{"id":"https://openalex.org/W7225387253","doi":"https://doi.org/10.3390/life16111876","title":"Effect of Whole-Cell Lysates on Invasion Rate of Eimeria Sporozoites In Vitro","display_name":"Effect of Whole-Cell Lysates on Invasion Rate of Eimeria Sporozoites In Vitro","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225387253","doi":"https://doi.org/10.3390/life16111876"},"language":"en","primary_location":{"id":"doi:10.3390/life16111876","doi":"https://doi.org/10.3390/life16111876","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life16111876","pdf_url":null,"source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/life16111876","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114675349","display_name":"Aaron Paul R. Serde\u00f1a","orcid":"https://orcid.org/0009-0007-3004-6391","observed_orcids":["https://orcid.org/0009-0007-3004-6391"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Aaron Paul R. Serde\u00f1a","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0007-3004-6391","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005680258","display_name":"Rochelle Alipio Flores","orcid":"https://orcid.org/0000-0002-8848-6652","observed_orcids":["https://orcid.org/0000-0002-8848-6652"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Rochelle A. Flores","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-8848-6652","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020199800","display_name":"Binh Thanh Nguyen","orcid":"https://orcid.org/0000-0001-9120-9712","observed_orcids":["https://orcid.org/0000-0001-9120-9712"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]},{"id":"https://openalex.org/I4210126287","display_name":"Thai Nguyen University of Agriculture and Forestry","ror":"https://ror.org/028zxrr95","country_code":"VN","type":"education","lineage":["https://openalex.org/I4210126287"]}],"countries":["KR","VN"],"is_corresponding":false,"raw_author_name":"Binh T. Nguyen","raw_affiliation_strings":["Faculty of Animal Science and Veterinary Medicine, Thai Nguyen University of Agriculture and Forestry, Thai Nguyen 24119, Vietnam","Hoxbio, Business Center, Gyeongsang National University, Jinju 52828, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-9120-9712","affiliations":[{"raw_affiliation_string":"Faculty of Animal Science and Veterinary Medicine, Thai Nguyen University of Agriculture and Forestry, Thai Nguyen 24119, Vietnam","institution_ids":["https://openalex.org/I4210126287"]},{"raw_affiliation_string":"Hoxbio, Business Center, Gyeongsang National University, Jinju 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122920085","display_name":"Hyunjin Je","orcid":"https://orcid.org/0009-0009-0768-0612","observed_orcids":["https://orcid.org/0009-0009-0768-0612"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunjin Je","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0009-0768-0612","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101811943","display_name":"Suk Kim","orcid":"https://orcid.org/0000-0001-5795-2019","observed_orcids":["https://orcid.org/0000-0001-5795-2019"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Suk Kim","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-5795-2019","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020302316","display_name":"Woo Hyun Kim","orcid":"https://orcid.org/0000-0002-6874-6787","observed_orcids":["https://orcid.org/0000-0002-6874-6787"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo H. Kim","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-6874-6787","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079340321","display_name":"Wongi Min","orcid":"https://orcid.org/0000-0003-2437-7366","observed_orcids":["https://orcid.org/0000-0003-2437-7366"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Wongi Min","raw_affiliation_strings":["College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea","Hoxbio, Business Center, Gyeongsang National University, Jinju 52828, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-2437-7366","affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]},{"raw_affiliation_string":"Hoxbio, Business Center, Gyeongsang National University, Jinju 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079340321"],"corresponding_institution_ids":["https://openalex.org/I189442560"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"1876","last_page":"1876"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12691","display_name":"Coccidia and coccidiosis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12691","display_name":"Coccidia and coccidiosis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eimeria-tenella","display_name":"Eimeria tenella","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sporozoites","display_name":"sporozoites","score":0.7319999933242798},{"id":"https://openalex.org/keywords/whole-cell-lysate","display_name":"whole cell lysate","score":0.9259999990463257},{"id":"https://openalex.org/keywords/coccidiosis","display_name":"coccidiosis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/poultry-parasites","display_name":"poultry parasites","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2777976947","wikidata":"https://www.wikidata.org/wiki/Q795375","display_name":"Eimeria","level":2,"score":0.8763999938964844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7598000168800354},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7027999758720398},{"id":"https://openalex.org/C2776576699","wikidata":"https://www.wikidata.org/wiki/Q487837","display_name":"Coccidiosis","level":2,"score":0.5529000163078308},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5221999883651733},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.5066999793052673},{"id":"https://openalex.org/C2781023229","wikidata":"https://www.wikidata.org/wiki/Q193030","display_name":"Apicomplexa","level":4,"score":0.45910000801086426},{"id":"https://openalex.org/C207812311","wikidata":"https://www.wikidata.org/wiki/Q426560","display_name":"Ribosomal DNA","level":4,"score":0.4526999890804291},{"id":"https://openalex.org/C11957725","wikidata":"https://www.wikidata.org/wiki/Q5533590","display_name":"Gentamicin protection assay","level":4,"score":0.4505999982357025},{"id":"https://openalex.org/C155794727","wikidata":"https://www.wikidata.org/wiki/Q2306414","display_name":"Internal transcribed spacer","level":4,"score":0.43709999322891235},{"id":"https://openalex.org/C2779310134","wikidata":"https://www.wikidata.org/wiki/Q652074","display_name":"Eimeria acervulina","level":3,"score":0.42980000376701355},{"id":"https://openalex.org/C2778566189","wikidata":"https://www.wikidata.org/wiki/Q101274","display_name":"Protozoa","level":2,"score":0.42179998755455017},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.4154999852180481},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.41119998693466187},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.3813999891281128},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.33070001006126404},{"id":"https://openalex.org/C3018607231","wikidata":"https://www.wikidata.org/wiki/Q1460730","display_name":"Recovery rate","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.30570000410079956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30309998989105225},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2700999975204468},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2635999917984009}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/life16111876","doi":"https://doi.org/10.3390/life16111876","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life16111876","pdf_url":null,"source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/life16111876","doi":"https://doi.org/10.3390/life16111876","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life16111876","pdf_url":null,"source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.40450000762939453}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2591742030","https://openalex.org/W2946972596","https://openalex.org/W3000731350","https://openalex.org/W3000763633","https://openalex.org/W3008332102","https://openalex.org/W3084637486","https://openalex.org/W3199246726","https://openalex.org/W4200438531","https://openalex.org/W4206459924","https://openalex.org/W4207047530","https://openalex.org/W4210426419","https://openalex.org/W4285495334","https://openalex.org/W4289130620","https://openalex.org/W4289745378","https://openalex.org/W4300980906","https://openalex.org/W4309707075","https://openalex.org/W4386222561","https://openalex.org/W4387107294","https://openalex.org/W4399172746","https://openalex.org/W4405930928","https://openalex.org/W4412776071","https://openalex.org/W7124769323","https://openalex.org/W7125482501","https://openalex.org/W7140983491","https://openalex.org/W7210272539"],"related_works":["https://openalex.org/W7062549082","https://openalex.org/W3170436552","https://openalex.org/W3092308810","https://openalex.org/W4206459924","https://openalex.org/W2322943618","https://openalex.org/W2117917339","https://openalex.org/W1981206746","https://openalex.org/W1980565229","https://openalex.org/W2014655116","https://openalex.org/W2381531926"],"abstract_inverted_index":{"One":[0],"of":[1,47,59,71,78,104,109,120,143,147,164],"the":[2,5,10,44,57,68,76,83,97,105,122,140,144,156,159],"diseases":[3],"causing":[4],"greatest":[6],"economic":[7],"damage":[8],"to":[9,113,130,174],"poultry":[11],"industry":[12],"is":[13,50,172],"coccidiosis.":[14],"Effective":[15],"in":[16,34,39,55],"vitro":[17],"screening":[18],"platforms":[19],"can":[20],"accelerate":[21],"research":[22],"on":[23],"coccidiosis":[24],"control":[25],"by":[26],"identifying":[27],"and":[28,37,62,81,89,153,161],"prioritizing":[29],"interventions":[30],"for":[31,150,158,178],"subsequent":[32],"validation":[33],"more":[35],"resource-":[36],"labor-intensive":[38],"vivo":[40],"studies.":[41],"Consequently,":[42],"increasing":[43],"invasion":[45,69,118,129],"rate":[46,70],"Eimeria":[48,182],"sporozoites":[49,74,148,166],"considered":[51],"a":[52],"crucial":[53],"step":[54],"elucidating":[56],"process":[58,163],"parasitic":[60],"infection":[61],"defense":[63],"mechanisms.":[64],"This":[65,170],"study":[66],"investigated":[67],"E.":[72,110],"tenella":[73],"upon":[75],"supplementation":[77,125],"whole-cell":[79,123],"lysates":[80],"quantified":[82],"sporozoite":[84,128],"load":[85],"using":[86],"microscopic":[87],"counting":[88],"an":[90],"absolute":[91],"quantitative":[92],"real-time":[93],"PCR":[94],"assay":[95],"targeting":[96],"internal":[98],"transcribed":[99],"spacer":[100],"1":[101],"(ITS-1)":[102],"region":[103],"nuclear":[106],"ribosomal":[107],"DNA":[108],"tenella.":[111],"Compared":[112],"cell":[114],"culture":[115],"media":[116],"with":[117],"rates":[119],"13.9\u201334.4%,":[121],"lysate":[124],"significantly":[126],"enhanced":[127],"38.7\u201381.3%":[131],"over":[132],"time":[133],"(p":[134],"<":[135],"0.05).":[136],"These":[137],"findings":[138],"enable":[139],"efficient":[141],"use":[142],"large":[145],"quantities":[146],"required":[149],"repeated":[151],"experiments":[152,180],"also":[154],"reduce":[155],"need":[157],"difficult":[160],"time-consuming":[162],"extracting":[165],"from":[167],"sporulated":[168],"oocysts.":[169],"result":[171],"expected":[173],"be":[175],"highly":[176],"beneficial":[177],"cell-based":[179],"utilizing":[181],"sporozoites.":[183]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}