{"id":"https://openalex.org/W7225396563","doi":"https://doi.org/10.1302/1358-992x.2026.11.044","title":"IN VITRO ACTIVITY OF ANTISEPTICS USED ALONE OR IN SEQUENTIAL COMBINATION AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS BIOFILMS ON TITANIUM","display_name":"IN VITRO ACTIVITY OF ANTISEPTICS USED ALONE OR IN SEQUENTIAL COMBINATION AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS BIOFILMS ON TITANIUM","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225396563","doi":"https://doi.org/10.1302/1358-992x.2026.11.044"},"language":"en","primary_location":{"id":"doi:10.1302/1358-992x.2026.11.044","doi":"https://doi.org/10.1302/1358-992x.2026.11.044","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.044","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130047499","display_name":"Freddy Bombah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Freddy Bombah","raw_affiliation_strings":["UCLouvain, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLouvain, Bruxelles, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160990726","display_name":"Randy Buzisa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Randy Buzisa","raw_affiliation_strings":["UCLouvain, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLouvain, Bruxelles, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124419870","display_name":"C\u00e9dric Dongmo Mayopa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Dongmo Mayopa","raw_affiliation_strings":["UCLouvain, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLouvain, Bruxelles, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161091122","display_name":"Thomas Schubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Thomas Schubert","raw_affiliation_strings":["UCLouvain, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLouvain, Bruxelles, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007113349","display_name":"Olivier Cornu","orcid":"https://orcid.org/0000-0003-3033-7408","observed_orcids":["https://orcid.org/0000-0003-3033-7408"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Olivier Cornu","raw_affiliation_strings":["UCLouvain, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLouvain, Bruxelles, Belgium","institution_ids":["https://openalex.org/I95674353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95674353"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"108-B","issue":"SUPP_11","first_page":"44","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bacterial-biofilms","display_name":"bacterial biofilms","score":0.8149999976158142},{"id":"https://openalex.org/keywords/titanium-implants","display_name":"titanium implants","score":0.7070000171661377},{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.9739999771118164},{"id":"https://openalex.org/keywords/antiseptic-irrigation","display_name":"antiseptic irrigation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/povidone-iodine","display_name":"povidone-iodine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chlorhexidine","display_name":"chlorhexidine","score":0.8809999823570251},{"id":"https://openalex.org/keywords/taurolidine","display_name":"taurolidine","score":0.9819999933242798},{"id":"https://openalex.org/keywords/polyhexamethylene-biguanide","display_name":"polyhexamethylene biguanide","score":0.8539999723434448},{"id":"https://openalex.org/keywords/biofilm-eradication","display_name":"biofilm eradication","score":0.8309999704360962},{"id":"https://openalex.org/keywords/biofilm-biomass-reduction","display_name":"biofilm biomass reduction","score":0.6930000185966492},{"id":"https://openalex.org/keywords/ti-6al-4v","display_name":"Ti-6Al-4V","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8919000029563904},{"id":"https://openalex.org/C2781460226","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antiseptic","level":2,"score":0.8407999873161316},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.715399980545044},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7069000005722046},{"id":"https://openalex.org/C2777084678","wikidata":"https://www.wikidata.org/wiki/Q15646788","display_name":"Chlorhexidine","level":2,"score":0.6575000286102295},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.5526999831199646},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5157999992370605},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.49470001459121704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49390000104904175},{"id":"https://openalex.org/C192285135","wikidata":"https://www.wikidata.org/wiki/Q954757","display_name":"Colony-forming unit","level":3,"score":0.4790000021457672},{"id":"https://openalex.org/C2777438270","wikidata":"https://www.wikidata.org/wiki/Q5248564","display_name":"Debridement (dental)","level":2,"score":0.4675000011920929},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.39899998903274536},{"id":"https://openalex.org/C2775965595","wikidata":"https://www.wikidata.org/wiki/Q1365581","display_name":"Micrococcaceae","level":4,"score":0.3797999918460846},{"id":"https://openalex.org/C107211472","wikidata":"https://www.wikidata.org/wiki/Q284486","display_name":"Human decontamination","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.33799999952316284},{"id":"https://openalex.org/C2779288629","wikidata":"https://www.wikidata.org/wiki/Q199695","display_name":"Staphylococcus","level":4,"score":0.336899995803833},{"id":"https://openalex.org/C539932907","wikidata":"https://www.wikidata.org/wiki/Q1103","display_name":"Iodine","level":2,"score":0.3346000015735626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33379998803138733},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3249000012874603},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C2785061","wikidata":"https://www.wikidata.org/wiki/Q17048601","display_name":"Viable count","level":3,"score":0.28200000524520874},{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C17741926","wikidata":"https://www.wikidata.org/wiki/Q762045","display_name":"Bacterial growth","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C2781221799","wikidata":"https://www.wikidata.org/wiki/Q73984","display_name":"Disinfectant","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.2578999996185303}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1302/1358-992x.2026.11.044","doi":"https://doi.org/10.1302/1358-992x.2026.11.044","is_oa":false,"landing_page_url":"https://doi.org/10.1302/1358-992x.2026.11.044","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopaedic Proceedings","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4378083231","https://openalex.org/W4315754375","https://openalex.org/W3158966007","https://openalex.org/W2884373491","https://openalex.org/W7225393980","https://openalex.org/W4404628915","https://openalex.org/W2098300761","https://openalex.org/W7202396749","https://openalex.org/W1937495621","https://openalex.org/W2883876037"],"abstract_inverted_index":{"Introduction":[0],"Prosthetic":[1],"joint":[2,338],"infections":[3],"are":[4],"predominantly":[5],"associated":[6],"with":[7,90,277,296],"mature":[8],"bacterial":[9,39,219],"biofilms,":[10],"particularly":[11],"those":[12,166],"formed":[13,65],"by":[14,147,221,240],"methicillin":[15],"resistant":[16],"Staphylococcus":[17],"aureus":[18],"(MRSA),":[19],"which":[20],"exhibit":[21],"marked":[22],"tolerance":[23],"to":[24,34,37,47,99,156,247],"antimicrobial":[25],"treatments.":[26],"Intraoperative":[27],"antiseptic":[28],"irrigation":[29,335],"represents":[30],"a":[31,143,157,287,303],"potential":[32,331],"adjuvant":[33],"surgical":[35],"debridement":[36],"reduce":[38],"burden":[40],"and":[41,70,93,109,132,153,183,195,197,212,230,253,258,312],"biofilm":[42,122,180,291],"biomass.":[43],"This":[44],"study":[45],"aimed":[46],"evaluate":[48],"in":[49,59,85,171,265,286,290,326,333],"vitro":[50],"the":[51,140,168,278],"activity":[52,170,315],"of":[53,128,139,142,233,245],"six":[54,100],"antiseptics":[55,101,309],"used":[56,323],"alone":[57,324],"or":[58,299,325],"sequential":[60,262,327],"combination":[61,136,163],"against":[62,316],"MRSA":[63,72,317],"biofilms":[64,73,318],"on":[66,81,118,319],"titanium":[67,83,320],"surfaces.":[68],"Materials":[69],"methods":[71],"(ATCC":[74],"33951)":[75],"were":[76,97,165,203],"grown":[77],"for":[78,125,162],"24":[79],"h":[80],"Ti6Al4V":[82],"coupons":[84],"TGN":[86],"medium":[87],"(TSB":[88],"supplemented":[89],"1%":[91],"glucose":[92],"2%":[94],"NaCl).":[95],"Coupons":[96],"exposed":[98],"(povidone":[102],"iodine,":[103],"hydrogen":[104,189,248,297],"peroxide,":[105],"chlorhexidine,":[106],"taurolidine,":[107,252],"polyhexanide,":[108],"an":[110,198],"antibiofilm":[111,199,214,279,305,314],"wound":[112,200,215,280],"lavage":[113,201,216,281],"solution*)":[114],"at":[115,210,256],"concentrations":[116],"based":[117],"previously":[119],"determined":[120],"minimal":[121],"eradication":[123],"concentrations,":[124],"exposure":[126,155,246],"times":[127],"1,":[129],"3,":[130],"5,":[131],"10":[133,224,271],"minutes.":[134],"Sequential":[135],"therapy":[137,164],"consisted":[138],"application":[141],"first":[144],"antiseptic,":[145],"followed":[146],"two":[148],"phosphate":[149],"buffered":[150],"saline":[151],"rinses,":[152],"then":[154],"second":[158],"antiseptic.":[159],"Antiseptics":[160],"selected":[161],"showing":[167],"highest":[169],"monotherapy.":[172],"Outcomes":[173],"included":[174],"colony":[175],"forming":[176],"unit":[177],"(CFU)":[178],"counts,":[179],"biomass":[181,237],"quantification,":[182],"fluorescence":[184],"microscopy.":[185],"Seven":[186],"combinations":[187,263],"involving":[188],"peroxide":[190,249,298],"1.5%,":[191,250],"povidone":[192,208,254,300],"iodine":[193,209,255,301],"(1%":[194],"0.35%),":[196],"solution*":[202,217,282],"tested.":[204],"Results":[205],"In":[206],"monotherapy,":[207],"2.5%":[211],"undiluted":[213,251],"reduced":[218,239],"load":[220],"3\u20134":[222],"log":[223,270],"CFU":[225,272],"per":[226,273],"coupon":[227],"from":[228],"3":[229,269],"5":[231],"minutes":[232],"exposure,":[234],"respectively.":[235],"Biofilm":[236],"was":[238],"50\u201380%":[241],"after":[242],"1":[243],"minute":[244],"0.35%":[257],"1%.":[259],"All":[260],"seven":[261],"resulted":[264],"reductions":[266],"greater":[267],"than":[268],"coupon.":[274],"Combinations":[275],"initiating":[276],"did":[283],"not":[284],"result":[285],"significant":[288,313],"reduction":[289],"biomass,":[292],"whereas":[293],"sequences":[294],"starting":[295],"maintained":[302],"substantial":[304],"effect.":[306],"Conclusion":[307],"Several":[308],"demonstrated":[310],"rapid":[311],"surfaces":[321],"when":[322],"combination,":[328],"supporting":[329],"their":[330],"role":[332],"intraoperative":[334],"during":[336],"prosthetic":[337],"infection":[339],"management.":[340],"*Bactisure":[341]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
