26809999346733093}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.03.26367178","doi":"https://doi.org/10.64898/2026.11.03.26367178","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.26367178","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.03.26367178.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.03.26367178","doi":"https://doi.org/10.64898/2026.11.03.26367178","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.26367178","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/06/2026.11.03.26367178.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1333236036","display_name":null,"funder_award_id":"5696/2024","funder_id":"https://openalex.org/F4320313831","funder_display_name":"Comunidad de Madrid"},{"id":"https://openalex.org/G638709848","display_name":null,"funder_award_id":"TEC\u20102024","funder_id":"https://openalex.org/F4320313831","funder_display_name":"Comunidad de Madrid"}],"funders":[{"id":"https://openalex.org/F4320313831","display_name":"Comunidad de Madrid","ror":null},{"id":"https://openalex.org/F4320322755","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225409645.pdf","grobid_xml":"https://content.openalex.org/works/W7225409645.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4416023748"],"related_works":["https://openalex.org/W4391539205","https://openalex.org/W4403662003","https://openalex.org/W7141030647","https://openalex.org/W7223781451","https://openalex.org/W4403816731","https://openalex.org/W4414429146","https://openalex.org/W4408328527","https://openalex.org/W7125743428","https://openalex.org/W4393947467","https://openalex.org/W4384661213"],"abstract_inverted_index":{"This":[0],"study":[1],"is":[2],"part":[3],"of":[4,28,143,182,185],"the":[5,12,108,161,173,180],"AI4Food":[6],"project,":[7],"which":[8],"aims":[9],"to":[10,94,99,190],"identify":[11],"physiological":[13,96],"and":[14,22,51,72,79,88,130,147,156,187,194],"behavioral":[15],"factors":[16],"influencing":[17],"weight":[18,100,105,131],"variation":[19],"in":[20,111,199],"overweight":[21],"obese":[23],"individuals":[24],"through":[25],"integrative":[26],"analysis":[27],"multi-source":[29],"data.":[30],"A":[31],"30-day":[32],"crossover":[33],"intervention":[34,82,175],"was":[35],"conducted":[36],"on":[37],"93":[38],"participants":[39],"at":[40],"IMDEA":[41],"Nutrition":[42],"Institute,":[43],"combining":[44],"a":[45,52],"traditional":[46],"phase":[47,54,110],"(questionnaires,":[48],"food":[49],"diaries)":[50],"digital":[53,109],"(Fitbit":[55],"Sense":[56],"Smartwatch,":[57],"FreeStyle":[58],"Libre":[59],"2":[60],"glucose":[61,150],"sensor).":[62],"The":[63],"collected":[64],"data":[65,189],"encompassed":[66],"sleep,":[67],"glucose,":[68],"skin":[69,128],"temperature,":[70,129],"nutrition,":[71],"gut":[73],"microbiome":[74,167],"information.":[75],"After":[76],"rigorous":[77],"preprocessing":[78],"alignment":[80],"by":[81],"days,":[83],"unsupervised":[84],"clustering,":[85],"association":[86],"analysis,":[87],"machine":[89],"learning":[90],"models":[91,139],"were":[92,117,122],"applied":[93],"uncover":[95],"patterns":[97],"linked":[98],"dynamics.":[101],"Results":[102],"showed":[103],"greater":[104],"reduction":[106],"during":[107],"Group":[112],"2,":[113],"while":[114],"between-group":[115],"differences":[116],"not":[118],"significant.":[119],"Significant":[120],"associations":[121],"observed":[123],"between":[124],"nocturnal":[125,157],"respiratory":[126,158],"rate,":[127],"variation.":[132],"Under":[133],"participant-level":[134],"five-fold":[135],"cross-validation,":[136],"Random":[137],"Forest":[138],"achieved":[140],"mean":[141],"accuracies":[142],"64.3%":[144],"for":[145,149],"thermoregulation":[146],"61.7%":[148],"phenotype":[151],"prediction,":[152],"with":[153],"RMSSD,":[154],"restlessness,":[155],"rate":[159],"among":[160],"most":[162],"influential":[163],"predictors.":[164],"In":[165],"contrast,":[166],"composition":[168],"remained":[169],"almost":[170],"stable":[171],"over":[172],"short":[174],"period.":[176],"These":[177],"findings":[178],"support":[179],"potential":[181],"AI-driven":[183],"integration":[184],"wearable":[186],"nutritional":[188],"stratify":[191],"metabolic":[192],"phenotypes":[193],"advance":[195],"personalized":[196],"nutrition":[197],"strategies":[198],"obesity":[200],"management.":[201]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}