{"id":"https://openalex.org/W7225378995","doi":"https://doi.org/10.1186/s10194-026-02563-0","title":"Resting facial behavioural signatures associated with migraine phenotype, clinical state, and disease burden","display_name":"Resting facial behavioural signatures associated with migraine phenotype, clinical state, and disease burden","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225378995","doi":"https://doi.org/10.1186/s10194-026-02563-0"},"language":"en","primary_location":{"id":"doi:10.1186/s10194-026-02563-0","doi":"https://doi.org/10.1186/s10194-026-02563-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-026-02563-0","pdf_url":null,"source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s10194-026-02563-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068953662","display_name":"Fu\u2010Jung Hsiao","orcid":"https://orcid.org/0000-0001-7824-8864","observed_orcids":["https://orcid.org/0000-0001-7824-8864"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Fu-Jung Hsiao","raw_affiliation_strings":["Brain Research Center, National Yang Ming Chiao Tung University, 155, Linong Street Sec 2, Taipei, 112, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-7824-8864","affiliations":[{"raw_affiliation_string":"Brain Research Center, National Yang Ming Chiao Tung University, 155, Linong Street Sec 2, Taipei, 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130861502","display_name":"Wei-Ta Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Ta Chen","raw_affiliation_strings":["Brain Research Center, National Yang Ming Chiao Tung University, 155, Linong Street Sec 2, Taipei, 112, Taiwan","Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Research Center, National Yang Ming Chiao Tung University, 155, Linong Street Sec 2, Taipei, 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037083403","display_name":"Kuan\u2010Lin Lai","orcid":"https://orcid.org/0000-0002-2436-6555","observed_orcids":["https://orcid.org/0000-0002-2436-6555"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuan-Lin Lai","raw_affiliation_strings":["Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112710753","display_name":"Yen-Feng Wang","orcid":"https://orcid.org/0000-0001-7027-3432","observed_orcids":["https://orcid.org/0000-0001-7027-3432"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Feng Wang","raw_affiliation_strings":["Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152395715","display_name":"Shih-Pin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Pin Chen","raw_affiliation_strings":["Brain Research Center, National Yang Ming Chiao Tung University, 155, Linong Street Sec 2, Taipei, 112, Taiwan","Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Research Center, National Yang Ming Chiao Tung University, 155, Linong Street Sec 2, Taipei, 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010978409","display_name":"Gianluca Coppola","orcid":"https://orcid.org/0000-0002-8510-6925","observed_orcids":["https://orcid.org/0000-0002-8510-6925"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Coppola","raw_affiliation_strings":["Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112265056","display_name":"Shuu-Jiun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shuu-Jiun Wang","raw_affiliation_strings":["Brain Research Center, National Yang Ming Chiao Tung University, 155, Linong Street Sec 2, Taipei, 112, Taiwan","Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Research Center, National Yang Ming Chiao Tung University, 155, Linong Street Sec 2, Taipei, 112, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068953662","https://openalex.org/A5112265056"],"corresponding_institution_ids":["https://openalex.org/I148366613","https://openalex.org/I2803004286"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/facial-action-units","display_name":"facial action units","score":0.8299999833106995},{"id":"https://openalex.org/keywords/chronic-migraine","display_name":"chronic migraine","score":0.6589999794960022},{"id":"https://openalex.org/keywords/episodic-migraine","display_name":"episodic migraine","score":1.0},{"id":"https://openalex.org/keywords/migraine-phenotypes","display_name":"migraine phenotypes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/disease-burden","display_name":"disease burden","score":0.8759999871253967},{"id":"https://openalex.org/keywords/emotional-distress","display_name":"emotional distress","score":0.9679999947547913},{"id":"https://openalex.org/keywords/headache-intensity","display_name":"headache severity","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8177000284194946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7585999965667725},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.6412000060081482},{"id":"https://openalex.org/C2910587157","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Chronic Migraine","level":3,"score":0.5181999802589417},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4269999861717224},{"id":"https://openalex.org/C195704467","wikidata":"https://www.wikidata.org/wiki/Q327968","display_name":"Facial expression","level":2,"score":0.41510000824928284},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.3903000056743622},{"id":"https://openalex.org/C2781419344","wikidata":"https://www.wikidata.org/wiki/Q47038","display_name":"Cheek","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.34940001368522644},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3208000063896179},{"id":"https://openalex.org/C2780966972","wikidata":"https://www.wikidata.org/wiki/Q86","display_name":"Headaches","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27970001101493835},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s10194-026-02563-0","doi":"https://doi.org/10.1186/s10194-026-02563-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-026-02563-0","pdf_url":null,"source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s10194-026-02563-0","doi":"https://doi.org/10.1186/s10194-026-02563-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-026-02563-0","pdf_url":null,"source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392631279","https://openalex.org/W1511411771","https://openalex.org/W3014158177","https://openalex.org/W1986142006","https://openalex.org/W7163554725","https://openalex.org/W2792311018","https://openalex.org/W2809899525","https://openalex.org/W4412230697","https://openalex.org/W7162038978","https://openalex.org/W4416783947"],"abstract_inverted_index":{"Migraine":[0,132],"lacks":[1],"an":[2],"objective,":[3],"scalable":[4],"signature":[5,299],"that":[6],"captures":[7],"its":[8,336],"heterogeneous":[9],"phenotypes":[10],"and":[11,30,41,46,57,75,86,113,128,150,160,175,182,193,212,221,224,238,265,269,293,304,329],"fluctuating":[12],"clinical":[13,31,291,294],"states.":[14],"We":[15,117],"investigated":[16],"whether":[17],"spontaneous":[18],"resting":[19,39,279],"facial":[20,51,105,280,315],"activity":[21,34,223,316],"reflects":[22],"migraine":[23,64,288],"phenotype,":[24,322],"headache":[25,115,252],"phase,":[26],"preventive":[27,73],"treatment":[28,74,151],"status,":[29,289],"burden.":[32,295],"Facial":[33],"was":[35,133,230,254],"extracted":[36],"from":[37],"10-s":[38],"videos":[40],"quantified":[42],"as":[43],"the":[44,69,167,196,262],"magnitude":[45,192],"temporal":[47],"variability":[48,194],"of":[49,91],"31":[50],"action":[52],"units.":[53],"Healthy":[54],"controls":[55,328],"(HCs)":[56],"patients":[58,70,125,154,165],"with":[59,68,93,108,126,130,171,209,218,232,242,256,287,326],"episodic":[60],"(EM)":[61],"or":[62,77,338],"chronic":[63],"(CM)":[65],"were":[66,82,272],"examined,":[67],"stratified":[71],"by":[72,135,140],"interictal":[76],"ictal":[78,198,301],"phase.":[79],"Group":[80],"differences":[81],"evaluated":[83],"using":[84],"age-":[85],"sex-adjusted":[87],"rank-based":[88],"permutation":[89],"analysis":[90,103],"covariance":[92],"false":[94],"discovery":[95],"rate":[96],"correction.":[97],"Behavioural":[98],"partial":[99],"least":[100],"squares":[101],"(PLS)":[102],"identified":[104],"patterns":[106,207,285],"covarying":[107],"disease":[109,210,327],"burden,":[110],"emotional":[111,213,228],"distress,":[112],"current":[114,251,290],"intensity.":[116],"consecutively":[118],"recruited":[119],"842":[120],"participants:":[121],"90":[122],"HCs,":[123],"252":[124],"CM":[127,183],"500":[129],"EM.":[131,203],"characterised":[134],"a":[136,257,319],"multiregional":[137],"pattern":[138,260],"dominated":[139],"diminished":[141],"bilateral":[142,190],"lip-corner":[143,234,244],"pulling,":[144,235],"which":[145],"persisted":[146],"across":[147],"phenotypes,":[148],"phases,":[149],"groups.":[152],"Drug-na\u00efve":[153],"exhibited":[155],"broader":[156],"reductions":[157],"in":[158,201,261,275],"cheek":[159,220,236],"lower-face":[161,176],"activity,":[162],"whereas":[163],"treated":[164,276],"retained":[166],"core":[168],"perioral":[169,222,298],"alteration":[170],"greater":[172,243],"periocular,":[173],"brow,":[174],"involvement.":[177],"Direct":[178],"comparisons":[179,309],"between":[180],"EM":[181],"revealed":[184,205,282],"few":[185],"statistically":[186],"significant":[187,274],"differences.":[188],"Increased":[189],"lid-tightening":[191],"represented":[195],"clearest":[197],"feature,":[199],"particularly":[200],"drug-na\u00efve":[202,266],"PLS":[204],"coordinated":[206],"associated":[208,231,255,286],"burden":[211,216],"distress.":[214],"Greater":[215],"covaried":[217],"reduced":[219,233],"increased":[225],"brow":[226],"activity;":[227],"distress":[229],"raising":[237],"lip":[239],"stretching,":[240],"together":[241],"depression.":[245],"Pain":[246],"intensity":[247],"categories,":[248],"but":[249,307],"not":[250,273],"intensity,":[253],"predominantly":[258],"periocular":[259,302],"overall":[263],"group":[264],"subgroups.":[267],"Emotional-distress":[268],"current-pain":[270],"models":[271],"patients.":[277],"Brief":[278],"recordings":[281],"complementary":[283],"group-level":[284],"state,":[292],"A":[296],"consistent":[297],"accompanied":[300],"activation":[303],"treatment-status":[305],"differences,":[306],"these":[308],"cannot":[310],"establish":[311,335],"preventive-therapy":[312],"effects.":[313],"Resting":[314],"may":[317],"represent":[318],"contactless":[320],"digital":[321],"although":[323],"longitudinal":[324],"studies":[325],"external":[330],"validation":[331],"are":[332],"required":[333],"to":[334],"diagnostic":[337],"monitoring":[339],"utility.":[340],"Not":[341],"applicable.":[342]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}