{"id":"https://openalex.org/W7225387704","doi":"https://doi.org/10.64898/2026.11.04.764411","title":"Application of metagenomic sequencing to improve sessile serrated lesion detection using the faecal immunochemical test","display_name":"Application of metagenomic sequencing to improve sessile serrated lesion detection using the faecal immunochemical test","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225387704","doi":"https://doi.org/10.64898/2026.11.04.764411"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.764411","doi":"https://doi.org/10.64898/2026.11.04.764411","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764411","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764411.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764411.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065459060","display_name":"Bradley J. Hart","orcid":"https://orcid.org/0000-0001-8110-2460","observed_orcids":["https://orcid.org/0000-0001-8110-2460"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bradley J Hart","raw_affiliation_strings":["Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0001-8110-2460","affiliations":[{"raw_affiliation_string":"Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018458697","display_name":"Geraldine Laven\u2010Law","orcid":"https://orcid.org/0000-0001-5326-1931","observed_orcids":["https://orcid.org/0000-0001-5326-1931"]},"institutions":[{"id":"https://openalex.org/I4405259444","display_name":"Adelaide University","ror":"https://ror.org/028g18b61","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Geraldine Laven-Law","raw_affiliation_strings":["South Australian ImmunoGENomics Cancer Institute, College of Medicine, Adelaide University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0001-5326-1931","affiliations":[{"raw_affiliation_string":"South Australian ImmunoGENomics Cancer Institute, College of Medicine, Adelaide University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038428879","display_name":"Clarice M. Harker","orcid":"https://orcid.org/0009-0008-6802-6799","observed_orcids":["https://orcid.org/0009-0008-6802-6799"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Clarice M Harker","raw_affiliation_strings":["Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0009-0008-6802-6799","affiliations":[{"raw_affiliation_string":"Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021067423","display_name":"Michael P. Doane","orcid":"https://orcid.org/0000-0001-9820-2193","observed_orcids":["https://orcid.org/0000-0001-9820-2193"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael P Doane","raw_affiliation_strings":["Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0001-9820-2193","affiliations":[{"raw_affiliation_string":"Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007491946","display_name":"Rachel Parker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802931750","display_name":"Flinders Medical Centre","ror":"https://ror.org/020aczd56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802931750"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rachel Parker","raw_affiliation_strings":["Department of Gastroenterology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, SA, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, SA, Australia","institution_ids":["https://openalex.org/I2802931750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018396563","display_name":"Martha Alemayehu Menberu","orcid":"https://orcid.org/0000-0002-0696-5140","observed_orcids":["https://orcid.org/0000-0002-0696-5140"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Martha Menberu","raw_affiliation_strings":["Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0002-0696-5140","affiliations":[{"raw_affiliation_string":"Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070052974","display_name":"Charles Cock","orcid":"https://orcid.org/0000-0003-3578-1137","observed_orcids":["https://orcid.org/0000-0003-3578-1137"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Charles Cock","raw_affiliation_strings":["Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0003-3578-1137","affiliations":[{"raw_affiliation_string":"Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036802114","display_name":"Robert Alan Edwards","orcid":"https://orcid.org/0000-0001-8383-8949","observed_orcids":["https://orcid.org/0000-0001-8383-8949"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert A Edwards","raw_affiliation_strings":["Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0001-8383-8949","affiliations":[{"raw_affiliation_string":"Flinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080837510","display_name":"Erin Leigh Symonds","orcid":"https://orcid.org/0000-0003-2451-0358","observed_orcids":["https://orcid.org/0000-0003-2451-0358"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Erin L Symonds","raw_affiliation_strings":["Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0003-2451-0358","affiliations":[{"raw_affiliation_string":"Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008463932","display_name":"Jean M. Winter","orcid":"https://orcid.org/0000-0002-2041-8602","observed_orcids":["https://orcid.org/0000-0002-2041-8602"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jean M Winter","raw_affiliation_strings":["Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0002-2041-8602","affiliations":[{"raw_affiliation_string":"Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026598479","display_name":"Michael J. Roach","orcid":"https://orcid.org/0000-0003-1488-5148","observed_orcids":["https://orcid.org/0000-0003-1488-5148"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Michael J Roach","raw_affiliation_strings":["Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;"],"raw_orcid":"https://orcid.org/0000-0003-1488-5148","affiliations":[{"raw_affiliation_string":"Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia;","institution_ids":["https://openalex.org/I169541294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026598479"],"corresponding_institution_ids":["https://openalex.org/I169541294"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9204000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.0478999987244606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sessile-serrated-lesions","display_name":"sessile serrated lesions","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fecal-immunochemical-test","display_name":"fecal immunochemical test","score":0.9639999866485596},{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fecal-microbiota","display_name":"fecal microbiota","score":0.9359999895095825},{"id":"https://openalex.org/keywords/metagenomics","display_name":"metagenomics","score":0.7409999966621399},{"id":"https://openalex.org/keywords/sample-collection-methods","display_name":"sample collection methods","score":0.5730000138282776},{"id":"https://openalex.org/keywords/microbial-biomarkers","display_name":"microbial biomarkers","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.9120000004768372},{"id":"https://openalex.org/keywords/polyamine-biosynthesis","display_name":"polyamine biosynthesis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/enterobacteriaceae","display_name":"Enterobacteriaceae","score":0.8790000081062317},{"id":"https://openalex.org/keywords/diagnostic-colonoscopy","display_name":"diagnostic colonoscopy","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7773000001907349},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.6876000165939331},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.569100022315979},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5440000295639038},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.4726000130176544},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46709999442100525},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4140999913215637},{"id":"https://openalex.org/C81566733","wikidata":"https://www.wikidata.org/wiki/Q1047544","display_name":"Hypervariable region","level":3,"score":0.3961000144481659},{"id":"https://openalex.org/C2781434637","wikidata":"https://www.wikidata.org/wiki/Q486396","display_name":"Shotgun","level":3,"score":0.3637999892234802},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34689998626708984},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.3400999903678894},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3377000093460083},{"id":"https://openalex.org/C151437367","wikidata":"https://www.wikidata.org/wiki/Q7884646","display_name":"UniFrac","level":4,"score":0.32089999318122864},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.29170000553131104},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.27250000834465027},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26669999957084656},{"id":"https://openalex.org/C2781092032","wikidata":"https://www.wikidata.org/wiki/Q327663","display_name":"Clostridium","level":3,"score":0.26510000228881836},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.25290000438690186},{"id":"https://openalex.org/C199465337","wikidata":"https://www.wikidata.org/wiki/Q6823168","display_name":"Metaproteomics","level":4,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.764411","doi":"https://doi.org/10.64898/2026.11.04.764411","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764411","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764411.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.764411","doi":"https://doi.org/10.64898/2026.11.04.764411","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764411","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.04.764411.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320312169","display_name":"National Computational Infrastructure","ror":"https://ror.org/04yx6dh41"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225387704.pdf","grobid_xml":"https://content.openalex.org/works/W7225387704.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1503057784","https://openalex.org/W1978709058","https://openalex.org/W1990204500","https://openalex.org/W2096604969","https://openalex.org/W2128769815","https://openalex.org/W2140679462","https://openalex.org/W2149573313","https://openalex.org/W2165188436","https://openalex.org/W2297247152","https://openalex.org/W2490521015","https://openalex.org/W2537258608","https://openalex.org/W2564393024","https://openalex.org/W2585923386","https://openalex.org/W2608438922","https://openalex.org/W2728460239","https://openalex.org/W2739592885","https://openalex.org/W2799752613","https://openalex.org/W2884733592","https://openalex.org/W2920247457","https://openalex.org/W2927453907","https://openalex.org/W2951912016","https://openalex.org/W2958334035","https://openalex.org/W2963202264","https://openalex.org/W3001925819","https://openalex.org/W3002898669","https://openalex.org/W3007853840","https://openalex.org/W3015439700","https://openalex.org/W3037635362","https://openalex.org/W3141470266","https://openalex.org/W3145856387","https://openalex.org/W3159504416","https://openalex.org/W3164378295","https://openalex.org/W4283726711","https://openalex.org/W4293485814","https://openalex.org/W4315796652","https://openalex.org/W4321611856","https://openalex.org/W4367548585","https://openalex.org/W4385330271","https://openalex.org/W4390403217","https://openalex.org/W4392558963","https://openalex.org/W4402622976","https://openalex.org/W4410974032","https://openalex.org/W6948538933","https://openalex.org/W7124283611","https://openalex.org/W7165778717"],"related_works":["https://openalex.org/W4387733917","https://openalex.org/W4414920303","https://openalex.org/W4387749886","https://openalex.org/W2314413252","https://openalex.org/W2553399478","https://openalex.org/W4392303260","https://openalex.org/W3203019764","https://openalex.org/W7148728763","https://openalex.org/W2995068393","https://openalex.org/W4321004306"],"abstract_inverted_index":{"Most":[0],"population":[1],"colorectal":[2],"cancer":[3],"(CRC)":[4],"screening":[5,288],"programs":[6,289],"use":[7],"the":[8,70,79,111,131,294],"faecal":[9,80,108],"immunochemical":[10],"test":[11],"(FIT),":[12],"which":[13,135],"quantifies":[14],"occult":[15],"haemoglobin":[16],"in":[17,25,230,263,280],"faeces":[18,176],"and":[19,27,31,87,106,162,168,190,202,212,240,283],"has":[20,47],"proven":[21],"to":[22,40,50,68,186,285],"be":[23],"effective":[24],"detecting":[26],"reducing":[28],"CRC":[29],"incidence":[30],"mortality.":[32],"Sessile":[33],"serrated":[34],"lesions":[35],"(SSLs)":[36],"account":[37],"for":[38,124,151],"up":[39],"30%":[41],"of":[42,95,103,118,147,188,227,297],"sporadic":[43],"CRC,":[44],"yet":[45],"FIT":[46,61,76,105,129,145,204],"low":[48],"sensitivity":[49],"detect":[51],"them.":[52],"Faecal":[53],"microbial":[54,93],"biomarkers":[55],"may":[56,292],"improve":[57],"their":[58],"detection,":[59],"but":[60],"samples":[62,77,109,146,234,286],"have":[63],"not":[64,209],"previously":[65],"been":[66],"used":[67],"study":[69],"SSL":[71,161,201,233],"microbiome.":[72],"We":[73,97,139],"asked":[74],"whether":[75,88],"preserve":[78],"microbiome":[81],"as":[82,84],"accurately":[83],"fresh":[85,107,175],"collection,":[86],"they":[89],"can":[90],"reveal":[91],"a":[92,100,173,225,264],"signature":[94,133],"SSL.":[96,231],"first":[98],"reanalysed":[99],"published":[101,174],"dataset":[102],"paired":[104],"from":[110,144],"same":[112],"participants.":[113],"Donor":[114],"identity":[115],"explained":[116,184],"63.5%":[117],"compositional":[119],"variance":[120],"compared":[121,169],"with":[122,155,164,172],"16.7%":[123],"collection":[125],"method,":[126],"indicating":[127],"that":[128,287],"preserves":[130],"donor-specific":[132],"on":[134,179,273],"biomarker":[136],"discovery":[137],"depends.":[138],"then":[140],"generated":[141],"shotgun":[142],"metagenomes":[143],"24":[148],"adults":[149],"scheduled":[150],"diagnostic":[152,272],"colonoscopy,":[153],"twelve":[154,163],"at":[156],"least":[157],"one":[158],"clinically":[159],"significant":[160],"no":[165,191,218],"neoplasia":[166],"(NN)":[167],"each":[170],"group":[171],"cohort":[177],"matched":[178],"colonoscopy":[180],"outcome.":[181],"Collection":[182],"method":[183],"6.3%":[185],"7.6%":[187],"variance,":[189],"individual":[192],"species":[193,251],"was":[194,271],"significantly":[195,210,236],"differentially":[196],"abundant":[197],"between":[198],"methods.":[199],"Between":[200],"NN":[203],"samples,":[205],"community":[206],"structure":[207],"did":[208],"differ,":[211],"conservative":[213],"differential":[214],"abundance":[215],"analysis":[216],"returned":[217],"results.":[219],"More":[220],"permissive":[221],"count-based":[222],"models":[223],"suggested":[224],"depletion":[226],"fermentative":[228],"commensals":[229],"Functionally,":[232],"encoded":[235],"fewer":[237],"KEGG":[238],"orthologs":[239,246],"less":[241],"polyamine":[242],"biosynthesis":[243],"capacity,":[244],"while":[245],"carried":[247],"by":[248],"several":[249],"Bifidobacterium":[250],"were":[252],"more":[253],"abundant.":[254],"Many":[255],"depleted":[256],"functions":[257],"reflected":[258],"Enterobacteriaceae":[259],"gene":[260],"content":[261],"concentrated":[262],"few":[265],"control":[266],"samples.":[267],"No":[268],"single":[269],"feature":[270],"its":[274],"own.":[275],"A":[276],"multi-feature":[277],"signature,":[278],"confirmed":[279],"larger":[281],"cohorts":[282],"applied":[284],"already":[290],"collect,":[291],"increase":[293],"detection":[295],"rate":[296],"SSLs.":[298]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
