{"id":"https://openalex.org/W7225393604","doi":"https://doi.org/10.29261/pakvetj/2026.241","title":"Exploration of Vaccine Candidates against Avian Pathogenic E. coli Using Proteome Mining","display_name":"Exploration of Vaccine Candidates against Avian Pathogenic E. coli Using Proteome Mining","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225393604","doi":"https://doi.org/10.29261/pakvetj/2026.241"},"language":"en","primary_location":{"id":"doi:10.29261/pakvetj/2026.241","doi":"https://doi.org/10.29261/pakvetj/2026.241","is_oa":true,"landing_page_url":"https://doi.org/10.29261/pakvetj/2026.241","pdf_url":"https://doi.org/10.29261/pakvetj/2026.241","source":{"id":"https://openalex.org/S12629481","display_name":"Pakistan Veterinary Journal","issn_l":"0253-8318","issn":["0253-8318","2074-7764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319262","host_organization_name":"University of Agriculture Faisalabad","host_organization_lineage":["https://openalex.org/P4310319262"],"host_organization_lineage_names":["University of Agriculture Faisalabad"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Veterinary Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.29261/pakvetj/2026.241","any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":15000,"currency":"PKR","value_usd":300},"apc_paid":{"value":15000,"currency":"PKR","value_usd":300},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.32670000195503235,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/avian-pathogenic-escherichia-coli","display_name":"avian pathogenic Escherichia coli","score":0.9929999709129333},{"id":"https://openalex.org/keywords/avian-colibacillosis","display_name":"avian colibacillosis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/vaccine-candidate","display_name":"vaccine candidate","score":0.7760000228881836},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.8700000047683716},{"id":"https://openalex.org/keywords/reverse-vaccinology","display_name":"reverse vaccinology","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chimeric-vaccine","display_name":"chimeric vaccine","score":0.8149999976158142},{"id":"https://openalex.org/keywords/epitope-design","display_name":"epitope design","score":0.5329999923706055},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.6190000176429749},{"id":"https://openalex.org/keywords/ompa","display_name":"OmpA","score":0.7940000295639038},{"id":"https://openalex.org/keywords/papc","display_name":"papC","score":0.9520000219345093},{"id":"https://openalex.org/keywords/phoe","display_name":"PhoE","score":0.9980000257492065},{"id":"https://openalex.org/keywords/poultry","display_name":"poultry","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2781152039","wikidata":"https://www.wikidata.org/wiki/Q7318278","display_name":"Reverse vaccinology","level":4,"score":0.784600019454956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7610999941825867},{"id":"https://openalex.org/C2779616913","wikidata":"https://www.wikidata.org/wiki/Q7144817","display_name":"Pathogenic Escherichia coli","level":4,"score":0.7384999990463257},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7351999878883362},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7023000121116638},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.5863000154495239},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5722000002861023},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.5586000084877014},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.5189999938011169},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5098000168800354},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4797999858856201},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4699999988079071},{"id":"https://openalex.org/C3019819676","wikidata":"https://www.wikidata.org/wiki/Q43987","display_name":"Highly pathogenic","level":4,"score":0.39169999957084656},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.3871000111103058},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37369999289512634},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.3084000051021576},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C2777264056","wikidata":"https://www.wikidata.org/wiki/Q12673555","display_name":"Spirochaete","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.25870001316070557}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.29261/pakvetj/2026.241","doi":"https://doi.org/10.29261/pakvetj/2026.241","is_oa":true,"landing_page_url":"https://doi.org/10.29261/pakvetj/2026.241","pdf_url":"https://doi.org/10.29261/pakvetj/2026.241","source":{"id":"https://openalex.org/S12629481","display_name":"Pakistan Veterinary Journal","issn_l":"0253-8318","issn":["0253-8318","2074-7764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319262","host_organization_name":"University of Agriculture Faisalabad","host_organization_lineage":["https://openalex.org/P4310319262"],"host_organization_lineage_names":["University of Agriculture Faisalabad"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Veterinary Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.29261/pakvetj/2026.241","doi":"https://doi.org/10.29261/pakvetj/2026.241","is_oa":true,"landing_page_url":"https://doi.org/10.29261/pakvetj/2026.241","pdf_url":"https://doi.org/10.29261/pakvetj/2026.241","source":{"id":"https://openalex.org/S12629481","display_name":"Pakistan Veterinary Journal","issn_l":"0253-8318","issn":["0253-8318","2074-7764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319262","host_organization_name":"University of Agriculture Faisalabad","host_organization_lineage":["https://openalex.org/P4310319262"],"host_organization_lineage_names":["University of Agriculture Faisalabad"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Veterinary Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225393604.pdf","grobid_xml":"https://content.openalex.org/works/W7225393604.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3215104431","https://openalex.org/W4414986573","https://openalex.org/W2760669560","https://openalex.org/W7151423148","https://openalex.org/W2746315003","https://openalex.org/W2057507996","https://openalex.org/W2963023956","https://openalex.org/W2786673948","https://openalex.org/W3028655732","https://openalex.org/W2758042787"],"abstract_inverted_index":{"Avian":[0],"Pathogenic":[1],"Escherichia":[2],"coli":[3],"(APEC)":[4],"is":[5],"a":[6,37,43,141],"major":[7],"causative":[8],"agent":[9],"of":[10,52,64,80,100,206],"avian":[11],"colibacillosis,":[12],"causing":[13],"significant":[14],"financial":[15],"losses":[16],"to":[17,31,127,199],"the":[18,50,84,128,164,174,180,185,201,207],"poultry":[19],"industry.Current":[20],"vaccines":[21],"offer":[22,58],"limited":[23],"protection":[24,60],"and":[25,33,67,73,88,123,138,155,170,176,184,191,203],"also":[26],"pose":[27],"logistical":[28],"challenges":[29],"related":[30],"storage":[32],"administration.Considering":[34],"this":[35],"fact,":[36],"subtractive":[38],"proteome":[39],"analysis":[40],"along":[41],"with":[42],"reverse":[44],"vaccinology":[45],"approach":[46],"was":[47,145],"performed":[48],"for":[49,77],"screening":[51],"promising":[53],"vaccine":[54,115,144,183,208],"candidates":[55],"that":[56],"would":[57],"broad":[59],"against":[61,147],"heterologous":[62],"serotypes":[63,99],"APEC.O1,":[65],"O2,":[66],"O78":[68],"are":[69],"APEC's":[70],"most":[71],"prevalent":[72],"pathogenic":[74,98,167],"serotypes,":[75],"responsible":[76],"over":[78],"80%":[79],"infections":[81],"in":[82,189,192],"poultry.Therefore,":[83],"essential,":[85],"highly":[86,161,166],"virulent,":[87],"strongly":[89],"antigenic":[90],"outer":[91,132],"membrane":[92,133],"proteins":[93],"(OMPs)":[94],"shared":[95],"among":[96,163],"these":[97],"APEC":[101,148],"were":[102,111,160],"screened":[103],"through":[104],"comprehensive":[105],"In":[106],"Silico":[107],"analysis.Thus,":[108],"six":[109],"OMPs":[110,125],"identified":[112],"as":[113],"viable":[114],"targets,":[116],"including":[117],"OmpA,":[118],"PapC,":[119],"Wza,":[120],"YehB,":[121],"PhoE,":[122],"EtsC.These":[124],"belong":[126],"four":[129,151,153],"functional":[130],"families:":[131],"protectin,":[134],"transporters,":[135],"capsular":[136],"biogenesis,":[137],"fimbrial":[139],"biogenesis.Afterwards,":[140],"novel":[142],"chimeric":[143,182],"designed":[146],"by":[149],"using":[150],"B-cell,":[152],"CTL,":[154],"five":[156],"HTL":[157],"epitopes,":[158],"which":[159],"conserved":[162],"three":[165],"serotypes.Molecular":[168],"docking":[169],"dynamic":[171],"simulations":[172],"revealed":[173],"stable":[175],"high-affinity":[177],"interactions":[178],"between":[179],"constructed":[181],"mammalian":[186],"TLR4":[187],"receptor.Nonetheless,":[188],"vitro":[190],"vivo":[193],"experimental":[194],"validation":[195],"will":[196],"be":[197],"required":[198],"confirm":[200],"immunogenicity":[202],"protective":[204],"efficacy":[205],"ensemble.":[209]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}