{"id":"https://openalex.org/W7225395296","doi":"https://doi.org/10.1007/s13318-026-01048-4","title":"Development of a Population Pharmacokinetic Model for Aqueous Progesterone in Chinese Postmenopausal Women: Integrating Machine Learning for Covariate Screening","display_name":"Development of a Population Pharmacokinetic Model for Aqueous Progesterone in Chinese Postmenopausal Women: Integrating Machine Learning for Covariate Screening","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225395296","doi":"https://doi.org/10.1007/s13318-026-01048-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42993469"},"language":"en","primary_location":{"id":"doi:10.1007/s13318-026-01048-4","doi":"https://doi.org/10.1007/s13318-026-01048-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13318-026-01048-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13318-026-01048-4.pdf","source":{"id":"https://openalex.org/S204244929","display_name":"European Journal of Drug Metabolism and Pharmacokinetics","issn_l":"0378-7966","issn":["0378-7966","2107-0180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s13318-026-01048-4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100364488","display_name":"Lu Wang","orcid":"https://orcid.org/0000-0002-8346-194X","observed_orcids":["https://orcid.org/0000-0002-8346-194X"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Wang","raw_affiliation_strings":["Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China","Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161039188","display_name":"Jie Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Tang","raw_affiliation_strings":["Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China","Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161025216","display_name":"Sufeng Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sufeng Zhou","raw_affiliation_strings":["Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China","Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102649023","display_name":"Tangping Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tangping Zhao","raw_affiliation_strings":["Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China","Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161043368","display_name":"Ying Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Ding","raw_affiliation_strings":["Changchun GeneScience Pharmaceutical Co., Ltd, 18th Floor, Block A, H88 Yuehong Plaza, No. 88 Hongcao Road, Xuhui District, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun GeneScience Pharmaceutical Co., Ltd, 18th Floor, Block A, H88 Yuehong Plaza, No. 88 Hongcao Road, Xuhui District, Shanghai, 200233, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133252932","display_name":"Weiwei Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiwei Gao","raw_affiliation_strings":["Changchun GeneScience Pharmaceutical Co., Ltd, 18th Floor, Block A, H88 Yuehong Plaza, No. 88 Hongcao Road, Xuhui District, Shanghai, 200233, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun GeneScience Pharmaceutical Co., Ltd, 18th Floor, Block A, H88 Yuehong Plaza, No. 88 Hongcao Road, Xuhui District, Shanghai, 200233, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161080559","display_name":"Xiaoyan Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiaoyan Zhu","raw_affiliation_strings":["Changchun GeneScience Pharmaceutical Co., Ltd, 18th Floor, Block A, H88 Yuehong Plaza, No. 88 Hongcao Road, Xuhui District, Shanghai, 200233, China. zhuxiaoyan01@genscigroup.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changchun GeneScience Pharmaceutical Co., Ltd, 18th Floor, Block A, H88 Yuehong Plaza, No. 88 Hongcao Road, Xuhui District, Shanghai, 200233, China. zhuxiaoyan01@genscigroup.com","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101434259","display_name":"Feng Shao","orcid":"https://orcid.org/0000-0001-8861-7299","observed_orcids":["https://orcid.org/0000-0001-8861-7299"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Shao","raw_affiliation_strings":["Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. jsphshaofeng@hotmail.com","Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China. jsphshaofeng@hotmail.com"],"raw_orcid":"https://orcid.org/0000-0001-8861-7299","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. jsphshaofeng@hotmail.com","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Phase I Clinical Trial Unit, The First Affiliated Hospital With Nanjing Medical University, Nanjing, 210029, China. jsphshaofeng@hotmail.com","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101434259","https://openalex.org/A5161080559"],"corresponding_institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population-pharmacokinetic-model","display_name":"population pharmacokinetic model","score":0.8410000205039978},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.949999988079071},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.8730000257492065},{"id":"https://openalex.org/keywords/lasso","display_name":"LASSO","score":0.8659999966621399},{"id":"https://openalex.org/keywords/elastic-net","display_name":"elastic net","score":0.8840000033378601},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.9980000257492065},{"id":"https://openalex.org/keywords/luteal-phase-support","display_name":"luteal phase support","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.734000027179718},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.6890000104904175},{"id":"https://openalex.org/keywords/chinese-women","display_name":"Chinese women","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.7613999843597412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7243000268936157},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6765999794006348},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5702000260353088},{"id":"https://openalex.org/C143228043","wikidata":"https://www.wikidata.org/wiki/Q2363481","display_name":"Luteal phase","level":3,"score":0.5223000049591064},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.5195000171661377},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.4584999978542328},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.3946000039577484},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.39070001244544983},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.38670000433921814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3675999939441681},{"id":"https://openalex.org/C2780186607","wikidata":"https://www.wikidata.org/wiki/Q416950","display_name":"Levonorgestrel","level":5,"score":0.3668000102043152},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C2776239304","wikidata":"https://www.wikidata.org/wiki/Q6954915","display_name":"NONMEM","level":3,"score":0.32109999656677246},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.31360000371932983},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3025999963283539},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C3020640247","wikidata":"https://www.wikidata.org/wiki/Q1981379","display_name":"Chinese population","level":4,"score":0.26499998569488525},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.26339998841285706},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25189998745918274},{"id":"https://openalex.org/C192670549","wikidata":"https://www.wikidata.org/wiki/Q5361061","display_name":"Elimination rate constant","level":4,"score":0.25040000677108765}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s13318-026-01048-4","doi":"https://doi.org/10.1007/s13318-026-01048-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13318-026-01048-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13318-026-01048-4.pdf","source":{"id":"https://openalex.org/S204244929","display_name":"European Journal of Drug Metabolism and Pharmacokinetics","issn_l":"0378-7966","issn":["0378-7966","2107-0180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"},{"id":"pmid:42993469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42993469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of drug metabolism and pharmacokinetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s13318-026-01048-4","doi":"https://doi.org/10.1007/s13318-026-01048-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13318-026-01048-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s13318-026-01048-4.pdf","source":{"id":"https://openalex.org/S204244929","display_name":"European Journal of Drug Metabolism and Pharmacokinetics","issn_l":"0378-7966","issn":["0378-7966","2107-0180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Drug Metabolism and Pharmacokinetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225395296.pdf","grobid_xml":"https://content.openalex.org/works/W7225395296.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W86353481","https://openalex.org/W1482208423","https://openalex.org/W1512555213","https://openalex.org/W1525774039","https://openalex.org/W1986085565","https://openalex.org/W1998163185","https://openalex.org/W2020925091","https://openalex.org/W2066825099","https://openalex.org/W2092602264","https://openalex.org/W2122825543","https://openalex.org/W2131752928","https://openalex.org/W2143481518","https://openalex.org/W2156332695","https://openalex.org/W2473943285","https://openalex.org/W2618851150","https://openalex.org/W2908029558","https://openalex.org/W2911964244","https://openalex.org/W3008094895","https://openalex.org/W3011115783","https://openalex.org/W3023643850","https://openalex.org/W3031647377","https://openalex.org/W3114892659","https://openalex.org/W3131105603","https://openalex.org/W3135906313","https://openalex.org/W3161192826","https://openalex.org/W3199492746","https://openalex.org/W4232570535","https://openalex.org/W4306377245","https://openalex.org/W4387869365","https://openalex.org/W4390614830","https://openalex.org/W4406599854","https://openalex.org/W4406982577","https://openalex.org/W4407295738","https://openalex.org/W4414363715","https://openalex.org/W4414660222","https://openalex.org/W4415366995","https://openalex.org/W4415370828","https://openalex.org/W7128516097"],"related_works":["https://openalex.org/W4306377245","https://openalex.org/W4391897178","https://openalex.org/W7214069109","https://openalex.org/W4296581822","https://openalex.org/W4417321581","https://openalex.org/W4401610602","https://openalex.org/W4416961144","https://openalex.org/W4414268258","https://openalex.org/W7203460269","https://openalex.org/W4406599854"],"abstract_inverted_index":{"This":[0,212],"study":[1,35],"developed":[2],"the":[3,54,107,131,168,183,196,206,215,223,239],"first":[4,216],"population":[5,198],"pharmacokinetic":[6,84],"(popPK)":[7],"model":[8,41,148],"of":[9,83,109,195,219],"subcutaneous":[10],"aqueous":[11,220],"progesterone":[12],"in":[13,36,130],"Chinese":[14,243],"healthy":[15],"postmenopausal":[16],"women,":[17],"integrating":[18],"machine":[19],"learning":[20],"(ML)":[21],"for":[22,208,228,234],"covariate":[23,61],"screening.":[24],"Data":[25],"were":[26,137],"obtained":[27],"from":[28],"an":[29],"open-label,":[30],"single-dose,":[31],"two-period":[32],"crossover":[33],"bioequivalence":[34],"50":[37],"subjects.":[38],"A":[39],"two-compartment":[40],"with":[42],"first-order":[43,50],"absorption":[44],"(including":[45],"a":[46,158,200],"lag":[47],"time)":[48],"and":[49,69,75,94,97,114,124,151,182],"elimination":[51],"best":[52],"described":[53],"concentration\u2013time":[55,169],"profiles.":[56],"Prior":[57],"to":[58,79,153],"conventional":[59],"stepwise":[60],"modeling,":[62],"ML":[63,88],"algorithms\u2014including":[64],"adaptive":[65],"least":[66],"absolute":[67],"shrinkage":[68],"selection":[70],"operator":[71],"(LASSO),":[72],"elastic":[73],"net,":[74],"random":[76],"forest\u2014were":[77],"employed":[78],"identify":[80],"physiological":[81],"predictors":[82],"(PK)":[85],"variability.":[86],"The":[87,146,163],"ensemble":[89],"demonstrated":[90],"high":[91],"predictive":[92],"performance":[93],"highlighted":[95],"height":[96,110],"weight":[98,116],"as":[99],"potential":[100],"covariates.":[101],"However,":[102],"subsequent":[103],"popPK":[104,217],"evaluation":[105],"retained":[106],"effects":[108],"on":[111,117,238],"clearance":[112,126],"(CL)":[113],"body":[115],"peripheral":[118],"volume":[119],"(":[120,186,247],"V":[121],"2":[122,128],")":[123,129,175,189],"intercompartmental":[125],"(CL":[127],"final":[132,147],"model.":[133],"While":[134],"these":[135],"relationships":[136],"statistically":[138],"identifiable,":[139],"their":[140],"clinical":[141],"significance":[142],"was":[143,149,176,190],"considered":[144],"limited.":[145],"robust":[150],"used":[152],"simulate":[154],"steady-state":[155,172],"exposure":[156],"following":[157],"once-daily":[159,226],"25":[160,224],"mg":[161,225],"regimen.":[162],"simulated":[164,197],"mean":[165],"area":[166],"under":[167],"curve":[170],"at":[171],"(AUC":[173],"ss":[174],"324":[177],"\u00b1":[178],"45.9":[179],"\u03bcg":[180],"h/L,":[181],"average":[184],"concentration":[185],"C":[187,201],"avg,ss":[188,202],"13.3":[191],"\u03bcg/L.":[192],"Notably,":[193],"98.9%":[194],"achieved":[199],"\u2265":[203],"10":[204],"\u03bcg/L,":[205],"threshold":[207],"adequate":[209],"luteal":[210,229],"support.":[211],"analysis":[213],"provides":[214],"characterization":[218],"progesterone,":[221],"supporting":[222],"regimen":[227],"phase":[230],"support,":[231],"without":[232],"need":[233],"dose":[235],"adjustment":[236],"based":[237],"evaluated":[240],"intrinsic":[241],"factors.":[242],"Clinical":[244],"Trial":[245],"Registry":[246],"CTR20221233,":[248],"registration":[249],"date:":[250],"30":[251],"May":[252],"2022;":[253],"prospectively":[254],"registered).":[255]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}