{"id":"https://openalex.org/W7225408259","doi":"https://doi.org/10.64898/2026.11.05.763689","title":"Charting the Structure and Functional Landscape of the SF3B1 Intrinsically Disordered Region","display_name":"Charting the Structure and Functional Landscape of the SF3B1 Intrinsically Disordered Region","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225408259","doi":"https://doi.org/10.64898/2026.11.05.763689"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.763689","doi":"https://doi.org/10.64898/2026.11.05.763689","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.763689","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.763689.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.763689.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117130442","display_name":"Silvia Oliveti","orcid":"https://orcid.org/0009-0002-1528-0853","observed_orcids":["https://orcid.org/0009-0002-1528-0853"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Oliveti","raw_affiliation_strings":["University of Florence;"],"raw_orcid":"https://orcid.org/0009-0002-1528-0853","affiliations":[{"raw_affiliation_string":"University of Florence;","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051383694","display_name":"Krishnendu Bera","orcid":"https://orcid.org/0000-0001-9966-5907","observed_orcids":["https://orcid.org/0000-0001-9966-5907"]},"institutions":[{"id":"https://openalex.org/I138549579","display_name":"Scuola Internazionale Superiore di Studi Avanzati","ror":"https://ror.org/004fze387","country_code":"IT","type":"education","lineage":["https://openalex.org/I138549579"]},{"id":"https://openalex.org/I4210101608","display_name":"Istituto Officina dei Materiali","ror":"https://ror.org/00yfw2296","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210101608","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Krishnendu Bera","raw_affiliation_strings":["CNR-IOM at SISSA;"],"raw_orcid":"https://orcid.org/0000-0001-9966-5907","affiliations":[{"raw_affiliation_string":"CNR-IOM at SISSA;","institution_ids":["https://openalex.org/I138549579","https://openalex.org/I4210101608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030741815","display_name":"Luisa M. R. Napolitano","orcid":"https://orcid.org/0009-0000-7866-9378","observed_orcids":["https://orcid.org/0009-0000-7866-9378","https://orcid.org/0000-0001-9214-7269"]},"institutions":[{"id":"https://openalex.org/I2802561039","display_name":"Elettra-Sincrotrone Trieste S.C.p.A.","ror":"https://ror.org/01c3rrh15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I2801626668","https://openalex.org/I2802561039"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisa MR Napolitano","raw_affiliation_strings":["Elettra-S.C.p.a.;"],"raw_orcid":"https://orcid.org/0009-0000-7866-9378","affiliations":[{"raw_affiliation_string":"Elettra-S.C.p.a.;","institution_ids":["https://openalex.org/I2802561039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053508895","display_name":"Melissa Ann Graewert","orcid":"https://orcid.org/0000-0001-7547-636X","observed_orcids":["https://orcid.org/0000-0001-7547-636X"]},"institutions":[{"id":"https://openalex.org/I4210138560","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/03mstc592","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melissa Graewert","raw_affiliation_strings":["European Molecular Biology Laboratory;"],"raw_orcid":"https://orcid.org/0000-0001-7547-636X","affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory;","institution_ids":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046425633","display_name":"Salvatore Di Marco","orcid":"https://orcid.org/0009-0000-0274-5805","observed_orcids":["https://orcid.org/0009-0000-0274-5805","https://orcid.org/0009-0008-5365-9446"]},"institutions":[{"id":"https://openalex.org/I138549579","display_name":"Scuola Internazionale Superiore di Studi Avanzati","ror":"https://ror.org/004fze387","country_code":"IT","type":"education","lineage":["https://openalex.org/I138549579"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Di Marco","raw_affiliation_strings":["Scuola Internazionale Superiore di Studi Avanzati (SISSA);"],"raw_orcid":"https://orcid.org/0009-0008-5365-9446","affiliations":[{"raw_affiliation_string":"Scuola Internazionale Superiore di Studi Avanzati (SISSA);","institution_ids":["https://openalex.org/I138549579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028254763","display_name":"Tommaso Staderini","orcid":"https://orcid.org/0000-0001-6993-4408","observed_orcids":["https://orcid.org/0000-0001-6993-4408"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Tommaso Staderini","raw_affiliation_strings":["University of Florence;"],"raw_orcid":"https://orcid.org/0000-0001-6993-4408","affiliations":[{"raw_affiliation_string":"University of Florence;","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091450180","display_name":"Bruno de Paula Oliveira Santos","orcid":"https://orcid.org/0000-0003-1854-8907","observed_orcids":["https://orcid.org/0000-0003-1854-8907"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno de Paula Oliveira Santos","raw_affiliation_strings":["UFMG;"],"raw_orcid":"https://orcid.org/0000-0003-1854-8907","affiliations":[{"raw_affiliation_string":"UFMG;","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067824121","display_name":"Luca Grisanti","orcid":"https://orcid.org/0000-0003-4311-4676","observed_orcids":["https://orcid.org/0000-0003-4311-4676"]},"institutions":[{"id":"https://openalex.org/I4210101608","display_name":"Istituto Officina dei Materiali","ror":"https://ror.org/00yfw2296","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210101608","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Grisanti","raw_affiliation_strings":["CNR-IOM;"],"raw_orcid":"https://orcid.org/0000-0003-4311-4676","affiliations":[{"raw_affiliation_string":"CNR-IOM;","institution_ids":["https://openalex.org/I4210101608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091239108","display_name":"Silvia Onesti","orcid":"https://orcid.org/0000-0002-0612-7948","observed_orcids":["https://orcid.org/0000-0002-0612-7948"]},"institutions":[{"id":"https://openalex.org/I2802561039","display_name":"Elettra-Sincrotrone Trieste S.C.p.A.","ror":"https://ror.org/01c3rrh15","country_code":"IT","type":"facility","lineage":["https://openalex.org/I2801626668","https://openalex.org/I2802561039"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Onesti","raw_affiliation_strings":["Elettra - Sincrotrone Trieste S.C.p.A"],"raw_orcid":"https://orcid.org/0000-0002-0612-7948","affiliations":[{"raw_affiliation_string":"Elettra - Sincrotrone Trieste S.C.p.A","institution_ids":["https://openalex.org/I2802561039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055129253","display_name":"Isabella C. Felli","orcid":"https://orcid.org/0000-0002-6018-9090","observed_orcids":["https://orcid.org/0000-0002-6018-9090"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Isabella C Felli","raw_affiliation_strings":["University of Florence;"],"raw_orcid":"https://orcid.org/0000-0002-6018-9090","affiliations":[{"raw_affiliation_string":"University of Florence;","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033448495","display_name":"Roberta Pierattelli","orcid":"https://orcid.org/0000-0001-7755-0885","observed_orcids":["https://orcid.org/0000-0001-7755-0885"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Pieratteli","raw_affiliation_strings":["University of Florence;"],"raw_orcid":"https://orcid.org/0000-0001-7755-0885","affiliations":[{"raw_affiliation_string":"University of Florence;","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029026743","display_name":"Alessandra Magistrato","orcid":"https://orcid.org/0000-0002-2003-1985","observed_orcids":["https://orcid.org/0000-0002-2003-1985"]},"institutions":[{"id":"https://openalex.org/I4210101608","display_name":"Istituto Officina dei Materiali","ror":"https://ror.org/00yfw2296","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210101608","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandra Magistrato","raw_affiliation_strings":["CNR-IOM;"],"raw_orcid":"https://orcid.org/0000-0002-2003-1985","affiliations":[{"raw_affiliation_string":"CNR-IOM;","institution_ids":["https://openalex.org/I4210101608"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5029026743"],"corresponding_institution_ids":["https://openalex.org/I4210101608"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.053199999034404755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sf3b1","display_name":"SF3B1","score":1.0},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.921999990940094},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.8840000033378601},{"id":"https://openalex.org/keywords/intramolecular-interactions","display_name":"intramolecular interactions","score":0.6779999732971191},{"id":"https://openalex.org/keywords/rna-binding","display_name":"RNA binding","score":0.6600000262260437},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7720000147819519},{"id":"https://openalex.org/keywords/conformational-landscape","display_name":"conformational landscape","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.663100004196167},{"id":"https://openalex.org/C119621388","wikidata":"https://www.wikidata.org/wiki/Q5377166","display_name":"Energy landscape","level":2,"score":0.4749999940395355},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4681999981403351},{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.43209999799728394},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4307999908924103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3944999873638153},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.382999986410141},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.37540000677108765},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.3752000033855438},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.37220001220703125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37139999866485596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3431999981403351},{"id":"https://openalex.org/C2777936996","wikidata":"https://www.wikidata.org/wiki/Q17148461","display_name":"Conformational ensembles","level":3,"score":0.33410000801086426},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.29440000653266907},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29260000586509705},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2745000123977661},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2533000111579895},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.2531999945640564},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.763689","doi":"https://doi.org/10.64898/2026.11.05.763689","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.763689","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.763689.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.763689","doi":"https://doi.org/10.64898/2026.11.05.763689","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.763689","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.763689.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1252718790","display_name":null,"funder_award_id":"B53C22001790006","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G1544354327","display_name":null,"funder_award_id":"IG 20778","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G1818510306","display_name":null,"funder_award_id":"CUP B53C22001790006","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1821171916","display_name":null,"funder_award_id":"MUR-Prin 2022","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G2278551787","display_name":null,"funder_award_id":"AIRC IG 24514","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G231133531","display_name":null,"funder_award_id":"PRIN2022","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G2372493982","display_name":null,"funder_award_id":"CN00000013","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G304590355","display_name":"Providing cutting edge cancer research services across Europe","funder_award_id":"101058620","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3159290502","display_name":null,"funder_award_id":"24514","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G3474244737","display_name":null,"funder_award_id":"CUP: B53C22001790006","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G3800566186","display_name":null,"funder_award_id":"CN00000041","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G4835723757","display_name":null,"funder_award_id":"IG 24514","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G5031004776","display_name":null,"funder_award_id":"CUP B13C22001010001","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5315675380","display_name":null,"funder_award_id":"CN00000041","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G5356239126","display_name":null,"funder_award_id":"CN00000013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G544149491","display_name":null,"funder_award_id":"CN 00000041","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6686516892","display_name":null,"funder_award_id":"B13C22001010001","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G6899556591","display_name":null,"funder_award_id":"CUP B13C22001010001","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G7526249834","display_name":null,"funder_award_id":"IR0000009","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7679820159","display_name":null,"funder_award_id":"IR0000009","funder_id":"https://openalex.org/F7311471023","funder_display_name":"NextGenerationEU"},{"id":"https://openalex.org/G7919348612","display_name":null,"funder_award_id":"PRIN2022","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"},{"id":"https://openalex.org/G8781761721","display_name":"Development of Magnetic Resonance in Latvia","funder_award_id":"101160091","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G972786147","display_name":null,"funder_award_id":"PRIN-2022","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F7311471023","display_name":"NextGenerationEU","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225408259.pdf","grobid_xml":"https://content.openalex.org/works/W7225408259.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W151377110","https://openalex.org/W1481607975","https://openalex.org/W1964680558","https://openalex.org/W1968790827","https://openalex.org/W1970103851","https://openalex.org/W1973010951","https://openalex.org/W1977038370","https://openalex.org/W1981225934","https://openalex.org/W1981346588","https://openalex.org/W1982126789","https://openalex.org/W1989800988","https://openalex.org/W1992468078","https://openalex.org/W1994840640","https://openalex.org/W2013446530","https://openalex.org/W2023298266","https://openalex.org/W2023652169","https://openalex.org/W2025938842","https://openalex.org/W2035687084","https://openalex.org/W2038972833","https://openalex.org/W2042745266","https://openalex.org/W2046740096","https://openalex.org/W2057477511","https://openalex.org/W2062344864","https://openalex.org/W2065572350","https://openalex.org/W2066088601","https://openalex.org/W2066690664","https://openalex.org/W2068227670","https://openalex.org/W2081046982","https://openalex.org/W2081693079","https://openalex.org/W2086862822","https://openalex.org/W2099386490","https://openalex.org/W2100736103","https://openalex.org/W2101137168","https://openalex.org/W2119320884","https://openalex.org/W2124983865","https://openalex.org/W2150576297","https://openalex.org/W2155930838","https://openalex.org/W2161605421","https://openalex.org/W2162685411","https://openalex.org/W2194238612","https://openalex.org/W2325644679","https://openalex.org/W2327581403","https://openalex.org/W2404280981","https://openalex.org/W2529778903","https://openalex.org/W2555870966","https://openalex.org/W2563208112","https://openalex.org/W2609870844","https://openalex.org/W2707646777","https://openalex.org/W2781364521","https://openalex.org/W2800697076","https://openalex.org/W2804980767","https://openalex.org/W2983543368","https://openalex.org/W3015712102","https://openalex.org/W3020669571","https://openalex.org/W3045963870","https://openalex.org/W3112415196","https://openalex.org/W3157400614","https://openalex.org/W3203735717","https://openalex.org/W3213473948","https://openalex.org/W4210641170","https://openalex.org/W4283742583","https://openalex.org/W4295762972","https://openalex.org/W4296127178","https://openalex.org/W4384627178","https://openalex.org/W4387440676","https://openalex.org/W4389991359","https://openalex.org/W4396721167","https://openalex.org/W4415052833","https://openalex.org/W7124930958","https://openalex.org/W7127941162","https://openalex.org/W7128919667","https://openalex.org/W7141894382"],"related_works":["https://openalex.org/W2066040214","https://openalex.org/W2223708856","https://openalex.org/W2750966778","https://openalex.org/W2004171735","https://openalex.org/W2987012959","https://openalex.org/W7124930958","https://openalex.org/W3009121584","https://openalex.org/W1995291358","https://openalex.org/W1973010951","https://openalex.org/W4309437834"],"abstract_inverted_index":{"Despite":[0],"its":[1,60,172],"essential":[2],"role":[3],"in":[4],"pre\u2013mRNA":[5],"splicing,":[6],"the":[7,13,25,53,57,67,109,124,130,158,165,169],"structure":[8],"and":[9,59,91,98,141,161,167,185],"functional":[10,162],"significance":[11],"of":[12,19,24,56,94,111,129,157,164,171,179],"intrinsically":[14],"disordered":[15],"N-terminal":[16],"domain":[17],"(NTD)":[18],"SF3B1,":[20],"a":[21,87,101,144,154],"core":[22],"component":[23],"SF3b":[26],"spliceosome":[27],"complex,":[28],"remain":[29],"poorly":[30],"understood.":[31],"Here,":[32],"we":[33,64,115],"combine":[34],"nuclear":[35],"magnetic":[36],"resonance":[37],"(NMR)":[38],"spectroscopy,":[39],"small-angle":[40],"X\u2013ray":[41],"scattering":[42],"(SAXS),":[43],"biochemistry,":[44],"bioinformatics":[45],"approaches,":[46],"with":[47,120],"molecular":[48],"dynamics":[49],"simulations":[50],"to":[51,189],"characterize":[52],"conformational":[54,159],"landscape":[55,160],"SF3B1-NTD":[58],"phosphorylation-dependent":[61],"remodelling.":[62],"Specifically,":[63],"focus":[65],"on":[66],"186\u2013341":[68],"region":[69],"(186\u2013341SF3B1),":[70],"which":[71],"contains":[72],"at":[73],"least":[74],"four":[75],"regulatory":[76],"phosphorylation":[77,93],"sites.":[78],"We":[79],"reveal":[80],"that":[81,92,117],"186\u2013341SF3B1":[82,118],"is":[83],"highly":[84],"dynamic,":[85],"lacking":[86],"stable":[88],"secondary":[89],"structure,":[90],"T211,":[95],"T235,":[96],"T313,":[97],"T328":[99],"induces":[100],"shift":[102],"toward":[103],"more":[104],"compact":[105],"states":[106],"driven":[107],"by":[108],"formation":[110],"intramolecular":[112],"interactions.":[113],"Additionally,":[114],"unveil":[116],"interacts":[119],"RNA":[121],"primarily":[122],"via":[123],"arginine":[125],"residues":[126],"flaking":[127],"one":[128],"conserved":[131],"tryptophan-centred":[132],"motifs":[133,187],"present":[134],"within":[135],"SF3B1\u2013NTD.":[136],"These":[137],"interactions":[138],"are":[139],"transient":[140],"heterogeneous,":[142],"reflecting":[143],"nonspecific":[145],"yet":[146],"sequence-dependent":[147],"recognition":[148],"mechanism.":[149],"Collectively,":[150],"this":[151],"study":[152],"provides":[153],"comprehensive":[155],"description":[156],"features":[163],"SF3B1-NTD,":[166],"expands":[168],"portfolio":[170],"possible":[173],"interactors,":[174],"thus":[175],"broadening":[176],"our":[177],"understanding":[178],"how":[180],"intrinsic":[181],"disorder,":[182],"post-translational":[183],"modifications,":[184],"sequence-encoded":[186],"cooperate":[188],"regulate":[190],"pre-mRNA":[191],"splicing.":[192]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
