{"id":"https://openalex.org/W7225405641","doi":"https://doi.org/10.3389/fmed.2026.1922352","title":"Serplulimab-induced toxic epidermal necrolysis-like reaction in a patient with extensive-stage small-cell lung cancer: a case report and literature review","display_name":"Serplulimab-induced toxic epidermal necrolysis-like reaction in a patient with extensive-stage small-cell lung cancer: a case report and literature review","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225405641","doi":"https://doi.org/10.3389/fmed.2026.1922352"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2026.1922352","doi":"https://doi.org/10.3389/fmed.2026.1922352","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1922352","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1922352/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1922352/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161022923","display_name":"Ying Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu","institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101264513","display_name":"Jia Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Hu","raw_affiliation_strings":["Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu","institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100851559","display_name":"Ying Wu Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Lan","raw_affiliation_strings":["Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu","institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161060785","display_name":"Zhigang Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Liang","raw_affiliation_strings":["Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu","institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141042840","display_name":"Min Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Xu","raw_affiliation_strings":["Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu","institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071410435","display_name":"Xiqian Zhang","orcid":"https://orcid.org/0000-0002-4486-8042","observed_orcids":["https://orcid.org/0000-0002-4486-8042"]},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Third People's Hospital of Chengdu","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiqian Zhang","raw_affiliation_strings":["Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu","institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071410435"],"corresponding_institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.49459999799728394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.49459999799728394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serplulimab","display_name":"serplulimab","score":1.0},{"id":"https://openalex.org/keywords/toxic-epidermal-necrolysis","display_name":"toxic epidermal necrolysis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/extensive-stage-small-cell-lung-cancer","display_name":"extensive-stage small cell lung cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9589999914169312},{"id":"https://openalex.org/keywords/anti-pd-1-monoclonal-antibody","display_name":"anti-PD-1 monoclonal antibody","score":0.9440000057220459},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.5120000243186951},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9490000009536743},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":1.0},{"id":"https://openalex.org/keywords/wound-care","display_name":"wound care","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nutritional-support","display_name":"nutritional support","score":0.9290000200271606}],"concepts":[{"id":"https://openalex.org/C2780664588","wikidata":"https://www.wikidata.org/wiki/Q1878682","display_name":"Toxic epidermal necrolysis","level":2,"score":0.933899998664856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8245999813079834},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5746999979019165},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5210999846458435},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4747999906539917},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.43160000443458557},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3846000134944916},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.3716000020503998},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.33869999647140503},{"id":"https://openalex.org/C2779890267","wikidata":"https://www.wikidata.org/wiki/Q1219805","display_name":"Mucous membrane","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33070001006126404},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3109000027179718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.290800005197525},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.2906000018119812},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C5337888","wikidata":"https://www.wikidata.org/wiki/Q7762436","display_name":"Bulla (seal)","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C2780542314","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Adverse drug reaction","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmed.2026.1922352","doi":"https://doi.org/10.3389/fmed.2026.1922352","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1922352","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1922352/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f1d04232a9f8446da89689c4691d1ba6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f1d04232a9f8446da89689c4691d1ba6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2026.1922352","doi":"https://doi.org/10.3389/fmed.2026.1922352","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2026.1922352","pdf_url":"https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1922352/pdf","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329861","display_name":"Natural Science Foundation of Sichuan Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225405641.pdf","grobid_xml":"https://content.openalex.org/works/W7225405641.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2064861244","https://openalex.org/W2079917706","https://openalex.org/W2134537227","https://openalex.org/W2346838547","https://openalex.org/W2558419428","https://openalex.org/W2995672816","https://openalex.org/W3043405635","https://openalex.org/W3133615050","https://openalex.org/W4205588910","https://openalex.org/W4280562150","https://openalex.org/W4284884589","https://openalex.org/W4297251744","https://openalex.org/W4322773236","https://openalex.org/W4367317756","https://openalex.org/W4384931169","https://openalex.org/W4391849225","https://openalex.org/W4393180730","https://openalex.org/W4393935425","https://openalex.org/W4401566375","https://openalex.org/W4402549751","https://openalex.org/W4402555331","https://openalex.org/W4402782167","https://openalex.org/W4405819297","https://openalex.org/W4408244035","https://openalex.org/W4408899961","https://openalex.org/W4409003423","https://openalex.org/W4411161514","https://openalex.org/W4413989259","https://openalex.org/W7129043037"],"related_works":["https://openalex.org/W7219827127","https://openalex.org/W4281787927","https://openalex.org/W4399670607","https://openalex.org/W4393231942","https://openalex.org/W4293194744","https://openalex.org/W4399979125","https://openalex.org/W7126082653","https://openalex.org/W4415477810","https://openalex.org/W7223154985","https://openalex.org/W4406338775"],"abstract_inverted_index":{"Background":[0],"Serplulimab":[1],"is":[2,275],"the":[3,13,69,85,101,120,154,200,205,240],"first":[4,102,121],"anti-PD-1":[5],"monoclonal":[6],"antibody":[7],"to":[8,34,129,135,153,214],"receive":[9],"marketing":[10],"approval":[11],"for":[12,92,100,277],"first-line":[14],"treatment":[15,56,91,184,201,262],"of":[16,28,44,84,97,123,145,156,171,177,203,207,242,245,265],"extensive-stage":[17],"small-cell":[18],"lung":[19],"cancer":[20],"(ES-SCLC)":[21],"worldwide.":[22],"To":[23],"date,":[24],"only":[25],"sporadic":[26,113],"cases":[27],"immune-induced":[29],"adverse":[30],"events":[31],"(irAEs)":[32],"secondary":[33,213],"serplulimab":[35,58,78,124,197,215,224],"have":[36],"been":[37],"reported.":[38],"Herein,":[39],"we":[40,67,257],"report":[41],"a":[42,45,50,81,93,140,146,157,166,175,227,235,260],"case":[43,221],"man":[46,108],"who":[47],"suffered":[48],"from":[49],"toxic":[51,72],"epidermal":[52,73,137],"necrolysis-like":[53],"reaction":[54,148,233],"after":[55,119],"with":[57,63,77,110,165],"and":[59,79,90,131,179,192,238,247,250,272],"was":[60,149,162],"successfully":[61,163],"treated":[62,164],"comprehensive":[64,95],"therapy.":[65],"Additionally,":[66],"review":[68],"literature":[70],"on":[71,186],"necrolysis":[74],"(TEN)":[75],"associated":[76],"provide":[80],"detailed":[82],"description":[83],"clinical":[86],"symptoms,":[87],"underlying":[88],"mechanisms,":[89],"more":[94],"understanding":[96],"immune-related":[98],"TEN":[99,212],"time.":[103,142],"Case":[104],"summary":[105],"A":[106,143],"76-year-old":[107],"diagnosed":[109],"ES-SCLC":[111],"developed":[112],"red":[114],"maculopapular":[115],"eruptions":[116],"7":[117],"days":[118],"cycle":[122],"infusion,":[125],"which":[126],"rapidly":[127],"progressed":[128],"blisters":[130],"ulceration,":[132],"ultimately":[133],"deteriorating":[134],"extensive":[136],"detachment":[138],"within":[139,234],"short":[141,236],"diagnosis":[144],"TEN-like":[147,232],"conservatively":[150],"made":[151],"due":[152],"lack":[155],"skin":[158,246],"biopsy.":[159],"The":[160],"patient":[161],"multifaceted":[167],"management":[168],"approach":[169,263],"consisting":[170,264],"immune":[172,266],"suppression":[173],"using":[174],"combination":[176],"corticosteroids":[178],"intravenous":[180],"immunoglobulin":[181],"(IVIG),":[182],"anti-infection":[183,268],"based":[185],"susceptibility":[187],"testing,":[188],"personalized":[189],"wound":[190,270],"care,":[191,271],"nutritional":[193,273],"support.":[194],"Conclusion":[195],"Despite":[196],"having":[198],"reshaped":[199],"landscape":[202],"ES-SCLC,":[204],"occurrence":[206],"rare":[208,228],"but":[209,229],"potentially":[210,230],"fatal":[211,231],"should":[216],"not":[217],"be":[218],"ignored.":[219],"This":[220],"illustrates":[222],"that":[223,259],"can":[225],"induce":[226],"time":[237],"underscores":[239],"importance":[241],"vigilant":[243],"monitoring":[244],"mucous":[248],"membranes":[249],"early":[251],"recognition":[252],"during":[253],"treatment.":[254],"In":[255],"addition,":[256],"highlight":[258],"multidimensional":[261],"suppression,":[267],"treatment,":[269],"support":[274],"pivotal":[276],"recovery.":[278]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
