{"id":"https://openalex.org/W7225403273","doi":"https://doi.org/10.1111/bcpt.70329","title":"Renal Function\u2013Guided Valganciclovir Dosing and Ganciclovir Exposure Variability: A Population Pharmacokinetic Simulation Study","display_name":"Renal Function\u2013Guided Valganciclovir Dosing and Ganciclovir Exposure Variability: A Population Pharmacokinetic Simulation Study","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225403273","doi":"https://doi.org/10.1111/bcpt.70329","pmid":"https://pubmed.ncbi.nlm.nih.gov/42989830","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13740662"},"language":"en","primary_location":{"id":"doi:10.1111/bcpt.70329","doi":"https://doi.org/10.1111/bcpt.70329","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcpt.70329","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.70329","source":{"id":"https://openalex.org/S44074210","display_name":"Basic & Clinical Pharmacology & Toxicology","issn_l":"1742-7835","issn":["1742-7835","1742-7843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic & Clinical Pharmacology & Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.70329","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119468310","display_name":"Franck Maizaud","orcid":"https://orcid.org/0009-0002-5103-0827","observed_orcids":["https://orcid.org/0009-0002-5103-0827"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Maizaud","raw_affiliation_strings":["Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France"],"raw_orcid":"https://orcid.org/0009-0002-5103-0827","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]},{"raw_affiliation_string":"INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027554290","display_name":"Marc Labriffe","orcid":"https://orcid.org/0000-0001-5840-8904","observed_orcids":["https://orcid.org/0000-0001-5840-8904"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Labriffe","raw_affiliation_strings":["Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","University Hospital Federation \u201cSurvival Optimization in Organ Transplantation\u201d (FHU SUPORT)  Limoges France"],"raw_orcid":"https://orcid.org/0000-0001-5840-8904","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]},{"raw_affiliation_string":"INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263"]},{"raw_affiliation_string":"University Hospital Federation \u201cSurvival Optimization in Organ Transplantation\u201d (FHU SUPORT)  Limoges France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098975797","display_name":"Hamza Sayadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hamza Sayadi","raw_affiliation_strings":["Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]},{"raw_affiliation_string":"INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065589041","display_name":"St\u00e9phanie Belaiche","orcid":"https://orcid.org/0000-0002-2890-4728","observed_orcids":["https://orcid.org/0000-0002-2890-4728"]},"institutions":[{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4387155751","display_name":"Evaluation des technologies de sant\u00e9 et des pratiques m\u00e9dicales","ror":"https://ror.org/01qygwc68","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4387155751"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Belaiche","raw_affiliation_strings":["Department of Gastroenterology CHU Lille  Lille France","Institute of Pharmacy CHU Lille  Lille France","METRICS Research Laboratory (ULR 2694) Lille University  Lille France"],"raw_orcid":"https://orcid.org/0000-0002-2890-4728","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology CHU Lille  Lille France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"Institute of Pharmacy CHU Lille  Lille France","institution_ids":["https://openalex.org/I3018718406"]},{"raw_affiliation_string":"METRICS Research Laboratory (ULR 2694) Lille University  Lille France","institution_ids":["https://openalex.org/I2279609970","https://openalex.org/I4387155751"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003712720","display_name":"Pierre Marquet","orcid":"https://orcid.org/0000-0001-7698-0760","observed_orcids":["https://orcid.org/0000-0001-7698-0760"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Marquet","raw_affiliation_strings":["Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","University Hospital Federation \u201cSurvival Optimization in Organ Transplantation\u201d (FHU SUPORT)  Limoges France"],"raw_orcid":"https://orcid.org/0000-0001-7698-0760","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]},{"raw_affiliation_string":"INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263"]},{"raw_affiliation_string":"University Hospital Federation \u201cSurvival Optimization in Organ Transplantation\u201d (FHU SUPORT)  Limoges France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010899888","display_name":"Jean\u2010Baptiste Woillard","orcid":"https://orcid.org/0000-0003-1695-0695","observed_orcids":["https://orcid.org/0000-0003-1695-0695"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Baptiste Woillard","raw_affiliation_strings":["Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","University Hospital Federation \u201cSurvival Optimization in Organ Transplantation\u201d (FHU SUPORT)  Limoges France"],"raw_orcid":"https://orcid.org/0000-0003-1695-0695","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]},{"raw_affiliation_string":"INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263"]},{"raw_affiliation_string":"University Hospital Federation \u201cSurvival Optimization in Organ Transplantation\u201d (FHU SUPORT)  Limoges France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026310327","display_name":"Caroline Monchaud","orcid":"https://orcid.org/0000-0002-9637-5813","observed_orcids":["https://orcid.org/0000-0002-9637-5813"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Caroline Monchaud","raw_affiliation_strings":["Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","University Hospital Federation \u201cSurvival Optimization in Organ Transplantation\u201d (FHU SUPORT)  Limoges France"],"raw_orcid":"https://orcid.org/0000-0002-9637-5813","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Pharmacovigilance CHU Limoges  Limoges France","institution_ids":["https://openalex.org/I4210118469"]},{"raw_affiliation_string":"INSERM UMR\u20101248 \u201cPharmacology & Transplantation\u201d Limoges France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263"]},{"raw_affiliation_string":"University Hospital Federation \u201cSurvival Optimization in Organ Transplantation\u201d (FHU SUPORT)  Limoges France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026310327"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":{"value":4650,"currency":"USD","value_usd":4650},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"139","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.35179999470710754,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valganciclovir","display_name":"valganciclovir","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ganciclovir","display_name":"ganciclovir","score":0.9679999947547913},{"id":"https://openalex.org/keywords/renal-dose-adjustment","display_name":"renal dose adjustment","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cockcroft-gault","display_name":"Cockcroft-Gault","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mdrd-equation","display_name":"MDRD equation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ckd-epi","display_name":"CKD-EPI","score":0.996999979019165},{"id":"https://openalex.org/keywords/solid-organ-transplant-recipients","display_name":"solid organ transplant recipients","score":0.8989999890327454},{"id":"https://openalex.org/keywords/antiviral-prophylaxis","display_name":"antiviral prophylaxis","score":0.875},{"id":"https://openalex.org/keywords/exposure-variability","display_name":"exposure variability","score":0.5600000023841858},{"id":"https://openalex.org/keywords/target-attainment","display_name":"target attainment","score":0.7870000004768372},{"id":"https://openalex.org/keywords/exposure-response-relationship","display_name":"exposure-response relationship","score":0.6959999799728394},{"id":"https://openalex.org/keywords/model-informed-precision-dosing","display_name":"model-informed precision dosing","score":0.8389999866485596},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.9315999746322632},{"id":"https://openalex.org/C2776317777","wikidata":"https://www.wikidata.org/wiki/Q423384","display_name":"Valganciclovir","level":5,"score":0.8970999717712402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8550000190734863},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6337000131607056},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6292999982833862},{"id":"https://openalex.org/C2777965375","wikidata":"https://www.wikidata.org/wiki/Q417640","display_name":"Ganciclovir","level":4,"score":0.513700008392334},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48570001125335693},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4503999948501587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3774000108242035},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31929999589920044},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.2766000032424927},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.2605000138282776},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.2522999942302704}],"mesh":[{"descriptor_ui":"D000077562","descriptor_name":"Valganciclovir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000077562","descriptor_name":"Valganciclovir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015774","descriptor_name":"Ganciclovir","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/bcpt.70329","doi":"https://doi.org/10.1111/bcpt.70329","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcpt.70329","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.70329","source":{"id":"https://openalex.org/S44074210","display_name":"Basic & Clinical Pharmacology & Toxicology","issn_l":"1742-7835","issn":["1742-7835","1742-7843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic & Clinical Pharmacology & Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13740662","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740662/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740662/pdf/BCPT-139-0.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Clin Pharmacol Toxicol","raw_type":"Text"},{"id":"pmid:42989830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42989830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic & clinical pharmacology & toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/bcpt.70329","doi":"https://doi.org/10.1111/bcpt.70329","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bcpt.70329","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcpt.70329","source":{"id":"https://openalex.org/S44074210","display_name":"Basic & Clinical Pharmacology & Toxicology","issn_l":"1742-7835","issn":["1742-7835","1742-7843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic & Clinical Pharmacology & Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225403273.pdf","grobid_xml":"https://content.openalex.org/works/W7225403273.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1847510258","https://openalex.org/W1976448676","https://openalex.org/W2127763131","https://openalex.org/W2133714268","https://openalex.org/W2291085969","https://openalex.org/W2524753328","https://openalex.org/W2580949479","https://openalex.org/W2893060017","https://openalex.org/W2919028801","https://openalex.org/W2989649849","https://openalex.org/W3036975907","https://openalex.org/W3092492681","https://openalex.org/W3164015288","https://openalex.org/W3202017675","https://openalex.org/W3203196895","https://openalex.org/W4312888796","https://openalex.org/W4319333828","https://openalex.org/W4368358165","https://openalex.org/W4391361389","https://openalex.org/W4399762060","https://openalex.org/W4408030456","https://openalex.org/W4409257869","https://openalex.org/W4410983347","https://openalex.org/W4413437222","https://openalex.org/W4416975339"],"related_works":["https://openalex.org/W4415157745","https://openalex.org/W2794366919","https://openalex.org/W2092091932","https://openalex.org/W4368358165","https://openalex.org/W1982816315","https://openalex.org/W1599285274","https://openalex.org/W4412523635","https://openalex.org/W2010223774","https://openalex.org/W2111007488","https://openalex.org/W4238824366"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Ganciclovir":[2],"(GCV)":[3],"exposure":[4,29,78],"after":[5],"standard":[6],"valganciclovir":[7],"(VGCV)":[8],"prophylaxis":[9],"is":[10],"highly":[11],"variable.":[12],"Guidelines":[13],"recommend":[14],"Cockcroft\u2013Gault":[15],"for":[16],"renal":[17,64,130,153],"dose":[18],"adjustment.":[19],"We":[20],"evaluated":[21],"whether":[22,35],"Cockcroft\u2013Gault\u2010based":[23],"dosing":[24,80,168],"achieves":[25],"the":[26,127,143,152,157,182,193],"target":[27,75,102,161,173],"prophylactic":[28],"(AUC":[30],"0\u201024h:":[31],"40\u201360":[32],"mg.h/L)":[33],"and":[34,77,84,91,95,105,119,142,145,185,203],"MDRD":[36,70,90],"or":[37,71],"CKD\u2010EPI":[38,92],"alters":[39],"exposure.":[40,162,175],"Methods":[41],"Using":[42],"a":[43],"validated":[44],"population":[45],"pharmacokinetic":[46],"model,":[47],"we":[48],"simulated":[49],"10":[50],"000":[51],"adult":[52],"solid":[53],"organ":[54],"transplant":[55],"recipients.":[56],"VGCV":[57,167],"doses":[58],"were":[59,87,149],"assigned":[60],"according":[61],"to":[62,124],"SmPC":[63],"function":[65,131,154,165],"categories":[66],"based":[67],"on":[68],"Cockcroft\u2013Gault,":[69],"CKD\u2010EPI.":[72],"Patient":[73],"reclassification,":[74],"attainment":[76,103,112,134],"around":[79],"thresholds":[81,148,177],"(25,":[82],"40":[83,146],"60":[85],"mL/min)":[86],"assessed.":[88],"Results":[89],"reclassified":[93],"45.1%":[94],"39.9%":[96],"of":[97],"patients,":[98],"mostly":[99],"downward,":[100],"lowering":[101],"(20.1%":[104],"22.7%":[106],"vs.":[107],"30.8%":[108],"with":[109,181],"Cockcroft\u2013Gault).":[110],"Target":[111,133],"never":[113],"exceeded":[114],"40%":[115],"in":[116,126],"any":[117],"category,":[118],"underexposure":[120],"predominated,":[121],"reaching":[122],"up":[123],"94.1%":[125],"most":[128],"impaired":[129],"categories.":[132],"was":[135],"consistently":[136],"lower":[137],"just":[138],"below":[139],"each":[140],"threshold,":[141],"25":[144],"mL/min":[147],"set":[150],"above":[151],"ranges":[155],"where":[156],"corresponding":[158],"regimens":[159],"achieved":[160],"Conclusions":[163],"Renal":[164],"category\u2010based":[166],"does":[169],"not":[170,191],"reliably":[171],"achieve":[172],"GCV":[174],"Current":[176],"are":[178],"poorly":[179],"aligned":[180],"exposure\u2010response":[183],"relationship":[184],"warrant":[186],"re\u2010examination.":[187],"Alternative":[188],"equations":[189],"do":[190],"reduce":[192],"variability,":[194],"supporting":[195],"exposure\u2010guided":[196],"approaches":[197],"such":[198],"as":[199],"therapeutic":[200],"drug":[201],"monitoring":[202],"model\u2010informed":[204],"precision":[205],"dosing.":[206]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-07T00:00:00"}