{"id":"https://openalex.org/W7225348583","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0007","title":"7 Mice humanized for the immune system as validated tool for therapeutic antibody development","display_name":"7 Mice humanized for the immune system as validated tool for therapeutic antibody development","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225348583","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0007"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0007","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0007","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0007","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A7.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A7.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000254066","display_name":"Lise Pasquet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lise Pasquet","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035117557","display_name":"Alice Marchand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice Marchand","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051451034","display_name":"Marion Mars","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marion Mars","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066650149","display_name":"Am\u00e9lie Largounez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Am\u00e9lie Largounez","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010788009","display_name":"Pauline Barron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pauline Barron","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029746113","display_name":"Sophie Chabot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sophie Chabot","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085203688","display_name":"Sulayman Benmerzoug","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sulayman Benmerzoug","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038563508","display_name":"Thibault Angles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thibault Angles","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028289965","display_name":"M\u00e9lanie Pichery","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melanie Pichery","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064379957","display_name":"Thomas Eden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Eden","raw_affiliation_strings":["Evotec International GmbH, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec International GmbH, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045058024","display_name":"Welbeck Danquah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Welbeck Danquah","raw_affiliation_strings":["Evotec International GmbH, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec International GmbH, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015600152","display_name":"S\u00e9bastien P. Tabruyn","orcid":"https://orcid.org/0000-0002-1917-1729","observed_orcids":["https://orcid.org/0000-0002-1917-1729"]},"institutions":[{"id":"https://openalex.org/I4210122275","display_name":"TransCure BioServices (France)","ror":"https://ror.org/02jfsex62","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210122275"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastien Tabruyn","raw_affiliation_strings":["TransCure bioServices, Archamps, Auvergne Rhone-Alpes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransCure bioServices, Archamps, Auvergne Rhone-Alpes, France","institution_ids":["https://openalex.org/I4210122275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087398585","display_name":"Dan Georgess","orcid":"https://orcid.org/0000-0003-3075-4527","observed_orcids":["https://orcid.org/0000-0003-3075-4527"]},"institutions":[{"id":"https://openalex.org/I4210122275","display_name":"TransCure BioServices (France)","ror":"https://ror.org/02jfsex62","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210122275"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dan Georgess","raw_affiliation_strings":["TransCure bioServices, Archamps, Auvergne Rhone-Alpes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TransCure bioServices, Archamps, Auvergne Rhone-Alpes, France","institution_ids":["https://openalex.org/I4210122275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016538112","display_name":"Gerhard J. Niederfellner","orcid":"https://orcid.org/0000-0001-5487-2929","observed_orcids":["https://orcid.org/0000-0001-5487-2929"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Niederfellner","raw_affiliation_strings":["Evotec International GmbH, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec International GmbH, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032011093","display_name":"Fr\u00e9d\u00e9rique Dol-Gleizes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederique Dol-gleizes","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046614767","display_name":"Pascale Lejeune","orcid":"https://orcid.org/0000-0002-0665-5783","observed_orcids":["https://orcid.org/0000-0002-0665-5783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pascale Lejeune","raw_affiliation_strings":["Evotec (France) SAS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec (France) SAS, Toulouse, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A7","last_page":"A7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5458999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0820000022649765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.9290000200271606},{"id":"https://openalex.org/keywords/therapeutic-antibody-development","display_name":"therapeutic antibody development","score":0.8669999837875366},{"id":"https://openalex.org/keywords/t-cell-engagers","display_name":"T-cell engagers","score":0.6959999799728394},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.8569999933242798},{"id":"https://openalex.org/keywords/relatlimab","display_name":"relatlimab","score":0.6159999966621399},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.996999979019165},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.7770000100135803},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.984000027179718},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.859000027179718},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tumor-infiltration","display_name":"tumor infiltration","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.8289999961853027},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7245000004768372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6535000205039978},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.570900022983551},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4803999960422516},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4683000147342682},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.43970000743865967},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.43939998745918274},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4221000075340271},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.40869998931884766},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.39489999413490295},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.3905999958515167},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3716999888420105},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.3393999934196472},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3050000071525574},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.272599995136261},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.2526000142097473}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.0007","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0007","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0007","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A7.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:ed65e1ad0d8a472baadaeff70e639b07","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ed65e1ad0d8a472baadaeff70e639b07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 14, Iss Suppl 2 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0007","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0007","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0007","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A7.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225348583.pdf","grobid_xml":"https://content.openalex.org/works/W7225348583.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W4206239577","https://openalex.org/W7164406392"],"related_works":["https://openalex.org/W4415900301","https://openalex.org/W4409628073","https://openalex.org/W4415900111","https://openalex.org/W7225332494","https://openalex.org/W7148860416","https://openalex.org/W4414145699","https://openalex.org/W4308379961","https://openalex.org/W4409821293","https://openalex.org/W4415898903","https://openalex.org/W3029206054"],"abstract_inverted_index":{"Background":[0],"Preclinical":[1],"evaluation":[2],"of":[3,13,70,74,118,159,174,188,200,241,291,354,394,439,477,480],"immunotherapies":[4],"is":[5,19,380],"often":[6],"limited":[7,261,303],"by":[8,63,304,325,489],"the":[9,50,65,71,110,116,119,127,185,198,227,231,292,327,385,470,473,481,490],"poor":[10],"translational":[11,375],"relevance":[12],"conventional":[14],"animal":[15],"models.":[16],"Hence,":[17],"there":[18],"a":[20,68,156,179,203,214,282,313,335,343,431],"critical":[21],"need":[22],"for":[23,206,276,338,351,445,472],"models":[24,41,259,333,348,360],"that":[25,149],"better":[26],"recapitulate":[27],"human":[28,78,251,344],"immune":[29,35,72,79,163,345,363],"response":[30],"and":[31,36,55,115,139,172,192,238,246,253,388,404,475,486],"relevant":[32,265],"interactions":[33],"between":[34,52],"cancer":[37,285],"cells.":[38,141],"Humanized":[39,331],"mouse":[40,332],"have":[42],"therefore":[43],"emerged":[44],"as":[45,202],"powerful":[46,336],"tools":[47],"to":[48,109,112,221,250,372,382],"bridge":[49],"gap":[51],"preclinical":[53],"research":[54],"clinical":[56,233,395],"outcomes.Methods":[57],"Such":[58],"humanized":[59],"mice":[60,131,235],"are":[61,302,349],"developed":[62],"reconstituting":[64],"whole":[66],"or":[67,96],"part":[69],"system":[73,364],"immunodeficient":[75],"animals":[76],"with":[77,226,244,312,384,430,469],"cells":[80,89,101],"from":[81,93,103,306],"2":[82],"possible":[83],"origins:":[84],"CD34":[85],"+":[86,130,359],"hematopoietic":[87],"stem":[88],"(huCD34+":[90],"mice)":[91],"isolated":[92],"cord":[94],"blood,":[95],"mature":[97],"peripheral":[98],"blood":[99],"mononuclear":[100],"prepared":[102],"buffy":[104],"coats":[105],"(huPBMC":[106],"mice).":[107],"According":[108],"compound":[111],"be":[113,124],"tested":[114],"goal":[117],"research,":[120],"one":[121],"model":[122,182,378],"may":[123],"preferred":[125],"over":[126,264],"other.Results":[128],"HuCD34":[129,358],"exhibited":[132],"multilineage":[133],"reconstitution,":[134],"including":[135],"T,":[136],"B,":[137],"NK,":[138],"myeloid":[140,152],"We":[142],"evaluated":[143,184],"an":[144],"efficient":[145,237],"cytokine":[146,170],"boosting":[147],"strategy":[148,187,212],"significantly":[150],"improved":[151,320],"cell":[153,442],"proportion,":[154],"overcoming":[155],"key":[157],"limitation":[158],"this":[160],"model.":[161],"Functional":[162],"activation":[164,176],"was":[165],"confirmed":[166],"in":[167,217,224,230,342,408,467],"vivo":[168],"through":[169],"production":[171],"expression":[173],"Tcell":[175,278],"markers.":[177],"In":[178,281],"A375":[180],"melanoma":[181,208],"we":[183,287],"combination":[186,211],"relatlimab":[189],"(anti-LAG-3":[190],"antibody)":[191,195],"nivolumab":[193,405,407],"(anti-PD-1":[194],"approved":[196,488],"at":[197],"beginning":[199],"2024":[201],"first-line":[204],"treatment":[205,444],"specific":[207],"indications.":[209],"The":[210],"induced":[213],"significant":[215],"decrease":[216],"tumor":[218,255],"growth":[219],"compared":[220],"single":[222],"agents":[223],"line":[225],"data":[228],"observed":[229],"RELATIVITY-047":[232,401],"trial.1HuPBMC":[234],"demonstrated":[236],"dose-dependent":[239,289],"engraftment":[240],"T-cells":[242],"exclusively,":[243],"CD4":[245],"CD8":[247],"proportions":[248],"comparable":[249],"circulation":[252],"effective":[254],"infiltration.":[256],"Importantly,":[257],"these":[258],"showed":[260,288],"graftversushost":[262],"disease":[263],"study":[266],"durations,":[267],"enabling":[268],"extended":[269],"therapeutic":[270,340,386],"windows.":[271],"They":[272],"proved":[273],"particularly":[274],"suitable":[275],"evaluating":[277,339],"engagers":[279,301],"(TCE).":[280],"BT474-Clone5":[283],"breast":[284],"model,":[286],"efficacy":[290,321,341],"CD3":[293,440],"x":[294,316],"EpCAM":[295],"bispecific":[296,318,435],"antibody":[297,319,436],"solitomab.":[298],"However,":[299],"T-cell":[300,308],"toxicity":[305,324],"sustained":[307],"activation.":[309],"Combining":[310],"solitomab":[311],"proprietary":[314],"HER2":[315],"CD2":[317],"while":[322],"reducing":[323],"lowering":[326],"required":[328],"TCE":[329],"dose.2Conclusions":[330],"provide":[334],"platform":[337],"context.":[346],"HuPBMC":[347],"optimal":[350],"rapid":[352],"assessment":[353],"T-cell\u2013driven":[355],"mechanisms,":[356],"whereas":[357],"enable":[361],"comprehensive":[362],"interrogation.":[365],"Despite":[366],"inherent":[367],"limitations,":[368],"ongoing":[369],"refinements":[370],"continue":[371],"enhance":[373],"their":[374],"relevance.":[376],"Careful":[377],"selection":[379],"essential":[381],"align":[383],"modality":[387],"biological":[389],"question,":[390],"ultimately":[391],"improving":[392],"prediction":[393],"outcomes.References":[396],"Tawbi":[397],"HA,":[398],"et":[399,426],"al.":[400,427],"investigators.":[402],"Relatlimab":[403],"versus":[406],"untreated":[409],"advanced":[410],"melanoma.":[411],"N":[412],"Engl":[413],"J":[414],"Med.":[415],"2022":[416],"Jan":[417],"6;386(1):24-34.":[418],"doi:":[419,452],"10.1056/NEJMoa2109970.":[420],"PMID:":[421,458],"34986285;":[422],"PMCID:":[423,460],"PMC9844513.Danquah":[424],"W,":[425],"Combination":[428],"therapy":[429],"novel":[432],"CD2-targeted":[433],"costimulatory":[434],"overcomes":[437],"limitations":[438],"T":[441],"engager":[443],"solid":[446],"tumors.":[447],"MAbsss":[448],"2026":[449,455],"Dec":[450],"31;18(1):2684378.":[451],"10.1080/19420862.2026.2684378.":[453],"Epub":[454],"Jun":[456],"10.":[457],"42271190;":[459],"PMC13271273.Ethics":[461],"Approval":[462],"All":[463],"procedures":[464],"were":[465,487],"conducted":[466],"accordance":[468],"Guide":[471],"Care":[474],"Use":[476],"Laboratory":[478],"Animals":[479],"European":[482],"Council":[483],"Directive":[484],"(2010/63/UE)":[485],"French":[491],"Animal":[492],"Ethical":[493],"Committee":[494],"(APAFIS#47793-2024022716325549":[495],"v2).":[496]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}