{"id":"https://openalex.org/W7225346759","doi":"https://doi.org/10.7717/peerj.21866","title":"Intrinsic replication advantage of a Hepatitis B Virus genotype C strain is independent of the basal core promoter A1762T/G1764A mutation","display_name":"Intrinsic replication advantage of a Hepatitis B Virus genotype C strain is independent of the basal core promoter A1762T/G1764A mutation","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225346759","doi":"https://doi.org/10.7717/peerj.21866","pmid":"https://pubmed.ncbi.nlm.nih.gov/43001121","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13744702"},"language":"en","primary_location":{"id":"doi:10.7717/peerj.21866","doi":"https://doi.org/10.7717/peerj.21866","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.21866","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7717/peerj.21866","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077942953","display_name":"Yihan Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Yihan Xiao","raw_affiliation_strings":["Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China","institution_ids":["https://openalex.org/I79731167","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054018685","display_name":"Xinjun Chen","orcid":"https://orcid.org/0000-0001-8352-7403","observed_orcids":["https://orcid.org/0000-0001-8352-7403"]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Xinjun Chen","raw_affiliation_strings":["Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China","institution_ids":["https://openalex.org/I79731167","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160870456","display_name":"Zongxin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Zongxin Li","raw_affiliation_strings":["Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China","institution_ids":["https://openalex.org/I79731167","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136289746","display_name":"Sheng Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Sheng Lei","raw_affiliation_strings":["Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China","institution_ids":["https://openalex.org/I79731167","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160806772","display_name":"Zhenbin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Zhenbin Chen","raw_affiliation_strings":["Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China","institution_ids":["https://openalex.org/I79731167","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160984757","display_name":"Junqi Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Junqi Cai","raw_affiliation_strings":["Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China","institution_ids":["https://openalex.org/I79731167","https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084962247","display_name":"\u5d14\u79c0\u5409","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Xiuji Cui","raw_affiliation_strings":["Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, College of Basic Medical Sciences, The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, China","institution_ids":["https://openalex.org/I79731167","https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5084962247"],"corresponding_institution_ids":["https://openalex.org/I79731167","https://openalex.org/I889458895"],"apc_list":{"value":1395,"currency":"USD","value_usd":1395},"apc_paid":{"value":1395,"currency":"USD","value_usd":1395},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"e21866","last_page":"e21866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.984000027179718},{"id":"https://openalex.org/keywords/hbv-genotype-c","display_name":"HBV genotype C","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hbv-genotype-b","display_name":"HBV genotype B","score":0.953000009059906},{"id":"https://openalex.org/keywords/coinfection","display_name":"co-infection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/viral-replication-capacity","display_name":"viral replication capacity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/basal-core-promoter-mutations","display_name":"basal core promoter mutations","score":0.6909999847412109},{"id":"https://openalex.org/keywords/core-promoter","display_name":"core promoter","score":0.4230000078678131},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.7440000176429749},{"id":"https://openalex.org/keywords/viral-fitness","display_name":"viral fitness","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.7383999824523926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7289000153541565},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7275000214576721},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6980000138282776},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6089000105857849},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.600600004196167},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5090000033378601},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45989999175071716},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4415999948978424},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4099999964237213},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3808000087738037},{"id":"https://openalex.org/C194575299","wikidata":"https://www.wikidata.org/wiki/Q2843746","display_name":"Hepatitis B virus DNA polymerase","level":4,"score":0.37700000405311584},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.3700999915599823},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.365200012922287},{"id":"https://openalex.org/C2780617729","wikidata":"https://www.wikidata.org/wiki/Q1356878","display_name":"Hepadnaviridae","level":4,"score":0.3549000024795532},{"id":"https://openalex.org/C73616013","wikidata":"https://www.wikidata.org/wiki/Q5731703","display_name":"Hepatitis B virus PRE beta","level":5,"score":0.35040000081062317},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.3418999910354614},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3377000093460083},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.31690001487731934},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C192122231","wikidata":"https://www.wikidata.org/wiki/Q4680754","display_name":"Adaptive mutation","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C2778600374","wikidata":"https://www.wikidata.org/wiki/Q6746239","display_name":"Orthohepadnavirus","level":5,"score":0.2874000072479248},{"id":"https://openalex.org/C102306862","wikidata":"https://www.wikidata.org/wiki/Q6943735","display_name":"Mutation frequency","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.2791999876499176},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.2671999931335449},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019694","descriptor_name":"Hepatitis B, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.7717/peerj.21866","doi":"https://doi.org/10.7717/peerj.21866","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.21866","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},{"id":"pmid:43001121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43001121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13744702","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13744702/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2003b6ee14d0401684a1fc19b1c91e11","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2003b6ee14d0401684a1fc19b1c91e11","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PeerJ, Vol 14, p e21866 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7717/peerj.21866","doi":"https://doi.org/10.7717/peerj.21866","is_oa":true,"landing_page_url":"https://doi.org/10.7717/peerj.21866","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1517467251","https://openalex.org/W1570168472","https://openalex.org/W1621859662","https://openalex.org/W1821077834","https://openalex.org/W1938933071","https://openalex.org/W1968635656","https://openalex.org/W1971248139","https://openalex.org/W1991359390","https://openalex.org/W1991592276","https://openalex.org/W2021826502","https://openalex.org/W2029356541","https://openalex.org/W2030049522","https://openalex.org/W2032161987","https://openalex.org/W2049144368","https://openalex.org/W2060691954","https://openalex.org/W2062368700","https://openalex.org/W2067252666","https://openalex.org/W2072654199","https://openalex.org/W2079445185","https://openalex.org/W2095745440","https://openalex.org/W2096249428","https://openalex.org/W2100916717","https://openalex.org/W2106882534","https://openalex.org/W2117210617","https://openalex.org/W2126475597","https://openalex.org/W2130935866","https://openalex.org/W2136445954","https://openalex.org/W2144375124","https://openalex.org/W2146614792","https://openalex.org/W2153732660","https://openalex.org/W2165230297","https://openalex.org/W2170643695","https://openalex.org/W2799524357","https://openalex.org/W4289274885","https://openalex.org/W4313379674","https://openalex.org/W4387157027","https://openalex.org/W4387378669","https://openalex.org/W4397004023","https://openalex.org/W4402536669"],"related_works":["https://openalex.org/W2054412906","https://openalex.org/W4387157027","https://openalex.org/W7130601713","https://openalex.org/W1517467251","https://openalex.org/W2074167960","https://openalex.org/W1994979797","https://openalex.org/W1980466828","https://openalex.org/W2359543871","https://openalex.org/W2031693649","https://openalex.org/W2027739150"],"abstract_inverted_index":{"This":[0],"study":[1],"aimed":[2],"to":[3,23,125],"isolate":[4],"and":[5,20,22,49,60,66,78],"characterize":[6],"individual":[7],"hepatitis":[8,37],"B":[9,19,38],"virus":[10],"(HBV)":[11],"strains":[12],"from":[13,34],"a":[14,35,101,150,167],"patient":[15],"co-infected":[16],"with":[17,173],"genotype":[18,104,147],"C,":[21],"directly":[24],"compare":[25],"their":[26],"intrinsic":[27],"replication":[28,72,110,153],"capacities.":[29],"HBV":[30,146],"DNA":[31],"was":[32,73,95,134],"isolated":[33],"chronic":[36],"patient.":[39],"Genotypes":[40],"were":[41,52,63],"determined":[42],"by":[43,97],"genotype-specific":[44],"polymerase":[45],"chain":[46],"reaction":[47],"(PCR),":[48],"full-length":[50],"genomes":[51],"cloned.":[53],"Two":[54],"clones":[55],"representing":[56],"subgenotype":[57],"B2":[58,114],"(c17)":[59],"C1":[61,93,105,123,148],"(c21)":[62],"selected,":[64],"sequenced":[65],"transfected":[67],"into":[68],"HepG2":[69],"cells.":[70],"Viral":[71],"assessed":[74],"via":[75],"Southern":[76],"blot":[77],"quantitative":[79],"PCR.":[80],"The":[81],"role":[82],"of":[83,139,158],"the":[84,92,103,113,118,122,136,159],"common":[85],"Adenine":[86],"(A)1762Thymine":[87],"(T/)Guanine":[88],"(G)1764A":[89],"mutation":[90,120,133],"in":[91,121,177],"clone":[94,106,124],"investigated":[96],"site-directed":[98],"mutagenesis.":[99],"As":[100],"result,":[102],"exhibited":[107],"significantly":[108],"higher":[109],"capacity":[111,154],"than":[112,155],"clone.":[115],"Counterintuitively,":[116],"reverting":[117],"A1762T/G1764A":[119],"wild-type":[126],"further":[127],"enhanced":[128],"its":[129,140,171],"replication,":[130],"indicating":[131],"this":[132],"not":[135],"primary":[137],"driver":[138],"high":[141],"replicative":[142],"fitness.":[143],"In":[144],"conclusion,":[145],"possesses":[149],"greater":[151],"inherent":[152],"B2,":[156],"independent":[157],"classic":[160],"basal":[161],"core":[162],"promoter":[163],"(BCP)":[164],"mutation,":[165],"providing":[166],"virological":[168],"explanation":[169],"for":[170],"association":[172],"severe":[174],"disease":[175],"outcomes":[176],"co-infection.":[178]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-06T00:00:00"}