{"id":"https://openalex.org/W7225404306","doi":"https://doi.org/10.3389/fendo.2026.1906978","title":"Expansion of the MEN1 tumor spectrum: convergent molecular evidence of MEN1 inactivation in a fibromyxosarcoma, VIPoma, and gastric neuroendocrine carcinoma","display_name":"Expansion of the MEN1 tumor spectrum: convergent molecular evidence of MEN1 inactivation in a fibromyxosarcoma, VIPoma, and gastric neuroendocrine carcinoma","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225404306","doi":"https://doi.org/10.3389/fendo.2026.1906978"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2026.1906978","doi":"https://doi.org/10.3389/fendo.2026.1906978","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1906978","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1906978/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1906978/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031780883","display_name":"Nath\u00e1lia Maria Gon\u00e7alves Siqueira","orcid":"https://orcid.org/0000-0002-7882-315X","observed_orcids":["https://orcid.org/0000-0002-7882-315X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nathalia Maria Gon\u00e7alves Siqueira","raw_affiliation_strings":["Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015066019","display_name":"Lucas Santos de Santana","orcid":"https://orcid.org/0000-0003-0428-2386","observed_orcids":["https://orcid.org/0000-0003-0428-2386"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lucas Santos de Santana","raw_affiliation_strings":["Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067343242","display_name":"Elisangela P S Quedas","orcid":"https://orcid.org/0000-0002-0337-7132","observed_orcids":["https://orcid.org/0000-0002-0337-7132"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elisangela Pereira de Souza Quedas","raw_affiliation_strings":["Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012119794","display_name":"Evandro Sobroza de Mello","orcid":"https://orcid.org/0000-0002-4383-2910","observed_orcids":["https://orcid.org/0000-0002-4383-2910"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Evandro Sobroza de Mello","raw_affiliation_strings":["Pathology Department, University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","Pathology Laboratory, Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Pathology Laboratory, Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090695793","display_name":"Iber\u00ea Cauduro Soares","orcid":"https://orcid.org/0000-0003-3830-4686","observed_orcids":["https://orcid.org/0000-0003-3830-4686"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Iber\u00ea Cauduro Soares","raw_affiliation_strings":["Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","Pathology Laboratory, Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]},{"raw_affiliation_string":"Pathology Laboratory, Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108502481","display_name":"R.D.A. Toledo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155398","display_name":"Vall d'Hebron Institute of Oncology","ror":"https://ror.org/054xx3904","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155398"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rodrigo Almeida Toledo","raw_affiliation_strings":["Vall d\u2019Hebron Institute of Oncology Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vall d\u2019Hebron Institute of Oncology Barcelona","institution_ids":["https://openalex.org/I4387155398"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088500248","display_name":"Delmar Muniz Louren\u00e7o","orcid":"https://orcid.org/0000-0003-1147-4159","observed_orcids":["https://orcid.org/0000-0003-1147-4159"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Delmar Muniz Louren\u00e7o Junior","raw_affiliation_strings":["Division of Endocrine Oncology, Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrine Oncology, Institute of Cancer of the State of S\u00e3o Paulo (ICESP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]},{"raw_affiliation_string":"Endocrine Genetics Unit, Laboratory of Cellular and Molecular Endocrinology (LIM-25), Division of Endocrinology and Metabolism, Hospital das Clinicas (HCFMUSP), University of S\u00e3o Paulo School of Medicine (FMUSP), Faculdade de Medicina da Universidade de S\u00e3o Paulo (FMUSP)","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5088500248"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998","https://openalex.org/I4210145268"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-1","display_name":"multiple endocrine neoplasia type 1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/vipoma","display_name":"VIPoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gastric-neuroendocrine-carcinoma","display_name":"gastric neuroendocrine carcinoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/wdha-syndrome","display_name":"WDHA syndrome","score":0.781000018119812},{"id":"https://openalex.org/keywords/primary-hyperparathyroidism","display_name":"primary hyperparathyroidism","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pituitary-microadenoma","display_name":"pituitary microadenoma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-predisposition-syndrome","display_name":"tumor predisposition syndrome","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2779469564","wikidata":"https://www.wikidata.org/wiki/Q1920577","display_name":"MEN1","level":4,"score":0.9603999853134155},{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.7961999773979187},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.6495000123977661},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5063999891281128},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.5045999884605408},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4844000041484833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4733000099658966},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40869998931884766},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.40139999985694885},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.39579999446868896},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.39100000262260437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3847000002861023},{"id":"https://openalex.org/C2780053029","wikidata":"https://www.wikidata.org/wiki/Q1501239","display_name":"Insulinoma","level":3,"score":0.37959998846054077},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.3720000088214874},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.3682999908924103},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.3571999967098236},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3447999954223633},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.3361999988555908},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3310000002384186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3228999972343445},{"id":"https://openalex.org/C2779926675","wikidata":"https://www.wikidata.org/wiki/Q6943700","display_name":"Mutant protein","level":4,"score":0.3163999915122986},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.2535000145435333}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fendo.2026.1906978","doi":"https://doi.org/10.3389/fendo.2026.1906978","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1906978","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1906978/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a4320f00786f420fb0dbc021dd269fa3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a4320f00786f420fb0dbc021dd269fa3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2026.1906978","doi":"https://doi.org/10.3389/fendo.2026.1906978","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2026.1906978","pdf_url":"https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1906978/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321992","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","ror":"https://ror.org/050zdnc69"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225404306.pdf","grobid_xml":"https://content.openalex.org/works/W7225404306.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W118005063","https://openalex.org/W1754037679","https://openalex.org/W1955704019","https://openalex.org/W1968200190","https://openalex.org/W1968558567","https://openalex.org/W1970999856","https://openalex.org/W1977861496","https://openalex.org/W1979754268","https://openalex.org/W1980438381","https://openalex.org/W1986503527","https://openalex.org/W1989282715","https://openalex.org/W2002416334","https://openalex.org/W2012589790","https://openalex.org/W2018139273","https://openalex.org/W2023367466","https://openalex.org/W2036995943","https://openalex.org/W2043416934","https://openalex.org/W2045581390","https://openalex.org/W2049919732","https://openalex.org/W2050413914","https://openalex.org/W2052007738","https://openalex.org/W2054258175","https://openalex.org/W2057520599","https://openalex.org/W2077300431","https://openalex.org/W2086923046","https://openalex.org/W2095944026","https://openalex.org/W2114789973","https://openalex.org/W2116589423","https://openalex.org/W2130251781","https://openalex.org/W2144625498","https://openalex.org/W2148929317","https://openalex.org/W2150241835","https://openalex.org/W2150638375","https://openalex.org/W2157212789","https://openalex.org/W2171395146","https://openalex.org/W2174854144","https://openalex.org/W2215781512","https://openalex.org/W2341622656","https://openalex.org/W2580165677","https://openalex.org/W2610195657","https://openalex.org/W2737129864","https://openalex.org/W2755533899","https://openalex.org/W2796215767","https://openalex.org/W2891703921","https://openalex.org/W2895012342","https://openalex.org/W2895443620","https://openalex.org/W2898050309","https://openalex.org/W2952192123","https://openalex.org/W3108711814","https://openalex.org/W3121258936","https://openalex.org/W3127620645","https://openalex.org/W3135785530","https://openalex.org/W4306377276","https://openalex.org/W4309047739","https://openalex.org/W4323859457","https://openalex.org/W4383534263","https://openalex.org/W4390718250","https://openalex.org/W4404801738","https://openalex.org/W4411260731"],"related_works":["https://openalex.org/W14922360","https://openalex.org/W2156912872","https://openalex.org/W120278977","https://openalex.org/W2022033224","https://openalex.org/W2140594333","https://openalex.org/W7154453998","https://openalex.org/W2174854144","https://openalex.org/W2255658708","https://openalex.org/W2466748302","https://openalex.org/W2075173469"],"abstract_inverted_index":{"Background":[0],"Multiple":[1],"endocrine":[2],"neoplasia":[3],"type":[4],"1":[5],"(MEN1)":[6],"is":[7],"an":[8,124,201],"autosomal":[9],"dominant":[10],"tumor":[11,88,312],"predisposition":[12],"syndrome":[13,110],"primarily":[14],"characterized":[15],"by":[16,102,180,254],"parathyroid,":[17],"pituitary,":[18],"and":[19,90,111,132,164,193,230,242,272,314],"pancreaticoduodenal":[20],"neuroendocrine":[21,87,95,121,166,244],"tumors.":[22,265],"Although":[23],"several":[24],"non-endocrine":[25],"neoplasms":[26],"have":[27],"been":[28],"associated":[29],"with":[30,50,75,104,183,249],"MEN1,":[31],"the":[32,55,108,119,140,149,160,171,177,187,197,221,226,234,238,286,298,316,319],"role":[33,306],"of":[34,107,113,148,155,170,186,196,200,220,233,251,288,307,322],"MEN1":[35,53,58,70,178,205,223,260,289,323],"inactivation":[36,261,290],"in":[37,67,159,225,237,297],"rare":[38,294],"mesenchymal":[39],"tumors":[40,295],"remains":[41],"incompletely":[42],"understood.":[43],"Case":[44],"presentation":[45],"We":[46],"report":[47,268],"a":[48,68,78,82,91,143,280,304],"woman":[49],"genetically":[51],"confirmed":[52,217],"carrying":[54],"pathogenic":[56],"germline":[57],"variant":[59,206],"c.249_252delGTCT":[60],"(":[61,207],"p.Ile85Serfs*":[62],"33,":[63],"exon":[64,191,212],"2),":[65],"identified":[66],"large":[69],"kindred.":[71],"The":[72,97],"patient":[73,141,300],"presented":[74],"primary":[76],"hyperparathyroidism,":[77],"non-functioning":[79],"pituitary":[80],"microadenoma,":[81],"pancreatic":[83,162],"vasoactive":[84],"intestinal":[85],"peptide-producing":[86],"(VIPoma),":[89],"poorly":[92],"differentiated":[93],"gastric":[94,120,165,243],"carcinoma.":[96,167],"VIPoma":[98,239],"was":[99],"successfully":[100],"cured":[101],"gastroduodenopancreatectomy,":[103],"complete":[105,153],"resolution":[106],"WDHA":[109],"normalization":[112],"serum":[114],"VIP":[115],"levels.":[116],"In":[117,138,284],"contrast,":[118],"carcinoma":[122,245],"followed":[123],"aggressive":[125],"clinical":[126],"course,":[127],"leading":[128],"to":[129],"disease":[130],"recurrence":[131],"death":[133],"30":[134],"months":[135],"after":[136],"surgery.":[137],"addition,":[139,285],"developed":[142],"recurrent":[144],"low-grade":[145,276],"odontogenic":[146,277],"fibromyxosarcoma":[147,172,227,278],"maxilla.":[150],"Immunohistochemistry":[151],"demonstrated":[152,231],"loss":[154,250,309],"nuclear":[156],"menin":[157,252,308],"expression":[158,253],"fibromyxosarcoma,":[161],"VIPoma,":[163],"Molecular":[168],"analyses":[169],"revealed":[173],"allelic":[174],"imbalance":[175],"at":[176,190],"locus":[179],"Sanger":[181],"sequencing,":[182],"apparent":[184],"absence":[185],"wild-type":[188],"allele":[189,199,224,236],"2":[192],"exclusive":[194],"detection":[195],"T":[198],"informative":[202],"heterozygous":[203],"synonymous":[204],"c.1269C>T":[208],";":[209],"p.Asp418=":[210],",":[211],"9).":[213],"Targeted":[214],"next-generation":[215],"sequencing":[216],"marked":[218],"enrichment":[219,232],"mutant":[222,235],"(VAF":[228,240,246],"81.8%)":[229],"68.2%)":[241],"70.6%).":[247],"Together":[248],"immunohistochemistry,":[255],"these":[256],"findings":[257],"support":[258],"somatic":[259],"across":[262,291,310],"all":[263],"three":[264,292],"Conclusions":[266],"This":[267],"provides":[269,301],"convergent":[270],"genetic":[271],"immunohistochemical":[273],"evidence":[274,302],"supporting":[275],"as":[279],"potential":[281],"MEN1-associated":[282],"neoplasm.":[283],"demonstration":[287],"exceptionally":[293],"arising":[296],"same":[299],"for":[303],"broader":[305],"distinct":[311],"types":[313],"supports":[315],"possibility":[317],"that":[318],"phenotypic":[320],"spectrum":[321],"extends":[324],"beyond":[325],"currently":[326],"recognized":[327],"manifestations.":[328]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
