{"id":"https://openalex.org/W7225388448","doi":"https://doi.org/10.64898/2026.11.04.764326","title":"Single-cell multi-omics identify OTP and NOVA1 as regulators of leptin action in hypothalamic feeding circuits","display_name":"Single-cell multi-omics identify OTP and NOVA1 as regulators of leptin action in hypothalamic feeding circuits","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225388448","doi":"https://doi.org/10.64898/2026.11.04.764326"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.764326","doi":"https://doi.org/10.64898/2026.11.04.764326","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764326","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764326.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764326.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016934016","display_name":"Han L. Tan","orcid":"https://orcid.org/0000-0001-5163-7720","observed_orcids":["https://orcid.org/0000-0001-5163-7720","https://orcid.org/0000-0002-7905-5818"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Han L. Tan","raw_affiliation_strings":["Department of Anatomy and Neurobiology, University of California Irvine School of Medicine, Irvine, CA, USA;"],"raw_orcid":"https://orcid.org/0000-0001-5163-7720","affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, University of California Irvine School of Medicine, Irvine, CA, USA;","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041761505","display_name":"Yuqi Tan","orcid":"https://orcid.org/0000-0002-7200-3222","observed_orcids":["https://orcid.org/0000-0002-7200-3222"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuqi Tan","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA;"],"raw_orcid":"https://orcid.org/0000-0002-7200-3222","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104754739","display_name":"Jenelys Ruiz Ortiz","orcid":"https://orcid.org/0000-0002-6442-2187","observed_orcids":["https://orcid.org/0000-0002-6442-2187"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenelys Ruiz-Ortiz","raw_affiliation_strings":["Bioinformatics Resource Center, The Rockefeller University, New York, NY, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Resource Center, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160990572","display_name":"Matt Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matt Paul","raw_affiliation_strings":["Bioinformatics Resource Center, The Rockefeller University, New York, NY, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Resource Center, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161120412","display_name":"Zhaoyu Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaoyu Han","raw_affiliation_strings":["Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067088278","display_name":"Leah Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Kelly","raw_affiliation_strings":["Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161118076","display_name":"Anduena Toci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anduena Toci","raw_affiliation_strings":["Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019060378","display_name":"Kaja Pluci\u0144ska","orcid":"https://orcid.org/0000-0002-2144-7712","observed_orcids":["https://orcid.org/0000-0002-2144-7712"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaja Plucinska","raw_affiliation_strings":["Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030876154","display_name":"Yoko Tajima","orcid":"https://orcid.org/0000-0002-0914-6394","observed_orcids":["https://orcid.org/0000-0002-0914-6394"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoko Tajima","raw_affiliation_strings":["Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029117020","display_name":"Rani Shiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rani Shiao","raw_affiliation_strings":["Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161136045","display_name":"Bora Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]},{"id":"https://openalex.org/I4210148121","display_name":"Chonnam National University Hwasun Hospital","ror":"https://ror.org/054gh2b75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I111277659","https://openalex.org/I4210092150","https://openalex.org/I4210148121"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Bora Lee","raw_affiliation_strings":["Department of Biochemistry, Chonnam National University Medical School, Hwasun, Republic of Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Chonnam National University Medical School, Hwasun, Republic of Korea;","institution_ids":["https://openalex.org/I111277659","https://openalex.org/I4210148121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005944989","display_name":"Anoj Ilanges","orcid":"https://orcid.org/0000-0003-2611-6768","observed_orcids":["https://orcid.org/0000-0003-2611-6768"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anoj Ilanges","raw_affiliation_strings":["Janelia Research Campus, Ashburn, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janelia Research Campus, Ashburn, VA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035034609","display_name":"Robert B. Darnell","orcid":"https://orcid.org/0000-0002-5134-8088","observed_orcids":["https://orcid.org/0000-0002-5134-8088"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B Darnell","raw_affiliation_strings":["Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;"],"raw_orcid":"https://orcid.org/0000-0002-5134-8088","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Neuro-Oncology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047214685","display_name":"Paul Cohen","orcid":"https://orcid.org/0000-0002-2786-8585","observed_orcids":["https://orcid.org/0000-0002-2786-8585"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Cohen","raw_affiliation_strings":["Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA;"],"raw_orcid":"https://orcid.org/0000-0002-2786-8585","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065622211","display_name":"Jeffrey M. Friedman","orcid":"https://orcid.org/0000-0003-2152-0868","observed_orcids":["https://orcid.org/0000-0003-2152-0868"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Friedman","raw_affiliation_strings":["Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;"],"raw_orcid":"https://orcid.org/0000-0003-2152-0868","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5016934016"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.9259999990463257},{"id":"https://openalex.org/keywords/paraventricular-nucleus","display_name":"paraventricular nucleus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/leptin-receptor-neurons","display_name":"leptin receptor neurons","score":0.9300000071525574},{"id":"https://openalex.org/keywords/agrp-neurons","display_name":"AgRP neurons","score":0.746999979019165},{"id":"https://openalex.org/keywords/otp","display_name":"OTP","score":0.6679999828338623},{"id":"https://openalex.org/keywords/nova1","display_name":"NOVA1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.7870000004768372},{"id":"https://openalex.org/keywords/single-nucleus-transcriptomics","display_name":"single-nucleus transcriptomics","score":0.9359999895095825},{"id":"https://openalex.org/keywords/rna-velocity","display_name":"RNA velocity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.8730000257492065},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.7960000038146973},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8029999732971191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7225000262260437},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.6711000204086304},{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.6184999942779541},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5633000135421753},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.5382000207901001},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.49549999833106995},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.47929999232292175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46950000524520874},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45239999890327454},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4503999948501587},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.4278999865055084},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42410001158714294},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4034000039100647},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.39590001106262207},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.39480000734329224},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36160001158714294},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.3598000109195709},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.3538999855518341},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.3239000141620636},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.32109999656677246},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.31459999084472656},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.29760000109672546},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2935999929904938}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.764326","doi":"https://doi.org/10.64898/2026.11.04.764326","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764326","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764326.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.764326","doi":"https://doi.org/10.64898/2026.11.04.764326","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764326","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764326.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225388448.pdf","grobid_xml":"https://content.openalex.org/works/W7225388448.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1805837212","https://openalex.org/W1972275518","https://openalex.org/W1975958907","https://openalex.org/W1996713062","https://openalex.org/W2008065864","https://openalex.org/W2022391162","https://openalex.org/W2023261615","https://openalex.org/W2024116770","https://openalex.org/W2059114469","https://openalex.org/W2063795094","https://openalex.org/W2066665477","https://openalex.org/W2069089843","https://openalex.org/W2069290560","https://openalex.org/W2073654740","https://openalex.org/W2074445557","https://openalex.org/W2075480833","https://openalex.org/W2098623033","https://openalex.org/W2135518377","https://openalex.org/W2171808845","https://openalex.org/W2252730995","https://openalex.org/W2573115784","https://openalex.org/W2586421092","https://openalex.org/W2605506485","https://openalex.org/W2652575518","https://openalex.org/W2729311324","https://openalex.org/W2745817264","https://openalex.org/W2750420823","https://openalex.org/W2750582226","https://openalex.org/W2766437506","https://openalex.org/W2800392236","https://openalex.org/W2803951926","https://openalex.org/W2901549151","https://openalex.org/W2909498090","https://openalex.org/W2953584518","https://openalex.org/W2966964832","https://openalex.org/W2999774672","https://openalex.org/W3029239725","https://openalex.org/W3044817976","https://openalex.org/W3047141442","https://openalex.org/W3132661792","https://openalex.org/W3157684336","https://openalex.org/W3158574224","https://openalex.org/W3164839005","https://openalex.org/W3180309675","https://openalex.org/W3209414730","https://openalex.org/W4311197765","https://openalex.org/W4315436955","https://openalex.org/W4318428409","https://openalex.org/W4384198561","https://openalex.org/W4385409675","https://openalex.org/W4391482515","https://openalex.org/W4393858127","https://openalex.org/W4402604581","https://openalex.org/W4403920984","https://openalex.org/W4405022810","https://openalex.org/W4408126305","https://openalex.org/W7129080381"],"related_works":["https://openalex.org/W4413793768","https://openalex.org/W4399213091","https://openalex.org/W1977571624","https://openalex.org/W1900852307","https://openalex.org/W7221181590","https://openalex.org/W2074275743","https://openalex.org/W4231926848","https://openalex.org/W3035759987","https://openalex.org/W2088517300","https://openalex.org/W163568174"],"abstract_inverted_index":{"Leptin":[0],"acts":[1],"directly":[2],"and":[3,12,46,55,63,88,122,141,223,249,258],"indirectly":[4],"on":[5],"multiple":[6,31],"neuronal":[7,28,114,171,188,221,231],"populations":[8,29],"to":[9,59,132,276],"regulate":[10],"feeding":[11,274],"numerous":[13],"other":[14],"physiologic":[15],"functions.":[16,194],"However,":[17],"our":[18],"understanding":[19],"of":[20,83,98,107,179,215,218,229,251],"how":[21,38],"a":[22,203,212,265],"single":[23],"circulating":[24],"signal":[25],"coordinates":[26],"diverse":[27],"across":[30,67,169],"circuits":[32,275],"is":[33,245],"limited.":[34],"To":[35],"further":[36],"elucidate":[37],"leptin":[39,84,105,147,164,248,271],"reshapes":[40],"molecular":[41],"states":[42],"in":[43,70,186,208,242],"its":[44],"direct":[45],"indirect":[47],"neural":[48],"targets,":[49],"we":[50],"combined":[51],"time-resolved":[52],"single-nucleus":[53],"transcriptomics":[54],"chromatin":[56,64],"accessibility":[57],"profiling":[58],"map":[60],"leptin-induced":[61],"transcriptional":[62,121],"state":[65,124,232],"changes":[66,125],"individual":[68],"neurons":[69],"two":[71],"key":[72],"hypothalamic":[73,91,149,273],"nuclei:":[74],"the":[75,81,89,130,198],"arcuate":[76],"nucleus":[77,92],"(ARC),":[78],"which":[79,270],"contains":[80],"majority":[82],"receptor":[85],"(LepR)":[86],"neurons,":[87,210,244],"paraventricular":[90],"(PVH),":[93],"an":[94,237],"established":[95],"downstream":[96,133,183],"target":[97],"ARC":[99,131],"LepR":[100,170],"neurons.":[101,135],"We":[102],"found":[103],"that":[104,126,146,177,235],"treatment":[106],"leptin-deficient":[108],"ob/ob":[109],"mice":[110],"does":[111],"not":[112],"alter":[113],"identity,":[115],"but":[116],"instead":[117],"induces":[118],"coordinated,":[119],"cell-type-specific":[120],"regulatory":[123,184,267],"propagate":[127],"hierarchically":[128],"from":[129],"PVH":[134,230],"Integrating":[136],"RNA":[137],"velocity,":[138],"cis-regulatory":[139],"analysis,":[140],"cell-cell":[142],"communication":[143],"inference":[144],"revealed":[145,176],"modulates":[148],"circuit":[150],"architecture":[151],"by":[152,247],"selectively":[153,206],"strengthening":[154],"specific":[155],"interactions":[156],"while":[157],"pruning":[158],"broadly":[159,165],"distributed,":[160],"low-specificity":[161],"signaling.":[162],"Although":[163],"activated":[166],"STAT3":[167,180],"signaling":[168],"subtypes,":[172],"integrated":[173],"multi-omic":[174],"analyses":[175,196],"activation":[178],"engages":[181],"distinct":[182],"programs":[185],"different":[187],"populations,":[189],"often":[190],"with":[191],"opposing":[192],"physiological":[193],"Functional":[195],"identified":[197],"homeobox":[199],"transcription":[200],"factor":[201],"OTP,":[202],"leptin-responsive":[204],"regulator":[205],"induced":[207],"AGRP":[209,220],"as":[211],"critical":[213],"mediator":[214],"leptin-mediated":[216],"inhibition":[217],"hunger-promoting":[219],"activity":[222],"feeding.":[224],"In":[225],"parallel,":[226],"unbiased":[227],"analysis":[228],"transitions":[233],"shows":[234],"NOVA1,":[236],"RNA-binding":[238],"protein":[239],"primarily":[240],"expressed":[241],"inhibitory":[243],"regulated":[246],"alterations":[250],"NOVA1":[252],"expression":[253],"bidirectionally":[254],"control":[255,277],"food":[256],"intake":[257],"body":[259],"weight.":[260],"Together,":[261],"these":[262],"findings":[263],"define":[264],"multi-layered":[266],"framework":[268],"through":[269],"regulates":[272],"energy":[278],"balance.":[279]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
