{"id":"https://openalex.org/W7225377229","doi":"https://doi.org/10.1002/hem3.70521","title":"Differential recovery of macrophage iron deficiency by oral iron formulations determines inflammation and autocrine hepcidin production in iron\u2010deficiency anemia","display_name":"Differential recovery of macrophage iron deficiency by oral iron formulations determines inflammation and autocrine hepcidin production in iron\u2010deficiency anemia","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225377229","doi":"https://doi.org/10.1002/hem3.70521","pmid":"https://pubmed.ncbi.nlm.nih.gov/42997707","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13743196"},"language":"en","primary_location":{"id":"doi:10.1002/hem3.70521","doi":"https://doi.org/10.1002/hem3.70521","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hem3.70521","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hem3.70521","source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hem3.70521","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002577611","display_name":"Ada Antypiuk","orcid":"https://orcid.org/0009-0008-5498-3440","observed_orcids":["https://orcid.org/0009-0008-5498-3440"]},"institutions":[{"id":"https://openalex.org/I1343675862","display_name":"New York Blood Center","ror":"https://ror.org/01xvcf081","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343675862"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ada Antypiuk","raw_affiliation_strings":["Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States"],"raw_orcid":"https://orcid.org/0009-0008-5498-3440","affiliations":[{"raw_affiliation_string":"Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States","institution_ids":["https://openalex.org/I1343675862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022385349","display_name":"Michela Asperti","orcid":"https://orcid.org/0000-0002-7830-6494","observed_orcids":["https://orcid.org/0000-0002-7830-6494"]},"institutions":[{"id":"https://openalex.org/I1343675862","display_name":"New York Blood Center","ror":"https://ror.org/01xvcf081","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343675862"]},{"id":"https://openalex.org/I167322064","display_name":"Universit\u00e0 degli Studi eCampus","ror":"https://ror.org/006maft66","country_code":"IT","type":"education","lineage":["https://openalex.org/I167322064"]},{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Michela Asperti","raw_affiliation_strings":["Department of Molecular and Translational Medicine University of Brescia Brescia Italy","Department of Theoretical and Applied Sciences eCampus University Novedrate Como Italy","Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States"],"raw_orcid":"https://orcid.org/0000-0002-7830-6494","affiliations":[{"raw_affiliation_string":"Department of Molecular and Translational Medicine University of Brescia Brescia Italy","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"Department of Theoretical and Applied Sciences eCampus University Novedrate Como Italy","institution_ids":["https://openalex.org/I167322064"]},{"raw_affiliation_string":"Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States","institution_ids":["https://openalex.org/I1343675862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035270361","display_name":"Richa Sharma","orcid":"https://orcid.org/0000-0001-8490-9761","observed_orcids":["https://orcid.org/0000-0001-8490-9761"]},"institutions":[{"id":"https://openalex.org/I1343675862","display_name":"New York Blood Center","ror":"https://ror.org/01xvcf081","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343675862"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richa Sharma","raw_affiliation_strings":["Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States","institution_ids":["https://openalex.org/I1343675862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044982292","display_name":"Shobana Navaneethabalakrishnan","orcid":"https://orcid.org/0000-0002-8768-4681","observed_orcids":["https://orcid.org/0000-0002-8768-4681"]},"institutions":[{"id":"https://openalex.org/I1343675862","display_name":"New York Blood Center","ror":"https://ror.org/01xvcf081","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343675862"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shobana Navaneethabalakrishnan","raw_affiliation_strings":["Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States"],"raw_orcid":"https://orcid.org/0000-0002-8768-4681","affiliations":[{"raw_affiliation_string":"Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States","institution_ids":["https://openalex.org/I1343675862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017540780","display_name":"Navdeep Jhita","orcid":"https://orcid.org/0000-0003-3862-0689","observed_orcids":["https://orcid.org/0000-0003-3862-0689"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navdeep Jhita","raw_affiliation_strings":["Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Atlanta Georgia United\u00a0States","Department of Pediatric Hematology/Oncology Emory University School of Medicine Atlanta Georgia United\u00a0States","Solve Sickle Cell Initiative Atlanta Georgia United\u00a0States"],"raw_orcid":"https://orcid.org/0000-0003-3862-0689","affiliations":[{"raw_affiliation_string":"Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Atlanta Georgia United\u00a0States","institution_ids":["https://openalex.org/I4210146983"]},{"raw_affiliation_string":"Department of Pediatric Hematology/Oncology Emory University School of Medicine Atlanta Georgia United\u00a0States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Solve Sickle Cell Initiative Atlanta Georgia United\u00a0States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069478739","display_name":"Quentinn Pearce","orcid":"https://orcid.org/0009-0008-5134-7190","observed_orcids":["https://orcid.org/0009-0008-5134-7190"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quentinn Pearce","raw_affiliation_strings":["Department of Biochemistry University of Utah Salt Lake City Utah United\u00a0States","Metabolomics, Mass Spectrometry, and Proteomics Core University of Utah Salt Lake City Utah United\u00a0States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry University of Utah Salt Lake City Utah United\u00a0States","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Metabolomics, Mass Spectrometry, and Proteomics Core University of Utah Salt Lake City Utah United\u00a0States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057351324","display_name":"James Eric Cox","orcid":"https://orcid.org/0000-0002-5977-2350","observed_orcids":["https://orcid.org/0000-0002-5977-2350"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Cox","raw_affiliation_strings":["Department of Biochemistry University of Utah Salt Lake City Utah United\u00a0States","Metabolomics, Mass Spectrometry, and Proteomics Core University of Utah Salt Lake City Utah United\u00a0States"],"raw_orcid":"https://orcid.org/0000-0002-5977-2350","affiliations":[{"raw_affiliation_string":"Department of Biochemistry University of Utah Salt Lake City Utah United\u00a0States","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Metabolomics, Mass Spectrometry, and Proteomics Core University of Utah Salt Lake City Utah United\u00a0States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034887371","display_name":"Elisa Brilli","orcid":"https://orcid.org/0000-0002-5053-5164","observed_orcids":["https://orcid.org/0000-0002-5053-5164"]},"institutions":[{"id":"https://openalex.org/I4405267938","display_name":"PharmaNutra SpA (Italy)","ror":"https://ror.org/053mtz659","country_code":"IT","type":"company","lineage":["https://openalex.org/I4405267938"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Brilli","raw_affiliation_strings":["Department of R&amp;D PharmaNutra S.p.A. Pisa Italy"],"raw_orcid":"https://orcid.org/0000-0002-5053-5164","affiliations":[{"raw_affiliation_string":"Department of R&amp;D PharmaNutra S.p.A. Pisa Italy","institution_ids":["https://openalex.org/I4405267938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030176255","display_name":"Germano Tarantino","orcid":"https://orcid.org/0000-0001-7264-1614","observed_orcids":["https://orcid.org/0000-0001-7264-1614"]},"institutions":[{"id":"https://openalex.org/I4405267938","display_name":"PharmaNutra SpA (Italy)","ror":"https://ror.org/053mtz659","country_code":"IT","type":"company","lineage":["https://openalex.org/I4405267938"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Germano Tarantino","raw_affiliation_strings":["Department of R&amp;D PharmaNutra S.p.A. Pisa Italy"],"raw_orcid":"https://orcid.org/0000-0001-7264-1614","affiliations":[{"raw_affiliation_string":"Department of R&amp;D PharmaNutra S.p.A. Pisa Italy","institution_ids":["https://openalex.org/I4405267938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076434308","display_name":"Francesca Vinchi","orcid":"https://orcid.org/0000-0003-1631-8286","observed_orcids":["https://orcid.org/0000-0003-1631-8286"]},"institutions":[{"id":"https://openalex.org/I1343675862","display_name":"New York Blood Center","ror":"https://ror.org/01xvcf081","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343675862"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210146983","display_name":"Children's Healthcare of Atlanta","ror":"https://ror.org/050fhx250","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146983"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Francesca Vinchi","raw_affiliation_strings":["Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Atlanta Georgia United\u00a0States","Department of Pediatric Hematology/Oncology Emory University School of Medicine Atlanta Georgia United\u00a0States","Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States","Solve Sickle Cell Initiative Atlanta Georgia United\u00a0States"],"raw_orcid":"https://orcid.org/0000-0003-1631-8286","affiliations":[{"raw_affiliation_string":"Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Atlanta Georgia United\u00a0States","institution_ids":["https://openalex.org/I4210146983"]},{"raw_affiliation_string":"Department of Pediatric Hematology/Oncology Emory University School of Medicine Atlanta Georgia United\u00a0States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Iron Research Laboratory Lindlsey F. Kimball Research Institute, New York Blood Center New York New York United\u00a0States","institution_ids":["https://openalex.org/I1343675862"]},{"raw_affiliation_string":"Solve Sickle Cell Initiative Atlanta Georgia United\u00a0States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5076434308"],"corresponding_institution_ids":["https://openalex.org/I1343675862","https://openalex.org/I150468666","https://openalex.org/I4210146983"],"apc_list":{"value":2480,"currency":"USD","value_usd":2480},"apc_paid":{"value":2480,"currency":"USD","value_usd":2480},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86935322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"11","first_page":"e70521","last_page":"e70521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.8960000276565552},{"id":"https://openalex.org/keywords/iron-sulfate","display_name":"iron sulfate","score":0.968999981880188},{"id":"https://openalex.org/keywords/sucrosomial-iron","display_name":"sucrosomial iron","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hepcidin","display_name":"hepcidin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/sterile-inflammation","display_name":"sterile inflammation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9779999852180481},{"id":"https://openalex.org/keywords/transferrin-receptor-1","display_name":"transferrin receptor 1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/labile-iron-pool","display_name":"labile iron pool","score":0.9039999842643738},{"id":"https://openalex.org/keywords/non-transferrin-bound-iron","display_name":"non-transferrin-bound iron","score":0.925000011920929},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6679999828338623},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2776768029","wikidata":"https://www.wikidata.org/wiki/Q14882371","display_name":"Hepcidin","level":3,"score":0.7775999903678894},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7020999789237976},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6488999724388123},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.6358000040054321},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.597100019454956},{"id":"https://openalex.org/C2776710925","wikidata":"https://www.wikidata.org/wiki/Q24777245","display_name":"Ferroportin","level":4,"score":0.5917999744415283},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.5424000024795532},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.5274999737739563},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4749999940395355},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.44369998574256897},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42320001125335693},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41819998621940613},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.4142000079154968},{"id":"https://openalex.org/C2776485076","wikidata":"https://www.wikidata.org/wiki/Q7558947","display_name":"Soluble transferrin receptor","level":5,"score":0.40529999136924744},{"id":"https://openalex.org/C2776732101","wikidata":"https://www.wikidata.org/wiki/Q954674","display_name":"Iron-deficiency anemia","level":3,"score":0.38749998807907104},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37709999084472656},{"id":"https://openalex.org/C2779540738","wikidata":"https://www.wikidata.org/wiki/Q125180","display_name":"Iron sulfate","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.36739999055862427},{"id":"https://openalex.org/C2779875672","wikidata":"https://www.wikidata.org/wiki/Q2537479","display_name":"Serum iron","level":3,"score":0.3564999997615814},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.3391000032424927},{"id":"https://openalex.org/C24763909","wikidata":"https://www.wikidata.org/wiki/Q1313218","display_name":"Direct reduced iron","level":2,"score":0.33320000767707825},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.32519999146461487},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.3084000051021576},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29829999804496765},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28630000352859497},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C200886947","wikidata":"https://www.wikidata.org/wiki/Q342083","display_name":"Aconitase","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2556000053882599}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/hem3.70521","doi":"https://doi.org/10.1002/hem3.70521","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hem3.70521","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hem3.70521","source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},{"id":"pmid:42997707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42997707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/hem3.70521","doi":"https://doi.org/10.1002/hem3.70521","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hem3.70521","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hem3.70521","source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000877833","display_name":"Center for Iron & Heme Disorders at the University of Utah","funder_award_id":"U54DK110858","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225377229.pdf","grobid_xml":"https://content.openalex.org/works/W7225377229.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1481874705","https://openalex.org/W2048448975","https://openalex.org/W2049123117","https://openalex.org/W2103553099","https://openalex.org/W2120882909","https://openalex.org/W2141387019","https://openalex.org/W2141687032","https://openalex.org/W2155330191","https://openalex.org/W2405628819","https://openalex.org/W2607982866","https://openalex.org/W2765726582","https://openalex.org/W2767749438","https://openalex.org/W2771204177","https://openalex.org/W2772433182","https://openalex.org/W2789351758","https://openalex.org/W2891236704","https://openalex.org/W2891690935","https://openalex.org/W2900365689","https://openalex.org/W2902622492","https://openalex.org/W2955084980","https://openalex.org/W2982441356","https://openalex.org/W2999262601","https://openalex.org/W3026203946","https://openalex.org/W3041190012","https://openalex.org/W3107345101","https://openalex.org/W3109180846","https://openalex.org/W3127156386","https://openalex.org/W3138583202","https://openalex.org/W3188853666","https://openalex.org/W4211008331","https://openalex.org/W4288716108","https://openalex.org/W4379800428","https://openalex.org/W4400934532","https://openalex.org/W4405030588","https://openalex.org/W4411941835","https://openalex.org/W4413309343","https://openalex.org/W4414399597"],"related_works":["https://openalex.org/W4386024047","https://openalex.org/W4310113019","https://openalex.org/W2891236704","https://openalex.org/W3122924054","https://openalex.org/W2998527649","https://openalex.org/W4284895586","https://openalex.org/W2365385426","https://openalex.org/W2317558968","https://openalex.org/W2121871264","https://openalex.org/W3217282922"],"abstract_inverted_index":{"Abstract":[0],"Exposure":[1],"of":[2,25,39,53,65,119,144,174,189,198,218],"macrophages":[3,55],"to":[4,90,192,243],"iron":[5,30,32,44,48,82,104,206,223],"has":[6],"been":[7],"implicated":[8],"in":[9,56,112,159,208,258],"sterile":[10],"inflammation":[11],"through":[12],"reactive":[13],"oxygen":[14],"species":[15],"(ROS)\u2010dependent":[16],"cell":[17,96,175,226],"pro\u2010inflammatory":[18],"activation.":[19],"Here,":[20],"we":[21,179],"compare":[22],"the":[23,26,47,116,141,199,216],"effect":[24],"commonly":[27],"used":[28],"oral":[29],"salt,":[31],"sulfate":[33],"(FeSO":[34],"4":[35,71,124,152,183,241],"),":[36],"with":[37,58,92,127,253,260],"that":[38,150,181,215],"an":[40],"innovative":[41],"formulation,":[42],"sucrosomial\u00ae":[43],"(SI),":[45],"on":[46,169],"status":[49],"and":[50,67,84,102,111,130,166,229,250],"inflammatory":[51,131,176,195,227,248,262],"activation":[52,197,228],"tissue":[54,68],"mice":[57],"iron\u2010deficiency":[59],"(ID)":[60],"anemia.":[61],"Despite":[62],"similar":[63],"recovery":[64],"anemia":[66],"ID,":[69],"FeSO":[70,123,151,182,240],"treatment,":[72],"but":[73,153],"not":[74,154],"SI,":[75,91,193],"elevated":[76],"transferrin":[77,97],"saturation,":[78],"generated":[79],"non\u2010transferrin":[80],"bound":[81],"(NTBI),":[83],"quickly":[85],"corrected":[86],"macrophage":[87,205,219],"ID":[88,114,120,220,256],"compared":[89,191],"a":[93,185,236],"more":[94],"pronounced":[95],"receptor":[98],"1":[99],"(TfR1)":[100],"suppression":[101],"labile":[103],"pool":[105],"expansion.":[106],"In":[107,210],"both":[108],"ex":[109],"vivo":[110],"vitro":[113],"macrophages,":[115,160],"rapid":[117],"kinetic":[118,143,217],"correction":[121,221],"by":[122,140,222],"was":[125],"associated":[126],"increased":[128],"ROS":[129],"cytokine":[132],"production,":[133],"whereas":[134],"these":[135],"responses":[136],"were":[137],"minimally":[138],"affected":[139],"slower":[142],"SI":[145,155,234],"uptake.":[146],"Metabolome":[147],"data":[148,213],"suggest":[149],"suppressed":[156],"lipid":[157],"metabolism":[158],"indicating":[161],"reduced":[162,245],"fatty":[163],"acid":[164],"\u03b2\u2010oxidation":[165],"limited":[167],"reliance":[168],"mitochondrial":[170],"activity,":[171],"metabolic":[172],"hallmarks":[173],"skewing.":[177],"Ultimately,":[178],"demonstrate":[180],"drives":[184],"higher":[186],"autocrine":[187],"production":[188],"hepcidin":[190,231,251],"via":[194],"cytokine\u2010mediated":[196],"STAT3":[200],"signaling":[201],"pathway,":[202],"further":[203],"limiting":[204],"recycling":[207],"ID.":[209],"conclusion,":[211],"our":[212],"prove":[214],"formulations":[224],"determines":[225],"modulates":[230],"production.":[232],"Overall,":[233],"appears":[235],"superior":[237],"formulation":[238],"than":[239],"due":[242],"its":[244],"pro\u2010oxidant":[246],"potential,":[247],"action,":[249],"induction,":[252],"relevance":[254],"for":[255],"treatment":[257],"individuals":[259],"pre\u2010existing":[261],"conditions.":[263]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
