{"id":"https://openalex.org/W7225406341","doi":"https://doi.org/10.1126/sciadv.aee1641","title":"A transcriptional and cellular exploration of obesity and type II diabetes in human adipose tissues","display_name":"A transcriptional and cellular exploration of obesity and type II diabetes in human adipose tissues","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225406341","doi":"https://doi.org/10.1126/sciadv.aee1641","pmid":"https://pubmed.ncbi.nlm.nih.gov/42993852","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13742184"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.aee1641","doi":"https://doi.org/10.1126/sciadv.aee1641","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aee1641","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1126/sciadv.aee1641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011898139","display_name":"William V. Trim","orcid":"https://orcid.org/0000-0002-5642-0608","observed_orcids":["https://orcid.org/0000-0002-5642-0608"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE","US"],"is_corresponding":true,"raw_author_name":"William V. Trim","raw_affiliation_strings":["Department of Endocrinology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Systems Biology, Harvard Medical School, Boston, MA, USA","School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-5642-0608","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079847110","display_name":"Kseniya Petrova","orcid":"https://orcid.org/0000-0002-6763-9744","observed_orcids":["https://orcid.org/0000-0002-6763-9744","https://orcid.org/0009-0001-6730-9470"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kseniia Petrova","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0009-0001-6730-9470","affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033369669","display_name":"Katie Healy","orcid":"https://orcid.org/0000-0002-7242-6604","observed_orcids":["https://orcid.org/0000-0002-7242-6604"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Healy","raw_affiliation_strings":["Department of Endocrinology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Molecular Biology, Princeton University, Princeton, NJ, USA","Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210150094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161121713","display_name":"Brenneth M. Stevens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Brenneth M. Stevens","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, NJ, USA","School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066352014","display_name":"John Scanlan","orcid":"https://orcid.org/0009-0001-9559-4731","observed_orcids":["https://orcid.org/0009-0001-9559-4731"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"John G. Scanlan","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0009-0001-9559-4731","affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052977145","display_name":"Heather J. Faust","orcid":"https://orcid.org/0000-0001-5305-3323","observed_orcids":["https://orcid.org/0000-0001-5305-3323"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather J. Faust","raw_affiliation_strings":["Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044774484","display_name":"Sara Svensson Akusj\u00e4rvi","orcid":"https://orcid.org/0000-0002-1086-5409","observed_orcids":["https://orcid.org/0000-0002-1086-5409"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Svensson Akusj\u00e4rvi","raw_affiliation_strings":["Division of Immunology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086234784","display_name":"Katie O\u2019Brien","orcid":"https://orcid.org/0000-0002-5247-561X","observed_orcids":["https://orcid.org/0000-0002-5247-561X"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Katie L. O\u2019Brien","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-5247-561X","affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060039916","display_name":"Donal Brendan O'Shea","orcid":"https://orcid.org/0000-0002-1408-5274","observed_orcids":["https://orcid.org/0000-0002-1408-5274"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Donal O\u2019Shea","raw_affiliation_strings":["Department of Surgery, School of Medicine, University College Dublin, Dublin, Ireland","St. Vincent\u2019s University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"St. Vincent\u2019s University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000815014","display_name":"Michael B. Brenner","orcid":"https://orcid.org/0000-0001-6202-8445","observed_orcids":["https://orcid.org/0000-0001-6202-8445"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Brenner","raw_affiliation_strings":["Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Inflammation, and Immunity, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037950266","display_name":"Helen Heneghan","orcid":"https://orcid.org/0000-0002-2009-3406","observed_orcids":["https://orcid.org/0000-0002-2009-3406"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Helen Heneghan","raw_affiliation_strings":["Department of Surgery, School of Medicine, University College Dublin, Dublin, Ireland","St. Vincent\u2019s University Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"St. Vincent\u2019s University Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082399313","display_name":"Lydia Lynch","orcid":"https://orcid.org/0000-0002-4273-4681","observed_orcids":["https://orcid.org/0000-0002-4273-4681"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210150094","display_name":"Ludwig Cancer Research","ror":"https://ror.org/05qdwtz81","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150094"]}],"countries":["IE","US"],"is_corresponding":true,"raw_author_name":"Lydia Lynch","raw_affiliation_strings":["Department of Endocrinology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Molecular Biology, Princeton University, Princeton, NJ, USA","Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA","School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-4273-4681","affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA","institution_ids":["https://openalex.org/I4210150094"]},{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5011898139","https://openalex.org/A5082399313"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I20089843","https://openalex.org/I205274468","https://openalex.org/I4210150094"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"45","first_page":"eaee1641","last_page":"eaee1641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.9800000190734863},{"id":"https://openalex.org/keywords/omental-adipose-tissue","display_name":"omental adipose tissue","score":0.902999997138977},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":1.0},{"id":"https://openalex.org/keywords/mesothelial-cells","display_name":"mesothelial cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9449999928474426},{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.7630000114440918},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9169999957084656},{"id":"https://openalex.org/keywords/innate-t-cells","display_name":"innate T cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8980000019073486},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7710000276565552},{"id":"https://openalex.org/keywords/adipose-tissue-heterogeneity","display_name":"adipose tissue heterogeneity","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.8485000133514404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6154999732971191},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.586899995803833},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.5472999811172485},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.52920001745224},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5199000239372253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5157999992370605},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4636000096797943},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.43140000104904175},{"id":"https://openalex.org/C17675752","wikidata":"https://www.wikidata.org/wiki/Q12898553","display_name":"Adipose tissue macrophages","level":4,"score":0.42980000376701355},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.39480000734329224},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3935000002384186},{"id":"https://openalex.org/C2778015335","wikidata":"https://www.wikidata.org/wiki/Q17051163","display_name":"Mass cytometry","level":4,"score":0.3822000026702881},{"id":"https://openalex.org/C2780745355","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Stromal vascular fraction","level":3,"score":0.3815999925136566},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.34279999136924744},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.33889999985694885},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33169999718666077},{"id":"https://openalex.org/C2909640154","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelial Cell","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.30250000953674316},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.3012999892234802},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2985999882221222},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.28630000352859497},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.25850000977516174},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009852","descriptor_name":"Omentum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009852","descriptor_name":"Omentum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050151","descriptor_name":"Subcutaneous Fat","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050151","descriptor_name":"Subcutaneous Fat","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/sciadv.aee1641","doi":"https://doi.org/10.1126/sciadv.aee1641","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aee1641","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13742184","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13742184/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13742184/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmid:42993852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42993852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.aee1641","doi":"https://doi.org/10.1126/sciadv.aee1641","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aee1641","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2322327649","display_name":"Regulatory iNKT Cells Suppress Inflammation and Drive Thermogenesis","funder_award_id":"R01AI113046","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320311496","display_name":"Ludwig Institute for Cancer Research","ror":"https://ror.org/05qdwtz81"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225406341.pdf","grobid_xml":"https://content.openalex.org/works/W7225406341.grobid-xml"},"referenced_works_count":138,"referenced_works":["https://openalex.org/W1570422974","https://openalex.org/W1572399582","https://openalex.org/W1599728413","https://openalex.org/W1914754661","https://openalex.org/W1948272236","https://openalex.org/W1975438745","https://openalex.org/W1980719167","https://openalex.org/W1993067007","https://openalex.org/W1994347380","https://openalex.org/W1995324236","https://openalex.org/W2001246569","https://openalex.org/W2007034244","https://openalex.org/W2013033239","https://openalex.org/W2021240626","https://openalex.org/W2024408216","https://openalex.org/W2024435928","https://openalex.org/W2028053287","https://openalex.org/W2028695285","https://openalex.org/W2031763777","https://openalex.org/W2033537905","https://openalex.org/W2033946555","https://openalex.org/W2038288742","https://openalex.org/W2045913350","https://openalex.org/W2049698508","https://openalex.org/W2055421595","https://openalex.org/W2062803398","https://openalex.org/W2064899968","https://openalex.org/W2065323571","https://openalex.org/W2078575306","https://openalex.org/W2081366429","https://openalex.org/W2088876544","https://openalex.org/W2095904729","https://openalex.org/W2099540110","https://openalex.org/W2100866502","https://openalex.org/W2101803122","https://openalex.org/W2102761049","https://openalex.org/W2103017472","https://openalex.org/W2107550410","https://openalex.org/W2112914472","https://openalex.org/W2115195372","https://openalex.org/W2115664664","https://openalex.org/W2120427955","https://openalex.org/W2131525837","https://openalex.org/W2132280604","https://openalex.org/W2135895956","https://openalex.org/W2138885070","https://openalex.org/W2141731752","https://openalex.org/W2143055774","https://openalex.org/W2144070823","https://openalex.org/W2147208509","https://openalex.org/W2148539755","https://openalex.org/W2149031002","https://openalex.org/W2160078193","https://openalex.org/W2161399063","https://openalex.org/W2166492500","https://openalex.org/W2171783221","https://openalex.org/W2190545194","https://openalex.org/W2262921329","https://openalex.org/W2272472492","https://openalex.org/W2406250479","https://openalex.org/W2509957998","https://openalex.org/W2560618496","https://openalex.org/W2587680743","https://openalex.org/W2590305749","https://openalex.org/W2593070710","https://openalex.org/W2620406790","https://openalex.org/W2735376054","https://openalex.org/W2743361508","https://openalex.org/W2745628640","https://openalex.org/W2750564155","https://openalex.org/W2759584129","https://openalex.org/W2782754314","https://openalex.org/W2784964036","https://openalex.org/W2787355693","https://openalex.org/W2791935879","https://openalex.org/W2799881184","https://openalex.org/W2800392236","https://openalex.org/W2804734969","https://openalex.org/W2805456840","https://openalex.org/W2808845633","https://openalex.org/W2810102400","https://openalex.org/W2889235433","https://openalex.org/W2897249806","https://openalex.org/W2901406707","https://openalex.org/W2950372712","https://openalex.org/W2951799803","https://openalex.org/W2955261360","https://openalex.org/W2965170138","https://openalex.org/W2966524054","https://openalex.org/W2972783888","https://openalex.org/W2984472267","https://openalex.org/W2994702596","https://openalex.org/W3009370296","https://openalex.org/W3023290106","https://openalex.org/W3032900131","https://openalex.org/W3033964929","https://openalex.org/W3038673218","https://openalex.org/W3099862724","https://openalex.org/W3101109668","https://openalex.org/W3128261063","https://openalex.org/W3132383992","https://openalex.org/W3136703878","https://openalex.org/W3139018950","https://openalex.org/W3157583546","https://openalex.org/W3159352569","https://openalex.org/W3196992636","https://openalex.org/W3204629563","https://openalex.org/W3208070538","https://openalex.org/W3208703010","https://openalex.org/W3217151720","https://openalex.org/W4200148796","https://openalex.org/W4206170515","https://openalex.org/W4206995124","https://openalex.org/W4221010612","https://openalex.org/W4229007625","https://openalex.org/W4230010647","https://openalex.org/W4242289937","https://openalex.org/W4281383249","https://openalex.org/W4294216483","https://openalex.org/W4310117562","https://openalex.org/W4323353100","https://openalex.org/W4327676110","https://openalex.org/W4376136840","https://openalex.org/W4378212544","https://openalex.org/W4379618480","https://openalex.org/W4380550659","https://openalex.org/W4390102357","https://openalex.org/W4392376250","https://openalex.org/W4392864366","https://openalex.org/W4396769613","https://openalex.org/W4404377716","https://openalex.org/W4405497278","https://openalex.org/W4408224540","https://openalex.org/W4416112189","https://openalex.org/W4417524991","https://openalex.org/W7117666630","https://openalex.org/W7125476051","https://openalex.org/W7131794331"],"related_works":["https://openalex.org/W2946644515","https://openalex.org/W3201765853","https://openalex.org/W2898750316","https://openalex.org/W4388809858","https://openalex.org/W7127116959","https://openalex.org/W2994702596","https://openalex.org/W2744804690","https://openalex.org/W4200034647","https://openalex.org/W2905083668","https://openalex.org/W2966524054"],"abstract_inverted_index":{"Obesity":[0],"is":[1],"tightly":[2],"linked":[3],"to":[4],"metabolic":[5],"disorders":[6],"such":[7],"as":[8],"type":[9],"II":[10],"diabetes":[11],"mellitus":[12],"(T2D),":[13],"although":[14],"a":[15,45,131,141],"subpopulation":[16],"of":[17,48,59,104,171],"individuals":[18,39],"with":[19,24,40,42],"obesity":[20,41],"do":[21],"not":[22],"present":[23],"these":[25],"morbidities.":[26],"The":[27],"biological":[28],"factors":[29],"conferring":[30],"T2D":[31,49,52,172],"vulnerability":[32],"remain":[33],"incompletely":[34],"understood.":[35],"We":[36,55,101],"recruited":[37],"58":[38],"or":[43],"without":[44],"clinical":[46],"diagnosis":[47],"(Ob":[50],"+":[51,128],"and":[53,61,76,83,91,112,120,126,150,176],"Ob).":[54],"profiled":[56],"paired":[57,98],"samples":[58],"omental":[60,106,137],"subcutaneous":[62,151],"adipose":[63,152,174],"by":[64,187],"single-cell":[65],"RNA":[66],"sequencing":[67],"(":[68,79,85],"n":[69,80,86],"=":[70,81,87],"10),":[71],"flow":[72],"cytometry":[73,90],"under":[74],"basal":[75],"stimulated":[77],"conditions":[78],"42),":[82],"histology":[84],"17).":[88],"Flow":[89],"chemokine":[92],"quantification":[93],"were":[94],"also":[95],"performed":[96],"in":[97,147,173],"whole":[99],"blood.":[100],"identified":[102],"reprogramming":[103],"the":[105,169,181],"stromal":[107],"compartment,":[108],"centered":[109],"on":[110],"mesothelial":[111],"endothelial":[113,138],"cells,":[114],"alongside":[115],"contrasting":[116],"innate":[117,153],"T":[118,154],"cell":[119],"macrophage":[121],"phenotypes":[122],"across":[123],"depots.":[124],"Mesothelial":[125],"IGFBP2":[127],"cells":[129,139,155],"exhibited":[130,140,156],"fibrotic,":[132],"epithelial-mesenchymal":[133],"transition\u2013like":[134],"phenotype,":[135],"while":[136],"lipid-overload,":[142],"inflammatory,":[143],"antigen":[144],"presentation":[145],"profile":[146],"T2D.":[148],"Omental":[149],"divergent":[157],"inflammatory":[158],"profiles":[159],"between":[160],"tissues.":[161],"These":[162],"findings":[163],"reveal":[164],"previously":[165],"unidentified":[166],"insights":[167],"into":[168],"pathophysiology":[170],"tissue":[175],"identify":[177],"compensatory":[178],"networks":[179],"within":[180],"tissues":[182],"that":[183],"could":[184],"be":[185],"exploited":[186],"targeted":[188],"therapeutics.":[189]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-07T00:00:00"}