{"id":"https://openalex.org/W7225348369","doi":"https://doi.org/10.3389/fbioe.2026.1871074","title":"KDELR2 promotes the progression of non-small cell lung cancer by regulating HIF-1\u03b1 mediated glycolysis","display_name":"KDELR2 promotes the progression of non-small cell lung cancer by regulating HIF-1\u03b1 mediated glycolysis","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225348369","doi":"https://doi.org/10.3389/fbioe.2026.1871074"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2026.1871074","doi":"https://doi.org/10.3389/fbioe.2026.1871074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1871074","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1871074/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1871074/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160929700","display_name":"Tongtong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongtong Li","raw_affiliation_strings":["Department of Respiratory Medicine, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160931807","display_name":"Ying Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Department of Respiratory Medicine, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160809234","display_name":"Zhenxiang Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenxiang Yu","raw_affiliation_strings":["Department of Respiratory Medicine, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108730676","display_name":"Wenwen Fu","orcid":"https://orcid.org/0000-0003-3863-508X","observed_orcids":["https://orcid.org/0000-0003-3863-508X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenwen Fu","raw_affiliation_strings":["Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126554610","display_name":"Huali Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huali Xu","raw_affiliation_strings":["Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101698382","display_name":"Tong Zhou","orcid":"https://orcid.org/0000-0001-9294-8234","observed_orcids":["https://orcid.org/0000-0001-9294-8234"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tong Zhou","raw_affiliation_strings":["Department of Endocrinology and Metabolism, The First Hospital of Jilin University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, The First Hospital of Jilin University","institution_ids":["https://openalex.org/I4210125137"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101698382","https://openalex.org/A5108730676","https://openalex.org/A5126554610"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210125137"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.652999997138977},{"id":"https://openalex.org/keywords/invasion-and-metastasis","display_name":"invasion and metastasis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6510000228881836},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5830000042915344},{"id":"https://openalex.org/keywords/hypoxia-signaling","display_name":"hypoxia signaling","score":0.5709999799728394},{"id":"https://openalex.org/keywords/glycolytic-metabolism","display_name":"glycolytic metabolism","score":0.46799999475479126},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7978000044822693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6067000031471252},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5884000062942505},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5135999917984009},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5041999816894531},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4968999922275543},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46950000524520874},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4494999945163727},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.436599999666214},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4341000020503998},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4041000008583069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39089998602867126},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.3824999928474426},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.37529999017715454},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3630000054836273},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.35989999771118164},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.358599990606308},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.3334999978542328},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3197999894618988},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27300000190734863},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26409998536109924},{"id":"https://openalex.org/C2778807442","wikidata":"https://www.wikidata.org/wiki/Q6152005","display_name":"Treatment of lung cancer","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26080000400543213},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.25690001249313354}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fbioe.2026.1871074","doi":"https://doi.org/10.3389/fbioe.2026.1871074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1871074","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1871074/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:cd43a80030c14e12b8f6df6fa5bf8116","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cd43a80030c14e12b8f6df6fa5bf8116","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbioe.2026.1871074","doi":"https://doi.org/10.3389/fbioe.2026.1871074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1871074","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1871074/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320322300","display_name":"Jilin University","ror":"https://ror.org/00js3aw79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225348369.pdf","grobid_xml":"https://content.openalex.org/works/W7225348369.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1550166107","https://openalex.org/W1979994407","https://openalex.org/W2066380767","https://openalex.org/W2072451938","https://openalex.org/W2768762463","https://openalex.org/W2797428900","https://openalex.org/W2912439423","https://openalex.org/W2963339867","https://openalex.org/W3026916394","https://openalex.org/W3047231683","https://openalex.org/W3111889155","https://openalex.org/W3161388680","https://openalex.org/W3172643069","https://openalex.org/W3178871955","https://openalex.org/W4281570882","https://openalex.org/W4289262068","https://openalex.org/W4307585126","https://openalex.org/W4307899216","https://openalex.org/W4308019611","https://openalex.org/W4310995080","https://openalex.org/W4386529053","https://openalex.org/W4387911517","https://openalex.org/W4389728348","https://openalex.org/W4391816901","https://openalex.org/W4391841157","https://openalex.org/W4391986782","https://openalex.org/W4399379068","https://openalex.org/W4400096493","https://openalex.org/W4400787684","https://openalex.org/W4402350538","https://openalex.org/W4403131079","https://openalex.org/W4403987806","https://openalex.org/W4407595268","https://openalex.org/W4409441717","https://openalex.org/W4411154293","https://openalex.org/W4412158217","https://openalex.org/W4412529601","https://openalex.org/W4412670547","https://openalex.org/W4413002938","https://openalex.org/W4415793990","https://openalex.org/W4416072218","https://openalex.org/W4416308671","https://openalex.org/W4416346079","https://openalex.org/W4416630091","https://openalex.org/W4416797349","https://openalex.org/W4417456023","https://openalex.org/W7130343332","https://openalex.org/W7130376254","https://openalex.org/W7131422535","https://openalex.org/W7134132187"],"related_works":["https://openalex.org/W7084128791","https://openalex.org/W4395676524","https://openalex.org/W2043498865","https://openalex.org/W2276797565","https://openalex.org/W6977049518","https://openalex.org/W4399390026","https://openalex.org/W2764047403","https://openalex.org/W4312842458","https://openalex.org/W7161270418","https://openalex.org/W6958171376"],"abstract_inverted_index":{"Introduction":[0],"Across":[1],"the":[2,7,25,63,90,100,103,112,119,159,215,260,306,312,321],"world,":[3],"lung":[4,31,40],"cancer":[5,22,32,41],"remains":[6],"foremost":[8],"cause":[9],"of":[10,21,37,59,65,89,102,116,135,140,182,206,210,240,245,265,274,292,301,314,340],"death":[11],"attributed":[12],"to":[13,16,203],"cancer,":[14],"contributing":[15],"nearly":[17],"one":[18,88],"in":[19,242,252],"five":[20],"deaths.":[23],"As":[24],"main":[26],"histological":[27],"form,":[28],"non-small":[29],"cell":[30,219],"(NSCLC)":[33],"constitutes":[34],"roughly":[35],"80%\u201385%":[36],"total":[38],"diagnosed":[39,44],"cases.":[42],"Patients":[43],"with":[45],"advanced":[46],"NSCLC":[47,141,211,253,275,302,315],"have":[48],"a":[49,154,167,172,288,336,346],"5-year":[50],"survival":[51],"rate":[52],"lower":[53],"than":[54],"20%,":[55],"and":[56,69,72,96,114,138,150,171,194,213,227,255,263,279],"persistent":[57],"problem":[58],"drug":[60,161],"resistance":[61],"underscores":[62],"importance":[64],"developing":[66],"new":[67,168],"safe":[68],"efficacious":[70],"drugs":[71],"exploring":[73],"innovative":[74],"therapeutic":[75,169,329,349],"targets.":[76],"The":[77,127,180],"Lys-Asp-Glu-Leu":[78],"(KDEL)":[79],"endoplasmic":[80],"reticulum":[81],"(ER)":[82],"protein":[83],"retention":[84],"receptors":[85,95],"(KDELRs)":[86],"is":[87,250,285,335],"earliest":[91],"discovered":[92],"intracellular":[93],"transport":[94],"essential":[97],"for":[98,158,177,237,331,351],"preserving":[99],"integrity":[101],"early":[104],"secretory":[105],"pathway.":[106],"Evidence":[107],"indicates":[108],"that":[109,130,270,297,343],"KDELR2":[110,131,152,183,207,248,271,284,310,334],"facilitates":[111],"invasion":[113,139],"migration":[115],"NSCLC,":[117],"although":[118],"fundamental":[120],"mechanisms":[121],"behind":[122],"this":[123],"remain":[124],"poorly":[125],"understood.":[126],"research":[128],"suggestes":[129],"could":[132],"enhance":[133,259],"abilities":[134],"proliferation,":[136,261],"migration,":[137],"through":[142,186,218,303],"hypoxia-inducible":[143],"factor":[144],"1\u03b1":[145],"(HIF-1\u03b1)":[146],"dependent":[147],"glycolytic":[148],"metabolism":[149],"identified":[151],"as":[153,287],"potential":[155,289,337],"molecular":[156,290,338],"target":[157,170,291,339],"novel":[160,348],"pseudoginsenoside":[162],"Rh2":[163],"(P-G-Rh2),":[164],"thereby":[165],"offering":[166],"potentially":[173],"effective":[174,328],"treatment":[175],"agent":[176],"NSCLC.":[178,246,266,332,352],"Methods":[179],"levels":[181,258],"were":[184,200,235],"measured":[185],"real-time":[187],"fluorescence":[188],"quantitative":[189],"PCR":[190],"(RT\u2010qPCR),":[191],"western":[192,223],"blot,":[193,224],"immunohistochemistry":[195],"(IHC).":[196],"In":[197],"vitro":[198],"assays":[199],"carried":[201],"out":[202],"evaluate":[204],"impact":[205],"on":[208],"functions":[209],"cells":[212],"explore":[214],"underlying":[216],"mechanism":[217],"counting":[220],"kit\u20108":[221],"(CCK\u20108),":[222],"transwell":[225],"assays,":[226],"wound":[228],"healing.":[229],"Additionally,":[230,283],"nude":[231],"mice":[232],"xenograft":[233],"models":[234],"conducted":[236],"validating":[238],"role":[239],"P\u2010G\u2010Rh2":[241,298,344],"suppressing":[243],"progression":[244,273,300,313],"Results":[247],"expression":[249],"upregulated":[251],"tissues,":[254],"its":[256],"increased":[257],"invasion,":[262],"metastasis":[264],"Mechanistic":[267],"studies":[268],"indicate":[269],"drives":[272],"by":[276,304],"elevating":[277],"HIF\u20101\u03b1":[278],"subsequently":[280],"activating":[281],"glycolysis.":[282,318],"recognized":[286],"P\u2010G\u2010Rh2.":[293],"Further":[294],"investigation":[295],"reveals":[296],"suppresses":[299],"regulating":[305],"KDELR2/HIF\u20101\u03b1/glycolysis":[307],"axis.":[308],"Conclusion":[309],"promotes":[311],"via":[316],"HIF\u20101\u03b1-mediated":[317],"Therefore,":[319],"targeting":[320],"KDELR2/HIF-1\u03b1/glycolysis":[322],"signaling":[323],"pathway":[324],"may":[325],"become":[326],"an":[327],"strategy":[330],"Meanwhile,":[333],"P\u2010G\u2010Rh2,":[341],"indicating":[342],"represents":[345],"promising":[347],"approach":[350]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}