{"id":"https://openalex.org/W7225398263","doi":"https://doi.org/10.1186/s12864-026-13468-2","title":"Structure of Caspase9 gene in Qianhua Mutton Merino and its association with spermatogenic function analysis","display_name":"Structure of Caspase9 gene in Qianhua Mutton Merino and its association with spermatogenic function analysis","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225398263","doi":"https://doi.org/10.1186/s12864-026-13468-2"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-026-13468-2","doi":"https://doi.org/10.1186/s12864-026-13468-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-026-13468-2","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12864-026-13468-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104153687","display_name":"Xinming Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210152006","display_name":"Jilin Agricultural University","ror":"https://ror.org/05dmhhd41","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210152006"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinming Sun","raw_affiliation_strings":["Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I4210152006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161093866","display_name":"Shuang Chai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210152006","display_name":"Jilin Agricultural University","ror":"https://ror.org/05dmhhd41","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210152006"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Chai","raw_affiliation_strings":["Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I4210152006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123301568","display_name":"Feng Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210152006","display_name":"Jilin Agricultural University","ror":"https://ror.org/05dmhhd41","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210152006"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"YU Feng","raw_affiliation_strings":["Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I4210152006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161090708","display_name":"Yang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210152006","display_name":"Jilin Agricultural University","ror":"https://ror.org/05dmhhd41","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210152006"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Chen","raw_affiliation_strings":["Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I4210152006"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5139673777","display_name":"Huaizhi Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210152006","display_name":"Jilin Agricultural University","ror":"https://ror.org/05dmhhd41","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210152006"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huaizhi Jiang","raw_affiliation_strings":["Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jilin Province Key Laboratory of Evaluation and Utilization of Livestock and Poultry Genetic Resources (Sheep), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130000, P.R. China","institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I4210152006"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5139673777"],"corresponding_institution_ids":["https://openalex.org/I4210151987","https://openalex.org/I4210152006"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.15309999883174896,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.5339999794960022},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7850000262260437},{"id":"https://openalex.org/keywords/semen-volume","display_name":"semen volume","score":0.8920000195503235},{"id":"https://openalex.org/keywords/testis-gene-expression","display_name":"testicular gene expression","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nfatc4","display_name":"NFATc4","score":0.9660000205039978},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/male-reproductive-traits","display_name":"male reproductive traits","score":0.5199999809265137},{"id":"https://openalex.org/keywords/synonymous-mutations","display_name":"synonymous mutations","score":0.5090000033378601},{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.3779999911785126},{"id":"https://openalex.org/keywords/sexual-maturity","display_name":"sexual maturity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.37700000405311584},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.3889999985694885},{"id":"https://openalex.org/keywords/sperm-concentration","display_name":"sperm concentration","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8790000081062317},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5745999813079834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49630001187324524},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4884999990463257},{"id":"https://openalex.org/C2778080409","wikidata":"https://www.wikidata.org/wiki/Q2916689","display_name":"Semen quality","level":3,"score":0.475600004196167},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.42500001192092896},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4140999913215637},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4049000144004822},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.38280001282691956},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3587000072002411},{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.33980000019073486},{"id":"https://openalex.org/C2777632594","wikidata":"https://www.wikidata.org/wiki/Q27116486","display_name":"Sperm motility","level":3,"score":0.3230000138282776},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.3172000050544739},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.3012000024318695},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.2948000133037567},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2775999903678894},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26910001039505005},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.25699999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12864-026-13468-2","doi":"https://doi.org/10.1186/s12864-026-13468-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-026-13468-2","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12864-026-13468-2","doi":"https://doi.org/10.1186/s12864-026-13468-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-026-13468-2","pdf_url":null,"source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2357957761","https://openalex.org/W2166672928","https://openalex.org/W986128316","https://openalex.org/W6989344226","https://openalex.org/W2138511527","https://openalex.org/W2434561617","https://openalex.org/W1804132127","https://openalex.org/W2014225830","https://openalex.org/W4283750279","https://openalex.org/W2335178406"],"abstract_inverted_index":{"Semen":[0],"quality":[1,23],"influences":[2],"mating":[3],"efficiency":[4],"and":[5,16,24,31,53,60,70,105,113,121,128,164,203,295,302,324,331,343,353,375],"is":[6,43],"a":[7,44,84,118,224,359,367],"key":[8,45],"trait":[9],"for":[10,174,361],"evaluating":[11],"reproductive":[12,271,287,351,381],"performance.":[13],"Sperm":[14],"concentration":[15],"motility":[17],"are":[18,25],"important":[19],"indicators":[20],"of":[21,34,47,86,103,110,117,180,198,364],"semen":[22],"closely":[26],"associated":[27,314,371],"with":[28,99,182,200,315,327,372],"the":[29,48,56,115,137,147,177,183,187,201,214,239,265,269,292,335],"microenvironment":[30],"dynamic":[32],"regulation":[33],"apoptosis":[35],"during":[36],"spermatogenesis.":[37],"Cysteinyl":[38],"aspartate-specific":[39],"proteinase":[40],"9":[41],"(Caspase9)":[42],"component":[46],"intrinsic":[49],"mitochondrial":[50],"apoptotic":[51],"pathway":[52],"contributes":[54],"to":[55,94],"balance":[57],"between":[58,286],"spermatogenesis":[59],"apoptosis.":[61],"However,":[62],"studies":[63],"on":[64],"Caspase9":[65,80,93,138,210,228,293,321,365],"gene":[66,294],"polymorphisms,":[67],"protein":[68,85,229,249,280,296,332],"characteristics,":[69],"expression":[71,212,230,237,250,260,281,333,348],"in":[72,136,213,227,238,264,268,297,334,379,383],"male":[73,380],"sheep":[74],"reproduction":[75],"remain":[76],"limited.":[77],"The":[78,140,306],"cloned":[79],"coding":[81],"sequence":[82],"encoded":[83],"426":[87],"amino":[88],"acids.":[89],"Bioinformatic":[90],"analyses":[91],"predicted":[92,114],"be":[95],"an":[96,100,106],"unstable":[97],"protein,":[98],"instability":[101],"index":[102],"50.11":[104],"average":[107],"hydropathy":[108],"score":[109],"\u2212":[111],"0.350,":[112],"absence":[116],"signal":[119],"peptide":[120],"transmembrane":[122],"regions.":[123],"Two":[124],"conserved":[125],"domains,":[126],"CARD":[127],"CASc,":[129],"were":[130,134,169],"identified.":[131],"Nine":[132],"SNPs":[133],"identified":[135,303],"gene.":[139],"g.252":[141,156],"locus":[142,192],"showed":[143,151,322],"low":[144],"polymorphism,":[145],"whereas":[146,247,277],"other":[148,270],"eight":[149],"loci":[150],"moderate":[152],"polymorphism.":[153],"Three":[154],"SNPs,":[155],"C":[157,189,308],">":[158,162,167,190,309],"T,":[159],"g.345":[160],"G":[161],"A,":[163],"g.397":[165],"T":[166,191,310],"C,":[168],"synonymous":[170],"mutations.":[171],"After":[172],"correction":[173],"multiple":[175],"comparisons,":[176],"ejaculate":[178,316],"volume":[179,317],"rams":[181,199,301],"CC":[184],"genotype":[185],"at":[186],"g.129":[188,307],"was":[193,216,241,251,261,312],"significantly":[194,217,242,252,262,285,313,337],"greater":[195],"than":[196,267],"that":[197],"CT":[202],"TT":[204],"genotypes":[205],"(":[206,231,254,273],"P":[207,232,255,274],"<":[208,233,256,275],"0.01).":[209,234,257],"mRNA":[211,236,259,330],"testis":[215,240,266,336],"upregulated":[218],"after":[219,244,318,339],"sexual":[220,245,340],"maturity,":[221,246],"accompanied":[222],"by":[223],"significant":[225],"increase":[226],"NFATc4":[235,342],"downregulated":[243],"its":[248,329,376],"increased":[253,338],"VEGF":[258,279,344],"higher":[263],"tissues":[272,352],"0.05),":[276],"testicular":[278],"did":[282],"not":[283],"differ":[284],"stages.":[288,355],"This":[289],"study":[290],"characterized":[291],"Qianhua":[298],"Mutton":[299],"Merino":[300],"nine":[304],"SNPs.":[305],"polymorphism":[311],"multiple-comparison":[319],"correction.":[320],"tissue-":[323],"reproductive-stage-dependent":[325],"expression,":[326],"both":[328],"maturity.":[341],"also":[345],"exhibited":[346],"distinct":[347],"patterns":[349],"among":[350],"developmental":[354],"These":[356],"findings":[357],"provide":[358],"basis":[360],"further":[362],"investigation":[363],"as":[366],"candidate":[368],"molecular":[369],"marker":[370],"semen-quality":[373],"traits":[374],"potential":[377],"role":[378],"function":[382],"sheep.":[384]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
