{"id":"https://openalex.org/W7225385128","doi":"https://doi.org/10.3390/cancers18213564","title":"Antibody\u2013Drug Conjugates Plus Immune Checkpoint Inhibitors for Sustained Disease Control in Advanced Solid Tumors","display_name":"Antibody\u2013Drug Conjugates Plus Immune Checkpoint Inhibitors for Sustained Disease Control in Advanced Solid Tumors","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225385128","doi":"https://doi.org/10.3390/cancers18213564"},"language":"en","primary_location":{"id":"doi:10.3390/cancers18213564","doi":"https://doi.org/10.3390/cancers18213564","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18213564","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cancers18213564","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161044513","display_name":"Meiling Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiling Xu","raw_affiliation_strings":["Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","Center of PRaG Therapy, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China","Jiangsu Key Laboratory of Radiation Injury Prevention and Hazardous Substance Control, Suzhou 215123, China","Laboratory for Combined Radiotherapy and Immunotherapy of Cancer, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Center of PRaG Therapy, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Radiation Injury Prevention and Hazardous Substance Control, Suzhou 215123, China","institution_ids":[]},{"raw_affiliation_string":"Laboratory for Combined Radiotherapy and Immunotherapy of Cancer, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161120997","display_name":"Jun Yin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Yin","raw_affiliation_strings":["Jiangsu Nuclear Power Corporation, Lianyungang 222042, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Nuclear Power Corporation, Lianyungang 222042, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161136591","display_name":"Yao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Li","raw_affiliation_strings":["Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","Center of PRaG Therapy, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China","Laboratory for Combined Radiotherapy and Immunotherapy of Cancer, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Center of PRaG Therapy, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Laboratory for Combined Radiotherapy and Immunotherapy of Cancer, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161013352","display_name":"Liyuan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liyuan Zhang","raw_affiliation_strings":["Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","Center of PRaG Therapy, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China","Jiangsu Key Laboratory of Radiation Injury Prevention and Hazardous Substance Control, Suzhou 215123, China","Laboratory for Combined Radiotherapy and Immunotherapy of Cancer, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Diagnosis and Treatment, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Center of PRaG Therapy, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Jiangsu Key Laboratory of Radiation Injury Prevention and Hazardous Substance Control, Suzhou 215123, China","institution_ids":[]},{"raw_affiliation_string":"Laboratory for Combined Radiotherapy and Immunotherapy of Cancer, The Second Affiliated Hospital of Soochow University, Suzhou 215025, China","institution_ids":["https://openalex.org/I4210124971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5161013352"],"corresponding_institution_ids":["https://openalex.org/I4210124971"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"21","first_page":"3564","last_page":"3564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7509999871253967},{"id":"https://openalex.org/keywords/advanced-solid-tumors","display_name":"advanced solid tumors","score":0.9279999732971191},{"id":"https://openalex.org/keywords/disease-control","display_name":"disease control","score":0.8169999718666077},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9649999737739563},{"id":"https://openalex.org/keywords/duration-of-response","display_name":"duration of response","score":0.8080000281333923},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.6940000057220459},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immune-microenvironment","display_name":"immune microenvironment","score":0.7429999709129333},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5410000085830688},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.6439999938011169},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7996000051498413},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6050999760627747},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5867999792098999},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5752999782562256},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5468000173568726},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5285000205039978},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5181999802589417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39259999990463257},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.38909998536109924},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.37689998745918274},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.3743000030517578},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.351500004529953},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33959999680519104},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.32109999656677246},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.32100000977516174},{"id":"https://openalex.org/C2781274730","wikidata":"https://www.wikidata.org/wiki/Q4669679","display_name":"Abscopal effect","level":4,"score":0.3158999979496002},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.3018999993801117},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2985000014305115},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2946000099182129},{"id":"https://openalex.org/C2987315675","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Disease control","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2757999897003174}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/cancers18213564","doi":"https://doi.org/10.3390/cancers18213564","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18213564","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/cancers18213564","doi":"https://doi.org/10.3390/cancers18213564","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18213564","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W2100106580","https://openalex.org/W2150011715","https://openalex.org/W2560525946","https://openalex.org/W2592467398","https://openalex.org/W2624275086","https://openalex.org/W2799596353","https://openalex.org/W2914738006","https://openalex.org/W3011642937","https://openalex.org/W3088588360","https://openalex.org/W3093708469","https://openalex.org/W4221034335","https://openalex.org/W4283813503","https://openalex.org/W4324136923","https://openalex.org/W4383302365","https://openalex.org/W4385212704","https://openalex.org/W4387950650","https://openalex.org/W4392498919","https://openalex.org/W4392639943","https://openalex.org/W4395083112","https://openalex.org/W4399374789","https://openalex.org/W4400011459","https://openalex.org/W4402223838","https://openalex.org/W4403418835","https://openalex.org/W4403876531","https://openalex.org/W4405175803","https://openalex.org/W4405423778","https://openalex.org/W4405990511","https://openalex.org/W4406763444","https://openalex.org/W4409148758","https://openalex.org/W4409315651","https://openalex.org/W4409528322","https://openalex.org/W4410799942","https://openalex.org/W4410929528","https://openalex.org/W4410935761","https://openalex.org/W4412581556","https://openalex.org/W4412634113","https://openalex.org/W4412724750","https://openalex.org/W4413011423","https://openalex.org/W4414555180","https://openalex.org/W4414757289","https://openalex.org/W4415340539","https://openalex.org/W4415507659","https://openalex.org/W4415509863","https://openalex.org/W4415680764","https://openalex.org/W4415709985","https://openalex.org/W4416088352","https://openalex.org/W7116124775","https://openalex.org/W7116884609","https://openalex.org/W7124963222","https://openalex.org/W7125394157","https://openalex.org/W7125662223","https://openalex.org/W7125778459","https://openalex.org/W7130433278","https://openalex.org/W7138849703","https://openalex.org/W7139985844","https://openalex.org/W7149012512","https://openalex.org/W7153064580","https://openalex.org/W7161629776","https://openalex.org/W7161762707","https://openalex.org/W7162754680","https://openalex.org/W7163881968","https://openalex.org/W7164842543","https://openalex.org/W7165762931","https://openalex.org/W7166071257","https://openalex.org/W7166667447","https://openalex.org/W7167808570","https://openalex.org/W7168254830","https://openalex.org/W7170067503","https://openalex.org/W7170658610","https://openalex.org/W7171829873","https://openalex.org/W7171952733","https://openalex.org/W7205010829","https://openalex.org/W7205708877","https://openalex.org/W7212165158","https://openalex.org/W7214180257","https://openalex.org/W7215027607","https://openalex.org/W7223573740"],"related_works":["https://openalex.org/W4412855702","https://openalex.org/W4402918612","https://openalex.org/W7162339337","https://openalex.org/W4382363185","https://openalex.org/W4312063631","https://openalex.org/W3207983141","https://openalex.org/W4223962346","https://openalex.org/W7122486577","https://openalex.org/W4414163422","https://openalex.org/W7203788777"],"abstract_inverted_index":{"Antibody\u2013drug":[0],"conjugates":[1],"(ADCs)":[2],"combined":[3],"with":[4],"immune":[5,103],"checkpoint":[6],"inhibitors":[7],"(ICIs)":[8],"improve":[9],"outcomes":[10],"in":[11,38,52,81],"selected":[12],"advanced":[13],"solid":[14],"tumors,":[15],"but":[16,110,131],"clinical":[17,72,112],"benefit":[18],"does":[19],"not":[20,121,174],"establish":[21],"pharmacological":[22],"synergy.":[23],"This":[24],"narrative":[25],"review":[26],"evaluates":[27],"disease":[28,44,136,183],"control":[29,45,137],"during":[30,138],"ADC\u2013ICI":[31,139],"therapy":[32,140],"and":[33,67,84,95,101,151,154,162,171],"the":[34,70,102],"implications":[35],"for":[36,157],"radiotherapy":[37,176],"recurrent":[39],"or":[40,178],"metastatic":[41],"disease.":[42],"Prolonged":[43],"is":[46],"assessed":[47],"primarily":[48],"through":[49],"progression-free":[50],"survival":[51],"randomized":[53],"trials;":[54],"response":[55],"duration":[56],"provides":[57],"complementary":[58],"evidence":[59,147,166],"among":[60],"responders.":[61],"Overall":[62],"survival,":[63],"quality":[64],"of":[65,74],"life,":[66],"toxicity":[68],"determine":[69],"broader":[71],"value":[73],"treatment.":[75],"Randomized":[76],"trials":[77],"support":[78],"specific":[79],"regimens":[80],"urothelial,":[82],"breast,":[83],"lung":[85],"cancers,":[86],"whereas":[87],"negative":[88],"studies":[89,153],"argue":[90],"against":[91],"generalization":[92],"across":[93,182],"drugs":[94],"diseases.":[96],"Antigen":[97],"expression,":[98],"payload":[99],"delivery,":[100],"microenvironment":[104],"may":[105],"contribute":[106],"to":[107],"heterogeneous":[108],"outcomes,":[109],"their":[111],"roles":[113],"remain":[114],"incompletely":[115],"established.":[116],"Reported":[117],"treatment":[118,169],"durations":[119],"do":[120],"define":[122],"optimal":[123],"stopping":[124],"times.":[125],"Radiotherapy":[126],"can":[127],"address":[128],"local":[129],"symptoms,":[130],"whether":[132],"it":[133],"improves":[134],"systemic":[135],"remains":[141],"unproven.":[142],"We":[143],"distinguish":[144],"direct":[145],"three-modality":[146],"from":[148],"indirect":[149],"ADC\u2013radiotherapy":[150],"ICI\u2013radiotherapy":[152],"identify":[155],"priorities":[156],"patient":[158],"selection,":[159],"outcome":[160],"assessment,":[161],"safety":[163],"monitoring.":[164],"Current":[165],"supports":[167],"regimen-specific":[168],"selection":[170],"toxicity-directed":[172],"modification,":[173],"routine":[175],"addition":[177],"elective":[179],"drug":[180],"withdrawal":[181],"settings.":[184]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}