{"id":"https://openalex.org/W7225404108","doi":"https://doi.org/10.1097/coh.0000000000001086","title":"Beyond neutralization: Fc-mediated antibody functions in HIV reservoir control","display_name":"Beyond neutralization: Fc-mediated antibody functions in HIV reservoir control","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225404108","doi":"https://doi.org/10.1097/coh.0000000000001086","pmid":"https://pubmed.ncbi.nlm.nih.gov/42993670"},"language":"en","primary_location":{"id":"doi:10.1097/coh.0000000000001086","doi":"https://doi.org/10.1097/coh.0000000000001086","is_oa":true,"landing_page_url":"https://doi.org/10.1097/coh.0000000000001086","pdf_url":null,"source":{"id":"https://openalex.org/S106953758","display_name":"Current Opinion in HIV and AIDS","issn_l":"1746-630X","issn":["1746-630X","1746-6318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in HIV and AIDS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/coh.0000000000001086","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012704807","display_name":"Mieke A. van der Mescht","orcid":"https://orcid.org/0000-0002-7521-1756","observed_orcids":["https://orcid.org/0000-0002-7521-1756"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mieke A. van der Mescht","raw_affiliation_strings":["Department of Surgery, Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050612131","display_name":"Guido Ferrari","orcid":"https://orcid.org/0000-0001-7747-3349","observed_orcids":["https://orcid.org/0000-0001-7747-3349"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guido Ferrari","raw_affiliation_strings":["Department of Surgery, Duke University","Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025648380","display_name":"Kali F. Crofts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kali F. Crofts","raw_affiliation_strings":["Department of Surgery, Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-reservoir","display_name":"HIV reservoir","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hiv-cure","display_name":"HIV cure","score":0.8389999866485596},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/therapeutic-vaccination","display_name":"therapeutic vaccination","score":0.7089999914169312},{"id":"https://openalex.org/keywords/broadly-neutralizing-antibodies","display_name":"broadly neutralizing antibodies","score":0.9990000128746033},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.7940000295639038},{"id":"https://openalex.org/keywords/viral-rebound","display_name":"viral rebound","score":0.7429999709129333},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.683899998664856},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6499000191688538},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6245999932289124},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5625},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5356000065803528},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.5163999795913696},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5045999884605408},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4587000012397766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43149998784065247},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4083999991416931},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39070001244544983},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3743000030517578},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.32739999890327454},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.32120001316070557},{"id":"https://openalex.org/C196594336","wikidata":"https://www.wikidata.org/wiki/Q1662341","display_name":"Antibody-dependent enhancement","level":4,"score":0.3203999996185303},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3027999997138977},{"id":"https://openalex.org/C2909828532","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"AIDS Vaccines","level":4,"score":0.30219998955726624},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3019999861717224},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.27140000462532043},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.2556999921798706}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/coh.0000000000001086","doi":"https://doi.org/10.1097/coh.0000000000001086","is_oa":true,"landing_page_url":"https://doi.org/10.1097/coh.0000000000001086","pdf_url":null,"source":{"id":"https://openalex.org/S106953758","display_name":"Current Opinion in HIV and AIDS","issn_l":"1746-630X","issn":["1746-630X","1746-6318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in HIV and AIDS","raw_type":"journal-article"},{"id":"pmid:42993670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42993670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in HIV and AIDS","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/coh.0000000000001086","doi":"https://doi.org/10.1097/coh.0000000000001086","is_oa":true,"landing_page_url":"https://doi.org/10.1097/coh.0000000000001086","pdf_url":null,"source":{"id":"https://openalex.org/S106953758","display_name":"Current Opinion in HIV and AIDS","issn_l":"1746-630X","issn":["1746-630X","1746-6318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in HIV and AIDS","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1601440281","https://openalex.org/W1601854877","https://openalex.org/W1965175217","https://openalex.org/W1979050735","https://openalex.org/W1995175639","https://openalex.org/W1997677784","https://openalex.org/W2019405644","https://openalex.org/W2020355483","https://openalex.org/W2024608724","https://openalex.org/W2029135056","https://openalex.org/W2030129290","https://openalex.org/W2030844138","https://openalex.org/W2045136276","https://openalex.org/W2055796578","https://openalex.org/W2114273761","https://openalex.org/W2137354517","https://openalex.org/W2139250164","https://openalex.org/W2143421242","https://openalex.org/W2143562636","https://openalex.org/W2147003561","https://openalex.org/W2147046090","https://openalex.org/W2152048324","https://openalex.org/W2156010727","https://openalex.org/W2163519490","https://openalex.org/W2172224306","https://openalex.org/W2229789789","https://openalex.org/W2256769101","https://openalex.org/W2531411520","https://openalex.org/W2624564350","https://openalex.org/W2735823938","https://openalex.org/W2766842037","https://openalex.org/W2890205877","https://openalex.org/W2982401945","https://openalex.org/W3003228485","https://openalex.org/W3007860422","https://openalex.org/W3012737185","https://openalex.org/W3023638170","https://openalex.org/W3042310203","https://openalex.org/W3042822293","https://openalex.org/W3045476609","https://openalex.org/W3092014111","https://openalex.org/W3133209382","https://openalex.org/W3138945586","https://openalex.org/W4205523133","https://openalex.org/W4283019102","https://openalex.org/W4306411715","https://openalex.org/W4307810688","https://openalex.org/W4316465742","https://openalex.org/W4399476305","https://openalex.org/W4400249174","https://openalex.org/W4400860547","https://openalex.org/W4401464643","https://openalex.org/W4402533775","https://openalex.org/W4407569356","https://openalex.org/W4407624491","https://openalex.org/W4407996278","https://openalex.org/W4408432203","https://openalex.org/W4412525315","https://openalex.org/W4414063955","https://openalex.org/W7161403709","https://openalex.org/W7162516879","https://openalex.org/W7163549251","https://openalex.org/W7166819728","https://openalex.org/W7171719363","https://openalex.org/W7203922181"],"related_works":["https://openalex.org/W4412793182","https://openalex.org/W3133209382","https://openalex.org/W4402910425","https://openalex.org/W2460321387","https://openalex.org/W3042310203","https://openalex.org/W2048130529","https://openalex.org/W3165386877","https://openalex.org/W2591355966","https://openalex.org/W3126684938","https://openalex.org/W2319031893"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Despite":[3],"advances":[4,20,127],"in":[5,21,106,122,155],"antiretroviral":[6],"therapy,":[7],"HIV":[8,137,181],"reservoirs":[9],"remain":[10],"a":[11,149],"major":[12],"barrier":[13],"to":[14,29,36,135,173],"cure.":[15],"This":[16],"review":[17],"highlights":[18],"recent":[19],"understanding":[22],"how":[23],"antibody":[24,100,115,133],"Fc-mediated":[25,114,132],"effector":[26,69],"functions":[27,134],"contribute":[28],"the":[30,129,165],"clearance":[31,49],"of":[32,50,66,92,131],"HIV-infected":[33,51,93,142],"cells":[34,52],"and":[35,64,82,90,97,117,170],"immune":[37,108,157],"modulation":[38],"that":[39],"may":[40],"support":[41],"durable":[42],"viral":[43,61,120,161],"control.":[44,162],"RECENT":[45],"FINDINGS:":[46],"Successful":[47],"antibody-mediated":[48,107],"is":[53],"dependent":[54],"on":[55],"efficient":[56],"target":[57],"cell":[58,143],"recognition,":[59],"overcoming":[60],"immune-evasion":[62],"mechanisms,":[63],"recruitment":[65],"functional":[67],"innate":[68],"cells.":[70,94],"Recent":[71],"approaches":[72],"including":[73],"CD4":[74],"mimetics,":[75],"Fc":[76,78],"glycoengineering,":[77],"amino":[79],"acid":[80],"modifications,":[81],"NK":[83],"cell-directed":[84],"strategies":[85,139],"enhance":[86],"antibody-dependent":[87],"cellular":[88],"cytotoxicity":[89],"phagocytosis":[91],"Therapeutic":[95],"vaccination":[96,111],"broadly":[98],"neutralizing":[99],"(bNAb)-based":[101],"interventions":[102],"have":[103],"renewed":[104],"interest":[105],"control,":[109],"with":[110,160],"inducing":[112],"multifunctional":[113],"responses":[116,158],"bNAbs":[118],"delaying":[119],"rebound":[121],"some":[123],"individuals.":[124],"SUMMARY:":[125],"These":[126],"highlight":[128],"potential":[130],"complement":[136],"cure":[138,182],"by":[140],"promoting":[141],"clearance.":[144],"Emerging":[145],"evidence":[146],"also":[147],"supports":[148],"role":[150],"for":[151,180],"antibody-induced":[152],"vaccinal":[153],"effects":[154,169],"shaping":[156],"associated":[159],"However,":[163],"defining":[164],"mechanisms":[166],"underlying":[167],"these":[168],"their":[171],"contribution":[172],"reservoir":[174],"reduction":[175],"remains":[176],"an":[177],"important":[178],"priority":[179],"research.":[183]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
