{"id":"https://openalex.org/W7225396206","doi":"https://doi.org/10.31234/osf.io/a4ekm","title":"The Third Allostasis: a biophysical displacement of regulatory purpose in neurodivergent, high-ability and other high processing cost phenotypes (HPCPh)","display_name":"The Third Allostasis: a biophysical displacement of regulatory purpose in neurodivergent, high-ability and other high processing cost phenotypes (HPCPh)","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225396206","doi":"https://doi.org/10.31234/osf.io/a4ekm"},"language":"en","primary_location":{"id":"doi:10.31234/osf.io/a4ekm","doi":"https://doi.org/10.31234/osf.io/a4ekm","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/a4ekm","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.31234/osf.io/a4ekm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076010924","display_name":"Simone Hauck","orcid":"https://orcid.org/0000-0001-7632-5758","observed_orcids":["https://orcid.org/0000-0001-7632-5758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simone Hauck","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7632-5758","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136389437","display_name":"Luciana Terra de Oliveira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luciana Terra de Oliveira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161058994","display_name":"Pricilla Braga Laskosky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pricilla Braga Laskosky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.3400999903678894,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.3400999903678894,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.18289999663829803,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13533","display_name":"Medical Case Reports and Studies","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurodivergence","display_name":"neurodivergence","score":0.9259999990463257},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.5720000267028809},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.6639999747276306},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8640000224113464},{"id":"https://openalex.org/keywords/burnout","display_name":"burnout","score":0.6169999837875366},{"id":"https://openalex.org/keywords/organic-osmolytes","display_name":"organic osmolytes","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.542900025844574},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4997999966144562},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47859999537467957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4246000051498413},{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.4169999957084656},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4081000089645386},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.39010000228881836},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3377000093460083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3203999996185303},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30730000138282776},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.301800012588501},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3005000054836273},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.28850001096725464},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.2879999876022339},{"id":"https://openalex.org/C2780243291","wikidata":"https://www.wikidata.org/wiki/Q605259","display_name":"Hyperkalemia","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.274399995803833},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C136792703","wikidata":"https://www.wikidata.org/wiki/Q377893","display_name":"Ultradian rhythm","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C2776184637","wikidata":"https://www.wikidata.org/wiki/Q6506039","display_name":"Living systems","level":2,"score":0.2599000036716461},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25870001316070557},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.25270000100135803}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.31234/osf.io/a4ekm","doi":"https://doi.org/10.31234/osf.io/a4ekm","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/a4ekm","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:share.osf.io:63e73145-d30e-430e-a23b-91e1894dc5c7","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/a4ekm","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.31234/osf.io/a4ekm","doi":"https://doi.org/10.31234/osf.io/a4ekm","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/a4ekm","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223113454","https://openalex.org/W7213775879","https://openalex.org/W2122376159","https://openalex.org/W3130421681","https://openalex.org/W4412871853","https://openalex.org/W2414414665","https://openalex.org/W2414691964","https://openalex.org/W7161398672","https://openalex.org/W7214319215","https://openalex.org/W406140881"],"abstract_inverted_index":{"Patients":[0],"within":[1,170],"the":[2,50,59,81,139,205,218],"neurodivergent":[3],"spectrum,":[4],"high-ability":[5],"profiles,":[6],"and":[7,28,64,77,112,144,150,167,202,232],"other":[8],"high":[9],"processing":[10],"cost":[11],"phenotypes":[12],"(HPCPh)":[13],"frequently":[14],"present":[15],"a":[16,223],"clinical":[17,183,209],"paradox:":[18],"marked":[19],"cognitive":[20,110],"domains":[21],"alongside":[22],"debilitating":[23],"functional":[24,234],"collapse,":[25],"burnout,":[26],"dysautonomia,":[27],"migrating":[29],"multisystem":[30],"symptoms.":[31],"Standard":[32],"cross-sectional":[33],"laboratory":[34,128],"investigations":[35],"against":[36],"population":[37],"references":[38],"routinely":[39],"prove":[40],"inconclusive":[41],"or":[42],"trigger":[43],"fragmented,":[44],"iatrogenic":[45],"interventions.":[46],"Here,":[47],"we":[48],"define":[49],"Third":[51,206],"Allostasis:":[52],"an":[53,175],"evolutionarily":[54],"conserved":[55],"biophysical":[56],"regime":[57,121],"wherein":[58],"organism":[60],"displaces":[61],"peripheral":[62],"homeostasis":[63],"lowers":[65],"systemic":[66],"throughput":[67],"to":[68,216],"defend":[69],"central":[70,230],"nervous":[71],"system":[72],"membrane":[73],"viability":[74],"when":[75,164],"environmental":[76],"informational":[78],"demands":[79],"approach":[80],"kinetic":[82],"limits":[83],"of":[84,92,147],"transmembrane":[85],"ion":[86],"clearance.":[87],"Through":[88],"within-person":[89],"longitudinal":[90],"follow-up":[91],"five":[93],"adult":[94],"HPCPh":[95],"trajectories\u2014spanning":[96],"stepped":[97],"recovery":[98],"from":[99,114,211],"decade-long":[100],"containment,":[101],"live":[102],"entry":[103],"into":[104],"acute":[105],"biological":[106],"helplessness,":[107],"endothelial\u2013natriuretic":[108],"decompression,":[109],"restoration,":[111],"exit":[113],"chronic":[115],"matrix":[116],"dysautonomia\u2014we":[117],"demonstrate":[118],"how":[119],"this":[120],"becomes":[122],"clinically":[123],"visible":[124],"using":[125],"four":[126],"routine":[127],"instruments.":[129],"We":[130],"introduce":[131],"accessible":[132],"arithmetic":[133],"tools":[134],"for":[135],"any":[136],"consulting":[137],"room:":[138],"red-cell":[140],"hydration":[141],"index":[142],"(Ht-3\u00d7Hb)":[143],"two":[145],"\"Rules":[146],"Three\"":[148],"(OsmP@290":[149],"Na@290)":[151],"that":[152,228],"unmask":[153],"hidden":[154],"plasma":[155],"osmolal":[156,177],"gaps":[157],"driven":[158],"by":[159],"uncharged":[160],"organic":[161],"osmolytes,":[162],"even":[163],"raw":[165],"osmolality":[166],"sodium":[168],"remain":[169],"normal":[171],"limits.":[172],"Crucially,":[173],"while":[174],"open":[176],"gap":[178],"signals":[179],"fast-axis":[180],"intercompartmental":[181],"shift,":[182],"direction":[184],"requires":[185],"\"whole-column":[186],"reading\"":[187],"across":[188],"slower":[189],"coupled":[190],"buffers,":[191],"including":[192],"circadian":[193],"cortisol,":[194],"tissue":[195],"thyroid":[196],"gating":[197],"(FT3/rT3),":[198],"iron-ferritin":[199],"dynamics,":[200],"prolactin,":[201],"monocytes.":[203],"Recognizing":[204],"Allostasis":[207],"shifts":[208],"practice":[210],"treating":[212],"isolated":[213],"organ":[214],"abnormalities":[215],"reading":[217],"organism's":[219],"adaptive":[220],"effort":[221],"as":[222],"whole,":[224],"guiding":[225],"contextual":[226],"adjustments":[227],"relieve":[229],"overload":[231],"restore":[233],"vitality.":[235]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
