{"id":"https://openalex.org/W7225384162","doi":"https://doi.org/10.24875/iris.26000005","title":"5-FU t\u00f3pico en OSSN diagnosticada cl\u00ednicamente: estudio retrospectivo chileno","display_name":"5-FU t\u00f3pico en OSSN diagnosticada cl\u00ednicamente: estudio retrospectivo chileno","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225384162","doi":"https://doi.org/10.24875/iris.26000005"},"language":"en","primary_location":{"id":"doi:10.24875/iris.26000005","doi":"https://doi.org/10.24875/iris.26000005","is_oa":true,"landing_page_url":"https://doi.org/10.24875/iris.26000005","pdf_url":"https://www.irisjournal.com/files/iris_26_5_1_020-027.pdf","source":{"id":"https://openalex.org/S4387285411","display_name":"Iris The International Journal of Research in Eye Sciences","issn_l":"2938-1509","issn":["2938-1509"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iris: The International Journal of Research in Eye Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.irisjournal.com/files/iris_26_5_1_020-027.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161039515","display_name":"Nathia Niklitschek-Toro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10457146","display_name":"Universidad de Santiago de Chile","ror":"https://ror.org/02ma57s91","country_code":"CL","type":"education","lineage":["https://openalex.org/I10457146"]},{"id":"https://openalex.org/I4210139206","display_name":"Clinique Pasteur","ror":"https://ror.org/03er61e50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210139206"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Nathia Niklitschek-Toro","raw_affiliation_strings":["Facultad de Ciencias M\u00e9dicas , Unidad de Postgrado de Oftalmolog\u00eda , Universidad de Santiago de Chile ;","Unidad de Docencia , Cl\u00ednica Oftalmol\u00f3gica Pasteur ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias M\u00e9dicas , Unidad de Postgrado de Oftalmolog\u00eda , Universidad de Santiago de Chile ;","institution_ids":["https://openalex.org/I10457146"]},{"raw_affiliation_string":"Unidad de Docencia , Cl\u00ednica Oftalmol\u00f3gica Pasteur ;","institution_ids":["https://openalex.org/I4210139206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161063539","display_name":"Marco Grand\u00f3n-Sol\u00eds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10457146","display_name":"Universidad de Santiago de Chile","ror":"https://ror.org/02ma57s91","country_code":"CL","type":"education","lineage":["https://openalex.org/I10457146"]},{"id":"https://openalex.org/I4210139206","display_name":"Clinique Pasteur","ror":"https://ror.org/03er61e50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210139206"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Marco Grand\u00f3n-Sol\u00eds","raw_affiliation_strings":["Facultad de Ciencias M\u00e9dicas , Unidad de Postgrado de Oftalmolog\u00eda , Universidad de Santiago de Chile ;","Unidad de Docencia , Cl\u00ednica Oftalmol\u00f3gica Pasteur ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias M\u00e9dicas , Unidad de Postgrado de Oftalmolog\u00eda , Universidad de Santiago de Chile ;","institution_ids":["https://openalex.org/I10457146"]},{"raw_affiliation_string":"Unidad de Docencia , Cl\u00ednica Oftalmol\u00f3gica Pasteur ;","institution_ids":["https://openalex.org/I4210139206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161081809","display_name":"Rebeca Vega-Sabaleta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139206","display_name":"Clinique Pasteur","ror":"https://ror.org/03er61e50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210139206"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rebeca Vega-Sabaleta","raw_affiliation_strings":["Instituto Oftalmol\u00f3gico Puerta del Sol ;","Unidad de Docencia , Cl\u00ednica Oftalmol\u00f3gica Pasteur ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Oftalmol\u00f3gico Puerta del Sol ;","institution_ids":[]},{"raw_affiliation_string":"Unidad de Docencia , Cl\u00ednica Oftalmol\u00f3gica Pasteur ;","institution_ids":["https://openalex.org/I4210139206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117633725","display_name":"Gabriela Ghirardelli-Vega","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriela Ghirardelli-Vega","raw_affiliation_strings":["Servicio de Urgencia ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Urgencia ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161009005","display_name":"Paula Jorquera-Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133599470","display_name":"Universidad del Desarrollo","ror":"https://ror.org/05y33vv83","country_code":"CL","type":"education","lineage":["https://openalex.org/I133599470"]},{"id":"https://openalex.org/I2801797538","display_name":"Cl\u00ednica Alemana","ror":"https://ror.org/028ynny55","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I2801797538"]},{"id":"https://openalex.org/I4405274131","display_name":"Hospital de Urgencia Asistencia P\u00fablica","ror":"https://ror.org/0144sj678","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4405274131"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Paula Jorquera-Torres","raw_affiliation_strings":["Hospital de Urgencia Asistencia P\u00fablica ; Escuela de Medicina , Facultad de Medicina , Cl\u00ednica Alemana , Universidad del Desarrollo. Santiago , Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Urgencia Asistencia P\u00fablica ; Escuela de Medicina , Facultad de Medicina , Cl\u00ednica Alemana , Universidad del Desarrollo. Santiago , Chile","institution_ids":["https://openalex.org/I133599470","https://openalex.org/I2801797538","https://openalex.org/I4405274131"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161039078","display_name":"Eduardo Labb\u00e9-Munzenmayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801797538","display_name":"Cl\u00ednica Alemana","ror":"https://ror.org/028ynny55","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I2801797538"]},{"id":"https://openalex.org/I4210139206","display_name":"Clinique Pasteur","ror":"https://ror.org/03er61e50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210139206"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Eduardo Labb\u00e9-Munzenmayer","raw_affiliation_strings":["Departamento de Oftalmolog\u00eda , Cl\u00ednica Alemana de Santiago ;","Unidad de Docencia , Cl\u00ednica Oftalmol\u00f3gica Pasteur ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Oftalmolog\u00eda , Cl\u00ednica Alemana de Santiago ;","institution_ids":["https://openalex.org/I2801797538"]},{"raw_affiliation_string":"Unidad de Docencia , Cl\u00ednica Oftalmol\u00f3gica Pasteur ;","institution_ids":["https://openalex.org/I4210139206"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.8479999899864197},{"id":"https://openalex.org/keywords/topical-chemotherapy","display_name":"topical chemotherapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ocular-surface-neoplasia","display_name":"ocular surface neoplasia","score":0.6610000133514404},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.6240000128746033},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.7409999966621399},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5569999814033508},{"id":"https://openalex.org/keywords/conjunctival-hyperemia","display_name":"conjunctival hyperemia","score":0.7149999737739563},{"id":"https://openalex.org/keywords/leucoplakia","display_name":"leucoplakia","score":0.6600000262260437},{"id":"https://openalex.org/keywords/chilean-patients","display_name":"Chilean patients","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7907000184059143},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.34150001406669617},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2442999929189682},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20990000665187836},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2093999981880188},{"id":"https://openalex.org/C3017884845","wikidata":"https://www.wikidata.org/wiki/Q1008","display_name":"Cote d ivoire","level":2,"score":0.19689999520778656},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.18809999525547028}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.24875/iris.26000005","doi":"https://doi.org/10.24875/iris.26000005","is_oa":true,"landing_page_url":"https://doi.org/10.24875/iris.26000005","pdf_url":"https://www.irisjournal.com/files/iris_26_5_1_020-027.pdf","source":{"id":"https://openalex.org/S4387285411","display_name":"Iris The International Journal of Research in Eye Sciences","issn_l":"2938-1509","issn":["2938-1509"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iris: The International Journal of Research in Eye Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.24875/iris.26000005","doi":"https://doi.org/10.24875/iris.26000005","is_oa":true,"landing_page_url":"https://doi.org/10.24875/iris.26000005","pdf_url":"https://www.irisjournal.com/files/iris_26_5_1_020-027.pdf","source":{"id":"https://openalex.org/S4387285411","display_name":"Iris The International Journal of Research in Eye Sciences","issn_l":"2938-1509","issn":["2938-1509"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iris: The International Journal of Research in Eye Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225384162.pdf","grobid_xml":"https://content.openalex.org/works/W7225384162.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7024928876","https://openalex.org/W2992690962","https://openalex.org/W3046099014","https://openalex.org/W2080064301","https://openalex.org/W7145023477","https://openalex.org/W1035511029","https://openalex.org/W977016468","https://openalex.org/W4388680124","https://openalex.org/W4205778567","https://openalex.org/W1981588075"],"abstract_inverted_index":{"Antecedentes:":[0],"La":[1],"neoplasia":[2],"escamosa":[3],"de":[4,17,56,62,67,77,81,89,100,110,116,171,211],"la":[5,18,41,135,147],"superficie":[6,19],"ocular":[7],"(OSSN)":[8],"es":[9],"el":[10,165],"tumor":[11],"maligno":[12],"no":[13],"pigmentado":[14],"m\u00e1s":[15,139],"frecuente":[16,140],"ocular.El":[20],"tratamiento":[21,37],"con":[22,53,64,70,98,122,162,168],"5-fluorouracilo":[23],"(5-FU)":[24],"t\u00f3pico":[25,47,72,202],"ha":[26],"surgido":[27],"como":[28],"una":[29,208],"alternativa":[30],"efectiva":[31],"y":[32,43,60,79,93,134,152,194,214],"menos":[33],"invasiva":[34],"frente":[35],"al":[36,48,73,203],"quir\u00fargico":[38],"convencional.Objetivo:":[39],"Evaluar":[40],"eficacia":[42],"seguridad":[44],"del":[45,124,145,150],"5-FU":[46,71,201],"1%":[49,74,204],"en":[50,132,175,185,217],"pacientes":[51,63,161],"chilenos":[52],"OSSN.M\u00e9todo:":[54],"Serie":[55],"casos":[57],"retrospectiva,":[58],"multic\u00e9ntrica":[59],"consecutiva":[61],"diagn\u00f3stico":[65],"cl\u00ednico":[66],"OSSN":[68],"tratados":[69],"entre":[75,192],"marzo":[76],"2022":[78],"noviembre":[80],"2025.Se":[82],"analizaron":[83],"caracter\u00edsticas":[84],"cl\u00ednicas,":[85],"respuesta":[86],"terap\u00e9utica,":[87],"n\u00famero":[88],"ciclos":[90,170],"requeridos,":[91],"recurrencia":[92,173],"eventos":[94],"adversos.Se":[95],"complement\u00f3":[96],"estudio":[97],"OCT":[99],"segmento":[101],"anterior":[102],"cuando":[103],"estuvo":[104],"disponible.Resultados:":[105],"Se":[106],"incluyeron":[107],"28":[108,111],"ojos":[109],"pacientes.La":[112],"edad":[113],"media":[114],"fue":[115,138,144],"64,9":[117],"a\u00f1os":[118],"(rango:":[119],"36-89":[120],"a\u00f1os),":[121],"predominio":[123],"sexo":[125],"masculino":[126],"(67,9%).La":[127],"localizaci\u00f3n":[128],"nasal":[129],"se":[130,156,188,205],"observ\u00f3":[131,179],"53,6%":[133],"morfolog\u00eda":[136,196],"leucopl\u00e1sica":[137],"(71,4%).La":[141],"remisi\u00f3n":[142,148,163,193,212],"completa":[143],"78,6%,":[146],"parcial":[149],"3,6%":[151],"un":[153,176,180],"17,9%":[154],"(5/28)":[155],"consider\u00f3":[157],"fracaso":[158],"terap\u00e9utico.Entre":[159],"los":[160],"completa,":[164],"68,2%":[166],"resolvi\u00f3":[167],"dos":[169],"tratamiento.La":[172],"ocurri\u00f3":[174],"caso":[177],"(4,5%).Se":[178],"evento":[181],"adverso":[182],"leve":[183],"consistente":[184],"inyecci\u00f3n":[186],"conjuntival.No":[187],"encontraron":[189],"asociaciones":[190],"significativas":[191],"edad,":[195],"tumoral":[197],"ni":[198],"sexo.Conclusiones:":[199],"El":[200],"asoci\u00f3":[206],"a":[207],"alta":[209],"tasa":[210],"cl\u00ednica":[213],"buena":[215],"tolerancia":[216],"esta":[218],"serie":[219],"retrospectiva":[220],"chilena.":[221]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
