{"id":"https://openalex.org/W7225399243","doi":"https://doi.org/10.1161/circ.154.suppl_1.16845","title":"Abstract 16845: Efficacy and Safety of Second Generation Cholesteryl Ester Transfer Protein Inhibitors in Patients with Heterozygous Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","display_name":"Abstract 16845: Efficacy and Safety of Second Generation Cholesteryl Ester Transfer Protein Inhibitors in Patients with Heterozygous Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225399243","doi":"https://doi.org/10.1161/circ.154.suppl_1.16845"},"language":"en","primary_location":{"id":"doi:10.1161/circ.154.suppl_1.16845","doi":"https://doi.org/10.1161/circ.154.suppl_1.16845","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.16845","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042314337","display_name":"Ahmed Farid Gadelmawla","orcid":"https://orcid.org/0000-0002-5802-2291","observed_orcids":["https://orcid.org/0000-0002-5802-2291","https://orcid.org/0009-0009-7065-381X"]},"institutions":[{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Farid Gadelmawla","raw_affiliation_strings":["Faculty of Medicine, Menoufia Univ, Menoufia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Menoufia Univ, Menoufia, Egypt","institution_ids":["https://openalex.org/I63601056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101425518","display_name":"Ahmed Elmorsy Mohamed","orcid":"https://orcid.org/0009-0000-1186-2595","observed_orcids":["https://orcid.org/0009-0000-1186-2595"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed E Mohamed","raw_affiliation_strings":["Faculty of Medicine, Tanta, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126945971","display_name":"Mustafa Abomohsen","orcid":"https://orcid.org/0009-0007-9939-7747","observed_orcids":["https://orcid.org/0009-0007-9939-7747"]},"institutions":[{"id":"https://openalex.org/I2802707398","display_name":"Brookdale University Hospital and Medical Center","ror":"https://ror.org/0065vkd37","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802707398"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mustafa Abomohsen","raw_affiliation_strings":["Brookdale Hosp, Brooklyn, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brookdale Hosp, Brooklyn, NY","institution_ids":["https://openalex.org/I2802707398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104939220","display_name":"Ahmed Wael Hageen","orcid":"https://orcid.org/0009-0000-0933-0426","observed_orcids":["https://orcid.org/0009-0000-0933-0426"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Wael Hageen","raw_affiliation_strings":["Tanta Univ, Tanta, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tanta Univ, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161112279","display_name":"Amira Mohamed Taha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amira Mohamed Taha","raw_affiliation_strings":["PASSIO Laboratory, North Carolina A&T State Univ, Greensboro, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PASSIO Laboratory, North Carolina A&T State Univ, Greensboro, NC","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121534648","display_name":"Amal A. Alsubaiei","orcid":"https://orcid.org/0009-0004-8170-8429","observed_orcids":["https://orcid.org/0009-0004-8170-8429"]},"institutions":[{"id":"https://openalex.org/I4210108420","display_name":"Kuwait Institute for Medical Specialization","ror":"https://ror.org/01tt4qx37","country_code":"KW","type":"facility","lineage":["https://openalex.org/I4210108420"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"AMAL A ALSUBAIEI","raw_affiliation_strings":["Kuwait Institute for Med Specializations, Kuwait City, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuwait Institute for Med Specializations, Kuwait City, Kuwait","institution_ids":["https://openalex.org/I4210108420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161075406","display_name":"najat alsejari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108420","display_name":"Kuwait Institute for Medical Specialization","ror":"https://ror.org/01tt4qx37","country_code":"KW","type":"facility","lineage":["https://openalex.org/I4210108420"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"najat alsejari","raw_affiliation_strings":["Kuwait Institute for Med Specializations, Kuwait City, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuwait Institute for Med Specializations, Kuwait City, Kuwait","institution_ids":["https://openalex.org/I4210108420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161035349","display_name":"ali alrtam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108420","display_name":"Kuwait Institute for Medical Specialization","ror":"https://ror.org/01tt4qx37","country_code":"KW","type":"facility","lineage":["https://openalex.org/I4210108420"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"ali alrtam","raw_affiliation_strings":["Kuwait Institute for Med Specializations, Kuwait City, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kuwait Institute for Med Specializations, Kuwait City, Kuwait","institution_ids":["https://openalex.org/I4210108420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108821503","display_name":"Abou Ghanima S.F. Shehata","orcid":"https://orcid.org/0009-0006-8356-5868","observed_orcids":["https://orcid.org/0009-0006-8356-5868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdalrahman S Shehata","raw_affiliation_strings":["Faculty of Medicine, Qena Univ, Qena, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Qena Univ, Qena, Egypt","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107669212","display_name":"Hamza A. Abdul\u2010Hafez","orcid":"https://orcid.org/0009-0003-6089-240X","observed_orcids":["https://orcid.org/0009-0003-6089-240X"]},"institutions":[{"id":"https://openalex.org/I17533244","display_name":"An-Najah National University","ror":"https://ror.org/0046mja08","country_code":"PS","type":"education","lineage":["https://openalex.org/I17533244"]}],"countries":["PS"],"is_corresponding":false,"raw_author_name":"Hamza A. Abdul-Hafez","raw_affiliation_strings":["An-Najah National Univ, Nablus, Palestinian Territory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"An-Najah National Univ, Nablus, Palestinian Territory","institution_ids":["https://openalex.org/I17533244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113164274","display_name":"Ahmed Diaa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Diaa","raw_affiliation_strings":["Faculty of Medicine, Al-Azhar Univ, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Al-Azhar Univ, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161002254","display_name":"Abdullah Alharran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53218197","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47","country_code":"BH","type":"education","lineage":["https://openalex.org/I53218197"]}],"countries":["BH"],"is_corresponding":false,"raw_author_name":"Abdullah Alharran","raw_affiliation_strings":["College of Medicine and Med Sciences, Arabian Gulf Univ, Manama, Bahrain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine and Med Sciences, Arabian Gulf Univ, Manama, Bahrain","institution_ids":["https://openalex.org/I53218197"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"154","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesteryl-ester-transfer-protein-inhibitors","display_name":"cholesteryl ester transfer protein inhibitors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/heterozygous-familial-hypercholesterolemia","display_name":"heterozygous familial hypercholesterolemia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.9240000247955322},{"id":"https://openalex.org/keywords/non-hdl-cholesterol","display_name":"non-HDL cholesterol","score":0.8130000233650208},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.984000027179718},{"id":"https://openalex.org/keywords/lipoprotein-a","display_name":"lipoprotein(a)","score":0.996999979019165},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9629999995231628},{"id":"https://openalex.org/keywords/apolipoprotein-a-i","display_name":"apolipoprotein A-I","score":0.9139999747276306},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7540000081062317},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.777999997138977},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6740000247955322},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6740000247955322},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7099999785423279},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.3659999966621399},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C45505151","wikidata":"https://www.wikidata.org/wiki/Q424706","display_name":"Cholesterylester transfer protein","level":4,"score":0.9642000198364258},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8917999863624573},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.7562000155448914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.580299973487854},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5735999941825867},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.5644999742507935},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5541999936103821},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5030999779701233},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41920000314712524},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39890000224113464},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.38929998874664307},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.37450000643730164},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3643999993801117},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34380000829696655},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.30410000681877136},{"id":"https://openalex.org/C202061045","wikidata":"https://www.wikidata.org/wiki/Q7200267","display_name":"Placebo-controlled study","level":5,"score":0.26980000734329224},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.154.suppl_1.16845","doi":"https://doi.org/10.1161/circ.154.suppl_1.16845","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.16845","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403497958","https://openalex.org/W4410850423","https://openalex.org/W4406326178","https://openalex.org/W2003160372","https://openalex.org/W4413637745","https://openalex.org/W7131776315","https://openalex.org/W1628000978","https://openalex.org/W2102238081","https://openalex.org/W2407498861","https://openalex.org/W4411992177"],"abstract_inverted_index":{"Introduction:":[0],"Heterozygous":[1],"familial":[2],"hypercholesterolemia":[3],"(HeFH)":[4],"is":[5],"a":[6],"common":[7],"inherited":[8],"lipid":[9,243,255],"disorder":[10],"characterized":[11],"by":[12],"elevated":[13],"low-density":[14],"lipoprotein":[15],"cholesterol":[16],"(LDL-C)":[17],"and":[18,44,66,113,172,187,210,252,285,296],"increased":[19,185],"cardiovascular":[20,293],"risk.":[21],"Second-generation":[22,246],"cholesteryl":[23],"ester":[24],"transfer":[25],"protein":[26],"(CETP)":[27],"inhibitors":[28,49,85,137,183,193,248],"may":[29],"provide":[30],"additional":[31],"lipid-lowering":[32,38,58,263],"benefit":[33,295],"when":[34],"added":[35],"to":[36,74,147,160,170,180,197,207,219,239,280,291],"background":[37,262],"therapy.":[39,59,264],"We":[40],"evaluated":[41],"the":[42,268],"efficacy":[43],"safety":[45,282],"of":[46,68,270],"second-generation":[47,83],"CETP":[48,84,136,182,192,247],"versus":[50],"placebo":[51,87],"in":[52,88,97,257],"adults":[53,89,258],"with":[54,86,90,134,259],"HeFH":[55,260],"receiving":[56,191,261],"stable":[57],"Methods:":[60],"PubMed,":[61],"EMBASE,":[62],"Cochrane":[63],"Library,":[64],"Scopus,":[65],"Web":[67],"Science":[69],"were":[70,131,194],"searched":[71],"from":[72],"inception":[73],"May":[75],"10,":[76],"2026,":[77],"for":[78,230,241],"randomized":[79,125,287],"controlled":[80,126],"trials":[81,127,288],"comparing":[82],"HeFH.":[91],"The":[92],"primary":[93],"outcome":[94,294],"was":[95,118,228,237],"change":[96],"LDL-C.":[98],"Secondary":[99],"outcomes":[100],"included":[101],"LDL-C":[102,140,199,211,251,274],"goal":[103],"attainment,":[104],"non-HDL-C,":[105],"apolipoprotein":[106,110,162,188],"B,":[107],"lipoprotein(a),":[108],"HDL-C,":[109],"A1,":[111],"triglycerides,":[112],"adverse":[114,234],"events.":[115,235],"Random-effects":[116],"meta-analysis":[117],"performed":[119],"using":[120],"R":[121],"software.":[122],"Results:":[123],"Three":[124],"including":[128],"728":[129],"participants":[130],"included.":[132],"Compared":[133],"placebo,":[135],"significantly":[138,249],"reduced":[139],"(MD":[141,154,164,174],"-43.38":[142],"mg/dL,":[143,156,166],"95%":[144,157,167,177,204,216],"CI":[145,158,168,178,205,217],"-52.85":[146],"-33.91;":[148],"P<0.001;":[149,221],"Figure":[150,222],"A":[151],"),":[152],"non-HDL-C":[153],"-48.77":[155],"-60.46":[159],"-37.09),":[161],"B":[163,223],"-23.45":[165],"-32.59":[169],"-14.30),":[171],"lipoprotein(a)":[173],"-34.92":[175],"nmol/L,":[176],"-57.48":[179],"-12.35).":[181],"also":[184,266],"HDL-C":[186],"A1.":[189],"Patients":[190],"more":[195],"likely":[196],"achieve":[198],"<100":[200],"mg/dL":[201,213],"(RR":[202,214],"2.56,":[203],"1.45":[206],"4.53;":[208],"P=0.001)":[209],"<70":[212],"5.65,":[215],"2.75":[218],"11.58;":[220],").":[224],"No":[225],"significant":[226],"difference":[227],"observed":[229],"triglycerides":[231],"or":[232],"overall":[233],"Heterogeneity":[236],"moderate":[238],"high":[240],"several":[242],"outcomes.":[244],"Conclusion:":[245],"improve":[250],"multiple":[253],"atherogenic":[254],"parameters":[256],"They":[265],"increase":[267],"likelihood":[269],"achieving":[271],"clinically":[272],"relevant":[273],"targets":[275],"without":[276],"an":[277],"obvious":[278],"short-":[279],"medium-term":[281],"signal.":[283],"Larger":[284],"longer-term":[286],"are":[289],"needed":[290],"confirm":[292],"long-term":[297],"safety.":[298]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-07T00:00:00"}