{"id":"https://openalex.org/W7225347644","doi":"https://doi.org/10.1186/s13062-026-01053-2","title":"HNRNPAB drives glioblastoma proliferation by stabilizing EZH2 mRNA","display_name":"HNRNPAB drives glioblastoma proliferation by stabilizing EZH2 mRNA","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225347644","doi":"https://doi.org/10.1186/s13062-026-01053-2"},"language":"en","primary_location":{"id":"doi:10.1186/s13062-026-01053-2","doi":"https://doi.org/10.1186/s13062-026-01053-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13062-026-01053-2","pdf_url":null,"source":{"id":"https://openalex.org/S42110715","display_name":"Biology Direct","issn_l":"1745-6150","issn":["1745-6150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Direct","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13062-026-01053-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160879175","display_name":"Qing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Wang","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160759764","display_name":"Honglei Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Honglei Cheng","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062963454","display_name":"Xinyi Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Feng","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113042570","display_name":"Fufu Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fufu Ji","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160854655","display_name":"Tao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["AU","CN"],"is_corresponding":true,"raw_author_name":"Tao Liu","raw_affiliation_strings":["School of Clinical Medicine, UNSW Medicine & Health, The University of New South Wales, Sydney, NSW, 2052, Australia","State Key Laboratory of Metabolic Dysregulation & the Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, School of Convergence Medicine, Zhengzhou University, Zhengzhou, Henan, 450000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, UNSW Medicine & Health, The University of New South Wales, Sydney, NSW, 2052, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"State Key Laboratory of Metabolic Dysregulation & the Prevention and Treatment of Esophageal Cancer, Tianjian Laboratory of Advanced Biomedical Sciences, School of Convergence Medicine, Zhengzhou University, Zhengzhou, Henan, 450000, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160925816","display_name":"Qing Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Lan","raw_affiliation_strings":["Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China","institution_ids":["https://openalex.org/I4210124971"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5160854655","https://openalex.org/A5160925816"],"corresponding_institution_ids":["https://openalex.org/I31746571","https://openalex.org/I38877650","https://openalex.org/I4210124971"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mrna-stabilization","display_name":"mRNA stabilization","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hnrnp","display_name":"heterogeneous nuclear ribonucleoproteins","score":0.8299999833106995},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9430000185966492},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9490000009536743},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":1.0},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.9020000100135803},{"id":"https://openalex.org/keywords/idh-wildtype-glioma","display_name":"IDH-wildtype glioma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7900000214576721},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8417999744415283},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.7542999982833862},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7350000143051147},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.67330002784729},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5659999847412109},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5372999906539917},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.48919999599456787},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.42669999599456787},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.390500009059906},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.37549999356269836},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.34369999170303345},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3427000045776367},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3418999910354614},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3255999982357025},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3255000114440918},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3073999881744385},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.2948000133037567},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2939000129699707},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C2909472194","wikidata":"https://www.wikidata.org/wiki/Q417662","display_name":"Heterogeneous nuclear ribonucleoprotein","level":5,"score":0.2824000120162964},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2565999925136566},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25450000166893005}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13062-026-01053-2","doi":"https://doi.org/10.1186/s13062-026-01053-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13062-026-01053-2","pdf_url":null,"source":{"id":"https://openalex.org/S42110715","display_name":"Biology Direct","issn_l":"1745-6150","issn":["1745-6150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Direct","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13062-026-01053-2","doi":"https://doi.org/10.1186/s13062-026-01053-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13062-026-01053-2","pdf_url":null,"source":{"id":"https://openalex.org/S42110715","display_name":"Biology Direct","issn_l":"1745-6150","issn":["1745-6150"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Direct","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9509000182151794}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409628884","https://openalex.org/W3092209712","https://openalex.org/W2099033106","https://openalex.org/W7140234994","https://openalex.org/W2985923016","https://openalex.org/W4214807123","https://openalex.org/W3217207028","https://openalex.org/W3160388166","https://openalex.org/W4311365490","https://openalex.org/W2793080384"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Glioblastoma":[2],"(GBM)":[3],"is":[4,68],"the":[5,38,53,90,206,213],"most":[6],"lethal":[7],"primary":[8],"brain":[9],"tumor,":[10],"characterized":[11],"by":[12],"profound":[13],"therapeutic":[14,105,244],"resistance":[15],"to":[16,60,102,229],"both":[17],"radiotherapy":[18],"and":[19,30,64,78,95,107,116,135,153,162,169,175,193,241],"chemotherapy,":[20],"resulting":[21],"in":[22,36,46,100,133,185,223,249],"universally":[23],"dismal":[24],"prognoses.":[25],"Although":[26],"aberrant":[27],"RNA":[28],"metabolism":[29],"post-transcriptional":[31],"regulation":[32],"are":[33,81],"increasingly":[34],"implicated":[35],"tumorigenesis,":[37],"functional":[39],"contributions":[40],"of":[41,98,114,220],"heterogeneous":[42],"nuclear":[43],"ribonucleoproteins":[44],"(HNRNPs)":[45],"GBM":[47],"progression":[48,203],"remain":[49],"largely":[50],"unexplored.":[51],"Specifically,":[52],"regulatory":[54],"network":[55],"connecting":[56],"HNRNP":[57,121],"family":[58,122],"members":[59],"oncogenic":[61,231],"epigenetic":[62],"modifications":[63],"downstream":[65],"proliferative":[66,196],"signaling":[67],"poorly":[69],"understood.":[70],"Moreover,":[71],"reliable":[72],"prognostic":[73,108,126,239],"biomarkers":[74],"for":[75],"risk":[76,127],"stratification":[77],"targeted":[79],"intervention":[80],"still":[82],"urgently":[83],"needed.":[84],"In":[85],"this":[86],"study,":[87],"we":[88],"investigated":[89],"clinical":[91],"significance,":[92],"biological":[93],"functions,":[94],"molecular":[96],"mechanisms":[97],"HNRNPAB":[99,130,146,159,183,200,225],"glioblastoma":[101,202,221],"identify":[103],"novel":[104],"vulnerabilities":[106],"indicators.":[109],"Results":[110],"Integrated":[111],"bioinformatic":[112],"analysis":[113],"TCGA":[115],"CGGA":[117],"cohorts":[118],"identified":[119],"five":[120],"genes":[123],"as":[124,216,237],"independent":[125],"factors,":[128],"with":[129,139],"markedly":[131],"upregulated":[132],"high-grade":[134],"IDH-wildtype":[136,250],"gliomas,":[137],"correlating":[138],"poor":[140],"survival.":[141],"Functional":[142],"assays":[143],"showed":[144],"that":[145,182,199],"knockdown":[147],"suppressed":[148],"proliferation,":[149],"induced":[150],"G1":[151],"arrest,":[152],"impaired":[154],"orthotopic":[155],"tumor":[156],"growth.":[157],"Mechanistically,":[158],"directly":[160],"bound":[161],"stabilized":[163],"EZH2":[164,167,191,227],"mRNA,":[165],"enhancing":[166],"expression":[168,192],"H3K27me3":[170],"modification,":[171],"which":[172,224],"activated":[173],"PI3K-AKT-mTOR":[174],"ERK":[176],"signaling.":[177,232],"Critically,":[178],"rescue":[179],"experiments":[180],"demonstrated":[181],"overexpression":[184],"HNRNPAB-knockdown":[186],"U251":[187],"cells":[188],"effectively":[189],"restored":[190],"rescued":[194],"cellular":[195],"capacity,":[197],"confirming":[198],"drives":[201],"specifically":[204],"through":[205],"EZH2-dependent":[207],"axis.":[208],"Conclusion":[209],"Our":[210],"study":[211],"identifies":[212],"HNRNPAB\u2013EZH2":[214],"axis":[215,234],"a":[217,238,242],"potential":[218],"driver":[219],"progression,":[222],"stabilizes":[226],"mRNA":[228],"activate":[230],"This":[233],"may":[235],"serve":[236],"biomarker":[240],"candidate":[243],"target":[245],"warranting":[246],"further":[247],"validation":[248],"glioblastoma.":[251]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}