{"id":"https://openalex.org/W7225375167","doi":"https://doi.org/10.1186/s12987-026-00893-4","title":"Neurovascular connectedness and blood-brain interfaces integrity under fetal growth restriction: between resilience and vulnerability","display_name":"Neurovascular connectedness and blood-brain interfaces integrity under fetal growth restriction: between resilience and vulnerability","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225375167","doi":"https://doi.org/10.1186/s12987-026-00893-4"},"language":"en","primary_location":{"id":"doi:10.1186/s12987-026-00893-4","doi":"https://doi.org/10.1186/s12987-026-00893-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12987-026-00893-4","pdf_url":null,"source":{"id":"https://openalex.org/S135377911","display_name":"Fluids and Barriers of the CNS","issn_l":"2045-8118","issn":["2045-8118"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fluids and Barriers of the CNS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12987-026-00893-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056786227","display_name":"Amel Amara","orcid":"https://orcid.org/0009-0005-7472-6474","observed_orcids":["https://orcid.org/0009-0005-7472-6474"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amel Amara","raw_affiliation_strings":["Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139382613","display_name":"Cindy Durand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cindy Durand","raw_affiliation_strings":["Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062096867","display_name":"Nathalie Strazielle","orcid":"https://orcid.org/0000-0002-9579-4805","observed_orcids":["https://orcid.org/0000-0002-9579-4805"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Strazielle","raw_affiliation_strings":["Brain-i, Lyon, 69000, France","Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain-i, Lyon, 69000, France","institution_ids":[]},{"raw_affiliation_string":"Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039873752","display_name":"Elodie Babina","orcid":"https://orcid.org/0000-0002-6566-8904","observed_orcids":["https://orcid.org/0000-0002-6566-8904"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210129939","display_name":"Institut Cellule Souche et Cerveau","ror":"https://ror.org/03m0zs870","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210088668","https://openalex.org/I4210129939"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elodie Babina","raw_affiliation_strings":["Stem Cell and Brain Research Institute, INSERM U1208, Lyon University, Bron, 69500, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Brain Research Institute, INSERM U1208, Lyon University, Bron, 69500, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210129939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088762696","display_name":"Sandrine Blondel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine Blondel","raw_affiliation_strings":["BIP Facility, Lyon Neurosciences Research Center, Bron, 69500, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIP Facility, Lyon Neurosciences Research Center, Bron, 69500, France","institution_ids":["https://openalex.org/I4210095118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092836632","display_name":"Justin Malcey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Justin Malcey","raw_affiliation_strings":["Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065746899","display_name":"Olivier Raineteau","orcid":"https://orcid.org/0000-0003-4294-2496","observed_orcids":["https://orcid.org/0000-0003-4294-2496"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210129939","display_name":"Institut Cellule Souche et Cerveau","ror":"https://ror.org/03m0zs870","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210088668","https://openalex.org/I4210129939"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Raineteau","raw_affiliation_strings":["Stem Cell and Brain Research Institute, INSERM U1208, Lyon University, Bron, 69500, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Brain Research Institute, INSERM U1208, Lyon University, Bron, 69500, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210129939"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060084331","display_name":"Jean\u2010Fran\u00e7ois Ghersi\u2010Egea","orcid":"https://orcid.org/0000-0002-0181-4909","observed_orcids":["https://orcid.org/0000-0002-0181-4909"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]},{"id":"https://openalex.org/I4210137640","display_name":"Centre Hospitalier Le Vinatier","ror":"https://ror.org/04c3yce28","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210137640"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Fran\u00e7ois Ghersi-Egea","raw_affiliation_strings":["BIP Facility, Lyon Neurosciences Research Center, Bron, 69500, France","Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France","Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Centre Hospitalier Le Vinatier - B\u00e2timent 462 \u2013 Neurocampus, 95 boulevard Pinel, Bron Cedex, 69675, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIP Facility, Lyon Neurosciences Research Center, Bron, 69500, France","institution_ids":["https://openalex.org/I4210095118"]},{"raw_affiliation_string":"Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Bron, 69500, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118"]},{"raw_affiliation_string":"Fluid Team, Lyon Neurosciences Research Center, INSERM U1028, CNRS UMR5292, Lyon University, Centre Hospitalier Le Vinatier - B\u00e2timent 462 \u2013 Neurocampus, 95 boulevard Pinel, Bron Cedex, 69675, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118","https://openalex.org/I4210137640"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060084331"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118","https://openalex.org/I4210137640"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":1.0},{"id":"https://openalex.org/keywords/protein-deficiency","display_name":"protein deficiency","score":0.5419999957084656},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7850000262260437},{"id":"https://openalex.org/keywords/blood-cerebrospinal-fluid-barrier","display_name":"blood-CSF barrier","score":0.9829999804496765},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":0.925000011920929},{"id":"https://openalex.org/keywords/cortical-neuronal-networks","display_name":"cortical neuronal networks","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cerebral-vasculature","display_name":"cerebral vasculature","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dendritic-branching","display_name":"dendritic branching","score":0.8019999861717224},{"id":"https://openalex.org/keywords/fetal-programming","display_name":"fetal programming","score":0.7129999995231628},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8209999799728394},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.6269999742507935},{"id":"https://openalex.org/keywords/placental-insufficiency","display_name":"placental insufficiency","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.6502000093460083},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6197999715805054},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6133999824523926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5047000050544739},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.45419999957084656},{"id":"https://openalex.org/C2779409897","wikidata":"https://www.wikidata.org/wiki/Q7631811","display_name":"Subplate","level":3,"score":0.4203999936580658},{"id":"https://openalex.org/C2777408375","wikidata":"https://www.wikidata.org/wiki/Q707810","display_name":"Arteriogenesis","level":3,"score":0.41670000553131104},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.4018999934196472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37630000710487366},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3450999855995178},{"id":"https://openalex.org/C103378370","wikidata":"https://www.wikidata.org/wiki/Q948647","display_name":"Neuroanatomy","level":2,"score":0.3197000026702881},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.3140999972820282},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3118000030517578},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.3027999997138977},{"id":"https://openalex.org/C2777619780","wikidata":"https://www.wikidata.org/wiki/Q205925","display_name":"Circumventricular organs","level":3,"score":0.30160000920295715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29670000076293945},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2957000136375427},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2870999872684479},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27410000562667847},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C2778941446","wikidata":"https://www.wikidata.org/wiki/Q545365","display_name":"Anhedonia","level":3,"score":0.26170000433921814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12987-026-00893-4","doi":"https://doi.org/10.1186/s12987-026-00893-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12987-026-00893-4","pdf_url":null,"source":{"id":"https://openalex.org/S135377911","display_name":"Fluids and Barriers of the CNS","issn_l":"2045-8118","issn":["2045-8118"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fluids and Barriers of the CNS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12987-026-00893-4","doi":"https://doi.org/10.1186/s12987-026-00893-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12987-026-00893-4","pdf_url":null,"source":{"id":"https://openalex.org/S135377911","display_name":"Fluids and Barriers of the CNS","issn_l":"2045-8118","issn":["2045-8118"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fluids and Barriers of the CNS","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F333745488","display_name":"ERA-Net NEURON","ror":null},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7151732256","https://openalex.org/W7205164069","https://openalex.org/W4386481907","https://openalex.org/W3202210641","https://openalex.org/W7152682187","https://openalex.org/W4306385486","https://openalex.org/W6958230441","https://openalex.org/W6902178733","https://openalex.org/W7119501740","https://openalex.org/W4308873216"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Fetal":[2],"growth":[3,68,205,240,282,330],"restriction":[4,69,241,331],"is":[5,43,274,310],"an":[6,25,208,289],"important":[7,278],"public":[8],"health":[9],"concern":[10],"caused":[11,270],"by":[12,45,71,271,301],"placental":[13],"insufficiency":[14],"or":[15],"malnutrition.":[16],"It":[17,284],"results":[18],"in":[19,116,146,148,188,199,259,306],"a":[20,101,275,286,311],"reduced":[21],"brain":[22,268,307],"weight":[23],"and":[24,48,55,83,92,100,113,125,128,134,161,164,196,207,296],"increased":[26],"risk":[27,287],"of":[28,33,66,80,86,108,122,158,179,192,210,227,266,280,337],"neurodevelopmental":[29],"disorders.":[30],"The":[31,225,262],"maturation":[32],"neuronal":[34,124,160],"networks":[35,82,127,163,174],"critically":[36],"depends":[37],"on":[38,76],"adequate":[39],"CNS":[40],"homeostasis,":[41],"which":[42,325],"controlled":[44],"the":[46,52,56,64,77,84,120,142,156,190,194,221,243,267,322,335],"blood-brain":[47,87,144,197],"blood-CSF":[49,195],"interfaces,":[50],"i.e.":[51],"cerebral":[53,291,298],"vasculature":[54,115],"choroid":[57],"plexuses.":[58],"In":[59],"this":[60,228],"paper,":[61],"we":[62],"investigate":[63],"impact":[65],"fetal":[67,181,204,239,281,329],"induced":[70,300],"protein":[72,170,272],"deficiency":[73,236],"during":[74,220],"gestation":[75],"postnatal":[78,223,294],"development":[79,121,157],"neurovascular":[81,260],"integrity":[85,265],"interfaces":[88,145,212],"under":[89],"normal":[90],"conditions":[91],"after":[93],"systemic":[94,217,342],"stresses.":[95,343],"Methods":[96],"We":[97,153,183],"used":[98],"snRNA-Seq":[99],"Supernova-based":[102],"approach":[103],"coupled":[104],"with":[105,215],"three-dimensional":[106],"analyses":[107],"pyramidal":[109],"cell":[110],"dendritic":[111],"arborization":[112],"associated":[114],"rats,":[117],"to":[118,132,140,169,203,213,317,324,334],"study":[119],"cortical":[123,159],"vascular":[126,162],"their":[129,165],"connectedness.":[130],"Permeability":[131],"sucrose":[133],"pleocytosis":[135],"measurements":[136],"has":[137],"been":[138],"performed":[139],"assess":[141],"integrityof":[143],"vivo":[147,189],"different":[149],"pathological":[150],"settings.":[151],"Results":[152],"show":[154],"that":[155,237,315],"connectedness":[166],"are":[167,332],"resilient":[168],"deprivation.":[171],"Yet,":[172],"these":[173,211],"exhibit":[175],"long-term":[176],"characteristics":[177],"indicative":[178],"impacted":[180],"programming.":[182],"provide":[184],"quantitative":[185],"data":[186],"showing":[187],"fragility":[191,309],"both":[193],"barriers":[198,269,308],"developing":[200],"animals":[201],"subjected":[202],"restriction,":[206],"inability":[209],"cope":[214],"additional":[216],"inflammatory":[218],"stresses":[219],"early":[222],"period.":[224],"extent":[226],"latter":[229],"impairment":[230],"varies":[231],"between":[232],"individuals.":[233],"Conclusions":[234],"Protein":[235],"induces":[238],"spares":[242],"structures":[244],"responsible":[245],"for":[246,288,297],"higher":[247],"cognitive":[248],"functions.":[249],"However,":[250],"it":[251],"does":[252],"induce":[253],"subtle":[254],"yet":[255],"potentially":[256],"deleterious":[257],"changes":[258],"interactions.":[261],"altered":[263],"functional":[264],"deprivation":[273],"neglected":[276],"but":[277],"consequence":[279],"restriction.":[283],"represents":[285],"unstable":[290],"environment":[292],"affecting":[293],"development,":[295],"toxicity":[299],"environmental":[302],"xenobiotics.":[303],"Inter-individual":[304],"variability":[305],"previously":[312],"undescribed":[313],"factor":[314],"needs":[316],"be":[318],"considered":[319],"when":[320],"determining":[321],"degree":[323],"infants":[326],"who":[327],"experienced":[328],"vulnerable":[333],"appearance":[336],"central":[338],"adverse":[339],"outcomes":[340],"following":[341]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-07T00:00:00"}
