{"id":"https://openalex.org/W7225399327","doi":"https://doi.org/10.1007/s00262-026-04624-4","title":"Single-cell and spatial transcriptomics reveal a JUN\u2013MIF program associated with secretory epithelial plasticity and CD74+ myeloid niches in colorectal cancer liver metastasis","display_name":"Single-cell and spatial transcriptomics reveal a JUN\u2013MIF program associated with secretory epithelial plasticity and CD74+ myeloid niches in colorectal cancer liver metastasis","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225399327","doi":"https://doi.org/10.1007/s00262-026-04624-4"},"language":"en","primary_location":{"id":"doi:10.1007/s00262-026-04624-4","doi":"https://doi.org/10.1007/s00262-026-04624-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00262-026-04624-4","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s00262-026-04624-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103193635","display_name":"Wei Yuan","orcid":"https://orcid.org/0000-0003-1052-9955","observed_orcids":["https://orcid.org/0000-0003-1052-9955"]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Yuan","raw_affiliation_strings":["Department of Oncology, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I160354188","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085581098","display_name":"\u5218\u6842\u4e3e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guiju Liu","raw_affiliation_strings":["Department of Oncology, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I160354188","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160993415","display_name":"Yingying Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Liu","raw_affiliation_strings":["The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158674042","display_name":"Ruiting Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiting Feng","raw_affiliation_strings":["Translational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158660860","display_name":"Peiyao Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiyao Hu","raw_affiliation_strings":["Scientific Research Management Office, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Management Office, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I160354188","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014687446","display_name":"Zongmian Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongmian Song","raw_affiliation_strings":["Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161073616","display_name":"Linlin Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Guo","raw_affiliation_strings":["The Second Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017359911","display_name":"Yun Qin","orcid":"https://orcid.org/0009-0004-0778-4263","observed_orcids":["https://orcid.org/0009-0004-0778-4263"]},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Qin","raw_affiliation_strings":["Department of Clinical Laboratory, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, 202150, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, 202150, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127534689","display_name":"Yinsen Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yinsen Song","raw_affiliation_strings":["Translational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074556380","display_name":"Yongtao Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongtao Duan","raw_affiliation_strings":["The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161017062","display_name":"Haozhe Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haozhe Zhang","raw_affiliation_strings":["Translational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210149496"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161028108","display_name":"Zhaorui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaorui Wang","raw_affiliation_strings":["Translational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Medicine Research Center, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People\u2019s Hospital), Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210149496"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017359911","https://openalex.org/A5074556380","https://openalex.org/A5127534689","https://openalex.org/A5161017062","https://openalex.org/A5161028108"],"corresponding_institution_ids":["https://openalex.org/I4210135985","https://openalex.org/I4210149496"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.23229999840259552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-liver-metastases","display_name":"colorectal liver metastases","score":0.9929999709129333},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8420000076293945},{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cd74","display_name":"CD74","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trefoil-factor-3","display_name":"TFF3","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fcgbp","display_name":"FCGBP","score":0.7049999833106995},{"id":"https://openalex.org/keywords/reg4","display_name":"REG4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxygen-response","display_name":"oxygen response","score":0.597000002861023},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6588000059127808},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6035000085830688},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5590000152587891},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5097000002861023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49619999527931213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43709999322891235},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4277999997138977},{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.40149998664855957},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.3919000029563904},{"id":"https://openalex.org/C102715595","wikidata":"https://www.wikidata.org/wiki/Q172861","display_name":"Ecological niche","level":3,"score":0.3005000054836273},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2978000044822693},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29269999265670776},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2768000066280365},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2630000114440918},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.25200000405311584},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00262-026-04624-4","doi":"https://doi.org/10.1007/s00262-026-04624-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00262-026-04624-4","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s00262-026-04624-4","doi":"https://doi.org/10.1007/s00262-026-04624-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00262-026-04624-4","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7225189702","https://openalex.org/W7223572468","https://openalex.org/W7005658930","https://openalex.org/W7134954773","https://openalex.org/W7225197417","https://openalex.org/W7130504986","https://openalex.org/W7161010725","https://openalex.org/W4401659517","https://openalex.org/W7162489358","https://openalex.org/W2886857400"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"liver":[2,34,115,189,228,304],"metastasis":[3,116,229],"(CRLM)":[4],"is":[5],"shaped":[6],"by":[7,130],"interactions":[8,164,259,285],"between":[9,165,241],"malignant":[10],"epithelial":[11,19,40,126],"plasticity":[12],"and":[13,33,41,56,84,91,106,113,134,137,141,167,197,201,210,226,230,243,255,269,280],"the":[14,18,76,80,181,194,281],"immune":[15,42],"microenvironment,":[16],"yet":[17],"programs":[20],"involved":[21],"remain":[22],"poorly":[23],"defined.":[24],"Single-cell":[25],"RNA":[26],"sequencing":[27],"data":[28,69],"from":[29,70],"primary":[30,183,298],"colorectal":[31,184,261,299],"tumors":[32,300],"metastases":[35],"were":[36,61,72,118,294],"integrated":[37],"to":[38,63,74],"characterize":[39],"heterogeneity.":[43],"Epithelial":[44],"subclustering,":[45],"pseudotime":[46],"analysis,":[47],"functional":[48,99,288],"enrichment,":[49],"CellChat-based":[50],"communication":[51,159],"inference,":[52],"transcription":[53],"factor":[54],"screening":[55],"scTenifoldKnk":[57],"virtual":[58],"knockout":[59],"analysis":[60,160,174],"performed":[62],"identify":[64],"regulatory":[65,253],"circuits.":[66],"Spatial":[67],"transcriptomics":[68],"GSE225857":[71],"used":[73,119],"assess":[75],"tissue-level":[77],"organization":[78],"of":[79,102],"JUN-MIF-CD74":[81],"axis.":[82],"TCGA-COAD":[83],"GSE39582":[85],"cohorts,":[86],"in":[87,107,139,180,188,260,297,302],"vitro":[88],"JUN":[89,144,192,203,213,242,264],"knockdown":[90,214,221],"overexpression":[92,204],"experiments,":[93],"ChIP-qPCR,":[94],"dual-luciferase":[95],"reporter":[96],"assays,":[97,100],"ELISA,":[98],"immunohistochemistry":[101],"clinical":[103],"CRLM":[104],"specimens":[105],"vivo":[108],"MC38-based":[109],"syngeneic":[110,223],"subcutaneous":[111],"tumor":[112,185,224],"intrasplenic":[114],"models":[117],"for":[120],"validation.":[121,289],"We":[122],"identified":[123,152,161],"a":[124,154,238,307],"secretory":[125],"state,":[127],"Epi_4,":[128],"characterized":[129],"SPINK4,":[131],"TFF3,":[132],"FCGBP":[133],"REG4":[135],"expression":[136,200],"enriched":[138],"oxygen-response":[140],"mitochondrial":[142],"programs.":[143],"emerged":[145],"as":[146,153],"an":[147,248],"Epi_4-associated":[148,249],"regulator,":[149],"with":[150,310],"MIF":[151,195,199,251,270,273],"major":[155],"downstream":[156],"candidate.":[157],"Cell\u2013cell":[158],"predicted":[162,256,282],"MIF\u2013CD74-related":[163,257,283],"Epi_4":[166],"myeloid":[168],"populations,":[169],"while":[170],"exploratory":[171],"spatial":[172,292],"transcriptomic":[173],"suggested":[175],"more":[176,295],"prominent":[177,296],"JUN\u2013MIF\u2013CD74":[178],"co-enrichment":[179],"analyzed":[182],"sections":[186],"than":[187,301,314],"metastatic":[190,311],"sections.":[191],"bound":[193],"promoter":[196],"increased":[198],"secretion.":[202],"enhanced":[205],"wound":[206],"closure,":[207],"cell":[208],"viability":[209],"clonogenicity,":[211],"whereas":[212],"produced":[215],"opposite":[216],"effects.":[217],"In":[218],"vivo,":[219],"Jun":[220],"suppressed":[222],"growth":[225],"experimental":[227],"reduced":[231],"Mif":[232],"expression.":[233],"Clinical":[234],"analyses":[235],"further":[236,287],"supported":[237],"positive":[239],"association":[240,309],"MIF.":[244],"These":[245],"findings":[246],"support":[247],"JUN-dependent":[250],"transcriptional":[252],"program":[254],"epithelial\u2013myeloid":[258,284],"cancer.":[262],"Although":[263],"perturbation":[265],"affected":[266],"tumor-associated":[267],"phenotypes":[268,277],"expression,":[271],"whether":[272],"functionally":[274],"mediates":[275],"these":[276],"remains":[278],"unresolved,":[279],"require":[286],"The":[290],"associated":[291],"signals":[293],"established":[303],"metastases,":[305],"suggesting":[306],"potential":[308],"competence":[312],"rather":[313],"liver-metastasis-specific":[315],"activation.":[316]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}