{"id":"https://openalex.org/W7225386990","doi":"https://doi.org/10.64898/2026.11.05.760234","title":"A single-cell transcriptomic atlas of paper wasp brains highlights Kenyon cells' role in social behavior","display_name":"A single-cell transcriptomic atlas of paper wasp brains highlights Kenyon cells' role in social behavior","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225386990","doi":"https://doi.org/10.64898/2026.11.05.760234"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.05.760234","doi":"https://doi.org/10.64898/2026.11.05.760234","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.760234","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.760234.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.760234.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005031129","display_name":"Colby Behrens","orcid":"https://orcid.org/0000-0003-4334-5044","observed_orcids":["https://orcid.org/0000-0003-4334-5044"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Colby Behrens","raw_affiliation_strings":["Cornell University;"],"raw_orcid":"https://orcid.org/0000-0003-4334-5044","affiliations":[{"raw_affiliation_string":"Cornell University;","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075507041","display_name":"Martik Chatterjee","orcid":"https://orcid.org/0000-0003-4689-6212","observed_orcids":["https://orcid.org/0000-0003-4689-6212"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martik Chatterjee","raw_affiliation_strings":["Cornell University;"],"raw_orcid":"https://orcid.org/0000-0003-4689-6212","affiliations":[{"raw_affiliation_string":"Cornell University;","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046234140","display_name":"Christopher M. Jernigan","orcid":"https://orcid.org/0000-0002-1877-953X","observed_orcids":["https://orcid.org/0000-0002-1877-953X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M Jernigan","raw_affiliation_strings":["Cornell University;"],"raw_orcid":"https://orcid.org/0000-0002-1877-953X","affiliations":[{"raw_affiliation_string":"Cornell University;","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010159336","display_name":"Robert D. Reed","orcid":"https://orcid.org/0000-0002-6065-6728","observed_orcids":["https://orcid.org/0000-0002-6065-6728"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Reed","raw_affiliation_strings":["Cornell University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University;","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074310320","display_name":"Amy L. Toth","orcid":"https://orcid.org/0000-0003-0824-0933","observed_orcids":["https://orcid.org/0000-0003-0824-0933"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Toth","raw_affiliation_strings":["Iowa State University"],"raw_orcid":"https://orcid.org/0000-0003-0824-0933","affiliations":[{"raw_affiliation_string":"Iowa State University","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074546048","display_name":"Michael J. Sheehan","orcid":"https://orcid.org/0000-0002-3949-7873","observed_orcids":["https://orcid.org/0000-0002-3949-7873"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Sheehan","raw_affiliation_strings":["Cornell University;"],"raw_orcid":"https://orcid.org/0000-0002-3949-7873","affiliations":[{"raw_affiliation_string":"Cornell University;","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005031129"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.4169999957084656,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polistes-fuscatus","display_name":"Polistes fuscatus","score":0.8820000290870667},{"id":"https://openalex.org/keywords/paper-wasps","display_name":"Polistinae","score":0.8840000033378601},{"id":"https://openalex.org/keywords/kenyon-cells","display_name":"Kenyon cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/social-behavior","display_name":"social behavior","score":0.7549999952316284},{"id":"https://openalex.org/keywords/caste","display_name":"caste","score":0.34200000762939453},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7590000033378601},{"id":"https://openalex.org/keywords/seasonal-variation","display_name":"seasonal variation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/social-interaction","display_name":"social interaction","score":0.5569999814033508},{"id":"https://openalex.org/keywords/social-observation","display_name":"social observation","score":0.925000011920929},{"id":"https://openalex.org/keywords/neuronal-activation","display_name":"neuronal activation","score":0.859000027179718},{"id":"https://openalex.org/keywords/brain-transcriptome","display_name":"brain transcriptome","score":0.671999990940094},{"id":"https://openalex.org/keywords/social-insects","display_name":"social insects","score":0.5709999799728394},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7282000184059143},{"id":"https://openalex.org/C130939695","wikidata":"https://www.wikidata.org/wiki/Q3307505","display_name":"Social animal","level":2,"score":0.6413000226020813},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6279000043869019},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5095000267028809},{"id":"https://openalex.org/C21204594","wikidata":"https://www.wikidata.org/wiki/Q921513","display_name":"Social behavior","level":2,"score":0.45410001277923584},{"id":"https://openalex.org/C2779987185","wikidata":"https://www.wikidata.org/wiki/Q1955518","display_name":"Polistes","level":4,"score":0.44749999046325684},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.43309998512268066},{"id":"https://openalex.org/C2776715869","wikidata":"https://www.wikidata.org/wiki/Q17152488","display_name":"Paper wasp","level":4,"score":0.426800012588501},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C170320452","wikidata":"https://www.wikidata.org/wiki/Q3111072","display_name":"Social neuroscience","level":4,"score":0.37869998812675476},{"id":"https://openalex.org/C130064352","wikidata":"https://www.wikidata.org/wiki/Q853725","display_name":"Social relation","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C3020766347","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Mammalian brain","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C2987946170","wikidata":"https://www.wikidata.org/wiki/Q853725","display_name":"Social relationship","level":2,"score":0.326200008392334},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C2983406839","wikidata":"https://www.wikidata.org/wiki/Q921513","display_name":"Social behaviour","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C2778144876","wikidata":"https://www.wikidata.org/wiki/Q4955745","display_name":"Brain Cell","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C126349790","wikidata":"https://www.wikidata.org/wiki/Q905036","display_name":"Computational sociology","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C86658582","wikidata":"https://www.wikidata.org/wiki/Q1432778","display_name":"Social cognition","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C2780972224","wikidata":"https://www.wikidata.org/wiki/Q17047956","display_name":"Brain atlas","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2526000142097473},{"id":"https://openalex.org/C2988890453","wikidata":"https://www.wikidata.org/wiki/Q5508815","display_name":"Functional diversity","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.05.760234","doi":"https://doi.org/10.64898/2026.11.05.760234","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.760234","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.760234.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.05.760234","doi":"https://doi.org/10.64898/2026.11.05.760234","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.05.760234","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/06/2026.11.05.760234.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1412074595","display_name":"EDGE:  Functional genomics in Polistes wasps, a model system in integrative organismal biology","funder_award_id":"1827567","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225386990.pdf","grobid_xml":"https://content.openalex.org/works/W7225386990.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W197955618","https://openalex.org/W2955496207","https://openalex.org/W4394806399","https://openalex.org/W4404014839","https://openalex.org/W4405815669","https://openalex.org/W4412631060"],"related_works":["https://openalex.org/W3197917768","https://openalex.org/W7096395617","https://openalex.org/W4403719011","https://openalex.org/W2625269607","https://openalex.org/W4404188009","https://openalex.org/W2105415244","https://openalex.org/W7213987942","https://openalex.org/W4399913781","https://openalex.org/W2113161824","https://openalex.org/W4409256052"],"abstract_inverted_index":{"Social":[0],"insects":[1],"provide":[2],"unique":[3],"opportunities":[4],"for":[5],"studying":[6],"social":[7,49,52,117,126,153,162,173,176],"interactions,":[8,118],"but":[9],"the":[10,28,57,60,65,69,79,121,144],"cellular":[11,66],"and":[12,44,51,72,92,103,111,119,146,175],"molecular":[13],"mechanisms":[14],"underlying":[15],"these":[16,96],"behaviors":[17],"are":[18,54],"poorly":[19],"understood.":[20],"Here,":[21],"we":[22],"performed":[23],"single-cell":[24],"sequencing":[25],"to":[26,46],"profile":[27],"transcriptomes":[29],"of":[30,36,59,68,78,83,86,95,124,134,139],"96,310":[31],"cells":[32],"across":[33,108,137],"four":[34],"phenotypes":[35],"Polistes":[37,70],"fuscatus":[38],"paper":[39],"wasps:":[40],"foundresses,":[41],"workers,":[42],"gynes,":[43],"males,":[45],"determine":[47],"how":[48],"states":[50],"interactions":[53,174],"encoded":[55],"in":[56],"physiology":[58],"central":[61],"brain.":[62],"We":[63,113],"characterized":[64],"diversity":[67],"brain":[71,80],"demonstrate":[73,115],"that":[74,116,165],"a":[75,125,152,166],"substantial":[76],"portion":[77],"is":[81],"composed":[82],"diverse":[84],"populations":[85,138],"Kenyon":[87,97,140],"cell":[88,105,141],"neurons.":[89,142],"The":[90],"composition":[91],"gene-expression":[93],"profiles":[94],"cells,":[98],"as":[99],"well":[100],"other":[101],"neural":[102,135,168],"non-neural":[104],"populations,":[106],"vary":[107],"sex,":[109],"caste,":[110],"season.":[112],"also":[114],"even":[120],"mere":[122],"observation":[123],"interaction,":[127,163],"induce":[128],"significant":[129],"transcriptomic":[130],"responses,":[131],"including":[132],"signatures":[133,148],"activation,":[136],"Notably,":[143],"transcriptional":[145],"activational":[147],"elicited":[149],"by":[150,160],"observing":[151],"interaction":[154],"frequently":[155],"overlapped":[156],"with":[157],"those":[158],"induced":[159],"direct":[161,172],"suggesting":[164],"shared":[167],"program":[169],"underlies":[170],"both":[171],"observation.":[177]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}