{"id":"https://openalex.org/W7225405245","doi":"https://doi.org/10.1097/md.0000000000051417","title":"Association between prior HBV vaccine responsiveness and booster-induced anti-SARS-CoV-2 spike antibody titers following the third BNT162b2 dose in Japanese healthcare workers: A prospective observational study","display_name":"Association between prior HBV vaccine responsiveness and booster-induced anti-SARS-CoV-2 spike antibody titers following the third BNT162b2 dose in Japanese healthcare workers: A prospective observational study","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225405245","doi":"https://doi.org/10.1097/md.0000000000051417","pmid":"https://pubmed.ncbi.nlm.nih.gov/42994824"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000051417","doi":"https://doi.org/10.1097/md.0000000000051417","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000051417","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000051417","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049674455","display_name":"Miwa Misawa","orcid":"https://orcid.org/0009-0005-2348-1665","observed_orcids":["https://orcid.org/0009-0005-2348-1665"]},"institutions":[{"id":"https://openalex.org/I4405284275","display_name":"Osaka Medical and Pharmaceutical University Hospital","ror":"https://ror.org/038xr9472","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284275"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miwa Misawa","raw_affiliation_strings":["Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan"],"raw_orcid":"https://orcid.org/0009-0005-2348-1665","affiliations":[{"raw_affiliation_string":"Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I4405284275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161123165","display_name":"Momoko Iwamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256591","display_name":"Kochi Health Sciences Center","ror":"https://ror.org/04b3jbx04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256591"]},{"id":"https://openalex.org/I4405284275","display_name":"Osaka Medical and Pharmaceutical University Hospital","ror":"https://ror.org/038xr9472","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284275"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Momoko Iwamoto","raw_affiliation_strings":["Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan","Department of Obstetrics and Gynecology, Kochi Health Sciences Center, Kochi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I4405284275"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Kochi Health Sciences Center, Kochi, Japan","institution_ids":["https://openalex.org/I4405256591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160995541","display_name":"Tomoyuki Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284275","display_name":"Osaka Medical and Pharmaceutical University Hospital","ror":"https://ror.org/038xr9472","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284275"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Yamada","raw_affiliation_strings":["Department of Pharmacy, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I4405284275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047814425","display_name":"Fumiko Kawanishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284275","display_name":"Osaka Medical and Pharmaceutical University Hospital","ror":"https://ror.org/038xr9472","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284275"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiko Kawanishi","raw_affiliation_strings":["Department of Nursing, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I4405284275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078097515","display_name":"Masami Nishihara","orcid":"https://orcid.org/0000-0001-7976-2750","observed_orcids":["https://orcid.org/0000-0001-7976-2750"]},"institutions":[{"id":"https://openalex.org/I4405284275","display_name":"Osaka Medical and Pharmaceutical University Hospital","ror":"https://ror.org/038xr9472","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284275"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Nishihara","raw_affiliation_strings":["Department of Pharmacy, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I4405284275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018505715","display_name":"Akira Asai","orcid":"https://orcid.org/0000-0002-2915-7875","observed_orcids":["https://orcid.org/0000-0002-2915-7875"]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Asai","raw_affiliation_strings":["Central Clinical Laboratory, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Clinical Laboratory, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113506512","display_name":"Yusuke Kusaka","orcid":"https://orcid.org/0009-0007-7551-0864","observed_orcids":["https://orcid.org/0009-0007-7551-0864"]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Kusaka","raw_affiliation_strings":["Department of Anesthesiology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048824271","display_name":"Taku Ogawa","orcid":"https://orcid.org/0000-0003-1569-4642","observed_orcids":["https://orcid.org/0000-0003-1569-4642"]},"institutions":[{"id":"https://openalex.org/I4405284275","display_name":"Osaka Medical and Pharmaceutical University Hospital","ror":"https://ror.org/038xr9472","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284275"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taku Ogawa","raw_affiliation_strings":["Infection Control Center, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Control Center, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I4405284275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108400592","display_name":"Takashi Nakano","orcid":"https://orcid.org/0000-0002-0135-1051","observed_orcids":["https://orcid.org/0000-0002-0135-1051"]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakano","raw_affiliation_strings":["Department of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039673181","display_name":"Akira Ukimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205143321","display_name":"Osaka Medical and Pharmaceutical University","ror":"https://ror.org/01y2kdt21","country_code":"JP","type":"education","lineage":["https://openalex.org/I205143321"]},{"id":"https://openalex.org/I4210166362","display_name":"Municipal Hirakata City Hospital","ror":"https://ror.org/05wvk1430","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166362"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Ukimura","raw_affiliation_strings":["Hirakata City Hospital, Hirakata, Osaka, Japan","Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hirakata City Hospital, Hirakata, Osaka, Japan","institution_ids":["https://openalex.org/I4210166362"]},{"raw_affiliation_string":"Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I205143321"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161142068","display_name":"Tomio Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405284275","display_name":"Osaka Medical and Pharmaceutical University Hospital","ror":"https://ror.org/038xr9472","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284275"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomio Suzuki","raw_affiliation_strings":["Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka, Japan","institution_ids":["https://openalex.org/I4405284275"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"45","first_page":"e51417","last_page":"e51417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2-spike-antibodies","display_name":"SARS-CoV-2 spike protein antibodies","score":0.7409999966621399},{"id":"https://openalex.org/keywords/bnt162b2","display_name":"BNT162b2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.8220000267028809},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.703000009059906},{"id":"https://openalex.org/keywords/healthcare-workers","display_name":"healthcare workers","score":0.5979999899864197},{"id":"https://openalex.org/keywords/antibody-titers","display_name":"antibody titers","score":0.4620000123977661},{"id":"https://openalex.org/keywords/vaccine-non-responders","display_name":"vaccine non-responders","score":0.6729999780654907},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.6600000262260437},{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.746999979019165},{"id":"https://openalex.org/keywords/japanese-workers","display_name":"Japanese workers","score":0.5230000019073486},{"id":"https://openalex.org/keywords/age-and-sex-adjustment","display_name":"age and sex adjustment","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9577000141143799},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6164000034332275},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6054999828338623},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5913000106811523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4950999915599823},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.49410000443458557},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4821999967098236},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.4645000100135803},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.45210000872612},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.43290001153945923},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4327999949455261},{"id":"https://openalex.org/C2781037505","wikidata":"https://www.wikidata.org/wiki/Q117749","display_name":"Hepatitis B vaccine","level":5,"score":0.40299999713897705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3846000134944916},{"id":"https://openalex.org/C2909509916","wikidata":"https://www.wikidata.org/wiki/Q22329850","display_name":"Spike Protein","level":5,"score":0.38199999928474426},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.3727000057697296},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.3555000126361847},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.3262999951839447},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3098999857902527},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.2743000090122223},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27070000767707825},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000090982","descriptor_name":"BNT162 Vaccine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006282","descriptor_name":"Health Personnel","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007117","descriptor_name":"Immunization, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017325","descriptor_name":"Hepatitis B Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017325","descriptor_name":"Hepatitis B Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/md.0000000000051417","doi":"https://doi.org/10.1097/md.0000000000051417","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000051417","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmid:42994824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42994824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000051417","doi":"https://doi.org/10.1097/md.0000000000051417","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000051417","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2783773804","https://openalex.org/W2986205132","https://openalex.org/W3111255098","https://openalex.org/W3131688063","https://openalex.org/W3158948419","https://openalex.org/W3173738234","https://openalex.org/W3212447088","https://openalex.org/W4214483034","https://openalex.org/W4214623605","https://openalex.org/W4225982774","https://openalex.org/W4280536240","https://openalex.org/W4304190315","https://openalex.org/W4389246333"],"related_works":["https://openalex.org/W4280536240","https://openalex.org/W4298140989","https://openalex.org/W4223987408","https://openalex.org/W4221056508","https://openalex.org/W3162064629","https://openalex.org/W4281643894","https://openalex.org/W4226281657","https://openalex.org/W4414740824","https://openalex.org/W6901984241","https://openalex.org/W4385576574"],"abstract_inverted_index":{"Inter-individual":[0],"variability":[1],"in":[2,183,256],"vaccine-induced":[3],"humoral":[4,286],"responses":[5,261,288],"has":[6],"been":[7],"reported":[8,65],"even":[9],"among":[10],"generally":[11],"healthy":[12],"individuals.":[13],"In":[14],"our":[15],"previous":[16],"study,":[17],"healthcare":[18,71],"workers":[19],"with":[20,142,202,246,263],"poor":[21],"hepatitis":[22],"B":[23],"virus":[24],"(HBV)":[25],"vaccine":[26,97,155,232,266,303],"responsiveness":[27,267],"were":[28,92,108,152,158,163,268,305],"more":[29],"likely":[30],"to":[31],"show":[32],"a":[33,52,63,136,239],"low":[34,124,240],"anti-SARS-CoV-2":[35,79,167,258],"spike":[36,80,168,259],"antibody":[37,81,143,169,241,260,287],"response":[38,106,181,242],"after":[39,51,86,129,147,191,227,275,289],"the":[40,77,87,111,130,148,184,205,228,276,298],"first":[41,131,229],"BNT162b2":[42,54,89,278],"dose.":[43,55,90,279],"This":[44,56],"study":[45,61],"examined":[46],"whether":[47],"such":[48],"differences":[49],"persisted":[50],"third":[53,88,149,277],"was":[57,76,133,171,210],"an":[58,235],"extended":[59],"follow-up":[60],"of":[62,69,238,284,302],"previously":[64],"prospective":[66],"observational":[67],"cohort":[68],"Japanese":[70],"workers.":[72],"The":[73,165],"primary":[74],"outcome":[75],"quantitative":[78],"titer":[82,170],"measured":[83,285],"12":[84,145,273],"weeks":[85,146,274],"Participants":[91],"classified":[93],"as":[94,135],"normal":[95,153,203,247],"HBV":[96,105,154,180,231,265],"responders,":[98,100,156,160,204],"weak":[99,159,216],"or":[101,190],"non-responders.":[102,164,224],"Comparisons":[103],"across":[104,179],"groups":[107,182],"performed":[109],"using":[110],"Kruskal-Wallis":[112],"test":[113],"and":[114,121,161,195,218],"multivariable":[115],"linear":[116],"regression":[117],"adjusted":[118,206],"for":[119,193,215,223],"age":[120,194],"sex.":[122],"A":[123],"antibody-response":[125],"analysis":[126,186],"(<15":[127,243],"U/mL)":[128,244],"dose":[132],"evaluated":[134],"secondary":[137],"analysis.":[138],"Among":[139],"741":[140],"participants":[141],"measurements":[144],"dose,":[150,230],"486":[151],"229":[157],"26":[162],"median":[166],"891,900":[172],"U/mL.":[173],"Titers":[174],"did":[175],"not":[176,295],"differ":[177],"significantly":[178],"unadjusted":[185],"(P":[187],"=":[188,199],".3718)":[189],"adjustment":[192],"sex":[196],"(global":[197],"P":[198],".3971).":[200],"Compared":[201],"geometric":[207],"mean":[208],"ratio":[209],"0.94":[211],"(95%":[212,220],"CI,":[213,221,253],"0.83-1.07)":[214],"responders":[217,248],"0.83":[219],"0.60-1.15)":[222],"By":[225],"contrast,":[226],"non-responders":[233],"had":[234],"increased":[236],"risk":[237],"compared":[245],"(adjusted":[249],"RR,":[250],"1.85;":[251],"95%":[252],"1.10-3.13).":[254],"Differences":[255],"early":[257],"associated":[262],"prior":[264],"no":[269],"longer":[270],"statistically":[271],"apparent":[272],"These":[280],"findings":[281],"suggest":[282],"convergence":[283],"booster":[290],"vaccination,":[291],"although":[292],"they":[293],"do":[294],"establish":[296],"that":[297],"underlying":[299],"biological":[300],"mechanisms":[301],"hyporesponsiveness":[304],"eliminated.":[306]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-07T00:00:00"}