{"id":"https://openalex.org/W7225399592","doi":"https://doi.org/10.17504/protocols.io.p2l64kzj1vqe/v1","title":"Potential application of the fungi Inonotus obliquus, Inonotus hispidus, and the genus Russula for the treatment of periodontal disease: A scoping review v1","display_name":"Potential application of the fungi Inonotus obliquus, Inonotus hispidus, and the genus Russula for the treatment of periodontal disease: A scoping review v1","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225399592","doi":"https://doi.org/10.17504/protocols.io.p2l64kzj1vqe/v1"},"language":"en","primary_location":{"id":"doi:10.17504/protocols.io.p2l64kzj1vqe/v1","doi":"https://doi.org/10.17504/protocols.io.p2l64kzj1vqe/v1","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.p2l64kzj1vqe/v1","pdf_url":"https://www.protocols.io/view/potential-application-of-the-fungi-inonotus-obliqu-p2l64kzj1vqe/v1.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.protocols.io/view/potential-application-of-the-fungi-inonotus-obliqu-p2l64kzj1vqe/v1.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161034918","display_name":"Dilan Sebastian Leguizamo Velasquez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dilan Sebastian Leguizamo Velasquez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009588914","display_name":"Sandra Guauque-Olarte","orcid":"https://orcid.org/0000-0003-0336-9682","observed_orcids":["https://orcid.org/0000-0003-0336-9682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Guauque-Olarte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periodontal-disease","display_name":"periodontal disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mycotherapy","display_name":"mycotherapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/inonotus-obliquus","display_name":"Inonotus obliquus","score":0.9769999980926514},{"id":"https://openalex.org/keywords/inonotus-hispidus","display_name":"Inonotus hispidus","score":1.0},{"id":"https://openalex.org/keywords/russula","display_name":"Russula","score":0.9559999704360962},{"id":"https://openalex.org/keywords/medicinal-fungi","display_name":"medicinal fungi","score":0.8450000286102295},{"id":"https://openalex.org/keywords/adjunctive-periodontal-therapy","display_name":"adjunctive periodontal therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/subgingival-plaque","display_name":"subgingival plaque","score":0.7160000205039978},{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.7350000143051147},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/non-surgical-periodontal-therapy","display_name":"non-surgical periodontal therapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C144374066","wikidata":"https://www.wikidata.org/wiki/Q938196","display_name":"Periodontology","level":2,"score":0.6510000228881836},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.6013000011444092},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5964999794960022},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.5544999837875366},{"id":"https://openalex.org/C2992452445","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontal disease","level":2,"score":0.5044000148773193},{"id":"https://openalex.org/C2777317274","wikidata":"https://www.wikidata.org/wiki/Q1956937","display_name":"Inonotus obliquus","level":2,"score":0.4950000047683716},{"id":"https://openalex.org/C2779958836","wikidata":"https://www.wikidata.org/wiki/Q1307844","display_name":"Sequestrum","level":3,"score":0.43720000982284546},{"id":"https://openalex.org/C2777084678","wikidata":"https://www.wikidata.org/wiki/Q15646788","display_name":"Chlorhexidine","level":2,"score":0.38100001215934753},{"id":"https://openalex.org/C2779337755","wikidata":"https://www.wikidata.org/wiki/Q5113988","display_name":"Chronic periodontitis","level":3,"score":0.3799000084400177},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34279999136924744},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33809998631477356},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.3314000070095062},{"id":"https://openalex.org/C2780802913","wikidata":"https://www.wikidata.org/wiki/Q601168","display_name":"Peri-implantitis","level":3,"score":0.32510000467300415},{"id":"https://openalex.org/C2778714489","wikidata":"https://www.wikidata.org/wiki/Q2174895","display_name":"Aggregatibacter actinomycetemcomitans","level":4,"score":0.3215000033378601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31029999256134033},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2937000095844269},{"id":"https://openalex.org/C2777327803","wikidata":"https://www.wikidata.org/wiki/Q7683667","display_name":"Tannerella forsythia","level":5,"score":0.28630000352859497},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2720000147819519},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.26269999146461487}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17504/protocols.io.p2l64kzj1vqe/v1","doi":"https://doi.org/10.17504/protocols.io.p2l64kzj1vqe/v1","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.p2l64kzj1vqe/v1","pdf_url":"https://www.protocols.io/view/potential-application-of-the-fungi-inonotus-obliqu-p2l64kzj1vqe/v1.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.17504/protocols.io.p2l64kzj1vqe/v1","doi":"https://doi.org/10.17504/protocols.io.p2l64kzj1vqe/v1","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.p2l64kzj1vqe/v1","pdf_url":"https://www.protocols.io/view/potential-application-of-the-fungi-inonotus-obliqu-p2l64kzj1vqe/v1.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225399592.pdf","grobid_xml":"https://content.openalex.org/works/W7225399592.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2174784305"],"related_works":["https://openalex.org/W7115927995","https://openalex.org/W7163052229","https://openalex.org/W4318928670","https://openalex.org/W7102784773","https://openalex.org/W4225274263","https://openalex.org/W4415836406","https://openalex.org/W4390747555","https://openalex.org/W4393898987","https://openalex.org/W4409975194","https://openalex.org/W4409764081"],"abstract_inverted_index":{"Periodontal":[0],"disease":[1,93],"is":[2,88,121,129],"defined":[3],"as":[4,107,140,146],"a":[5,130,157,172,220],"multifactorial":[6],"condition":[7],"characterized":[8],"by":[9,46],"chronic":[10],"inflammation":[11],"of":[12,29,50,56,67,81,105,116,194,208,229],"the":[13,19,27,30,35,47,54,57,64,78,89,103,114,141,192,200,205,209,216,227],"periodontium,":[14],"resulting":[15],"from":[16,77],"dysbiosis":[17],"within":[18],"subgingival":[20],"biofilm":[21],"(Darveau,":[22],"2010).":[23],"The":[24],"microbiota":[25],"disrupts":[26],"homeostasis":[28],"oral":[31,159],"cavity":[32],"and":[33,53,148,160,181,215],"alters":[34],"host's":[36],"innate":[37],"immune":[38],"response,":[39],"triggering":[40],"an":[41,108],"aggressive":[42],"inflammatory":[43],"reaction":[44],"marked":[45],"massive":[48],"release":[49],"pro-inflammatory":[51],"cytokines":[52],"activation":[55],"RANKL":[58],"pathway\u2014a":[59],"process":[60],"that":[61],"leads":[62],"to":[63,75,167,177,188],"progressive":[65],"destruction":[66],"periodontal":[68,111,138,195],"tissues":[69],"(Hajishengallis":[70],"&":[71],"Korostoff,":[72],"2017).":[73],"According":[74],"data":[76],"Global":[79],"Burden":[80],"Disease":[82],"Study":[83],"(GBD,":[84],"2023),":[85],"severe":[86],"periodontitis":[87],"eleventh":[90],"most":[91,142],"prevalent":[92],"worldwide,":[94],"affecting":[95],"approximately":[96],"1.09":[97],"billion":[98],"people.":[99],"This":[100,120],"research":[101],"proposes":[102],"introduction":[104],"mycotherapy":[106],"innovation":[109],"in":[110,226],"treatment":[112],"through":[113],"use":[115,166],"mycological":[117,174],"adjunctive":[118,134],"therapies.":[119],"based":[122],"on":[123,156,204,222],"two":[124],"key":[125],"reasons:":[126],"first,":[127],"there":[128],"need":[131],"for":[132,137,231],"additional":[133],"therapeutic":[135],"alternatives":[136],"treatment,":[139],"commonly":[143],"used":[144],"agents\u2014such":[145],"chlorhexidine":[147],"systemic":[149,161],"or":[150,190],"local":[151],"antibiotics\u2014can":[152],"have":[153],"adverse":[154],"effects":[155],"patient\u2019s":[158],"health,":[162],"which":[163],"limits":[164],"their":[165,223],"complex":[168],"cases.":[169],"Second,":[170],"if":[171],"potential":[173,224],"therapy":[175],"proves":[176],"be":[178,185],"both":[179],"safe":[180],"effective,":[182],"it":[183],"could":[184],"employed":[186],"preventively":[187],"avoid":[189],"control":[191],"progression":[193],"disease.":[196],"Aim":[197],"To":[198],"synthesize":[199],"available":[201],"scientific":[202],"evidence":[203],"medicinal":[206],"properties":[207],"fungi":[210],"Inonotus":[211,213],"obliquus,":[212],"hispidus,":[214],"genus":[217],"Russula,":[218],"with":[219],"focus":[221],"application":[225],"field":[228],"periodontics":[230],"future":[232],"non-surgical":[233],"treatments.":[234]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}