{"id":"https://openalex.org/W7225376184","doi":"https://doi.org/10.1080/01443615.2026.2753612","title":"RPL22 mutation is a favourable prognostic subset within mismatch repair-deficient endometrial cancer: a retrospective cohort study","display_name":"RPL22 mutation is a favourable prognostic subset within mismatch repair-deficient endometrial cancer: a retrospective cohort study","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225376184","doi":"https://doi.org/10.1080/01443615.2026.2753612","pmid":"https://pubmed.ncbi.nlm.nih.gov/42993741"},"language":"en","primary_location":{"id":"doi:10.1080/01443615.2026.2753612","doi":"https://doi.org/10.1080/01443615.2026.2753612","is_oa":true,"landing_page_url":"https://doi.org/10.1080/01443615.2026.2753612","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/01443615.2026.2753612?needAccess=true","source":{"id":"https://openalex.org/S35334646","display_name":"Journal of Obstetrics and Gynaecology","issn_l":"0144-3615","issn":["0144-3615","1364-6893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obstetrics and Gynaecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/01443615.2026.2753612?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125477238","display_name":"Chien-Chi Lu","orcid":"https://orcid.org/0009-0002-0276-7961","observed_orcids":["https://orcid.org/0009-0002-0276-7961"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chien-Chi Lu","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036225275","display_name":"Wei-Jiun Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210111603","display_name":"Keelung Chang Gung Memorial Hospital","ror":"https://ror.org/020dg9f27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210111603"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Jiun Tang","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Keelung","Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Keelung","institution_ids":["https://openalex.org/I3020100970","https://openalex.org/I4210111603"]},{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001553839","display_name":"An\u2010Shine Chao","orcid":"https://orcid.org/0000-0002-1293-2230","observed_orcids":["https://orcid.org/0000-0002-1293-2230"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"An-Shine Chao","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","Department of Obstetrics and Gynaecology, New Taipei City Tucheng Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, New Taipei City Tucheng Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007309809","display_name":"Chiao-Yun Lin","orcid":"https://orcid.org/0000-0002-8188-0729","observed_orcids":["https://orcid.org/0000-0002-8188-0729"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chiao-Yun Lin","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101494835","display_name":"Ting\u2010Chang Chang","orcid":"https://orcid.org/0000-0003-1870-7453","observed_orcids":["https://orcid.org/0000-0003-1870-7453"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ting-Chang Chang","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038937737","display_name":"Jung\u2010Erh Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jung-Erh Yang","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042815543","display_name":"Yun\u2010Shien Lee","orcid":"https://orcid.org/0000-0001-9617-335X","observed_orcids":["https://orcid.org/0000-0001-9617-335X"]},"institutions":[{"id":"https://openalex.org/I192703390","display_name":"Ming Chuan University","ror":"https://ror.org/02pgvzy25","country_code":"TW","type":"education","lineage":["https://openalex.org/I192703390"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yun-Shien Lee","raw_affiliation_strings":["Department of Biotechnology, Ming-Chuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Ming-Chuan University","institution_ids":["https://openalex.org/I192703390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160078773","display_name":"Chen-Yang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen-Yang Huang","raw_affiliation_strings":["Department of Medical Oncology, Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103930757","display_name":"WU Ren-Chin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ren-Chin Wu","raw_affiliation_strings":["Department of Anatomical Pathology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomical Pathology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054615146","display_name":"Angel Chao","orcid":"https://orcid.org/0000-0003-3834-2754","observed_orcids":["https://orcid.org/0000-0003-3834-2754"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Angel Chao","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","Department of Obstetrics and Gynaecology, New Taipei City Tucheng Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]},{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, New Taipei City Tucheng Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057973652","display_name":"Chyong\u2010Huey Lai","orcid":"https://orcid.org/0000-0002-9977-9645","observed_orcids":["https://orcid.org/0000-0002-9977-9645"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chyong-Huey Lai","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054615146","https://openalex.org/A5103930757"],"corresponding_institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"],"apc_list":{"value":3265,"currency":"AUD","value_usd":2390},"apc_paid":{"value":3265,"currency":"AUD","value_usd":2390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.89906506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"46","issue":"1","first_page":"2753612","last_page":"2753612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.13989999890327454,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.7929999828338623},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cancer-specific-survival","display_name":"cancer-specific survival","score":0.7730000019073486},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.734000027179718},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.6340000033378601},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.7369999885559082},{"id":"https://openalex.org/keywords/mmr-protein-expression","display_name":"MMR protein expression","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9187999963760376},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.7666000127792358},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5608000159263611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5551999807357788},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4291999936103821},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.39959999918937683},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.38190001249313354},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.36410000920295715},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.34060001373291016},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.2913999855518341}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053843","descriptor_name":"DNA Mismatch Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/01443615.2026.2753612","doi":"https://doi.org/10.1080/01443615.2026.2753612","is_oa":true,"landing_page_url":"https://doi.org/10.1080/01443615.2026.2753612","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/01443615.2026.2753612?needAccess=true","source":{"id":"https://openalex.org/S35334646","display_name":"Journal of Obstetrics and Gynaecology","issn_l":"0144-3615","issn":["0144-3615","1364-6893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obstetrics and Gynaecology","raw_type":"journal-article"},{"id":"pmid:42993741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42993741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:476498359d9c42d28e32938fed99ce81","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/476498359d9c42d28e32938fed99ce81","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Obstetrics and Gynaecology, Vol 46, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/01443615.2026.2753612","doi":"https://doi.org/10.1080/01443615.2026.2753612","is_oa":true,"landing_page_url":"https://doi.org/10.1080/01443615.2026.2753612","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/01443615.2026.2753612?needAccess=true","source":{"id":"https://openalex.org/S35334646","display_name":"Journal of Obstetrics and Gynaecology","issn_l":"0144-3615","issn":["0144-3615","1364-6893"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Obstetrics and Gynaecology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"},{"id":"https://openalex.org/F4320331164","display_name":"National Science and Technology Council","ror":"https://ror.org/00wnb9798"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225376184.pdf","grobid_xml":"https://content.openalex.org/works/W7225376184.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1971211622","https://openalex.org/W1993005351","https://openalex.org/W2001010927","https://openalex.org/W2041440766","https://openalex.org/W2044142706","https://openalex.org/W2129925362","https://openalex.org/W2264001446","https://openalex.org/W2760942750","https://openalex.org/W2763815927","https://openalex.org/W2921262733","https://openalex.org/W2947159010","https://openalex.org/W3026325163","https://openalex.org/W4289595367","https://openalex.org/W4360991857","https://openalex.org/W4381309093","https://openalex.org/W4381686659","https://openalex.org/W4387032944","https://openalex.org/W4387840851","https://openalex.org/W4401242049","https://openalex.org/W4401564780","https://openalex.org/W4406374695","https://openalex.org/W4406431707","https://openalex.org/W4408161023","https://openalex.org/W4410118638","https://openalex.org/W4414984917"],"related_works":["https://openalex.org/W2044142706","https://openalex.org/W4414091602","https://openalex.org/W2607413382","https://openalex.org/W7115438495","https://openalex.org/W4414091637","https://openalex.org/W4281694434","https://openalex.org/W4387135498","https://openalex.org/W4281869413","https://openalex.org/W1993005351","https://openalex.org/W3174259825"],"abstract_inverted_index":{"Background":[0],"Although":[1],"mismatch":[2],"repair-deficient":[3],"(dMMR)":[4],"endometrial":[5,51,69,254],"cancers":[6],"are":[7],"highly":[8],"immunogenic":[9],"and":[10,74,85,103,124,131,150,177,185,227,260,269],"commonly":[11],"responsive":[12],"to":[13,27,89,134],"immune":[14],"checkpoint":[15],"inhibitors,":[16],"their":[17],"heterogeneous":[18],"outcomes":[19],"indicate":[20],"that":[21],"dMMR":[22,50,68,115,253],"status":[23],"alone":[24],"is":[25,279],"insufficient":[26],"predict":[28],"therapeutic":[29],"benefit.":[30],"The":[31,76],"RPL22":[32,77,107,194,210,244],"gene":[33],"\u2013":[34,41],"frequently":[35],"mutated":[36],"in":[37,49,87,111,121,276],"microsatellite":[38],"instability-high":[39],"tumours":[40,142,159,165,173,181,259],"represents":[42],"a":[43,118,248],"candidate":[44],"biomarker":[45],"whose":[46],"prognostic":[47,250],"significance":[48],"cancer":[52,70],"remains":[53],"largely":[54],"unexplored.Methods":[55],"In":[56,190,204,238],"this":[57,170,239],"retrospective":[58,241],"cohort":[59],"study,":[60],"we":[61],"analysed":[62,86],"250":[63],"patients":[64],"with":[65,198,215],"immunohistochemically":[66],"confirmed":[67],"diagnosed":[71],"between":[72],"2008":[73],"2022.":[75],"p.K15Rfs*5":[78,245],"mutation":[79,246],"was":[80,266],"detected":[81],"by":[82],"Sanger":[83],"sequencing":[84],"relation":[88],"MMR":[90],"protein":[91],"expression":[92],"pattern,":[93,99],"histologic":[94,192,262],"subtype,":[95],"treatment":[96,265],"modality,":[97],"recurrence":[98,139],"cancer-specific":[100,270],"survival":[101,105],"(CSS),":[102],"progression-free":[104],"(PFS).Results":[106],"mutations":[108,195,211],"were":[109,132,196,272],"identified":[110,247],"78.4%":[112],"(196/250)":[113],"of":[114],"tumours,":[116],"at":[117],"comparable":[119],"frequency":[120],"MLH1-PMS2-deficient":[122,158,258],"(79.2%)":[123],"MSH2-MSH6-deficient":[125,164],"(76.1%)":[126],"cases":[127],"(p":[128,147,152,166,182,201],"=":[129,153,167,187,202,219,225,230,236],"0.596),":[130],"unrelated":[133],"FIGO":[135,208],"stage,":[136,209],"treatment,":[137],"or":[138],"pattern.":[140],"RPL22-mutant":[141,172],"had":[143,174],"significantly":[144],"better":[145,175,199,216],"CSS":[146,162,176,200,217],"<":[148,183],"0.001)":[149,226],"PFS":[151,178,228],"0.002)":[154],"than":[155,163,179],"wild-type":[156,180],"tumours.":[157],"showed":[160],"worse":[161],"0.008);":[168],"within":[169,252],"subgroup,":[171],"0.001":[184],"p":[186,224,235],"0.005,":[188],"respectively).":[189],"aggressive":[191,261],"subtypes,":[193],"associated":[197,214],"0.003).":[203],"multivariable":[205],"analysis":[206],"including":[207],"remained":[212],"independently":[213],"(HR":[218,229],"0.14;":[220],"95%":[221,232],"CI,":[222,233],"0.05\u20130.43;":[223],"0.43;":[231],"0.23\u20130.81;":[234],"0.009).Conclusions":[237],"hypothesis-generating":[240],"cohort,":[242],"the":[243],"favourable":[249],"subset":[251],"cancers,":[255],"particularly":[256],"among":[257],"subtypes.":[263],"Because":[264],"not":[267],"modelled":[268],"deaths":[271],"few,":[273],"prospective":[274],"validation":[275],"treatment-annotated":[277],"cohorts":[278],"required":[280],"before":[281],"routine":[282],"clinical":[283],"implementation.":[284]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-07T00:00:00"}
