{"id":"https://openalex.org/W7225407965","doi":"https://doi.org/10.1097/hjh.0000000000004496","title":"Early childhood blood pressure in relation to umbilical cord homocysteine and folate: insights from the ENVIRonmental influence ON AGEing birth cohort Study","display_name":"Early childhood blood pressure in relation to umbilical cord homocysteine and folate: insights from the ENVIRonmental influence ON AGEing birth cohort Study","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225407965","doi":"https://doi.org/10.1097/hjh.0000000000004496","pmid":"https://pubmed.ncbi.nlm.nih.gov/42992420"},"language":"en","primary_location":{"id":"doi:10.1097/hjh.0000000000004496","doi":"https://doi.org/10.1097/hjh.0000000000004496","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0000000000004496","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026013611","display_name":"Huizhong Shi","orcid":"https://orcid.org/0009-0008-9231-5937","observed_orcids":["https://orcid.org/0009-0008-9231-5937"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hui-Zhong Shi","raw_affiliation_strings":["Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen","Research Unit Environment and Health, Department of Public Health and Primary Care, University of Leuven, Leuven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen","institution_ids":[]},{"raw_affiliation_string":"Research Unit Environment and Health, Department of Public Health and Primary Care, University of Leuven, Leuven","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028178296","display_name":"Dries S. Martens","orcid":"https://orcid.org/0000-0001-7893-3642","observed_orcids":["https://orcid.org/0000-0001-7893-3642"]},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dries S. Martens","raw_affiliation_strings":["Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","institution_ids":["https://openalex.org/I878454856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002423829","display_name":"Hanne Croons","orcid":"https://orcid.org/0000-0002-9903-2146","observed_orcids":["https://orcid.org/0000-0002-9903-2146"]},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hanne Croons","raw_affiliation_strings":["Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","institution_ids":["https://openalex.org/I878454856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093120088","display_name":"Lore Verheyen","orcid":"https://orcid.org/0000-0003-4641-6901","observed_orcids":["https://orcid.org/0000-0003-4641-6901"]},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lore Verheyen","raw_affiliation_strings":["Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","institution_ids":["https://openalex.org/I878454856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058617859","display_name":"Nick Giesberts","orcid":"https://orcid.org/0000-0001-5056-4849","observed_orcids":["https://orcid.org/0000-0001-5056-4849"]},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nick Giesberts","raw_affiliation_strings":["Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","institution_ids":["https://openalex.org/I878454856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073409843","display_name":"Hanne Sleurs","orcid":"https://orcid.org/0000-0002-3411-591X","observed_orcids":["https://orcid.org/0000-0002-3411-591X"]},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hanne Sleurs","raw_affiliation_strings":["Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","institution_ids":["https://openalex.org/I878454856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046616310","display_name":"Eleni Renaers","orcid":"https://orcid.org/0000-0001-7535-1970","observed_orcids":["https://orcid.org/0000-0001-7535-1970"]},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eleni Renaers","raw_affiliation_strings":["Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","institution_ids":["https://openalex.org/I878454856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161051664","display_name":"Yu-Chen Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Chen Wang","raw_affiliation_strings":["Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101694213","display_name":"Zhikai Yang","orcid":"https://orcid.org/0009-0009-1208-1366","observed_orcids":["https://orcid.org/0009-0009-1208-1366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-Kai Yang","raw_affiliation_strings":["Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073859325","display_name":"Yu-ling YU","orcid":"https://orcid.org/0000-0002-8255-3770","observed_orcids":["https://orcid.org/0000-0002-8255-3770"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Yu-Ling Yu","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039854776","display_name":"De\u2010Wei An","orcid":"https://orcid.org/0000-0002-1395-7050","observed_orcids":["https://orcid.org/0000-0002-1395-7050"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]},{"id":"https://openalex.org/I4210129240","display_name":"Shanghai Institute of Hypertension","ror":"https://ror.org/038j9sn30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210129240"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-Wei An","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517","https://openalex.org/I4210129240","https://openalex.org/I4392021104"]},{"raw_affiliation_string":"Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161078219","display_name":"Dong-Yan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]},{"id":"https://openalex.org/I4210129240","display_name":"Shanghai Institute of Hypertension","ror":"https://ror.org/038j9sn30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210129240"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong-Yan Zhang","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517","https://openalex.org/I4210129240","https://openalex.org/I4392021104"]},{"raw_affiliation_string":"Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161141144","display_name":"Yan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]},{"id":"https://openalex.org/I4210129240","display_name":"Shanghai Institute of Hypertension","ror":"https://ror.org/038j9sn30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210129240"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517","https://openalex.org/I4210129240","https://openalex.org/I4392021104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088986004","display_name":"Karel Allegaert","orcid":"https://orcid.org/0000-0001-9921-5105","observed_orcids":["https://orcid.org/0000-0001-9921-5105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karel Allegaert","raw_affiliation_strings":["Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160991947","display_name":"Peter Verhamme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Verhamme","raw_affiliation_strings":["Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068602843","display_name":"Michelle Plusquin","orcid":"https://orcid.org/0000-0002-7271-9722","observed_orcids":["https://orcid.org/0000-0002-7271-9722"]},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Michelle Plusquin","raw_affiliation_strings":["Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","institution_ids":["https://openalex.org/I878454856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043512811","display_name":"Jan A. Staessen","orcid":"https://orcid.org/0000-0002-3026-1637","observed_orcids":["https://orcid.org/0000-0002-3026-1637"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]},{"id":"https://openalex.org/I4210129240","display_name":"Shanghai Institute of Hypertension","ror":"https://ror.org/038j9sn30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210129240"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","CN"],"is_corresponding":false,"raw_author_name":"Jan A. Staessen","raw_affiliation_strings":["Biomedical Research Group, Faculty of Medicine, University of Leuven, Leuven, Belgium","Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Group, Faculty of Medicine, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517","https://openalex.org/I4210129240","https://openalex.org/I4392021104"]},{"raw_affiliation_string":"Non-Profit Research Alliance for the Promotion of Preventive Medicine, Mechelen","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080031073","display_name":"Tim S. Nawrot","orcid":"https://orcid.org/0000-0002-3583-3593","observed_orcids":["https://orcid.org/0000-0002-3583-3593"]},"institutions":[{"id":"https://openalex.org/I878454856","display_name":"Hasselt University","ror":"https://ror.org/04nbhqj75","country_code":"BE","type":"education","lineage":["https://openalex.org/I878454856"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tim S. Nawrot","raw_affiliation_strings":["Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","Research Unit Environment and Health, Department of Public Health and Primary Care, University of Leuven, Leuven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Epidemiology, Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium","institution_ids":["https://openalex.org/I878454856"]},{"raw_affiliation_string":"Research Unit Environment and Health, Department of Public Health and Primary Care, University of Leuven, Leuven","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-blood-pressure","display_name":"childhood blood pressure","score":0.8859999775886536},{"id":"https://openalex.org/keywords/one-carbon-metabolism","display_name":"one-carbon metabolism","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prenatal-programming","display_name":"prenatal programming","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hypertension-risk","display_name":"hypertension risk","score":0.6890000104904175},{"id":"https://openalex.org/keywords/diastolic-blood-pressure","display_name":"diastolic blood pressure","score":0.953000009059906},{"id":"https://openalex.org/keywords/maternal-biomarkers","display_name":"maternal biomarkers","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.460999995470047},{"id":"https://openalex.org/keywords/environage-birth-cohort","display_name":"ENVIRONAGE birth cohort","score":0.875}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.932200014591217},{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6743000149726868},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.6406000256538391},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.6234999895095825},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6218000054359436},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.612500011920929},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5978999733924866},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5838000178337097},{"id":"https://openalex.org/C2779425982","wikidata":"https://www.wikidata.org/wiki/Q2323264","display_name":"Generation R","level":3,"score":0.5540000200271606},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5175999999046326},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5144000053405762},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.47600001096725464},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.46779999136924744},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.4104999899864197},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.40230000019073486},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3928999900817871},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38019999861717224},{"id":"https://openalex.org/C2779632786","wikidata":"https://www.wikidata.org/wiki/Q920297","display_name":"Cord","level":2,"score":0.3650999963283539},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32580000162124634},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.30959999561309814},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3057999908924103},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C2776523773","wikidata":"https://www.wikidata.org/wiki/Q1093815","display_name":"Hyperhomocysteinemia","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.26190000772476196},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/hjh.0000000000004496","doi":"https://doi.org/10.1097/hjh.0000000000004496","is_oa":false,"landing_page_url":"https://doi.org/10.1097/hjh.0000000000004496","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:42992420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42992420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hypertension","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1537125811","https://openalex.org/W1792110071","https://openalex.org/W1886365915","https://openalex.org/W1913878472","https://openalex.org/W1965791931","https://openalex.org/W1992371031","https://openalex.org/W2013248460","https://openalex.org/W2038442206","https://openalex.org/W2046327489","https://openalex.org/W2051043692","https://openalex.org/W2058703570","https://openalex.org/W2099076759","https://openalex.org/W2100088202","https://openalex.org/W2107533098","https://openalex.org/W2110901042","https://openalex.org/W2114949397","https://openalex.org/W2115443997","https://openalex.org/W2117611302","https://openalex.org/W2123918107","https://openalex.org/W2127149147","https://openalex.org/W2129511051","https://openalex.org/W2133602954","https://openalex.org/W2134277458","https://openalex.org/W2164832415","https://openalex.org/W2165074567","https://openalex.org/W2170457280","https://openalex.org/W2323783182","https://openalex.org/W2491849061","https://openalex.org/W2520894026","https://openalex.org/W2611349559","https://openalex.org/W2767791831","https://openalex.org/W2910232955","https://openalex.org/W2914316479","https://openalex.org/W3009306142","https://openalex.org/W3045667212","https://openalex.org/W3111864206","https://openalex.org/W3135023909","https://openalex.org/W3136814113","https://openalex.org/W3137054874","https://openalex.org/W4292528167","https://openalex.org/W4316664909","https://openalex.org/W4318754943","https://openalex.org/W4361268354","https://openalex.org/W4362520822","https://openalex.org/W4378715838","https://openalex.org/W4400203461","https://openalex.org/W7153289562"],"related_works":["https://openalex.org/W4380793407","https://openalex.org/W2611349559","https://openalex.org/W2593522612","https://openalex.org/W4296035499","https://openalex.org/W2123918107","https://openalex.org/W3127879893","https://openalex.org/W2148278559","https://openalex.org/W2164832415","https://openalex.org/W3136814113","https://openalex.org/W4402483330"],"abstract_inverted_index":{"BACKGROUND:":[0],"High":[1],"blood":[2],"pressure":[3],"(BP)":[4],"tracks":[5],"from":[6],"childhood":[7,32,149],"into":[8],"adulthood,":[9],"contributing":[10],"to":[11,182],"cardiovascular":[12],"risk.":[13],"How":[14],"the":[15,65,91,96,199,230],"prenatal":[16],"one-carbon":[17],"(1-C)":[18],"metabolism,":[19],"as":[20,153],"reflected":[21],"by":[22,59,75,81],"umbilical":[23],"cord":[24,51,114,162,210,222],"homocysteine":[25,54,115,212,227],"and":[26,52,55,68,77,80,93,100,102,107,121,139,176,187,253],"folate,":[27],"affects":[28],"BP":[29,67,72,123,160,242],"in":[30,218,243,251],"early":[31,219],"is":[33,246],"unknown.":[34],"METHODS:":[35],"The":[36,62,144,233],"prospective":[37,205],"population-based":[38],"birth":[39,206],"cohort":[40,207],"ENVIRonmental":[41],"influence":[42],"ON":[43],"early\ufeffAGEing":[44],"(ENVIRONAGE)":[45],"comprised":[46],"500":[47],"mother-offspring":[48],"pairs.":[49],"Umbilical":[50],"maternal":[53,103],"folate":[56,163,168,223],"were":[57,86,164,195],"measured":[58],"electrochemiluminescence":[60],"immunoassay.":[61],"association":[63,129],"of":[64,70,90,131,159,249],"offspring":[66],"risk":[69],"high":[71,148,241],"was":[73,116,155,213,224],"assessed":[74],"linear":[76],"logistic":[78],"regression":[79],"mediation":[82],"analysis.":[83],"Association":[84],"sizes":[85,130,180],"expressed":[87],"per":[88],"doubling":[89],"biomarkers":[92,194],"adjusted":[94],"for":[95,147,239],"children's":[97],"sex,":[98],"age":[99,104],"weight":[101],"at":[105],"delivery":[106],"parity.":[108],"RESULTS:":[109],"At":[110],"4.5":[111],"years":[112],"(median),":[113],"associated":[117,197,214,228],"with":[118,128,151,161,178,198,215,229],"higher":[119,209,216],"diastolic":[120],"mean":[122],"(MBP),":[124],"but":[125],"not":[126,165,196],"SBP":[127],"1.67":[132],"mmHg":[133,141],"[95%":[134],"confidence":[135],"interval":[136],"(CI),":[137],"0.36-2.99]":[138],"1.19":[140],"(0.01-2.38),":[142],"respectively.":[143],"odds":[145],"ratio":[146],"DBP":[150,175,217],"normotension":[152],"reference":[154],"2.22":[156],"(1.34-3.68).":[157],"Associations":[158],"significant.":[166],"Cord":[167],"had":[169],"only":[170,225],"an":[171],"indirect":[172],"effect":[173,179],"on":[174],"MBP":[177],"amounting":[181],"-3.04":[183],"(P":[184,189],"=":[185,190],"0.027)":[186],"-2.30":[188],"0.061)":[191],"mmHg.":[192],"Maternal":[193],"offspring's":[200,231],"BP.":[201,232],"CONCLUSION:":[202],"In":[203],"this":[204],"study,":[208],"plasma":[211],"childhood,":[220,244],"whereas":[221],"via":[226],"1-C":[234],"metabolism":[235],"provides":[236],"a":[237,247],"mechanism":[238],"preventing":[240],"which":[245],"forerunner":[248],"hypertension":[250],"adolescence":[252],"adulthood.":[254]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}