{"id":"https://openalex.org/W7225378679","doi":"https://doi.org/10.3390/ani16213517","title":"GnIH Modulates Proliferation, Apoptosis, and Steroid Hormone Secretion in Tibetan Sheep Granulosa Cells","display_name":"GnIH Modulates Proliferation, Apoptosis, and Steroid Hormone Secretion in Tibetan Sheep Granulosa Cells","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225378679","doi":"https://doi.org/10.3390/ani16213517"},"language":"en","primary_location":{"id":"doi:10.3390/ani16213517","doi":"https://doi.org/10.3390/ani16213517","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16213517","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ani16213517","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101472256","display_name":"Yuxiang Zhang","orcid":"https://orcid.org/0000-0003-4185-2392","observed_orcids":["https://orcid.org/0000-0003-4185-2392","https://orcid.org/0009-0001-7202-2968"]},"institutions":[{"id":"https://openalex.org/I116265982","display_name":"Qinghai University","ror":"https://ror.org/05h33bt13","country_code":"CN","type":"education","lineage":["https://openalex.org/I116265982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxiang Zhang","raw_affiliation_strings":["College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China"],"raw_orcid":"https://orcid.org/0009-0001-7202-2968","affiliations":[{"raw_affiliation_string":"College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China","institution_ids":["https://openalex.org/I116265982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153363599","display_name":"Litan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116265982","display_name":"Qinghai University","ror":"https://ror.org/05h33bt13","country_code":"CN","type":"education","lineage":["https://openalex.org/I116265982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Litan Zhang","raw_affiliation_strings":["College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China","institution_ids":["https://openalex.org/I116265982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161079933","display_name":"Xinyu Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116265982","display_name":"Qinghai University","ror":"https://ror.org/05h33bt13","country_code":"CN","type":"education","lineage":["https://openalex.org/I116265982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Ji","raw_affiliation_strings":["College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China","institution_ids":["https://openalex.org/I116265982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146967802","display_name":"Zelin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116265982","display_name":"Qinghai University","ror":"https://ror.org/05h33bt13","country_code":"CN","type":"education","lineage":["https://openalex.org/I116265982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zelin Liu","raw_affiliation_strings":["College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China","institution_ids":["https://openalex.org/I116265982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161044817","display_name":"Bin Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Huang","raw_affiliation_strings":["Qinghai Provincial Sheep Breeding and Promotion Service Center, Haibei 812200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qinghai Provincial Sheep Breeding and Promotion Service Center, Haibei 812200, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153240490","display_name":"Na He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Na He","raw_affiliation_strings":["Qinghai Provincial Sheep Breeding and Promotion Service Center, Haibei 812200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qinghai Provincial Sheep Breeding and Promotion Service Center, Haibei 812200, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158462907","display_name":"Xin Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Gu","raw_affiliation_strings":["Qinghai Provincial Sheep Breeding and Promotion Service Center, Haibei 812200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qinghai Provincial Sheep Breeding and Promotion Service Center, Haibei 812200, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153199450","display_name":"Yuting Deng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuting Deng","raw_affiliation_strings":["Tongde County Animal Husbandry and Veterinary Station, Tongde 813200, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tongde County Animal Husbandry and Veterinary Station, Tongde 813200, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089757543","display_name":"Junxia Zhang","orcid":"https://orcid.org/0000-0002-5561-0290","observed_orcids":["https://orcid.org/0000-0002-5561-0290"]},"institutions":[{"id":"https://openalex.org/I116265982","display_name":"Qinghai University","ror":"https://ror.org/05h33bt13","country_code":"CN","type":"education","lineage":["https://openalex.org/I116265982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junxia Zhang","raw_affiliation_strings":["College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Agriculture and Animal Husbandry, Qinghai University, Xining 810016, China","institution_ids":["https://openalex.org/I116265982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089757543"],"corresponding_institution_ids":["https://openalex.org/I116265982"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2896},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2896},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"21","first_page":"3517","last_page":"3517"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.6776999831199646,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadotropin-inhibitory-hormone","display_name":"gonadotropin-inhibitory hormone","score":0.972000002861023},{"id":"https://openalex.org/keywords/tibetan-sheep","display_name":"Tibetan sheep","score":0.7850000262260437},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.781000018119812},{"id":"https://openalex.org/keywords/estradiol-secretion","display_name":"estradiol secretion","score":0.9229999780654907},{"id":"https://openalex.org/keywords/progesterone-synthesis","display_name":"progesterone secretion","score":0.9879999756813049},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/follicular-development","display_name":"folliculogenesis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ovary","display_name":"ovary","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6413999795913696},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6399999856948853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6320000290870667},{"id":"https://openalex.org/C2777203538","wikidata":"https://www.wikidata.org/wiki/Q1543282","display_name":"Granulosa cell","level":3,"score":0.5333999991416931},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.4821000099182129},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.40310001373291016},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.39820000529289246},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.38830000162124634},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.37880000472068787},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.34950000047683716},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3188999891281128},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3075000047683716},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30149999260902405},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2851000130176544},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.2838999927043915},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C2780536345","wikidata":"https://www.wikidata.org/wiki/Q953556","display_name":"Ovarian follicle","level":3,"score":0.2646999955177307},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ani16213517","doi":"https://doi.org/10.3390/ani16213517","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16213517","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/ani16213517","doi":"https://doi.org/10.3390/ani16213517","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ani16213517","pdf_url":null,"source":{"id":"https://openalex.org/S4210168508","display_name":"Animals","issn_l":"2076-2615","issn":["2076-2615"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animals","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327085","display_name":"Qinghai Provincial Department of Science and Technology","ror":"https://ror.org/03vz7b375"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1963842388","https://openalex.org/W1968626027","https://openalex.org/W1986765859","https://openalex.org/W1992784217","https://openalex.org/W2009424714","https://openalex.org/W2026247947","https://openalex.org/W2033011212","https://openalex.org/W2038039689","https://openalex.org/W2044549752","https://openalex.org/W2054588522","https://openalex.org/W2069314415","https://openalex.org/W2116806096","https://openalex.org/W2127199761","https://openalex.org/W2140360329","https://openalex.org/W2156579339","https://openalex.org/W2168056910","https://openalex.org/W2194825281","https://openalex.org/W2324317342","https://openalex.org/W2466567869","https://openalex.org/W2625197785","https://openalex.org/W2737575038","https://openalex.org/W2782606838","https://openalex.org/W2790972191","https://openalex.org/W2913118109","https://openalex.org/W2937156545","https://openalex.org/W3158233488","https://openalex.org/W3208347687","https://openalex.org/W4200571345","https://openalex.org/W4206264721","https://openalex.org/W4213074681","https://openalex.org/W4293686403","https://openalex.org/W4318275822","https://openalex.org/W4319985746","https://openalex.org/W4363675789","https://openalex.org/W4393427453","https://openalex.org/W4401377208","https://openalex.org/W4408301126","https://openalex.org/W4414000966","https://openalex.org/W4414414170","https://openalex.org/W7142183177"],"related_works":["https://openalex.org/W2375473511","https://openalex.org/W2585100785","https://openalex.org/W3197401345","https://openalex.org/W2144993213","https://openalex.org/W1989260936","https://openalex.org/W4205802833","https://openalex.org/W4391172304","https://openalex.org/W2003181565","https://openalex.org/W3184203963","https://openalex.org/W2896662941"],"abstract_inverted_index":{"Gonadotropin-inhibitory":[0],"hormone":[1,140,290],"(GnIH)":[2],"is":[3],"a":[4,23,269],"key":[5],"neuropeptide":[6],"that":[7,159,265],"negatively":[8],"regulates":[9],"animal":[10],"reproduction.":[11],"This":[12],"study":[13],"aims":[14],"to":[15,54,103],"elucidate":[16],"its":[17],"functional":[18],"mechanism":[19],"in":[20,35,80,98,110,164,179,191,293,305],"Tibetan":[21,31,52,128,169],"sheep,":[22],"characteristic":[24],"plateau-adapted":[25],"breed.":[26],"A":[27],"total":[28],"of":[29,49,78,108,147,168,175,194,226,242,251,272,303],"12":[30],"sheep":[32,53,129],"were":[33,44,63,92,123,142,188],"used":[34],"this":[36],"study.":[37],"For":[38],"granulosa":[39,42,112,131,196,201,243,273,306],"cell":[40,136,202,205,246,274,282,285,307],"experiments,":[41],"cells":[43],"isolated":[45],"from":[46],"the":[47,85,105,145,180,184,192,219,224,239,249,300],"ovaries":[48],"three":[50,56,60],"independent":[51],"generate":[55],"biological":[57,73],"replicates,":[58],"and":[59,67,90,96,119,125,139,154,214,217,229,254,258,287,309],"technical":[61],"replicates":[62],"set":[64],"for":[65],"qPCR":[66],"Western":[68],"blot":[69],"detection":[70],"within":[71],"each":[72],"replicate.":[74],"The":[75,114,156,171],"mRNA":[76,173],"levels":[77],"GnIH":[79,109,118,160,176,186,198,236,266,304],"gonadal":[81,165],"axis":[82,166],"tissues,":[83],"including":[84],"hypothalamus,":[86,181],"pituitary,":[87],"ovary,":[88],"uterus":[89],"oviduct,":[91],"detected":[93],"using":[94],"RT-qPCR,":[95],"fluorescence":[97],"situ":[99],"hybridization":[100],"was":[101,161,177,232],"performed":[102],"identify":[104],"subcellular":[106],"localization":[107],"ovarian":[111,130,195],"cells.":[113,132,197],"overexpression":[115,199],"plasmid":[116],"pcDNA3.1":[117],"GnIH-targeted":[120],"siRNA":[121],"fragments":[122],"constructed":[124],"transfected":[126],"into":[127],"Cell":[133],"proliferation,":[134,283],"apoptosis,":[135,247],"cycle":[137,206],"distribution,":[138],"secretion":[141,225],"examined":[143],"with":[144],"aid":[146],"CCK":[148],"8":[149],"assay,":[150],"flow":[151],"cytometry,":[152],"RT-qPCR":[153],"ELISA.":[155],"results":[157,263],"showed":[158],"widely":[162],"expressed":[163],"tissues":[167],"ewes.":[170],"highest":[172],"abundance":[174],"found":[178],"followed":[182],"by":[183,280],"ovary.":[185],"signals":[187],"mainly":[189],"localized":[190],"cytoplasm":[193],"reduced":[200],"viability,":[203],"arrested":[204],"progression,":[207],"upregulated":[208],"proapoptotic":[209],"genes":[210],"BAX,":[211],"Caspase":[212,215],"3":[213],"9,":[216],"downregulated":[218],"proliferation-related":[220],"gene":[221],"PCNA.":[222],"Simultaneously,":[223],"estradiol":[227,260],"(E2)":[228],"progesterone":[230],"(P4)":[231],"simultaneously":[233],"reduced.":[234],"Endogenous":[235],"knockdown":[237],"enhanced":[238],"proliferative":[240],"capacity":[241],"cells,":[244,257],"inhibited":[245],"uplifted":[248],"proportions":[250],"S":[252],"phase":[253,256],"G2/M":[255],"elevated":[259],"secretion.":[261],"These":[262,292],"confirm":[264],"acts":[267],"as":[268],"negative":[270],"regulator":[271],"function.":[275],"It":[276],"inhibits":[277],"follicular":[278],"development":[279],"suppressing":[281],"promoting":[284],"apoptosis":[286],"reducing":[288],"steroid":[289],"synthesis.":[291],"vitro":[294],"observations":[295],"offer":[296],"preliminary":[297],"clues":[298],"regarding":[299],"regulatory":[301],"role":[302],"proliferation":[308],"apoptosis.":[310]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
