{"id":"https://openalex.org/W7225403283","doi":"https://doi.org/10.1302/1358-992x.2026.11.053","title":"EFFECTIVENESS AND SAFETY OF CEFIDEROCOL IN THE TREATMENT OF ORTHOPEDIC IMPLANT INFECTIONS BY EXTENSIVELY DRUG-RESISTANT GRAM-NEGATIVE BACTERIA","display_name":"EFFECTIVENESS AND SAFETY OF CEFIDEROCOL IN THE TREATMENT OF ORTHOPEDIC IMPLANT INFECTIONS BY EXTENSIVELY DRUG-RESISTANT GRAM-NEGATIVE BACTERIA","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225403283","doi":"https://doi.org/10.1302/1358-992x.2026.11.053"},"language":"en","primary_location":{"id":"doi:10.1302/1358-992x.2026.11.053","doi":"https://doi.org/10.1302/1358-992x.2026.11.053","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.053","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161052524","display_name":"Anastasia Dimitriou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasia Dimitriou","raw_affiliation_strings":["1st Department of Internal Medicine, NKUA LAIKO General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, NKUA LAIKO General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015179307","display_name":"Elpida Mastrogianni","orcid":"https://orcid.org/0000-0003-3081-9415","observed_orcids":["https://orcid.org/0000-0003-3081-9415"]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Elpida Mastrogianni","raw_affiliation_strings":["1st Department of Internal Medicine, NKUA LAIKO General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Internal Medicine, NKUA LAIKO General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161094676","display_name":"Georgios Pariotis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios Pariotis","raw_affiliation_strings":["Department of Orthopaedics, LAIKO General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, LAIKO General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058941600","display_name":"Aggeliki Pantazatou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Aggeliki Pantazatou","raw_affiliation_strings":["Department of Clinical Microbiology NKUA, LAIKO General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology NKUA, LAIKO General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067515248","display_name":"Ioannis Deliolanis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioannis Deliolanis","raw_affiliation_strings":["Department of Clinical Microbiology NKUA, LAIKO General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology NKUA, LAIKO General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045459693","display_name":"Antonios Markogiannakis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonios Markogiannakis","raw_affiliation_strings":["Department of Pharmacy, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Athens, Greece","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022243182","display_name":"Georgios C Thivaios","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Georgios C. Thivaios","raw_affiliation_strings":["Department of Orthopaedics, LAIKO General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, LAIKO General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052626943","display_name":"Efthymia Giannitsioti","orcid":"https://orcid.org/0000-0003-2715-7457","observed_orcids":["https://orcid.org/0000-0003-2715-7457"]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Efthymia Giannitsioti","raw_affiliation_strings":["1st Department of Propaedeutic and Internal Medicine, NKUA, LAIKo General Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Propaedeutic and Internal Medicine, NKUA, LAIKo General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108-B","issue":"SUPP_11","first_page":"53","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.17260000109672546,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefiderocol","display_name":"cefiderocol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/orthopedic-implant-infection","display_name":"orthopedic implant infection","score":0.9710000157356262},{"id":"https://openalex.org/keywords/extensively-drug-resistant-gram-negative-bacteria","display_name":"extensively drug-resistant Gram-negative bacteria","score":0.9340000152587891},{"id":"https://openalex.org/keywords/carbapenemase-producing-bacteria","display_name":"carbapenemase-producing bacteria","score":0.8600000143051147},{"id":"https://openalex.org/keywords/acinetobacter-baumannii","display_name":"Acinetobacter baumannii","score":0.8799999952316284},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9729999899864197},{"id":"https://openalex.org/keywords/serratia-marcescens","display_name":"Serratia marcescens","score":0.9779999852180481},{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.9710000157356262},{"id":"https://openalex.org/keywords/off-label-antibiotic-use","display_name":"off-label antibiotic use","score":0.6690000295639038},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5849999785423279},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7580000162124634},{"id":"https://openalex.org/C2776315533","wikidata":"https://www.wikidata.org/wiki/Q3241189","display_name":"Acinetobacter baumannii","level":4,"score":0.6168000102043152},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.5983999967575073},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.5575000047683716},{"id":"https://openalex.org/C2776309202","wikidata":"https://www.wikidata.org/wiki/Q140004","display_name":"Serratia marcescens","level":4,"score":0.5521000027656555},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.5259000062942505},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.499099999666214},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.49549999833106995},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.4375},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.3912000060081482},{"id":"https://openalex.org/C2778120723","wikidata":"https://www.wikidata.org/wiki/Q16872681","display_name":"Periprosthetic","level":3,"score":0.38760000467300415},{"id":"https://openalex.org/C2777304102","wikidata":"https://www.wikidata.org/wiki/Q1667915","display_name":"Osteosynthesis","level":2,"score":0.34450000524520874},{"id":"https://openalex.org/C2778523567","wikidata":"https://www.wikidata.org/wiki/Q310457","display_name":"Acinetobacter","level":3,"score":0.3197000026702881},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.31209999322891235},{"id":"https://openalex.org/C2776450100","wikidata":"https://www.wikidata.org/wiki/Q134980","display_name":"Serratia","level":4,"score":0.29499998688697815},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2833000123500824},{"id":"https://openalex.org/C2777438270","wikidata":"https://www.wikidata.org/wiki/Q5248564","display_name":"Debridement (dental)","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26570001244544983},{"id":"https://openalex.org/C2776685102","wikidata":"https://www.wikidata.org/wiki/Q410897","display_name":"Carbapenem","level":3,"score":0.25279998779296875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1302/1358-992x.2026.11.053","doi":"https://doi.org/10.1302/1358-992x.2026.11.053","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.053","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4315651656","https://openalex.org/W4409280168","https://openalex.org/W4408377109","https://openalex.org/W3196872974","https://openalex.org/W3026559215","https://openalex.org/W4412553593","https://openalex.org/W3165004308","https://openalex.org/W3176499846","https://openalex.org/W7154964012","https://openalex.org/W3117453923"],"abstract_inverted_index":{"Introduction":[0],"Cefiderocol":[1],"is":[2,8,28,296],"a":[3,258,297],"novel":[4],"siderophore":[5],"cephalosporin":[6],"which":[7,251],"effective":[9],"against":[10],"multidrug":[11],"resistant":[12,17],"(MDR)":[13],"and":[14,36,45,115,163,299],"extensively":[15],"drug":[16,27,69,276],"(XDR)":[18],"Gram":[19],"negative":[20],"bacteria":[21],"(GNB)":[22],"producing":[23],"carbapenemases":[24],"(CP).":[25],"The":[26,212],"licensed":[29],"for":[30,42,90,302],"nosocomial":[31],"pneumonia,":[32],"complicated":[33],"urinary":[34],"tract":[35],"bloodstream":[37],"infections.":[38,54],"Few":[39],"data":[40],"exist":[41],"its":[43],"safety":[44],"efficacy":[46],"in":[47,70,191,197,209,311],"the":[48,63,68,239,272,275],"prolonged":[49],"treatment":[50,114,217,254,280,288],"of":[51,67,83,109,113,124,148,193,215,238,274,317],"orthopedic":[52,91,305],"implant":[53,74,92,187,306],"We":[55],"aim":[56],"to":[57,103,235,279],"present":[58],"our":[59],"clinical":[60],"experience":[61],"with":[62,72,88,136,186,195,201,249,268,289,292,304,314,321],"off-labeled,":[64],"salvage":[65],"use":[66],"patients":[71,86,120,131,242,303],"orthopaedic":[73],"infections":[75,93,307],"by":[76,95,230,308],"XDR":[77,174,309],"GNB.":[78],"Patients-Methods":[79],"An":[80],"observational":[81],"study":[82],"consecutively":[84],"hospitalized":[85],"treated":[87],"cefiderocol":[89,216,227,250,290],"caused":[94],"MDR/XDR":[96],"GNB":[97,310],"was":[98,189,207,218,228],"launched":[99],"from":[100,159],"July":[101],"2025":[102],"March":[104],"2026.":[105],"Patients'":[106],"demographics,":[107],"type":[108],"infection,":[110],"pathogens,":[111],"length":[112],"outcome":[116],"were":[117,153,157,168],"recorded.":[118],"Cured":[119],"had":[121],"no":[122],"relapse":[123],"infection":[125,139,269],"during":[126,257],"follow":[127,262],"up.":[128],"Results":[129],"Five":[130],"(male,":[132],"n=3;":[133],"female,":[134],"n=-2)":[135],"periprosthetic":[137],"joint":[138],"(PJI,":[140],"n=1),":[141],"external":[142],"osteosynthesis":[143,146],"(n=1),":[144,179],"internal":[145],"(n=3)":[147],"lower":[149],"arms":[150],"(femoral/tibial":[151],"implants)":[152],"assessed.":[154],"Clinical":[155],"isolates":[156],"retrieved":[158],"intraoperative":[160],"tissue":[161],"(n=4)":[162],"blood":[164],"(n=1)":[165],"cultures;":[166],"all":[167],"CP":[169],"strains":[170],":":[171],"Acinetobacter":[172],"baumannii":[173],"(n=3),":[175],"Pseudomonas":[176],"aeruginosa":[177],"NDM":[178],"Serratia":[180],"marcescens":[181],"VIM":[182],"(n=1).":[183],"Surgical":[184],"debridement":[185],"removal":[188],"performed":[190,208],"75%":[192],"cases":[194],"re-implantation":[196],"3":[198,259],"cases.":[199,211],"Co-administration":[200],"other":[202,231,293],"antibiotics":[203,295],"(tigecycline,":[204],"ampicillin/sulbactam,":[205],"fosfomycin)":[206],"4":[210],"mean":[213],"duration":[214],"18.6":[219],"days":[220],"(range":[221],"10-42":[222],"days).":[223],"In":[224],"2":[225],"cases,":[226],"replaced":[229],"available":[232],"antibiotic,":[233],"due":[234],"temporary":[236],"lack":[237],"drug.":[240],"Two":[241],"presented":[243,267],"grade":[244],"1":[245],"side":[246],"effects":[247],"correlated":[248],"resolved":[252],"without":[253],"discontinuation.":[255],"Overall,":[256],"month":[260],"post-treatment":[261],"up":[263],"only":[264],"one":[265],"patient":[266],"relapse,":[270],"therefore":[271],"administratin":[273],"has":[277],"contributed":[278],"success.":[281],"Conclusion":[282],"Prolonged":[283],"(more":[284],"than":[285],"14":[286],"days)":[287],"combined":[291],"potent":[294],"safe":[298],"promising":[300],"choice":[301],"hospital":[312],"settings":[313],"high":[315],"endemicity":[316],"antimicrobial":[318],"resistance":[319],"along":[320],"prompt":[322],"surgical":[323],"therapy.":[324]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}