{"id":"https://openalex.org/W7225385335","doi":"https://doi.org/10.1038/s41598-026-78509-y","title":"Plant glycan-conditioned probiotic cell-free supernatants reduce growth and biofilm formation in methicillin-resistant Staphylococcus aureus","display_name":"Plant glycan-conditioned probiotic cell-free supernatants reduce growth and biofilm formation in methicillin-resistant Staphylococcus aureus","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225385335","doi":"https://doi.org/10.1038/s41598-026-78509-y"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-78509-y","doi":"https://doi.org/10.1038/s41598-026-78509-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78509-y","pdf_url":"https://www.nature.com/articles/s41598-026-78509-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-78509-y_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022008788","display_name":"Rasha Elsayim","orcid":"https://orcid.org/0000-0002-6937-2588","observed_orcids":["https://orcid.org/0000-0002-6937-2588"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Rasha Elsayim","raw_affiliation_strings":["Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-6937-2588","affiliations":[{"raw_affiliation_string":"Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114301603","display_name":"Monerah S M Alqahtani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Monerah S. M. Alqahtani","raw_affiliation_strings":["Biology Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Faculty of Science, King Khalid University, Abha, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161102320","display_name":"Jwaher Haji Alhaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Jwaher Haji Alhaji","raw_affiliation_strings":["Department of Health Sciences, College of Applied Studies, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, College of Applied Studies, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006262434","display_name":"Hany M. Yehia","orcid":"https://orcid.org/0000-0001-5387-8026","observed_orcids":["https://orcid.org/0000-0001-5387-8026","https://orcid.org/0000-0001-6801-9849"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hany M. Yehia","raw_affiliation_strings":["Department of Food Science and Nutrition, College of Food and Agriculture Science, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Nutrition, College of Food and Agriculture Science, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090182768","display_name":"Alaa Alnoor Alameen","orcid":"https://orcid.org/0000-0002-4073-2375","observed_orcids":["https://orcid.org/0000-0002-4073-2375"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Alaa Alnoor Alameen","raw_affiliation_strings":["Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071202740","display_name":"Horiah A. Aldehaish","orcid":"https://orcid.org/0000-0002-6524-9347","observed_orcids":["https://orcid.org/0000-0002-6524-9347"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Horiah Abdulaziz ALdehaish","raw_affiliation_strings":["Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084465450","display_name":"Khadijah Ahmad Mohammad","orcid":"https://orcid.org/0000-0003-0338-1139","observed_orcids":["https://orcid.org/0000-0003-0338-1139"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Khadijah A. Mohammad","raw_affiliation_strings":["Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093730126","display_name":"Rawan M. Alshalan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Rawan M. Alshalan","raw_affiliation_strings":["Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022008788"],"corresponding_institution_ids":["https://openalex.org/I28022161"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.8838000297546387,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cell-free-supernatant","display_name":"cell-free supernatant","score":0.8399999737739563},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.6399999856948853},{"id":"https://openalex.org/keywords/lactiplantibacillus-plantarum","display_name":"Lactobacillus plantarum","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bifidobacterium-longum","display_name":"Bifidobacterium longum","score":1.0},{"id":"https://openalex.org/keywords/gum-arabic","display_name":"gum arabic","score":0.9200000166893005},{"id":"https://openalex.org/keywords/adansonia-digitata","display_name":"Adansonia digitata","score":0.9779999852180481},{"id":"https://openalex.org/keywords/carbohydrate-active-enzymes","display_name":"carbohydrate-active enzymes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/glycoside-hydrolases","display_name":"glycoside hydrolases","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pbp2a","display_name":"PBP2a","score":0.796999990940094},{"id":"https://openalex.org/keywords/glucuronic-acid","display_name":"glucuronic acid","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C2778985185","wikidata":"https://www.wikidata.org/wiki/Q1756682","display_name":"Lactobacillus plantarum","level":4,"score":0.7505999803543091},{"id":"https://openalex.org/C2776996202","wikidata":"https://www.wikidata.org/wiki/Q4904768","display_name":"Bifidobacterium longum","level":5,"score":0.739300012588501},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.7350999712944031},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.680400013923645},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6489999890327454},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.6335999965667725},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.4977000057697296},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.4787999987602234},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.47440001368522644},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.46389999985694885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4629000127315521},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.43860000371932983},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4226999878883362},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.41920000314712524},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4000000059604645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36340001225471497},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.35499998927116394},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.3395000100135803},{"id":"https://openalex.org/C2778724459","wikidata":"https://www.wikidata.org/wiki/Q127900","display_name":"Lactose","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30799999833106995},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2780777981","wikidata":"https://www.wikidata.org/wiki/Q3266947","display_name":"Beta-glucosidase","level":4,"score":0.2964000105857849},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.29499998688697815},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C196032511","wikidata":"https://www.wikidata.org/wiki/Q375795","display_name":"Glycoside hydrolase","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C2779288629","wikidata":"https://www.wikidata.org/wiki/Q199695","display_name":"Staphylococcus","level":4,"score":0.2632000148296356}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-78509-y","doi":"https://doi.org/10.1038/s41598-026-78509-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78509-y","pdf_url":"https://www.nature.com/articles/s41598-026-78509-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-78509-y","doi":"https://doi.org/10.1038/s41598-026-78509-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78509-y","pdf_url":"https://www.nature.com/articles/s41598-026-78509-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5747394850","display_name":null,"funder_award_id":"ORF-2026-1876","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"},{"id":"https://openalex.org/G602733861","display_name":null,"funder_award_id":"ORF-2026","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"}],"funders":[{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225385335.pdf","grobid_xml":"https://content.openalex.org/works/W7225385335.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2055613435"],"related_works":["https://openalex.org/W4210484163","https://openalex.org/W3004958120","https://openalex.org/W4211179537","https://openalex.org/W4200281114","https://openalex.org/W3015092404","https://openalex.org/W4281298269","https://openalex.org/W3097597111","https://openalex.org/W3155990106","https://openalex.org/W3049255020","https://openalex.org/W2736290810"],"abstract_inverted_index":{"Abstract":[0],"Managing":[1],"Methicillin-resistant":[2],"Staphylococcus":[3],"aureus":[4,109],"(MRSA)":[5],"remains":[6],"challenging":[7],"due":[8],"to":[9,12,18,38,114,158,272,289],"its":[10,16],"resistance":[11],"\u03b2-lactam":[13],"antibiotics":[14],"and":[15,34,43,52,78,93,117,129,139,152,183,200,217,233,264,277,284,288,297,299,309,319],"capacity":[17],"form":[19],"biofilms.":[20],"This":[21],"study":[22],"employed":[23],"carbohydrate-active":[24],"enzyme":[25],"(CAZyme)":[26],"profiling,":[27],"an":[28],"independent":[29],"hypothesis-generating":[30,318],"molecular":[31,169],"modeling":[32],"analysis,":[33,126],"in":[35,86,106,193,255],"vitro":[36],"fermentation":[37,234,298],"evaluate":[39],"Arabic":[40],"gum":[41],"(AG)":[42],"baobab":[44],"(BB)":[45],"as":[46,82],"fermentable":[47],"substrates":[48],"for":[49,162],"Lactiplantibacillus":[50],"plantarum":[51,92],"Bifidobacterium":[53],"longum":[54,95],".":[55],"Additionally,":[56],"the":[57,60,74,87,107,124,163,229,313],"activity":[58],"of":[59,76,90,136,149,275],"resulting":[61],"cell-free":[62],"supernatants":[63],"(CFS)":[64],"against":[65,143],"MRSA":[66,241,268,307],"was":[67],"assessed.":[68],"The":[69],"consensus":[70],"CAZyme":[71],"profiling":[72],"revealed":[73],"presence":[75],"52":[77],"55":[79],"genes":[80,103],"annotated":[81],"glycoside":[83],"hydrolases":[84],"(GH)":[85],"reference":[88,165],"genomes":[89],"L.":[91],"B.":[94],",":[96],"respectively.":[97,122],"In":[98,123],"contrast,":[99],"only":[100],"13":[101],"such":[102],"were":[104],"identified":[105],"S.":[108],"genome.":[110],"These":[111,192],"findings":[112,195,316],"correspond":[113],"19,":[115],"25,":[116],"six":[118],"distinct":[119],"GH":[120],"families,":[121],"computational":[125,314],"digalacturonic":[127,186],"acid":[128,131,173,187],"D-glucuronic":[130,172],"exhibited":[132],"predicted":[133,176,197],"docking":[134],"scores":[135],"\u2212":[137,140,150,153,159],"7.0":[138],"6.8":[141],"kcal/mol":[142,161],"PBP2a,":[144],"with":[145,178,225,303],"MM/GBSA":[146],"\u0394Gbind":[147],"values":[148],"24.22":[151],"4.53":[154],"kcal/mol,":[155],"respectively,":[156],"compared":[157],"47.27":[160],"co-crystallized":[164],"ligand.":[166],"During":[167],"300-ns":[168],"dynamics":[170],"simulations,":[171],"maintained":[174],"repeated":[175],"contacts":[177],"Lys597,":[179],"Gly599,":[180],"Thr600,":[181],"His583,":[182],"Ser598,":[184],"whereas":[185],"demonstrated":[188],"greater":[189],"conformational":[190],"mobility.":[191],"silico":[194],"represent":[196],"ligand\u2013PBP2a":[198],"interactions":[199],"do":[201],"not":[202],"demonstrate":[203],"experimental":[204],"PBP2a":[205,315],"inhibition.":[206],"Experimentally,":[207],"substrate":[208],"supplementation":[209],"significantly":[210,266],"affected":[211],"probiotic":[212,295],"OD\u2086\u2080\u2080,":[213],"viable":[214],"cell":[215],"counts,":[216],"culture":[218],"pH":[219],"(all":[220],"ANOVA,":[221],"P":[222,247,281],"\u2264":[223],"0.0004),":[224],"2%":[226,265],"AG":[227,237],"producing":[228],"strongest":[230],"overall":[231],"growth":[232,242,258,296,308],"response.":[235],"Selected":[236],"pH-matched":[238],"preparations":[239,253,302],"reduced":[240,267],"by":[243],"approximately":[244,256],"47\u2013100%":[245],"(":[246],"<":[248],"0.0001),":[249],"while":[250,312],"selected":[251],"BB-derived":[252],"resulted":[254],"39\u201394%":[257],"reduction.":[259],"AG-derived":[260],"CFS":[261,301],"at":[262],"1%":[263],"biofilm":[269,310],"biomass,":[270,311],"corresponding":[271],"calculated":[273],"reductions":[274],"65.94%":[276],"71.70%,":[278],"respectively":[279],"(adjusted":[280],"=":[282],"0.0401":[283],"0.0135).":[285],"Overall,":[286],"AG,":[287],"a":[290],"lesser":[291],"extent":[292],"BB,":[293],"supported":[294],"generated":[300],"measurable":[304],"effects":[305],"on":[306],"remain":[317],"require":[320],"direct":[321],"biochemical":[322],"validation.":[323]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
