{"id":"https://openalex.org/W7225401389","doi":"https://doi.org/10.3389/fcell.2026.1990689","title":"Single-cell transcriptomic and proteomic analyses identify cellular programs associated with post-traumatic osteoarthritis resistance in MRL/MpJ mice","display_name":"Single-cell transcriptomic and proteomic analyses identify cellular programs associated with post-traumatic osteoarthritis resistance in MRL/MpJ mice","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225401389","doi":"https://doi.org/10.3389/fcell.2026.1990689"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1990689","doi":"https://doi.org/10.3389/fcell.2026.1990689","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1990689","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1990689/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1990689/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025969818","display_name":"Aimy Sebastian","orcid":"https://orcid.org/0000-0002-7822-7040","observed_orcids":["https://orcid.org/0000-0002-7822-7040"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aimy Sebastian","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Science Directorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Science Directorate","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014656113","display_name":"Nicholas R. Hum","orcid":"https://orcid.org/0000-0003-1605-3193","observed_orcids":["https://orcid.org/0000-0003-1605-3193"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas R. Hum","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Science Directorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Science Directorate","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040648354","display_name":"Jillian L. McCool","orcid":"https://orcid.org/0000-0002-5317-8764","observed_orcids":["https://orcid.org/0000-0002-5317-8764"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]},{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jillian L. McCool","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Science Directorate","School of Natural Sciences, University of California Merced"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Science Directorate","institution_ids":["https://openalex.org/I1282311441"]},{"raw_affiliation_string":"School of Natural Sciences, University of California Merced","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051366974","display_name":"Deepa K. Murugesh","orcid":"https://orcid.org/0000-0002-4232-8480","observed_orcids":["https://orcid.org/0000-0002-4232-8480"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepa K. Murugesh","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Science Directorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Science Directorate","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084665522","display_name":"Bria M. Gorman","orcid":"https://orcid.org/0000-0002-3360-0956","observed_orcids":["https://orcid.org/0000-0002-3360-0956"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bria M. Gorman","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Science Directorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Science Directorate","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052976934","display_name":"Benjamin Osipov","orcid":"https://orcid.org/0000-0001-9456-3311","observed_orcids":["https://orcid.org/0000-0001-9456-3311"]},"institutions":[{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Osipov","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California Davis Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California Davis Health","institution_ids":["https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034403911","display_name":"Oscar A. Davalos","orcid":"https://orcid.org/0000-0002-9608-5701","observed_orcids":["https://orcid.org/0000-0002-9608-5701"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar A. Davalos","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Science Directorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Science Directorate","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157872642","display_name":"Silvana A. Sidhom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvana A. Sidhom","raw_affiliation_strings":["Lawrence Livermore National Laboratory, Physical and Life Science Directorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Science Directorate","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161015812","display_name":"Samhitha C. Tumkur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samhitha C. Tumkur","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California Davis Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California Davis Health","institution_ids":["https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161021382","display_name":"Nosisa G. Ncube","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nosisa G. Ncube","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California Davis Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California Davis Health","institution_ids":["https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109035472","display_name":"Bernd Christiansen","orcid":"https://orcid.org/0000-0002-0105-6458","observed_orcids":["https://orcid.org/0000-0002-0105-6458"]},"institutions":[{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blaine A. Christiansen","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California Davis Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California Davis Health","institution_ids":["https://openalex.org/I4210160856","https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012395081","display_name":"Gabriela G. Loots","orcid":"https://orcid.org/0000-0001-9546-5561","observed_orcids":["https://orcid.org/0000-0001-9546-5561"]},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]},{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]},{"id":"https://openalex.org/I4210160856","display_name":"UC Davis Health","ror":"https://ror.org/05q8kyc69","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriela G. Loots","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of California Davis Health","Lawrence Livermore National Laboratory, Physical and Life Science Directorate","School of Natural Sciences, University of California Merced"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of California Davis Health","institution_ids":["https://openalex.org/I4210160856","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Lawrence Livermore National Laboratory, Physical and Life Science Directorate","institution_ids":["https://openalex.org/I1282311441"]},{"raw_affiliation_string":"School of Natural Sciences, University of California Merced","institution_ids":["https://openalex.org/I156087764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012395081","https://openalex.org/A5025969818"],"corresponding_institution_ids":["https://openalex.org/I1282311441","https://openalex.org/I156087764","https://openalex.org/I4210160856","https://openalex.org/I84218800"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-traumatic-osteoarthritis","display_name":"post-traumatic osteoarthritis","score":1.0},{"id":"https://openalex.org/keywords/mrl-mice","display_name":"MRL mice","score":0.9800000190734863},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.875},{"id":"https://openalex.org/keywords/anterior-cruciate-ligament-tear","display_name":"anterior cruciate ligament rupture","score":0.8629999756813049},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.796999990940094},{"id":"https://openalex.org/keywords/antioxidant-stress-response","display_name":"antioxidant stress response","score":0.5979999899864197},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6899999976158142},{"id":"https://openalex.org/keywords/extracellular-matrix-proteins","display_name":"extracellular matrix proteins","score":0.6949999928474426},{"id":"https://openalex.org/keywords/strain-differences","display_name":"strain differences","score":0.49399998784065247},{"id":"https://openalex.org/keywords/disease-resistance","display_name":"disease resistance","score":0.5189999938011169},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7599999904632568},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3630000054836273},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.5989999771118164},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.753600001335144},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7310000061988831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5863999724388123},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5821999907493591},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5634999871253967},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.516700029373169},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41760000586509705},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41499999165534973},{"id":"https://openalex.org/C2780699576","wikidata":"https://www.wikidata.org/wiki/Q15327913","display_name":"MMP2","level":4,"score":0.4072999954223633},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.3903999924659729},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.3781999945640564},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.36970001459121704},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3693000078201294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3596000075340271},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3560999929904938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3305000066757202},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.328000009059906},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3188000023365021},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C86153913","wikidata":"https://www.wikidata.org/wiki/Q7682439","display_name":"Tandem mass tag","level":5,"score":0.3021000027656555},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29829999804496765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2969000041484833},{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2793999910354614},{"id":"https://openalex.org/C2781032047","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Articular cartilage damage","level":5,"score":0.2711000144481659},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2705000042915344},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.2540999948978424},{"id":"https://openalex.org/C2778615650","wikidata":"https://www.wikidata.org/wiki/Q18031972","display_name":"TGFBI","level":3,"score":0.2517000138759613},{"id":"https://openalex.org/C2778434673","wikidata":"https://www.wikidata.org/wiki/Q611127","display_name":"Anterior cruciate ligament","level":2,"score":0.25119999051094055},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fcell.2026.1990689","doi":"https://doi.org/10.3389/fcell.2026.1990689","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1990689","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1990689/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5761979f8cd642fcb218fcce90bc29de","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5761979f8cd642fcb218fcce90bc29de","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1990689","doi":"https://doi.org/10.3389/fcell.2026.1990689","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1990689","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1990689/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225401389.pdf","grobid_xml":"https://content.openalex.org/works/W7225401389.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W375218548","https://openalex.org/W1891967301","https://openalex.org/W1956183633","https://openalex.org/W1983832419","https://openalex.org/W1999355235","https://openalex.org/W2011038175","https://openalex.org/W2018647053","https://openalex.org/W2035618305","https://openalex.org/W2090733427","https://openalex.org/W2105559013","https://openalex.org/W2118963985","https://openalex.org/W2124649657","https://openalex.org/W2128358050","https://openalex.org/W2414985338","https://openalex.org/W2476959454","https://openalex.org/W2763329657","https://openalex.org/W2890911471","https://openalex.org/W2920957425","https://openalex.org/W2929434466","https://openalex.org/W2943022153","https://openalex.org/W2999097847","https://openalex.org/W3007757041","https://openalex.org/W3022329594","https://openalex.org/W3027031175","https://openalex.org/W3080435317","https://openalex.org/W3099862724","https://openalex.org/W3118004748","https://openalex.org/W3130810608","https://openalex.org/W3171420350","https://openalex.org/W4206655305","https://openalex.org/W4220837089","https://openalex.org/W4220902555","https://openalex.org/W4225884744","https://openalex.org/W4238581030","https://openalex.org/W4288710132","https://openalex.org/W4307286642","https://openalex.org/W4323663538","https://openalex.org/W4361293128","https://openalex.org/W4378212544","https://openalex.org/W4379376877","https://openalex.org/W4383047304","https://openalex.org/W4386624324","https://openalex.org/W4390772161","https://openalex.org/W4391375230","https://openalex.org/W4399331493","https://openalex.org/W4401120186","https://openalex.org/W4406027716","https://openalex.org/W4407121104","https://openalex.org/W4417486189","https://openalex.org/W7117311572"],"related_works":["https://openalex.org/W4406027716","https://openalex.org/W2890911471","https://openalex.org/W2724486555","https://openalex.org/W2794140878","https://openalex.org/W7025050824","https://openalex.org/W4367835371","https://openalex.org/W2341927347","https://openalex.org/W2792116008","https://openalex.org/W4402781114","https://openalex.org/W3007848865"],"abstract_inverted_index":{"Osteoarthritis":[0],"affects":[1],"over":[2],"30":[3],"million":[4],"U.S.":[5],"adults":[6],"and":[7,14,23,57,74,94,117,149,164,176,189,199,206,233,237,241,263,273,284,291,293],"is":[8],"a":[9,133],"leading":[10],"cause":[11],"of":[12,136,162,197,225,230,238,255,282],"pain":[13],"disability.":[15],"Post-traumatic":[16],"osteoarthritis":[17],"(PTOA)":[18],"develops":[19],"after":[20,82,104],"joint":[21,35,67],"injury":[22,105,210],"can":[24],"progress":[25],"to":[26,61,107,279],"chronic":[27],"disease;":[28],"however,":[29],"no":[30],"approved":[31],"therapies":[32],"halt":[33],"structural":[34],"degeneration.":[36],"We":[37,214],"previously":[38],"showed":[39,194],"that":[40,221],"\u201csuper-healer\u201d":[41],"MRL/MpJ":[42],"(MRL)":[43],"mice":[44,78],"are":[45],"protected":[46],"from":[47,71,101,156,192],"injury-induced":[48,63],"cartilage":[49,89],"damage.":[50],"Here,":[51],"we":[52],"used":[53],"single-cell":[54],"RNA":[55],"sequencing":[56],"mass":[58],"spectrometry-based":[59],"proteomics":[60],"compare":[62],"molecular":[64],"changes":[65],"in":[66,99,114,123,141,144,146,235,243,258],"connective-tissue":[68],"cell":[69],"populations":[70],"PTOA-resistant":[72],"MRL":[73,116,124,142,157,236],"PTOA-susceptible":[75],"C57BL/6J":[76],"(B6)":[77],"at":[79,125],"4":[80],"weeks":[81],"noninvasive":[83],"anterior":[84],"cruciate":[85],"ligament":[86],"rupture.":[87],"Anabolic":[88],"genes,":[90,166,201],"including":[91,167,202,227,266],"Col2a1,":[92],"Acan,":[93],"Col9a2":[95],",":[96,169,171,173,175,178,204,208,268,270,272],"were":[97,222],"downregulated":[98],"chondrocytes":[100],"both":[102,147],"strains":[103],"relative":[106],"uninjured":[108,148],"controls,":[109],"with":[110,180,212,246,288],"similar":[111],"transcript":[112],"levels":[113],"injured":[115,150],"B6":[118,145,193],"joints":[119],"but":[120],"higher":[121,134,228],"expression":[122,161,196,219,229],"baseline.":[126],"However,":[127],"extracellular":[128],"matrix-enriched":[129],"proteomic":[130,250],"analysis":[131,251],"revealed":[132],"abundance":[135,254],"the":[137],"corresponding":[138],"cartilage-matrix":[139],"proteins":[140,256],"than":[143],"joints.":[151],"Joint":[152],"connective":[153],"tissue":[154],"cells":[155],"also":[158,215],"exhibited":[159],"increased":[160,195],"antioxidant":[163,283],"detoxification-associated":[165],"Gpx1":[168],"Glo1":[170,269],"Gstm1":[172],"Gstm2":[174],"Gstp1":[177,271],"consistent":[179],"an":[181],"enhanced":[182],"stress-adaptive":[183],"program.":[184],"In":[185],"contrast,":[186],"chondrocytes,":[187],"fibroblasts,":[188],"synovial":[190],"fibroblasts":[191],"fibrosis-":[198],"remodeling-associated":[200],"Col1a1":[203],"Col1a2":[205],"Spp1":[207],"following":[209],"compared":[211],"MRL.":[213],"identified":[216,252],"strain-specific":[217],"gene":[218],"differences":[220],"evident":[223],"independent":[224],"injury,":[226],"Vwa5a,":[231],"Glo1,":[232],"Lysmd2":[234],"Ubc,":[239],"Capg,":[240],"Pttg1":[242],"B6.":[244],"Consistent":[245],"these":[247,276],"transcriptomic":[248],"patterns,":[249],"differential":[253,280],"involved":[257],"cellular":[259],"stress":[260],"responses,":[261],"metabolism,":[262],"cytoskeletal":[264],"dynamics,":[265],"Vwa5a":[267],"Capg.":[274],"Together,":[275],"findings":[277],"point":[278],"engagement":[281],"fibrotic":[285],"pathways":[286,296],"associated":[287],"PTOA":[289],"resistance":[290],"susceptibility":[292],"identify":[294],"candidate":[295],"for":[297],"disease-modifying":[298],"therapy":[299],"development.":[300]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
