{"id":"https://openalex.org/W7225406795","doi":"https://doi.org/10.3390/cimb48111173","title":"EBP50 and Merlin Expression Across the Spectrum of Serous Ovarian Tumors: Clinicopathological Associations and Exploratory Diagnostic Value","display_name":"EBP50 and Merlin Expression Across the Spectrum of Serous Ovarian Tumors: Clinicopathological Associations and Exploratory Diagnostic Value","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225406795","doi":"https://doi.org/10.3390/cimb48111173"},"language":"en","primary_location":{"id":"doi:10.3390/cimb48111173","doi":"https://doi.org/10.3390/cimb48111173","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111173","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cimb48111173","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101559101","display_name":"Ay\u015fe Nur Kele\u015f","orcid":"https://orcid.org/0000-0003-2617-2591","observed_orcids":["https://orcid.org/0000-0003-2617-2591"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015fe Nur Kele\u015f","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-2617-2591","affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002321399","display_name":"\u0130smail Y\u0131ld\u0131z","orcid":"https://orcid.org/0000-0001-5505-838X","observed_orcids":["https://orcid.org/0000-0001-5505-838X"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130smail Yildiz","raw_affiliation_strings":["Department of Biostatistics, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014682309","display_name":"Reyhan G\u00fcnd\u00fcz","orcid":"https://orcid.org/0000-0001-8468-7038","observed_orcids":["https://orcid.org/0000-0001-8468-7038"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Reyhan G\u00fcnd\u00fcz","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-8468-7038","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075464633","display_name":"Zuhat Urak\u00e7\u0131","orcid":"https://orcid.org/0000-0003-3878-988X","observed_orcids":["https://orcid.org/0000-0003-3878-988X","https://orcid.org/0000-0002-1817-0476"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zuhat Urak\u00e7i","raw_affiliation_strings":["Department of Medical Oncology, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015731739","display_name":"Ula\u015f Alabal\u0131k","orcid":"https://orcid.org/0000-0003-4551-8439","observed_orcids":["https://orcid.org/0000-0003-4551-8439"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ula\u015f Alabalik","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-4551-8439","affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Dicle University, Dicle University Campus, 21280 Diyarbak\u0131r, T\u00fcrkiye","institution_ids":["https://openalex.org/I123466251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015731739"],"corresponding_institution_ids":["https://openalex.org/I123466251"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":"11","first_page":"1173","last_page":"1173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebp50","display_name":"EBP50","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nherf1","display_name":"NHERF1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/merlin","display_name":"Merlin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neurofibromatosis-type-2","display_name":"neurofibromatosis type 2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/serous-ovarian-tumors","display_name":"serous ovarian tumors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/serous-borderline-tumor","display_name":"serous borderline tumor","score":0.7540000081062317},{"id":"https://openalex.org/keywords/low-grade-serous-carcinoma","display_name":"low-grade serous carcinoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/high-grade-serous-carcinoma","display_name":"high-grade serous carcinoma","score":1.0},{"id":"https://openalex.org/keywords/serous-cystadenoma","display_name":"serous cystadenoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8130000233650208},{"id":"https://openalex.org/keywords/mitotic-rate","display_name":"mitotic activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6790000200271606},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.597000002861023},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7260000109672546},{"id":"https://openalex.org/keywords/epithelial-cell-polarity","display_name":"epithelial polarity","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.892799973487854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5253000259399414},{"id":"https://openalex.org/C178628643","wikidata":"https://www.wikidata.org/wiki/Q410233","display_name":"Merlin (protein)","level":4,"score":0.4885999858379364},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.4796999990940094},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4081000089645386},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3939000070095062},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.39089998602867126},{"id":"https://openalex.org/C66640590","wikidata":"https://www.wikidata.org/wiki/Q4296711","display_name":"Mitotic index","level":3,"score":0.3797999918460846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37209999561309814},{"id":"https://openalex.org/C2777632260","wikidata":"https://www.wikidata.org/wiki/Q19000698","display_name":"Serous carcinoma","level":4,"score":0.3276999890804291},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3269999921321869},{"id":"https://openalex.org/C2780964533","wikidata":"https://www.wikidata.org/wiki/Q5201177","display_name":"Cystadenocarcinoma","level":4,"score":0.32269999384880066},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31769999861717224},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3142000138759613},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2912999987602234},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.2630999982357025},{"id":"https://openalex.org/C2780084626","wikidata":"https://www.wikidata.org/wiki/Q11793790","display_name":"Ovarian tumor","level":4,"score":0.2615000009536743},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.258899986743927}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/cimb48111173","doi":"https://doi.org/10.3390/cimb48111173","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111173","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/cimb48111173","doi":"https://doi.org/10.3390/cimb48111173","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb48111173","pdf_url":null,"source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1966714873","https://openalex.org/W1972035031","https://openalex.org/W1985531875","https://openalex.org/W2010453590","https://openalex.org/W2024028178","https://openalex.org/W2053263835","https://openalex.org/W2064335213","https://openalex.org/W2086757750","https://openalex.org/W2114852376","https://openalex.org/W2129355295","https://openalex.org/W2152575748","https://openalex.org/W2161064152","https://openalex.org/W2328176404","https://openalex.org/W2548970172","https://openalex.org/W2567714959","https://openalex.org/W2569161709","https://openalex.org/W2621872033","https://openalex.org/W3184902103","https://openalex.org/W4211166667","https://openalex.org/W4382344222","https://openalex.org/W4385563411","https://openalex.org/W4385949246","https://openalex.org/W4398143466","https://openalex.org/W4400361681"],"related_works":["https://openalex.org/W2418275256","https://openalex.org/W2268200004","https://openalex.org/W2553607116","https://openalex.org/W4206417068","https://openalex.org/W6944426622","https://openalex.org/W26501277","https://openalex.org/W4322719365","https://openalex.org/W3089344659","https://openalex.org/W3165149807","https://openalex.org/W3006096748"],"abstract_inverted_index":{"Background:":[0],"Serous":[1],"ovarian":[2,43,222],"tumors":[3,13,75,139],"comprise":[4],"biologically":[5],"distinct":[6],"entities":[7],"ranging":[8],"from":[9,180],"benign":[10],"and":[11,17,23,30,35,48,51,57,65,78,81,99,104,124,137,143,174,209,225,243,253,259],"borderline":[12,74],"to":[14],"low-grade":[15],"(LGSC)":[16],"high-grade":[18],"serous":[19,42,61,71,73,221],"carcinoma":[20],"(HGSC).":[21],"EBP50/NHERF1":[22],"Merlin/NF2":[24],"regulate":[25],"epithelial":[26],"polarity,":[27],"membrane\u2013cytoskeletal":[28],"organization,":[29],"signaling.":[31],"We":[32],"evaluated":[33,69,93],"EBP50":[34,64,110,131,213,258],"Merlin":[36,66,156,239,260],"expression":[37,111,123,145,157,219],"across":[38,220],"the":[39,121,200,235,247],"spectrum":[40],"of":[41,199,238,257],"tumors,":[44],"explored":[45],"their":[46],"clinicopathological":[47],"diagnostic":[49,232,236],"associations,":[50],"compared":[52],"these":[53],"findings":[54],"with":[55,120,148,191],"Ki67":[56,80,173,188,242],"mitotic":[58,82,175,244],"activity":[59,83,176,245],"in":[60,70,86,129,195,218,230,261],"carcinomas.":[62],"Methods:":[63],"immunoreactivity":[67],"was":[68,92,146,189],"cystadenomas,":[72],"(SBTs),":[76],"LGSCs,":[77],"HGSCs.":[79],"were":[84],"assessed":[85],"malignant":[87],"tumors.":[88],"Exploratory":[89],"discriminatory":[90,168],"performance":[91,169],"by":[94,102],"receiver":[95],"operating":[96],"characteristic":[97],"analysis,":[98,197],"overall":[100,193],"survival":[101,194,204],"Kaplan\u2013Meier":[103],"Cox":[105],"proportional":[106],"hazards":[107],"analyses.":[108],"Results:":[109],"differed":[112,159],"significantly":[113],"among":[114,160],"tumor":[115,223],"groups":[116,161],"(p":[117,162],"<":[118],"0.001),":[119],"lowest":[122],"most":[125],"frequent":[126],"complete":[127],"loss":[128],"HGSC.":[130,254],"showed":[132,166,214],"moderate":[133],"discrimination":[134],"between":[135,251],"carcinomas":[136],"non-carcinoma":[138],"(AUC":[140,170,182],"=":[141,163,171,183],"0.790)":[142],"lower":[144],"associated":[147,190],"more":[149],"advanced":[150],"disease,":[151],"including":[152],"higher":[153],"FIGO":[154,210],"stage.":[155,211],"also":[158],"0.003)":[164],"but":[165],"limited":[167],"0.605).":[172],"strongly":[177],"distinguished":[178],"LGSC":[179,252],"HGSC":[181],"0.992":[184],"for":[185,207],"both).":[186],"Although":[187],"poorer":[192],"univariable":[196],"none":[198],"biomarkers":[201],"independently":[202],"predicted":[203],"after":[205],"adjustment":[206],"age":[208],"Conclusions:":[212],"potentially":[215],"useful":[216],"differences":[217],"categories":[224],"may":[226],"provide":[227],"adjunctive":[228],"information":[229],"selected":[231],"settings,":[233],"whereas":[234],"contribution":[237],"appeared":[240],"limited.":[241],"confirm":[246],"established":[248],"proliferative":[249],"distinction":[250],"Further":[255],"validation":[256],"independent":[262],"cohorts":[263],"is":[264],"warranted.":[265]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}