{"id":"https://openalex.org/W7225407640","doi":"https://doi.org/10.64898/2026.11.04.764422","title":"Measuring satellite arrays of the human Y chromosome from sequencing reads","display_name":"Measuring satellite arrays of the human Y chromosome from sequencing reads","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225407640","doi":"https://doi.org/10.64898/2026.11.04.764422"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.764422","doi":"https://doi.org/10.64898/2026.11.04.764422","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764422","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764422.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764422.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044036054","display_name":"Alejandro Ortigas-V\u00e1squez","orcid":"https://orcid.org/0000-0001-5233-9573","observed_orcids":["https://orcid.org/0000-0001-5233-9573"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Ortigas-Vasquez","raw_affiliation_strings":["Translational Genomics Research Institute (TGen);"],"raw_orcid":"https://orcid.org/0000-0001-5233-9573","affiliations":[{"raw_affiliation_string":"Translational Genomics Research Institute (TGen);","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028113588","display_name":"Andrea Guarracino","orcid":"https://orcid.org/0000-0001-9744-131X","observed_orcids":["https://orcid.org/0000-0001-9744-131X"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea Guarracino","raw_affiliation_strings":["Translational Genomics Research Institute"],"raw_orcid":"https://orcid.org/0000-0001-9744-131X","affiliations":[{"raw_affiliation_string":"Translational Genomics Research Institute","institution_ids":["https://openalex.org/I1284308235"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028113588"],"corresponding_institution_ids":["https://openalex.org/I1284308235"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.334199994802475,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.1256999969482422,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/y-chromosome-lineages","display_name":"Y-chromosome lineages","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C19269812","wikidata":"https://www.wikidata.org/wiki/Q26540","display_name":"Satellite","level":2,"score":0.636900007724762},{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.5852000117301941},{"id":"https://openalex.org/C2780246931","wikidata":"https://www.wikidata.org/wiki/Q202771","display_name":"Y chromosome","level":3,"score":0.5354999899864197},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4912000000476837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47620001435279846},{"id":"https://openalex.org/C140367098","wikidata":"https://www.wikidata.org/wiki/Q425319","display_name":"Satellite DNA","level":4,"score":0.45239999890327454},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.4474000036716461},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.44339999556541443},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4253000020980835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3977999985218048},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.39410001039505005},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.33169999718666077},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.29649999737739563},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28929999470710754},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.26589998602867126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.764422","doi":"https://doi.org/10.64898/2026.11.04.764422","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764422","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764422.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.764422","doi":"https://doi.org/10.64898/2026.11.04.764422","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764422","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764422.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225407640.pdf","grobid_xml":"https://content.openalex.org/works/W7225407640.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2132510972","https://openalex.org/W2972549276","https://openalex.org/W2028513990","https://openalex.org/W6948591108","https://openalex.org/W2398492654","https://openalex.org/W4386091025","https://openalex.org/W754772903","https://openalex.org/W1973155025","https://openalex.org/W6977229940","https://openalex.org/W3204581349"],"abstract_inverted_index":{"Human":[0],"Y":[1,29],"chromosome":[2],"satellites":[3],"vary":[4],"widely":[5],"but":[6],"remain":[7],"difficult":[8],"to":[9,23],"measure":[10,24],"in":[11],"large":[12],"cohorts.":[13],"In":[14],"response,":[15],"we":[16],"developed":[17],"Yruler,":[18],"which":[19],"uses":[20],"pangenome":[21],"assemblies":[22],"satellite":[25,67],"lengths,":[26],"composition":[27,58],"and":[28,52,57],"dosage":[30],"from":[31],"sequencing":[32],"reads":[33],"without":[34],"alignment.":[35],"Analyses":[36],"reveal":[37],"centromere-length":[38],"differences":[39],"between":[40],"related":[41],"lineages,":[42],"extend":[43],"observations":[44],"of":[45],"short":[46],"non-centromeric":[47],"arrays":[48],"across":[49],"a":[50],"lineage,":[51],"show":[53],"unequal":[54],"component":[55],"variability":[56],"changes":[59],"with":[60],"heterochromatin":[61],"length":[62],"within":[63],"lineages.":[64],"Yruler":[65],"brings":[66],"variation":[68],"into":[69],"population-scale":[70],"phenotype":[71],"studies.":[72]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}