{"id":"https://openalex.org/W7225385203","doi":"https://doi.org/10.1021/acs.inorgchem.6c03608","title":"Trans-Picolinate Functionalization of a Cyclen-Based Chelator Enables Complexation of Large Radiometals for Cancer Theranostics","display_name":"Trans-Picolinate Functionalization of a Cyclen-Based Chelator Enables Complexation of Large Radiometals for Cancer Theranostics","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225385203","doi":"https://doi.org/10.1021/acs.inorgchem.6c03608"},"language":"en","primary_location":{"id":"doi:10.1021/acs.inorgchem.6c03608","doi":"https://doi.org/10.1021/acs.inorgchem.6c03608","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.inorgchem.6c03608","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014312956","display_name":"Simona Mastroianni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304378839","display_name":"TRIUMF","ror":"https://ror.org/03kgj4539","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1304378839"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Simona Mastroianni","raw_affiliation_strings":["Simon Fraser University , , , ,","TRIUMF , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Simon Fraser University , , , ,","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"TRIUMF , , , ,","institution_ids":["https://openalex.org/I1304378839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092455952","display_name":"Thomas E. Karpiuk","orcid":"https://orcid.org/0000-0002-7307-3222","observed_orcids":["https://orcid.org/0000-0002-7307-3222"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas E. Karpiuk","raw_affiliation_strings":["Simon Fraser University , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-7307-3222","affiliations":[{"raw_affiliation_string":"Simon Fraser University , , , ,","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010289223","display_name":"Marianna Tosato","orcid":"https://orcid.org/0000-0002-3726-6174","observed_orcids":["https://orcid.org/0000-0002-3726-6174","https://orcid.org/0009-0005-5636-5716"]},"institutions":[{"id":"https://openalex.org/I1304378839","display_name":"TRIUMF","ror":"https://ror.org/03kgj4539","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1304378839"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marianna Tosato","raw_affiliation_strings":["Simon Fraser University , , , ,","TRIUMF , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-3726-6174","affiliations":[{"raw_affiliation_string":"Simon Fraser University , , , ,","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"TRIUMF , , , ,","institution_ids":["https://openalex.org/I1304378839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096741479","display_name":"Harrison Meeres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304378839","display_name":"TRIUMF","ror":"https://ror.org/03kgj4539","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1304378839"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Harrison Meeres","raw_affiliation_strings":["TRIUMF , , , ,","University of British Columbia , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TRIUMF , , , ,","institution_ids":["https://openalex.org/I1304378839"]},{"raw_affiliation_string":"University of British Columbia , , , ,","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081198806","display_name":"Scott McNeil","orcid":"https://orcid.org/0000-0001-8121-8471","observed_orcids":["https://orcid.org/0000-0001-8121-8471"]},"institutions":[{"id":"https://openalex.org/I1304378839","display_name":"TRIUMF","ror":"https://ror.org/03kgj4539","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1304378839"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Scott W. McNeil","raw_affiliation_strings":["TRIUMF , , , ,","University of British Columbia , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TRIUMF , , , ,","institution_ids":["https://openalex.org/I1304378839"]},{"raw_affiliation_string":"University of British Columbia , , , ,","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076875770","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0003-1833-9515","observed_orcids":["https://orcid.org/0000-0003-1833-9515"]},"institutions":[{"id":"https://openalex.org/I1304378839","display_name":"TRIUMF","ror":"https://ror.org/03kgj4539","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1304378839"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":["Simon Fraser University , , , ,","TRIUMF , , , ,","University of British Columbia , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-1833-9515","affiliations":[{"raw_affiliation_string":"Simon Fraser University , , , ,","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"TRIUMF , , , ,","institution_ids":["https://openalex.org/I1304378839"]},{"raw_affiliation_string":"University of British Columbia , , , ,","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016804317","display_name":"Caterina F. Ramogida","orcid":"https://orcid.org/0000-0003-4815-2647","observed_orcids":["https://orcid.org/0000-0003-4815-2647"]},"institutions":[{"id":"https://openalex.org/I1304378839","display_name":"TRIUMF","ror":"https://ror.org/03kgj4539","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1304378839"]},{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Caterina F. Ramogida","raw_affiliation_strings":["Simon Fraser University , , , ,","TRIUMF , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-4815-2647","affiliations":[{"raw_affiliation_string":"Simon Fraser University , , , ,","institution_ids":["https://openalex.org/I18014758"]},{"raw_affiliation_string":"TRIUMF , , , ,","institution_ids":["https://openalex.org/I1304378839"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016804317"],"corresponding_institution_ids":["https://openalex.org/I1304378839","https://openalex.org/I18014758"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actinium-225","display_name":"actinium-225","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lead-203","display_name":"lead-203","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lead-212","display_name":"lead-212","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lutetium-177","display_name":"lutetium-177","score":0.9359999895095825},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.6349999904632568},{"id":"https://openalex.org/keywords/kinetic-inertness","display_name":"kinetic inertness","score":0.6269999742507935},{"id":"https://openalex.org/keywords/fluxional-behavior","display_name":"fluxional behavior","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cancer-theranostics","display_name":"cancer theranostics","score":0.7829999923706055},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9700999855995178},{"id":"https://openalex.org/C2777459166","wikidata":"https://www.wikidata.org/wiki/Q416407","display_name":"Cyclen","level":2,"score":0.8409000039100647},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.5573999881744385},{"id":"https://openalex.org/C555894677","wikidata":"https://www.wikidata.org/wiki/Q1801","display_name":"Lanthanum","level":2,"score":0.4625999927520752},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.4560999870300293},{"id":"https://openalex.org/C520551903","wikidata":"https://www.wikidata.org/wiki/Q1857","display_name":"Lutetium","level":4,"score":0.43959999084472656},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.36660000681877136},{"id":"https://openalex.org/C164304813","wikidata":"https://www.wikidata.org/wiki/Q25276","display_name":"Isotope","level":2,"score":0.3255999982357025},{"id":"https://openalex.org/C68913812","wikidata":"https://www.wikidata.org/wiki/Q238156","display_name":"Coordination complex","level":3,"score":0.319599986076355},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C91967747","wikidata":"https://www.wikidata.org/wiki/Q2770033","display_name":"Group 2 organometallic chemistry","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C107814960","wikidata":"https://www.wikidata.org/wiki/Q611957","display_name":"Solid-state","level":2,"score":0.27300000190734863},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.27079999446868896},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2639999985694885},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C36674120","wikidata":"https://www.wikidata.org/wiki/Q370228","display_name":"Isotopic labeling","level":2,"score":0.2556000053882599}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.inorgchem.6c03608","doi":"https://doi.org/10.1021/acs.inorgchem.6c03608","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.inorgchem.6c03608","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334601","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06"},{"id":"https://openalex.org/F4320334617","display_name":"Social Sciences and Humanities Research Council of Canada","ror":"https://ror.org/04j5jqy92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1966335626","https://openalex.org/W1969360633","https://openalex.org/W1980431006","https://openalex.org/W2059205366","https://openalex.org/W2070059498","https://openalex.org/W2132454074","https://openalex.org/W2167590372","https://openalex.org/W2330177826","https://openalex.org/W2330683408","https://openalex.org/W2912567202","https://openalex.org/W2941929477","https://openalex.org/W2965362447","https://openalex.org/W2965892863","https://openalex.org/W2982416819","https://openalex.org/W2991188715","https://openalex.org/W3042735900","https://openalex.org/W3045665740","https://openalex.org/W3112653960","https://openalex.org/W4214727494","https://openalex.org/W4283163361","https://openalex.org/W4291130989","https://openalex.org/W4309152354","https://openalex.org/W4382680859","https://openalex.org/W4386704893","https://openalex.org/W4386726110","https://openalex.org/W4387241284","https://openalex.org/W4390362964","https://openalex.org/W4399752617","https://openalex.org/W4401070507","https://openalex.org/W4403637630","https://openalex.org/W4406732743","https://openalex.org/W4415533858","https://openalex.org/W4415614218","https://openalex.org/W7158953206"],"related_works":["https://openalex.org/W4415533858","https://openalex.org/W4410800240","https://openalex.org/W7171335342","https://openalex.org/W4289262172","https://openalex.org/W3186409853","https://openalex.org/W3135461085","https://openalex.org/W3173952288","https://openalex.org/W2340668568","https://openalex.org/W2258290076","https://openalex.org/W4403887025"],"abstract_inverted_index":{"Abstract":[0],"The":[1,69],"development":[2],"of":[3,26,35,122,151],"chelators":[4],"with":[5,33,92,126,142],"diverse":[6],"coordination":[7,186],"properties":[8],"is":[9],"essential":[10],"for":[11,16,104,168,188],"expanding":[12],"the":[13,23,61,88,127],"radiometals":[14,171,190],"available":[15],"imaging":[17],"and":[18,42,57,59,84,107,119,124,149,174],"targeted":[19],"therapy.":[20],"We":[21],"investigate":[22],"metal-binding":[24],"behavior":[25,103],"DO2A-2PA,":[27,143],"a":[28,73,165],"trans-picolinic":[29],"acid-functionalized":[30],"cyclen":[31,89],"chelator,":[32],"isotopes":[34],"lanthanum":[36],"(133/155La/natLa),":[37],"actinium":[38],"(225Ac),":[39],"lead":[40],"(203Pb/212Pb/natPb),":[41],"lutetium":[43],"(117Lu/natLu).":[44],"Metal":[45],"complexes":[46],"were":[47],"characterized":[48],"in":[49,60,96,134],"solution":[50],"by":[51,64,111],"1H":[52],"NMR":[53,99],"spectroscopy":[54],"(natLa3+,":[55,67],"natPb2+,":[56],"natLu3+)":[58],"solid":[62],"state":[63],"X-ray":[65],"crystallography":[66],"natPb2+).":[68],"solid-state":[70],"structures":[71],"revealed":[72],"10-coordinate":[74],"La3+":[75],"complex,":[76],"whereas":[77],"Pb2+":[78],"engaged":[79],"only":[80],"six":[81],"donor":[82],"atoms":[83],"resided":[85],"deeper":[86],"within":[87],"cavity,":[90],"consistent":[91],"shorter":[93],"M-NDO2A":[94],"distances":[95],"[Pb(H4DO2A-2PA)]2+.":[97],"Solution-state":[98],"studies":[100,115],"showed":[101],"fluxional":[102],"La3+,":[105],"Pb2+,":[106],"Lu3+":[108],"complexes,":[109],"supported":[110],"variable-temperature":[112],"experiments.":[113],"Radiolabeling":[114],"demonstrated":[116],"efficient,":[117],"quantitative,":[118],"ambient-temperature":[120],"incorporation":[121,150],"[225Ac]Ac3+":[123,173],"[133/135La]La3+,":[125],"resulting":[128],"radiocomplexes":[129],"exhibiting":[130],"high":[131],"kinetic":[132],"inertness":[133],"vitro.":[135],"Although":[136],"quantitative":[137],"[203Pb]/[212Pb]Pb2+":[138],"labeling":[139],"was":[140],"achieved":[141],"performance":[144,187],"did":[145],"not":[146,183],"exceed":[147],"DOTAM,":[148],"[177Lu]Lu3+":[152],"remained":[153],"inefficient":[154],"even":[155],"at":[156],"elevated":[157],"temperatures.":[158],"Overall,":[159],"these":[160],"results":[161],"identify":[162],"DO2A-2PA":[163],"as":[164,192],"promising":[166],"chelator":[167],"large,":[169],"hard":[170],"particularly":[172],"[133/135La]La3+":[175],"while":[176],"underscoring":[177],"that":[178],"increased":[179],"donor-atom":[180],"density":[181],"does":[182],"universally":[184],"enhance":[185],"softer":[189],"such":[191],"[203Pb]/[212Pb]Pb2+.":[193]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
