{"id":"https://openalex.org/W7225406973","doi":"https://doi.org/10.3389/fendo.2026.1996235","title":"Early-stage follicle development regulated by RGD peptide and ovarian fragment size in three-dimensional culture","display_name":"Early-stage follicle development regulated by RGD peptide and ovarian fragment size in three-dimensional culture","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225406973","doi":"https://doi.org/10.3389/fendo.2026.1996235"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2026.1996235","doi":"https://doi.org/10.3389/fendo.2026.1996235","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1996235","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1996235/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1996235/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075367705","display_name":"Sandy Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Sandy Chen","raw_affiliation_strings":["Department of Frontier Medicine, Institute of Medical Science, St. Marianna University School of Medicine","Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Frontier Medicine, Institute of Medical Science, St. Marianna University School of Medicine","institution_ids":["https://openalex.org/I163917720"]},{"raw_affiliation_string":"Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038513234","display_name":"Cassandra Matsushige","orcid":"https://orcid.org/0000-0001-9881-4341","observed_orcids":["https://orcid.org/0000-0001-9881-4341"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassandra Matsushige","raw_affiliation_strings":["Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161022705","display_name":"Lleyton Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lleyton Chen","raw_affiliation_strings":["Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161062403","display_name":"Makayla Horsley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Makayla Horsley","raw_affiliation_strings":["Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161051482","display_name":"Margaux Mongue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaux Mongue","raw_affiliation_strings":["Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094223138","display_name":"Alexandra Masca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Masca","raw_affiliation_strings":["Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066093802","display_name":"Michelle D. Tallquist","orcid":"https://orcid.org/0000-0002-1383-144X","observed_orcids":["https://orcid.org/0000-0002-1383-144X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle D. Tallquist","raw_affiliation_strings":["Center for Cardiovascular Research, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Research, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa","institution_ids":["https://openalex.org/I117965899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102913504","display_name":"Yukiko Yamazaki","orcid":"https://orcid.org/0000-0001-5089-1487","observed_orcids":["https://orcid.org/0000-0001-5089-1487"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yukiko Yamazaki","raw_affiliation_strings":["Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa","institution_ids":["https://openalex.org/I117965899"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102913504"],"corresponding_institution_ids":["https://openalex.org/I117965899"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.9409999847412109},{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.800000011920929},{"id":"https://openalex.org/keywords/integrin-alphavbeta5","display_name":"integrin \u03b1v\u03b25","score":1.0},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.7710000276565552},{"id":"https://openalex.org/keywords/neonatal-ovary","display_name":"neonatal ovary","score":0.7070000171661377},{"id":"https://openalex.org/keywords/dextran-hydrogels","display_name":"dextran hydrogels","score":0.8309999704360962},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cilengitide","display_name":"cilengitide","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ovarian-stromal-cells","display_name":"ovarian stromal cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.7253999710083008},{"id":"https://openalex.org/C142773365","wikidata":"https://www.wikidata.org/wiki/Q3499793","display_name":"Antral follicle","level":3,"score":0.714900016784668},{"id":"https://openalex.org/C2780536345","wikidata":"https://www.wikidata.org/wiki/Q953556","display_name":"Ovarian follicle","level":3,"score":0.6610999703407288},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6378999948501587},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5695000290870667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5139999985694885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49720001220703125},{"id":"https://openalex.org/C5512455","wikidata":"https://www.wikidata.org/wiki/Q2142940","display_name":"Folliculogenesis","level":4,"score":0.47530001401901245},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.4207000136375427},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4002000093460083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3659999966621399},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36309999227523804},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.36039999127388},{"id":"https://openalex.org/C29390026","wikidata":"https://www.wikidata.org/wiki/Q14904760","display_name":"Follicle-stimulating hormone receptor","level":5,"score":0.3553999960422516},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.34790000319480896},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.34119999408721924},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3400000035762787},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.29829999804496765},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.28619998693466187},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.2782999873161316},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.27070000767707825}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fendo.2026.1996235","doi":"https://doi.org/10.3389/fendo.2026.1996235","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1996235","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1996235/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3755fd126aa6440bbb868273a5cfc8e6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3755fd126aa6440bbb868273a5cfc8e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2026.1996235","doi":"https://doi.org/10.3389/fendo.2026.1996235","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1996235","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1996235/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G793341727","display_name":null,"funder_award_id":"U54MD007601","funder_id":"https://openalex.org/F4320306371","funder_display_name":"Hawaii Community Foundation"},{"id":"https://openalex.org/G9000116421","display_name":"Ola HAWAII","funder_award_id":"U54MD007601","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"}],"funders":[{"id":"https://openalex.org/F4320306371","display_name":"Hawaii Community Foundation","ror":"https://ror.org/03jwgbj27"},{"id":"https://openalex.org/F4320309030","display_name":"Small Business Innovation Research","ror":"https://ror.org/015t55b95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225406973.pdf","grobid_xml":"https://content.openalex.org/works/W7225406973.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1484931749","https://openalex.org/W1802789137","https://openalex.org/W1966723290","https://openalex.org/W1967490869","https://openalex.org/W1969342647","https://openalex.org/W1993317008","https://openalex.org/W1994091018","https://openalex.org/W1997246078","https://openalex.org/W2042617428","https://openalex.org/W2047715073","https://openalex.org/W2065363896","https://openalex.org/W2068364416","https://openalex.org/W2069044303","https://openalex.org/W2088514214","https://openalex.org/W2097192405","https://openalex.org/W2105300288","https://openalex.org/W2105356859","https://openalex.org/W2124556975","https://openalex.org/W2126760626","https://openalex.org/W2126846194","https://openalex.org/W2129326119","https://openalex.org/W2136471260","https://openalex.org/W2138818297","https://openalex.org/W2157053069","https://openalex.org/W2158206238","https://openalex.org/W2165422332","https://openalex.org/W2171501785","https://openalex.org/W2174037899","https://openalex.org/W2340757132","https://openalex.org/W2763710570","https://openalex.org/W2953039196","https://openalex.org/W2993606239","https://openalex.org/W3012605887","https://openalex.org/W3035330028","https://openalex.org/W3047792719","https://openalex.org/W3102856167","https://openalex.org/W3139674283","https://openalex.org/W3148037344","https://openalex.org/W3189920043","https://openalex.org/W4200272132","https://openalex.org/W4212965146","https://openalex.org/W4281258398","https://openalex.org/W4379231894","https://openalex.org/W4386765174","https://openalex.org/W4402629789","https://openalex.org/W4403679339","https://openalex.org/W4406766802","https://openalex.org/W4408035206","https://openalex.org/W4408422420","https://openalex.org/W4415731702","https://openalex.org/W6941170192","https://openalex.org/W7135407072"],"related_works":["https://openalex.org/W4403679339","https://openalex.org/W4212965146","https://openalex.org/W1597313159","https://openalex.org/W2063496039","https://openalex.org/W3044547175","https://openalex.org/W3188958959","https://openalex.org/W7131403164","https://openalex.org/W3033704784","https://openalex.org/W7135407072","https://openalex.org/W2125048296"],"abstract_inverted_index":{"The":[0],"tripeptide":[1],"Arg-Gly-Asp":[2],"(RGD)":[3],"is":[4,253],"a":[5,114,176],"minimal":[6],"integrin-binding":[7],"motif":[8],"found":[9,154],"in":[10,24,38,65,83,113,165,201,239,243,260,276,305],"multiple":[11],"extracellular":[12],"matrix":[13],"(ECM)":[14],"proteins.":[15],"We":[16,153],"previously":[17],"determined":[18],"that":[19,140,155,249,267],"immature":[20],"ovarian":[21,58,141,203,268,281,302],"fragments":[22,80,122,168,242,312],"cultured":[23,37,82,172],"the":[25,39,52,84,119,150,156,161,166,189,202,208,211,224,232,240,250,280,288,292,314],"RGD-immobilized":[26],"dextran":[27,40,85],"hydrogel":[28,41,86],"significantly":[29,123,271],"promoted":[30,124],"antral":[31],"follicle":[32,63,111,125,145,229,258,274,298],"development":[33,64,92,112,126,146,230,259,275,299],"compared":[34,127,169],"to":[35,128,170,180,183,287],"those":[36,171],"control.":[42],"In":[43,117,188,223],"this":[44],"study,":[45],"using":[46,220],"neonatal":[47,71,190],"mouse":[48],"ovaries,":[49],"we":[50,214],"examined":[51],"effects":[53],"of":[54,149,210,226,294],"RGD":[55,107,157,178,295],"peptide":[56],"and":[57,81,196,218,231],"fragment":[59,96,269,303],"size":[60,97,270,304],"on":[61,297,301],"early-stage":[62,144,257,273],"our":[66,264,306],"3D":[67,244,261,307],"culture":[68,308],"system.":[69],"One":[70],"ovary":[72],"was":[73],"cut":[74],"into":[75],"1/2,":[76],"1/4,":[77],"or":[78,88,133],"1/8":[79,121,167,241,311],"with":[87,132,310],"without":[89,134,173],"RGD.":[90,135,174],"Follicle":[91],"progressively":[93],"increased":[94,160],"as":[95],"decreased":[98],"(intact":[99],"<":[100,102,104],"1/2":[101],"1/4":[103],"1/8).":[105],"Notably,":[106],"treatment":[108,158,296],"further":[109,159],"enhanced":[110],"size-dependent":[115],"manner.":[116],"particular,":[118],"RGD-treated":[120],"all":[129],"other":[130],"groups":[131],"Previous":[136],"studies":[137],"have":[138],"shown":[139],"fragmentation":[142],"stimulates":[143],"through":[147],"disruption":[148,164,235],"Hippo":[151,162,233],"pathway.":[152],"pathway":[163,234],"As":[175],"ligand,":[177],"binds":[179],"integrin":[181],"receptors":[182],"induce":[184],"various":[185],"cell":[186],"functions.":[187],"ovary,":[191],"ovary-specific":[192],"RGD-binding":[193,285],"integrins":[194,216,286],"\u03b1v\u03b23":[195,217],"\u03b1v\u03b25":[197,219],"were":[198,236],"predominantly":[199],"localized":[200],"interstitial/theca":[204],"cells.":[205],"To":[206],"evaluate":[207],"role":[209],"RGD-integrin":[212,251],"interaction,":[213],"blocked":[215],"Cilengitide":[221],"(Ci).":[222],"presence":[225],"Ci,":[227],"RGD-induced":[228],"completely":[237],"suppressed":[238],"culture.":[245,262,277],"These":[246],"results":[247],"suggest":[248],"interaction":[252],"crucial":[254],"for":[255],"promoting":[256],"Overall,":[263],"study":[265],"demonstrates":[266],"influences":[272],"Fragmentation":[278],"exposes":[279],"stromal":[282],"compartment":[283],"expressing":[284],"surrounding":[289],"hydrogel.":[290],"Moreover,":[291],"effect":[293],"depends":[300],"system,":[309],"yielding":[313],"greatest":[315],"enhancement.":[316]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-07T00:00:00"}
