{"id":"https://openalex.org/W7225386342","doi":"https://doi.org/10.1161/circ.154.suppl_1.16576","title":"Abstract 16576: Decomposing the Effects of Pharmacological Cardioprotection, Lifestyle Interventions, Cardiac Monitoring Frequency, and Risk Stratification Tools in Preventing Chemotherapy-Induced Cardiotoxicity: A Component Network Meta-Analysis","display_name":"Abstract 16576: Decomposing the Effects of Pharmacological Cardioprotection, Lifestyle Interventions, Cardiac Monitoring Frequency, and Risk Stratification Tools in Preventing Chemotherapy-Induced Cardiotoxicity: A Component Network Meta-Analysis","publication_year":2026,"publication_date":"2026-11-02","ids":{"openalex":"https://openalex.org/W7225386342","doi":"https://doi.org/10.1161/circ.154.suppl_1.16576"},"language":"en","primary_location":{"id":"doi:10.1161/circ.154.suppl_1.16576","doi":"https://doi.org/10.1161/circ.154.suppl_1.16576","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.16576","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117386469","display_name":"Adithya Andanappa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adithya Andanappa","raw_affiliation_strings":["Shasta Regional Med Cntr, Redding, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shasta Regional Med Cntr, Redding, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120229216","display_name":"Krish Keswani","orcid":"https://orcid.org/0009-0005-2874-4786","observed_orcids":["https://orcid.org/0009-0005-2874-4786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krish Keswani","raw_affiliation_strings":["GMERS Med College Gotri, Vadodara, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GMERS Med College Gotri, Vadodara, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117479094","display_name":"Raveen Muzaffer","orcid":"https://orcid.org/0009-0006-2250-5167","observed_orcids":["https://orcid.org/0009-0006-2250-5167"]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Raveen Muzaffer","raw_affiliation_strings":["Dow Univ of Health Sciences, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Univ of Health Sciences, Karachi, Pakistan","institution_ids":["https://openalex.org/I39727005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137275413","display_name":"Dadullah Faiz","orcid":"https://orcid.org/0009-0000-2446-940X","observed_orcids":["https://orcid.org/0009-0000-2446-940X"]},"institutions":[{"id":"https://openalex.org/I3129452663","display_name":"Kandahar University","ror":"https://ror.org/0157yqb81","country_code":"AF","type":"education","lineage":["https://openalex.org/I3129452663"]}],"countries":["AF"],"is_corresponding":false,"raw_author_name":"Dadullah Faiz","raw_affiliation_strings":["Kandahar Univ Faculty of Medicine, Kandahar, Afghanistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kandahar Univ Faculty of Medicine, Kandahar, Afghanistan","institution_ids":["https://openalex.org/I3129452663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121324609","display_name":"Safia Bibi","orcid":"https://orcid.org/0009-0006-5022-1567","observed_orcids":["https://orcid.org/0009-0006-5022-1567"]},"institutions":[{"id":"https://openalex.org/I4405265791","display_name":"Quetta Institute of Medical Sciences","ror":"https://ror.org/05qy8pm97","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405265791"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Safia Bibi","raw_affiliation_strings":["Quetta Institute of Med Sciences, Quetta, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quetta Institute of Med Sciences, Quetta, Pakistan","institution_ids":["https://openalex.org/I4405265791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161081311","display_name":"Syeda Farwa Rizvi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Syeda Farwa Rizvi","raw_affiliation_strings":["Dow Med College, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow Med College, Karachi, Pakistan","institution_ids":["https://openalex.org/I39727005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120632731","display_name":"Yahya Samadi","orcid":"https://orcid.org/0009-0005-4872-5603","observed_orcids":["https://orcid.org/0009-0005-4872-5603"]},"institutions":[{"id":"https://openalex.org/I4403386551","display_name":"Kateb University","ror":"https://ror.org/012hzxe25","country_code":"AF","type":"education","lineage":["https://openalex.org/I4403386551"]}],"countries":["AF"],"is_corresponding":false,"raw_author_name":"Yahya Samadi","raw_affiliation_strings":["Kateb Univ, Kabul, Afghanistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kateb Univ, Kabul, Afghanistan","institution_ids":["https://openalex.org/I4403386551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111213940","display_name":"Muskan Devi","orcid":"https://orcid.org/0009-0003-9533-685X","observed_orcids":["https://orcid.org/0009-0003-9533-685X"]},"institutions":[{"id":"https://openalex.org/I1318157472","display_name":"Liaquat University of Medical & Health Sciences","ror":"https://ror.org/015jxh185","country_code":"PK","type":"education","lineage":["https://openalex.org/I1318157472"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muskan Devi","raw_affiliation_strings":["Liaquat Univ of Med and Health Sciences, Jamshoro, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaquat Univ of Med and Health Sciences, Jamshoro, Pakistan","institution_ids":["https://openalex.org/I1318157472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160997205","display_name":"Mahnoor Gelani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1318157472","display_name":"Liaquat University of Medical & Health Sciences","ror":"https://ror.org/015jxh185","country_code":"PK","type":"education","lineage":["https://openalex.org/I1318157472"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mahnoor Gelani","raw_affiliation_strings":["Liaquat Univ of Med and Health Sciences, Jamshoro, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaquat Univ of Med and Health Sciences, Jamshoro, Pakistan","institution_ids":["https://openalex.org/I1318157472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161057505","display_name":"Muhammad Raza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801518632","display_name":"Jinnah Sindh Medical University","ror":"https://ror.org/010pmyd80","country_code":"PK","type":"education","lineage":["https://openalex.org/I2801518632"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Raza","raw_affiliation_strings":["Jinnah Sindh Med Univ, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinnah Sindh Med Univ, Karachi, Pakistan","institution_ids":["https://openalex.org/I2801518632"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"154","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotherapy-induced-cardiotoxicity","display_name":"chemotherapy-induced cardiotoxicity","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9739999771118164},{"id":"https://openalex.org/keywords/component-network-meta-analysis","display_name":"component network meta-analysis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.6970000267028809},{"id":"https://openalex.org/keywords/dexrazoxane","display_name":"dexrazoxane","score":0.9929999709129333},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.6890000104904175},{"id":"https://openalex.org/keywords/exercise-intervention","display_name":"exercise intervention","score":0.6169999837875366},{"id":"https://openalex.org/keywords/cardiac-risk-stratification","display_name":"cardiac risk stratification","score":0.7329999804496765},{"id":"https://openalex.org/keywords/echocardiography","display_name":"echocardiography","score":0.8529999852180481},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.7900000214576721},{"id":"https://openalex.org/keywords/anthracycline-based-chemotherapy","display_name":"anthracycline chemotherapy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cardio-oncology","display_name":"cardio-oncology","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.958299994468689},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.6151000261306763},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5564000010490417},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.4745999872684479},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.47290000319480896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4404999911785126},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.42179998755455017},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.361299991607666},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34459999203681946},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C2779720357","wikidata":"https://www.wikidata.org/wiki/Q524995","display_name":"Dexrazoxane","level":5,"score":0.33399999141693115},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.33309999108314514},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3222000002861023},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.2971999943256378},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.154.suppl_1.16576","doi":"https://doi.org/10.1161/circ.154.suppl_1.16576","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.154.suppl_1.16576","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223693339","https://openalex.org/W4321178781","https://openalex.org/W2947684708","https://openalex.org/W4408961884","https://openalex.org/W2098886952","https://openalex.org/W6958768090","https://openalex.org/W3109274515","https://openalex.org/W2991322788","https://openalex.org/W4365141386","https://openalex.org/W4410817327"],"abstract_inverted_index":{"Background:":[0],"Current":[1],"cardio-oncology":[2,320],"guidelines":[3],"recommend":[4],"multimodal":[5],"strategies":[6],"to":[7,53,71,162,171,198,210,222],"prevent":[8],"chemotherapy-induced":[9],"cardiotoxicity":[10],"(CTRCD),":[11],"yet":[12],"the":[13,291],"independent":[14,146],"and":[15,25,110,126,180,235,256,288,307],"synergistic":[16,272,282,316],"contributions":[17],"of":[18,42],"pharmacological":[19,266,294,313],"agents,":[20],"lifestyle":[21],"interventions,":[22,101],"monitoring":[23,106,214,258],"protocols,":[24],"risk":[26,111,203],"stratification":[27],"remain":[28],"poorly":[29],"quantified.":[30],"Traditional":[31],"pairwise":[32],"meta-analyses":[33],"cannot":[34],"disentangle":[35],"these":[36],"co-administered":[37],"components,":[38],"limiting":[39],"evidence-based":[40],"optimization":[41],"cardioprotective":[43],"bundles.":[44],"Component":[45],"network":[46],"meta-analysis":[47],"(CNMA)":[48],"offers":[49],"a":[50,63],"novel":[51],"framework":[52],"decompose":[54,72],"complex":[55],"interventions":[56],"into":[57],"constituent":[58],"elements.":[59],"Methods:":[60],"We":[61],"conducted":[62],"CNMA":[64],"using":[65],"additive":[66],"weighted":[67],"least":[68],"squares":[69],"modeling":[70],"eight":[73],"intervention":[74,166],"components":[75],"across":[76],"17":[77],"randomized":[78],"controlled":[79],"trials":[80],"enrolling":[81],"1,933":[82],"patients":[83],"receiving":[84],"anthracycline-based":[85],"and/or":[86],"HER2-targeted":[87],"chemotherapy":[88],"regimens.":[89],"Components":[90],"included":[91],"beta-blockers,":[92],"ACE":[93],"inhibitors/angiotensin":[94],"receptor":[95],"blockers":[96],"(ACEi/ARB),":[97],"statins,":[98],"dexrazoxane,":[99],"dietary":[100,165],"structured":[102],"exercise":[103,270],"programs,":[104],"serial":[105,257],"(echocardiography":[107],"plus":[108],"biomarkers),":[109],"stratification-guided":[112,204],"therapy.":[113],"Primary":[114],"endpoints":[115],"were":[116],"left":[117],"ventricular":[118],"ejection":[119],"fraction":[120],"(LVEF)":[121],"mean":[122,276],"difference":[123,149,277],"from":[124],"baseline":[125],"cancer":[127],"therapeutics-related":[128],"cardiac":[129],"dysfunction":[130],"(CTRCD)":[131],"odds":[132],"ratios.":[133],"Interaction":[134],"analyses":[135],"evaluated":[136],"pharmacological-exercise":[137],"synergy.":[138],"Results:":[139],"For":[140,225],"LVEF":[141,275,306],"preservation,":[142],"statins":[143,249,300],"demonstrated":[144,271],"robust":[145,305],"effects":[147],"(mean":[148],"+2.1%,":[150],"95%":[151,159,168,176,183,195,207,219,231,239,252,261],"CI":[152,160,169,177,184,196,208,220,232,240,253,262],"0.1-4.0,":[153],"p=0.035),":[154],"followed":[155],"by":[156],"dexrazoxane":[157],"(+2.6%,":[158],"\u20130.6":[161],"5.6,":[163],"p=0.107),":[164],"(+2.9%,":[167],"\u20130.2":[170],"6.1,":[172],"p=0.070),":[173],"beta-blockers":[174,228],"(+2.0%,":[175],"1.0-2.9,":[178],"p<0.001),":[179],"ACEi/ARB":[181,236,289],"(+1.3%,":[182,218],"0.3-2.2,":[185],"p=0.011).":[186],"Exercise":[187,311],"programs":[188,322],"alone":[189],"showed":[190],"no":[191],"significant":[192],"effect":[193,309],"(\u20130.2%,":[194],"\u20131.7":[197],"1.3,":[199],"p=0.814),":[200],"nor":[201],"did":[202],"therapy":[205],"(\u20130.4%,":[206],"\u20132.3":[209],"1.4,":[211],"p=0.654).":[212],"Serial":[213],"trended":[215],"toward":[216],"benefit":[217],"\u20130.4":[221],"2.9,":[223],"p=0.126).":[224],"CTRCD":[226,297,308],"prevention,":[227,298],"(OR":[229,237,250,259],"0.59,":[230],"0.41-0.86,":[233],"p=0.005)":[234],"0.66,":[238],"0.46-0.96,":[241],"p=0.030)":[242],"achieved":[243],"statistical":[244],"significance,":[245],"with":[246,269,299],"trends":[247],"for":[248,296],"0.41,":[251],"0.16-1.03,":[254],"p=0.057)":[255],"0.44,":[260],"0.19-1.03,":[263],"p=0.058).":[264],"Critically,":[265],"cardioprotection":[267,314],"combined":[268],"interaction":[273,283],"(combined":[274],"+5.8%":[278],"vs":[279],"+2.4%":[280],"pharmacological-only;":[281],"term":[284],"\u0394=+2.5%).":[285],"Conclusions:":[286],"Beta-blockers":[287],"constitute":[290],"minimum":[292],"effective":[293],"bundle":[295],"warranting":[301],"guideline":[302],"consideration":[303],"given":[304],"estimates.":[310],"amplifies":[312],"through":[315],"mechanisms,":[317],"supporting":[318],"integrated":[319],"rehabilitation":[321],"rather":[323],"than":[324],"isolated":[325],"interventions.":[326]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}