{"id":"https://openalex.org/W7225344817","doi":"https://doi.org/10.5281/zenodo.23971107","title":"Ferroptosis-Based Cancer Therapy: Molecular Regulation, Resistance Mechanisms, and Combination Strategies","display_name":"Ferroptosis-Based Cancer Therapy: Molecular Regulation, Resistance Mechanisms, and Combination Strategies","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225344817","doi":"https://doi.org/10.5281/zenodo.23971107"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23971107","doi":"https://doi.org/10.5281/zenodo.23971107","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23971107","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23971107","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160866783","display_name":"Samiksha Anandache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287382","display_name":"Fergana Medical Institute of Public Health","ror":"https://ror.org/050ycf013","country_code":"UZ","type":"education","lineage":["https://openalex.org/I4405287382"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Samiksha Anandache","raw_affiliation_strings":["MBBS Third Year, Department of Pharmacology, Fergana Medical Institute of Public Health, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MBBS Third Year, Department of Pharmacology, Fergana Medical Institute of Public Health, Uzbekistan","institution_ids":["https://openalex.org/I4405287382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051366942","display_name":"Shivprasad Dhage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287382","display_name":"Fergana Medical Institute of Public Health","ror":"https://ror.org/050ycf013","country_code":"UZ","type":"education","lineage":["https://openalex.org/I4405287382"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Shivprasad Dhage","raw_affiliation_strings":["Assistant Professor Department Of Pharmacology, Fergana Medical Institute of Public Health, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor Department Of Pharmacology, Fergana Medical Institute of Public Health, Uzbekistan","institution_ids":["https://openalex.org/I4405287382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405287382"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.8199999928474426},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9449999928474426},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.5649999976158142},{"id":"https://openalex.org/keywords/phospholipid-peroxidation","display_name":"phospholipid peroxidation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ferroptosis-resistance","display_name":"ferroptosis resistance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5379999876022339},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6679999828338623},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.5649999976158142},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9079999923706055},{"id":"https://openalex.org/keywords/bap1","display_name":"BAP1","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.656000018119812},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.5049999952316284},{"id":"https://openalex.org/keywords/drug-tolerance","display_name":"drug tolerance","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.689300000667572},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5958999991416931},{"id":"https://openalex.org/C2781264002","wikidata":"https://www.wikidata.org/wiki/Q3724651","display_name":"Phospholipid-hydroperoxide glutathione peroxidase","level":5,"score":0.5697000026702881},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5407999753952026},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5027999877929688},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4936000108718872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4738999903202057},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4731000065803528},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.37940001487731934},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35850000381469727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34709998965263367},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.32600000500679016},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.32589998841285706},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.32519999146461487},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C2777376040","wikidata":"https://www.wikidata.org/wiki/Q418384","display_name":"Fisetin","level":4,"score":0.2953000068664551},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29170000553131104},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.26019999384880066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26010000705718994}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23971107","doi":"https://doi.org/10.5281/zenodo.23971107","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23971107","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.23971108","doi":"https://doi.org/10.5281/zenodo.23971108","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23971108","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23971107","doi":"https://doi.org/10.5281/zenodo.23971107","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23971107","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214282616","https://openalex.org/W7133208752","https://openalex.org/W4390426991","https://openalex.org/W7167045397","https://openalex.org/W4210967640","https://openalex.org/W7131236915","https://openalex.org/W3044608231","https://openalex.org/W7162771545","https://openalex.org/W4211067224","https://openalex.org/W3091181647"],"abstract_inverted_index":{"Ferroptosis":[0],"is":[1],"a":[2,31,40],"regulated":[3],"form":[4],"of":[5,12,84,147],"cell":[6,37],"death":[7],"driven":[8],"by":[9],"iron-dependent":[10],"peroxidation":[11],"polyunsaturated":[13],"phospholipids":[14],"in":[15,23,35],"cellular":[16],"membranes.":[17],"Since":[18],"the":[19,25,60,81,92,145,148,165,183],"term":[20],"was":[21],"introduced":[22],"2012,":[24],"field":[26],"has":[27],"moved":[28],"quickly":[29],"from":[30,134],"chemical":[32],"curiosity":[33],"observed":[34],"RAS-mutant":[36],"lines":[38],"to":[39,138,185],"recognised":[41],"vulnerability":[42],"across":[43],"many":[44],"tumour":[45],"types.":[46],"Cancer":[47],"cells":[48,121,171],"that":[49,193],"are":[50,132,161,207],"mesenchymal,":[51],"drug-tolerant":[52],"or":[53],"metabolically":[54],"rewired":[55],"often":[56],"depend":[57,196],"heavily":[58],"on":[59,67,144,168,198,203,211],"glutathione":[61],"peroxidase":[62],"4":[63],"(GPX4)":[64],"axis":[65],"and":[66,71,91,96,105,113,118,127,159,188,210],"parallel":[68],"antioxidant":[69],"systems,":[70],"this":[72],"dependency":[73],"can":[74],"be":[75],"exploited":[76],"pharmacologically.":[77],"This":[78],"review":[79],"summarises":[80],"biochemical":[82],"core":[83],"ferroptosis,":[85],"including":[86],"iron":[87],"handling,":[88],"phospholipid":[89],"remodelling":[90],"GPX4,":[93],"FSP1,":[94],"GCH1":[95],"DHODH":[97],"defence":[98],"systems.":[99],"We":[100,191],"then":[101],"discuss":[102],"how":[103,119,169],"oncogenic":[104],"tumour-suppressor":[106],"pathways":[107],"such":[108],"as":[109],"p53,":[110],"BAP1,":[111],"NRF2":[112],"Hippo":[114],"signalling":[115],"tune":[116],"sensitivity,":[117],"cancer":[120],"escape":[122],"ferroptosis":[123],"through":[124],"transcriptional,":[125],"metabolic":[126],"microenvironmental":[128],"adaptation.":[129],"Pharmacological":[130],"strategies":[131],"surveyed,":[133],"system":[135],"xc\u2212":[136],"inhibition":[137],"covalent":[139],"GPX4":[140],"inhibitors,":[141],"with":[142,154,164,214],"emphasis":[143],"limits":[146],"currently":[149],"available":[150],"compounds.":[151],"Combination":[152],"approaches":[153],"chemotherapy,":[155],"targeted":[156],"therapy,":[157],"radiotherapy":[158],"immunotherapy":[160],"examined,":[162],"along":[163],"conflicting":[166],"evidence":[167],"ferroptotic":[170],"shape":[172],"antitumour":[173],"immunity.":[174],"Finally,":[175],"we":[176],"consider":[177],"candidate":[178],"biomarkers":[179],"for":[180],"patient":[181],"selection,":[182],"obstacles":[184],"clinical":[186],"translation,":[187],"research":[189],"priorities.":[190],"argue":[192],"progress":[194],"will":[195],"less":[197],"discovering":[199],"further":[200],"inducers":[201,213],"than":[202],"defining":[204],"which":[205],"tumours":[206],"truly":[208],"ferroptosis-prone":[209],"delivering":[212],"acceptable":[215],"selectivity.":[216]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}
