{"id":"https://openalex.org/W7225396256","doi":"https://doi.org/10.1128/aem.01397-26","title":"Unraveling the relationship between population composition and metabolite induction in high-precision cellulosic bacterial\u2013fungal co-cultivations","display_name":"Unraveling the relationship between population composition and metabolite induction in high-precision cellulosic bacterial\u2013fungal co-cultivations","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225396256","doi":"https://doi.org/10.1128/aem.01397-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/42992828"},"language":"en","primary_location":{"id":"doi:10.1128/aem.01397-26","doi":"https://doi.org/10.1128/aem.01397-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01397-26","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/aem.01397-26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008653078","display_name":"Ana M. Palacio\u2010Barrera","orcid":"https://orcid.org/0000-0002-2910-719X","observed_orcids":["https://orcid.org/0000-0002-2910-719X"]},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ana M. Palacio-Barrera","raw_affiliation_strings":["Balance of the Microverse, Friedrich-Schiller-University Jena","Biopilot Plant Department, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (Leibniz-HKI)","Faculty of Biological Sciences, Friedrich-Schiller-University Jena"],"raw_orcid":"https://orcid.org/0000-0002-2910-719X","affiliations":[{"raw_affiliation_string":"Balance of the Microverse, Friedrich-Schiller-University Jena","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Biopilot Plant Department, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (Leibniz-HKI)","institution_ids":["https://openalex.org/I4210162077"]},{"raw_affiliation_string":"Faculty of Biological Sciences, Friedrich-Schiller-University Jena","institution_ids":["https://openalex.org/I76198965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009734293","display_name":"Jethro L. Hemmann","orcid":"https://orcid.org/0000-0003-4687-5577","observed_orcids":["https://orcid.org/0000-0003-4687-5577"]},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jethro L. Hemmann","raw_affiliation_strings":["Junior Research Group Metabolomics-guided Natural Product Discovery, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (Leibniz-HKI)"],"raw_orcid":"https://orcid.org/0000-0003-4687-5577","affiliations":[{"raw_affiliation_string":"Junior Research Group Metabolomics-guided Natural Product Discovery, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (Leibniz-HKI)","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057532506","display_name":"Ivan Schlembach","orcid":"https://orcid.org/0000-0003-1827-7887","observed_orcids":["https://orcid.org/0000-0003-1827-7887"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ivan Schlembach","raw_affiliation_strings":["Biotechnology Research Institute for the Green Transition (BRIGHT), Technical University of Denmark"],"raw_orcid":"https://orcid.org/0000-0003-1827-7887","affiliations":[{"raw_affiliation_string":"Biotechnology Research Institute for the Green Transition (BRIGHT), Technical University of Denmark","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000958649","display_name":"Maurice Finger","orcid":"https://orcid.org/0000-0001-7384-8625","observed_orcids":["https://orcid.org/0000-0001-7384-8625"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maurice Finger","raw_affiliation_strings":["AVT\u2014Biochemical Engineering, RWTH Aachen University"],"raw_orcid":"https://orcid.org/0000-0001-7384-8625","affiliations":[{"raw_affiliation_string":"AVT\u2014Biochemical Engineering, RWTH Aachen University","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022603631","display_name":"Jochen B\u00fcchs","orcid":"https://orcid.org/0000-0002-2012-3476","observed_orcids":["https://orcid.org/0000-0002-2012-3476"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen B\u00fcchs","raw_affiliation_strings":["AVT\u2014Biochemical Engineering, RWTH Aachen University"],"raw_orcid":"https://orcid.org/0000-0002-2012-3476","affiliations":[{"raw_affiliation_string":"AVT\u2014Biochemical Engineering, RWTH Aachen University","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031318965","display_name":"Gerald Lackner","orcid":"https://orcid.org/0000-0002-0307-8319","observed_orcids":["https://orcid.org/0000-0002-0307-8319"]},"institutions":[{"id":"https://openalex.org/I54009628","display_name":"University of Bayreuth","ror":"https://ror.org/0234wmv40","country_code":"DE","type":"education","lineage":["https://openalex.org/I54009628"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerald Lackner","raw_affiliation_strings":["Chair of Biochemistry of Microorganisms, University of Bayreuth"],"raw_orcid":"https://orcid.org/0000-0002-0307-8319","affiliations":[{"raw_affiliation_string":"Chair of Biochemistry of Microorganisms, University of Bayreuth","institution_ids":["https://openalex.org/I54009628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016954737","display_name":"Miriam A. Rosenbaum","orcid":"https://orcid.org/0000-0002-4566-8624","observed_orcids":["https://orcid.org/0000-0002-4566-8624","https://orcid.org/0000-0001-5348-8247"]},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Miriam A. Rosenbaum","raw_affiliation_strings":["Balance of the Microverse, Friedrich-Schiller-University Jena","Biopilot Plant Department, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (Leibniz-HKI)","Faculty of Biological Sciences, Friedrich-Schiller-University Jena"],"raw_orcid":"https://orcid.org/0000-0002-4566-8624","affiliations":[{"raw_affiliation_string":"Balance of the Microverse, Friedrich-Schiller-University Jena","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Biopilot Plant Department, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (Leibniz-HKI)","institution_ids":["https://openalex.org/I4210162077"]},{"raw_affiliation_string":"Faculty of Biological Sciences, Friedrich-Schiller-University Jena","institution_ids":["https://openalex.org/I76198965"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e0139726","last_page":"e0139726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichoderma-reesei","display_name":"Trichoderma reesei","score":0.949999988079071},{"id":"https://openalex.org/keywords/streptomyces-coelicolor","display_name":"Streptomyces coelicolor","score":1.0},{"id":"https://openalex.org/keywords/cellulose-degradation","display_name":"cellulose degradation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/population-dynamics","display_name":"population dynamics","score":0.6320000290870667},{"id":"https://openalex.org/keywords/withanolides","display_name":"withanolides","score":0.7409999966621399},{"id":"https://openalex.org/keywords/steroidal-lactones","display_name":"steroidal lactones","score":0.8820000290870667},{"id":"https://openalex.org/keywords/siderophores","display_name":"siderophores","score":0.7739999890327454},{"id":"https://openalex.org/keywords/metal-acquisition","display_name":"metal acquisition","score":0.7329999804496765},{"id":"https://openalex.org/keywords/natural-product-discovery","display_name":"natural product discovery","score":0.5360000133514404},{"id":"https://openalex.org/keywords/fluorescence-monitoring","display_name":"fluorescence monitoring","score":0.3889999985694885},{"id":"https://openalex.org/keywords/fungal-bacterial-interactions","display_name":"fungal-bacterial interactions","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2780681812","wikidata":"https://www.wikidata.org/wiki/Q22286833","display_name":"Streptomyces coelicolor","level":4,"score":0.7286999821662903},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7192999720573425},{"id":"https://openalex.org/C2778265057","wikidata":"https://www.wikidata.org/wiki/Q537299","display_name":"Axenic","level":3,"score":0.6693999767303467},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6098999977111816},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5753999948501587},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.5562999844551086},{"id":"https://openalex.org/C2777347573","wikidata":"https://www.wikidata.org/wiki/Q522244","display_name":"Secondary metabolite","level":3,"score":0.5442000031471252},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5365999937057495},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.49950000643730164},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4869999885559082},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.48350000381469727},{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.47510001063346863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47029998898506165},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.41620001196861267},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3874000012874603},{"id":"https://openalex.org/C2776260651","wikidata":"https://www.wikidata.org/wiki/Q292314","display_name":"Corynebacterium glutamicum","level":3,"score":0.36340001225471497},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.361299991607666},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3483000099658966},{"id":"https://openalex.org/C175605896","wikidata":"https://www.wikidata.org/wiki/Q39833","display_name":"Microorganism","level":3,"score":0.33880001306533813},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.3158999979496002},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C2776125036","wikidata":"https://www.wikidata.org/wiki/Q2749932","display_name":"Trichoderma reesei","level":4,"score":0.28209999203681946},{"id":"https://openalex.org/C196235758","wikidata":"https://www.wikidata.org/wiki/Q3333419","display_name":"Primary metabolite","level":3,"score":0.27309998869895935},{"id":"https://openalex.org/C2777301280","wikidata":"https://www.wikidata.org/wiki/Q6821615","display_name":"Mesorhizobium","level":5,"score":0.257099986076355},{"id":"https://openalex.org/C2777916119","wikidata":"https://www.wikidata.org/wiki/Q3498295","display_name":"Chromobacterium violaceum","level":5,"score":0.25589999556541443}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1128/aem.01397-26","doi":"https://doi.org/10.1128/aem.01397-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01397-26","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},{"id":"pmid:42992828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42992828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and environmental microbiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/aem.01397-26","doi":"https://doi.org/10.1128/aem.01397-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01397-26","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W1491098680","https://openalex.org/W2013362131","https://openalex.org/W2019715072","https://openalex.org/W2030808222","https://openalex.org/W2045545415","https://openalex.org/W2068092274","https://openalex.org/W2081465448","https://openalex.org/W2081726096","https://openalex.org/W2087466721","https://openalex.org/W2097215480","https://openalex.org/W2106281303","https://openalex.org/W2106479662","https://openalex.org/W2116904877","https://openalex.org/W2124230856","https://openalex.org/W2125125680","https://openalex.org/W2130959679","https://openalex.org/W2153707479","https://openalex.org/W2179948434","https://openalex.org/W2241667714","https://openalex.org/W2321179534","https://openalex.org/W2328024645","https://openalex.org/W2436067889","https://openalex.org/W2502105049","https://openalex.org/W2504691963","https://openalex.org/W2515810634","https://openalex.org/W2519072018","https://openalex.org/W2545950570","https://openalex.org/W2569330080","https://openalex.org/W2603246388","https://openalex.org/W2741590375","https://openalex.org/W2743651217","https://openalex.org/W2754066094","https://openalex.org/W2765108388","https://openalex.org/W2785338167","https://openalex.org/W2800780732","https://openalex.org/W2905340019","https://openalex.org/W2913882268","https://openalex.org/W2922522932","https://openalex.org/W2944231932","https://openalex.org/W2999177106","https://openalex.org/W3000153187","https://openalex.org/W3005299705","https://openalex.org/W3006073147","https://openalex.org/W3043544282","https://openalex.org/W3080789666","https://openalex.org/W3118798276","https://openalex.org/W3134912112","https://openalex.org/W3138738723","https://openalex.org/W3161596995","https://openalex.org/W3183557051","https://openalex.org/W3191745354","https://openalex.org/W3193286519","https://openalex.org/W3201498129","https://openalex.org/W3206878019","https://openalex.org/W3217188025","https://openalex.org/W4210938022","https://openalex.org/W4211121954","https://openalex.org/W4220872277","https://openalex.org/W4225015755","https://openalex.org/W4225091055","https://openalex.org/W4225416490","https://openalex.org/W4291912968","https://openalex.org/W4291989548","https://openalex.org/W4300972466","https://openalex.org/W4322739219","https://openalex.org/W4362523777","https://openalex.org/W4377194119","https://openalex.org/W4378009171","https://openalex.org/W4380786160","https://openalex.org/W4385332430","https://openalex.org/W4386315717","https://openalex.org/W4386570438","https://openalex.org/W4390046175","https://openalex.org/W4390739996","https://openalex.org/W4391027117","https://openalex.org/W4392354374","https://openalex.org/W4409832851","https://openalex.org/W4411077678","https://openalex.org/W4414606070","https://openalex.org/W7116945062","https://openalex.org/W7126202853","https://openalex.org/W7161272568"],"related_works":["https://openalex.org/W6907416184","https://openalex.org/W4300972466","https://openalex.org/W6943990478","https://openalex.org/W2329512762","https://openalex.org/W2735699618","https://openalex.org/W3202095884","https://openalex.org/W2565949874","https://openalex.org/W850561000","https://openalex.org/W3082651101","https://openalex.org/W2999177106"],"abstract_inverted_index":{"ABSTRACT":[0],"Co-cultures":[1],"of":[2,34,70,92,101,127,140,151,166,177,205,221,232,263,369,383],"filamentous":[3,295],"microorganisms":[4,296],"are":[5,22],"a":[6,44,53,88,163,175,180,202,244,260,270,291,303,321,336,345,351],"tool":[7],"to":[8,23,30,66,81,155,173,214,218,253,315,379],"unlock":[9],"the":[10,32,56,68,71,98,124,128,148,189,222,227,230,236,326,333],"biosynthetic":[11],"machinery":[12],"encoded":[13],"in":[14,160,210,269,290,385],"silent":[15],"gene":[16],"clusters.":[17],"However,":[18],"if":[19],"bioactive":[20],"compounds":[21],"be":[24,215,250,377],"produced":[25,183,324],"biotechnologically,":[26],"it":[27],"is":[28,79,158,329],"essential":[29,341],"understand":[31],"dynamics":[33,100,265],"microbial":[35,272,370],"partnership.":[36],"In":[37],"this":[38,364],"context,":[39],"we":[40],"have":[41],"previously":[42],"introduced":[43],"co-cultivation":[45,85,312],"platform":[46,237,365],"based":[47],"on":[48],"low-cost":[49],"crystalline":[50],"cellulose":[51],"as":[52],"substrate.":[54,306],"Here,":[55],"fungus":[57],"Trichoderma":[58],"reesei":[59,186],"RUT-C30":[60],"degrades":[61],"\u03b1-cellulose":[62],"into":[63,188],"soluble":[64],"sugars":[65],"support":[67],"growth":[69],"natural":[72,93,233,240],"product-producing":[73],"bacterium":[74],"Streptomyces":[75],"coelicolor":[76,199],"A3(2),":[77],"which":[78],"unable":[80],"utilize":[82],"cellulose.":[83],"This":[84,169,257,274],"approach":[86,275],"mimics":[87],"carbon-limited":[89],"interaction":[90,318],"scenario":[91],"habitats.":[94],"We":[95,121],"investigated":[96],"how":[97],"population":[99,141,264],"both":[102,167],"strains":[103],"affect":[104],"metabolite":[105,267,361],"production":[106,246,268],"by":[107,184,197,325,332],"combining":[108],"high-throughput":[109,281],"online":[110,282],"fluorescence":[111,288],"monitoring":[112,283],"with":[113,162,243,297],"high-resolution":[114],"liquid":[115],"chromatography\u2013tandem":[116],"mass":[117],"spectrometry":[118],"(LC-MS/MS)-based":[119],"metabolomics.":[120],"then":[122],"determined":[123],"metabolic":[125,317],"profile":[126],"cultures":[129,157],"and":[130,143,194,266,300,302,372],"identified":[131],"metabolites":[132,153,207],"specifically":[133],"induced":[134,152,209],"during":[135,311,359],"co-cultivation.":[136],"The":[137],"coupled":[138],"analysis":[139,170,262,310],"ratios":[142],"metabolomic":[144],"data":[145],"indicated":[146],"that":[147,248,354,375],"highest":[149],"number":[150],"compared":[154],"axenic":[156],"observed":[159],"co-cultures":[161,211],"balanced":[164],"ratio":[165],"strains.":[168],"further":[171],"led":[172],"deciphering":[174],"biotransformation":[176],"dimerumic":[178],"acid,":[179],"hydroxamate":[181],"siderophore":[182],"T.":[185],",":[187],"dehydroxylated":[190],"derivatives":[191],"eleutherazine":[192],"B":[193],"talarazine":[195],"A":[196],"S.":[198],".":[200],"Additionally,":[201],"small":[203],"cluster":[204],"unique":[206],"strongly":[208],"was":[212],"found":[213],"structurally":[216],"similar":[217],"steroidal":[219],"lactones":[220],"withanolide":[223],"class,":[224],"thus":[225],"highlighting":[226],"potential":[228],"for":[229,339],"discovery":[231],"products.":[234],"Overall,":[235,363],"described":[238],"combines":[239],"product":[241],"prospecting":[242],"biotechnological":[245,346],"strategy":[247,338,353],"can":[249,376],"extended":[251],"also":[252],"other":[254,380],"co-cultures.":[255],"IMPORTANCE":[256],"work":[258],"provides":[259],"comprehensive":[261],"complex":[271],"co-culture.":[273],"integrates":[276],"three":[277],"key":[278],"aspects.":[279],"First,":[280],"enables":[284],"biomass":[285],"tracking":[286],"through":[287],"labeling":[289],"system":[292],"containing":[293],"two":[294],"distinct":[298],"macro-":[299],"micromorphologies":[301],"non-soluble":[304],"fibrous":[305],"Second,":[307],"concomitant":[308],"metabolomics":[309],"settings":[313],"helps":[314],"resolve":[316],"patterns.":[319],"Interestingly,":[320],"metal-acquisition":[322],"compound":[323],"first":[327],"microbe":[328],"chemically":[330],"modified":[331],"second,":[334],"suggesting":[335],"competition":[337],"an":[340],"micronutrient.":[342],"Third,":[343],"from":[344],"perspective,":[347],"substrate":[348],"solubilization":[349],"resembles":[350],"fed-batch":[352],"minimizes":[355],"carbon":[356],"catabolite":[357],"repression":[358],"secondary":[360],"production.":[362],"advances":[366],"our":[367],"understanding":[368],"interactions":[371],"culture":[373,381],"conditions":[374],"transferred":[378],"platforms":[382],"relevance":[384],"bioprocess":[386],"intensification.":[387]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}