{"id":"https://openalex.org/W7225404189","doi":"https://doi.org/10.1097/pas.0000000000002640","title":"Spatial Clonal Discordance in Early Mycosis Fungoides Revealed by Compartment-specific TRBC1 Immunohistochemistry","display_name":"Spatial Clonal Discordance in Early Mycosis Fungoides Revealed by Compartment-specific TRBC1 Immunohistochemistry","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225404189","doi":"https://doi.org/10.1097/pas.0000000000002640","pmid":"https://pubmed.ncbi.nlm.nih.gov/42989715"},"language":"en","primary_location":{"id":"doi:10.1097/pas.0000000000002640","doi":"https://doi.org/10.1097/pas.0000000000002640","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pas.0000000000002640","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5141245100","display_name":"Chujun Huang","orcid":"https://orcid.org/0009-0001-1424-1767","observed_orcids":["https://orcid.org/0009-0001-1424-1767","https://orcid.org/0009-0009-2656-6604"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chujun Huang","raw_affiliation_strings":["Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China"],"raw_orcid":"https://orcid.org/0009-0001-1424-1767","affiliations":[{"raw_affiliation_string":"Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005379258","display_name":"\u90b5\u96ea\u5b9d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuebao Shao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101849316","display_name":"Jie Zang","orcid":"https://orcid.org/0000-0003-2377-1097","observed_orcids":["https://orcid.org/0000-0003-2377-1097","https://orcid.org/0009-0002-8281-9177"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jie Zang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160997861","display_name":"Huiting Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huiting Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161031260","display_name":"Hao Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161037406","display_name":"Ying Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161084869","display_name":"Hao Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycosis-fungoides","display_name":"mycosis fungoides","score":0.9829999804496765},{"id":"https://openalex.org/keywords/trbc1","display_name":"TRBC1","score":0.8040000200271606},{"id":"https://openalex.org/keywords/t-cell-clonality","display_name":"T cell clonality","score":0.8659999966621399},{"id":"https://openalex.org/keywords/sezary-syndrome","display_name":"S\u00e9zary syndrome","score":0.7990000247955322},{"id":"https://openalex.org/keywords/epidermotropism","display_name":"epidermotropism","score":0.859000027179718},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.828000009059906},{"id":"https://openalex.org/keywords/dilution-effect","display_name":"dilution effect","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2777756187","wikidata":"https://www.wikidata.org/wiki/Q1891209","display_name":"Mycosis fungoides","level":3,"score":0.9099000096321106},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.781499981880188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7178999781608582},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6991000175476074},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6407999992370605},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.5152000188827515},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4634000062942505},{"id":"https://openalex.org/C90583042","wikidata":"https://www.wikidata.org/wiki/Q1952456","display_name":"Multiplex polymerase chain reaction","level":4,"score":0.3659999966621399},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C549673821","wikidata":"https://www.wikidata.org/wiki/Q683455","display_name":"Anatomical pathology","level":3,"score":0.3427000045776367},{"id":"https://openalex.org/C2777891184","wikidata":"https://www.wikidata.org/wiki/Q7168693","display_name":"Peripheral T-cell lymphoma","level":4,"score":0.30090001225471497},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/pas.0000000000002640","doi":"https://doi.org/10.1097/pas.0000000000002640","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pas.0000000000002640","pdf_url":null,"source":{"id":"https://openalex.org/S37879208","display_name":"The American Journal of Surgical Pathology","issn_l":"0147-5185","issn":["0147-5185","1532-0979"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Surgical Pathology","raw_type":"journal-article"},{"id":"pmid:42989715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42989715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of surgical pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2768338596","https://openalex.org/W2909964376","https://openalex.org/W2921606116","https://openalex.org/W2935834835","https://openalex.org/W3019174138","https://openalex.org/W3088597010","https://openalex.org/W3091638028","https://openalex.org/W3091782042","https://openalex.org/W3133427263","https://openalex.org/W4281395391","https://openalex.org/W4304845757","https://openalex.org/W4386174212","https://openalex.org/W4389396111","https://openalex.org/W4400788255","https://openalex.org/W4404106160","https://openalex.org/W4412572418","https://openalex.org/W4413048637","https://openalex.org/W4414774144","https://openalex.org/W4415228250"],"related_works":["https://openalex.org/W7119467924","https://openalex.org/W7222352429","https://openalex.org/W3034612838","https://openalex.org/W3205164459","https://openalex.org/W1971197383","https://openalex.org/W2314948639","https://openalex.org/W4404568976","https://openalex.org/W4414774144","https://openalex.org/W7162794815","https://openalex.org/W2084989603"],"abstract_inverted_index":{"Diagnosis":[0],"of":[1,18,46,54,129,167],"early":[2,55,58,171],"mycosis":[3],"fungoides":[4],"(MF)":[5],"is":[6,71,139],"hindered":[7],"by":[8,14,96,141],"overlap":[9],"with":[10],"benign":[11],"dermatoses":[12],"and":[13,88,106,123,146],"the":[15,52,150,164],"variable":[16],"sensitivity":[17],"conventional":[19,179],"polymerase":[20],"chain":[21],"reaction-based":[22],"molecular":[23,98,180],"clonality":[24,48,93],"assays":[25,99],"in":[26,100,170],"paucicellular":[27,101],"specimens.":[28],"We":[29],"demonstrate":[30],"that":[31,49],"T-cell":[32,47],"receptor":[33],"\u03b2-chain":[34],"constant":[35],"region":[36],"1":[37],"(TRBC1)":[38],"immunohistochemistry":[39],"(IHC)":[40],"provides":[41],"a":[42,62,156,175],"spatially":[43,110,158],"resolved":[44],"assessment":[45],"may":[50,89],"aid":[51],"evaluation":[53],"MF.":[56],"In":[57],"MF,":[59,172],"we":[60],"identified":[61],"characteristic":[63],"\"spatial":[64],"clonal":[65,185],"discordance,\"":[66],"where":[67],"monotypic":[68],"TRBC1":[69,153],"expression":[70],"confined":[72],"to":[73,178],"intraepidermal":[74],"T":[75],"cells":[76,169],"while":[77],"dermal":[78],"infiltrates":[79],"remain":[80],"polytypic.":[81],"This":[82],"compartment-specific":[83,184],"pattern":[84],"reflects":[85],"neoplastic":[86],"epidermotropism":[87],"help":[90],"explain":[91],"discordant":[92],"results":[94],"obtained":[95],"bulk":[97],"lesions.":[102],"Conversely,":[103],"tumor-stage":[104],"MF":[105],"S\u00e9zary":[107],"syndrome":[108],"exhibited":[109],"concordant,":[111],"pan-compartmental":[112],"restriction.":[113],"Digital":[114],"image":[115],"analysis":[116],"showed":[117],"high":[118],"concordance":[119],"between":[120],"single-stain":[121],"IHC":[122,154],"multiplex":[124],"immunofluorescence,":[125],"establishing":[126],"TRBC1+":[127],"thresholds":[128],"\u226425%":[130],"or":[131],"\u226575%":[132],"for":[133,182],"defining":[134],"clonality.":[135],"Although":[136],"this":[137],"study":[138],"limited":[140],"its":[142],"retrospective,":[143],"single-center":[144],"design":[145],"relatively":[147],"small":[148],"cohort,":[149],"findings":[151],"establish":[152],"as":[155,174],"powerful,":[157],"informative":[159],"tool.":[160],"It":[161],"effectively":[162],"overcomes":[163],"\"dilution":[165],"effect\"":[166],"reactive":[168],"serving":[173],"high-sensitivity":[176],"adjunct":[177],"testing":[181],"accurate,":[183],"evaluation.":[186]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
