{"id":"https://openalex.org/W7225344709","doi":"https://doi.org/10.1021/acs.jpcb.6c03870","title":"Field Cycling NMR Relaxometry as a Tool for Detecting the Quality of Biotechnological Drugs","display_name":"Field Cycling NMR Relaxometry as a Tool for Detecting the Quality of Biotechnological Drugs","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225344709","doi":"https://doi.org/10.1021/acs.jpcb.6c03870"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jpcb.6c03870","doi":"https://doi.org/10.1021/acs.jpcb.6c03870","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpcb.6c03870","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046995575","display_name":"Evrim Umut","orcid":"https://orcid.org/0000-0003-0344-1365","observed_orcids":["https://orcid.org/0000-0003-0344-1365"]},"institutions":[{"id":"https://openalex.org/I193615760","display_name":"Dokuz Eyl\u00fcl University","ror":"https://ror.org/00dbd8b73","country_code":"TR","type":"education","lineage":["https://openalex.org/I193615760"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"E. Umut","raw_affiliation_strings":["Dokuz Eylul University , , ,"],"raw_orcid":"https://orcid.org/0000-0003-0344-1365","affiliations":[{"raw_affiliation_string":"Dokuz Eylul University , , ,","institution_ids":["https://openalex.org/I193615760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160859020","display_name":"H. Alam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H. Alam","raw_affiliation_strings":["Middle East Technical University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Middle East Technical University , , ,","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160858891","display_name":"O. Gezici Ko\u00e7","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198068145","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77","country_code":"TR","type":"government","lineage":["https://openalex.org/I198068145"]},{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"O. Gezici Koc\u0327","raw_affiliation_strings":["Middle East Technical University , , ,","Scientific and Technological Research Council of Tu\u0308rkiye (TUBITAK) , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Middle East Technical University , , ,","institution_ids":["https://openalex.org/I201799495"]},{"raw_affiliation_string":"Scientific and Technological Research Council of Tu\u0308rkiye (TUBITAK) , ,","institution_ids":["https://openalex.org/I198068145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160893125","display_name":"A. Mieloch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47996466","display_name":"University of Warmia and Mazury in Olsztyn","ror":"https://ror.org/05s4feg49","country_code":"PL","type":"education","lineage":["https://openalex.org/I47996466"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"A. Mieloch","raw_affiliation_strings":["University of Warmia and Mazury in Olsztyn , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Warmia and Mazury in Olsztyn , , ,","institution_ids":["https://openalex.org/I47996466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002271472","display_name":"Cem Yamal\u0131","orcid":"https://orcid.org/0000-0002-4833-7900","observed_orcids":["https://orcid.org/0000-0002-4833-7900"]},"institutions":[{"id":"https://openalex.org/I55931168","display_name":"Cukurova University","ror":"https://ror.org/05wxkj555","country_code":"TR","type":"education","lineage":["https://openalex.org/I55931168"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"C. Yamali","raw_affiliation_strings":["C\u0327ukurova University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-4833-7900","affiliations":[{"raw_affiliation_string":"C\u0327ukurova University , , ,","institution_ids":["https://openalex.org/I55931168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038662981","display_name":"Mecit Halil \u00d6ztop","orcid":"https://orcid.org/0000-0001-6414-8942","observed_orcids":["https://orcid.org/0000-0001-6414-8942"]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M. H. Oztop","raw_affiliation_strings":["Middle East Technical University , , ,"],"raw_orcid":"https://orcid.org/0000-0001-6414-8942","affiliations":[{"raw_affiliation_string":"Middle East Technical University , , ,","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052721323","display_name":"Danuta Kruk","orcid":"https://orcid.org/0000-0003-3083-9395","observed_orcids":["https://orcid.org/0000-0003-3083-9395"]},"institutions":[{"id":"https://openalex.org/I47996466","display_name":"University of Warmia and Mazury in Olsztyn","ror":"https://ror.org/05s4feg49","country_code":"PL","type":"education","lineage":["https://openalex.org/I47996466"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"D. Kruk","raw_affiliation_strings":["University of Warmia and Mazury in Olsztyn , , ,"],"raw_orcid":"https://orcid.org/0000-0003-3083-9395","affiliations":[{"raw_affiliation_string":"University of Warmia and Mazury in Olsztyn , , ,","institution_ids":["https://openalex.org/I47996466"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5046995575"],"corresponding_institution_ids":["https://openalex.org/I193615760"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.06859999895095825,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/field-cycling-nmr-relaxometry","display_name":"field-cycling NMR relaxometry","score":0.9750000238418579},{"id":"https://openalex.org/keywords/biopharmaceutical-quality-control","display_name":"biopharmaceutical quality control","score":0.7599999904632568},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/glycation","display_name":"glycation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6629999876022339},{"id":"https://openalex.org/keywords/bovine-serum-albumin","display_name":"bovine serum albumin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.878000020980835},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.7200000286102295},{"id":"https://openalex.org/keywords/non-invasive-detection","display_name":"non-invasive detection","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C73286259","wikidata":"https://www.wikidata.org/wiki/Q7310885","display_name":"Relaxometry","level":4,"score":0.9678999781608582},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.8711000084877014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6876999735832214},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.478300005197525},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4401000142097473},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.40540000796318054},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3889000117778778},{"id":"https://openalex.org/C2776029896","wikidata":"https://www.wikidata.org/wiki/Q3935810","display_name":"Relaxation (psychology)","level":2,"score":0.37529999017715454},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.319599986076355},{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.3010999858379364},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2549000084400177},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jpcb.6c03870","doi":"https://doi.org/10.1021/acs.jpcb.6c03870","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jpcb.6c03870","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324256","display_name":"Y\u00fcksek\u00f6\u011fretim Kurulu","ror":"https://ror.org/00j1q0b46"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W131973759","https://openalex.org/W1575723364","https://openalex.org/W1972824304","https://openalex.org/W1980599353","https://openalex.org/W2011324645","https://openalex.org/W2012140419","https://openalex.org/W2016392996","https://openalex.org/W2040189649","https://openalex.org/W2040537235","https://openalex.org/W2046561695","https://openalex.org/W2062446285","https://openalex.org/W2063145632","https://openalex.org/W2064803002","https://openalex.org/W2066594795","https://openalex.org/W2072076892","https://openalex.org/W2084037378","https://openalex.org/W2087497084","https://openalex.org/W2096780302","https://openalex.org/W2131904845","https://openalex.org/W2135255832","https://openalex.org/W2328502884","https://openalex.org/W2335201762","https://openalex.org/W2340056068","https://openalex.org/W2341967814","https://openalex.org/W2557963596","https://openalex.org/W2566108937","https://openalex.org/W2585892048","https://openalex.org/W2782767874","https://openalex.org/W2904641630","https://openalex.org/W2955232437","https://openalex.org/W2967044453","https://openalex.org/W3014847721","https://openalex.org/W3023739036","https://openalex.org/W3149103991","https://openalex.org/W3162626584","https://openalex.org/W3170946139","https://openalex.org/W3198634444","https://openalex.org/W3203859104","https://openalex.org/W4210415172","https://openalex.org/W4210926597","https://openalex.org/W4211145022","https://openalex.org/W4220940590","https://openalex.org/W4223542076","https://openalex.org/W4281968513","https://openalex.org/W4321175694","https://openalex.org/W4323254829","https://openalex.org/W4389578810","https://openalex.org/W4394749915","https://openalex.org/W4399096248","https://openalex.org/W4406034929","https://openalex.org/W4411452673","https://openalex.org/W4411800588","https://openalex.org/W4412957151","https://openalex.org/W7133351278"],"related_works":["https://openalex.org/W4412957151","https://openalex.org/W2115365714","https://openalex.org/W6941388045","https://openalex.org/W1575723364","https://openalex.org/W1974663677","https://openalex.org/W7058616098","https://openalex.org/W3162626584","https://openalex.org/W3132813705","https://openalex.org/W2914063157","https://openalex.org/W2123049711"],"abstract_inverted_index":{"Abstract":[0],"Biotechnological":[1],"drugs":[2],"mostly":[3],"contain":[4],"proteins":[5],"or":[6,245],"peptides;":[7],"therefore,":[8],"any":[9,240],"change":[10],"in":[11,26,75,89,115],"ambient":[12],"conditions":[13,143],"during":[14],"their":[15],"storage":[16],"and":[17,40,48,101,195,232],"administration":[18],"to":[19,71,201],"patients":[20],"may":[21],"cause":[22],"structural":[23],"modifications,":[24],"which,":[25],"turn,":[27],"lower":[28],"the":[29,42,76,178,182,185,202,212,218],"drug":[30,34,38,79,99,221],"quality/effectiveness.":[31],"Among":[32],"different":[33,141],"quality":[35,80,222],"issues":[36],"hampering":[37],"stability":[39],"pharmacokinetics,":[41],"commonly":[43],"observed":[44],"ones":[45],"are":[46],"aggregation":[47,92,203],"glycation.":[49],"Both":[50],"processes":[51],"include":[52],"changes":[53],"at":[54,150],"a":[55,86,95,110,147,151,160,230],"molecular":[56],"level":[57],"that":[58,164,236],"can":[59,165],"indeed":[60],"be":[61,166],"probed":[62],"by":[63,120,205],"field":[64],"cycling":[65],"NMR":[66,124,225],"relaxometry":[67,125,226],"as":[68,85,109,229],"an":[69],"alternative":[70],"traditional":[72],"techniques":[73],"used":[74],"detection":[77,219],"of":[78,104,122,171,214,220,247],"issues.":[81],"In":[82],"this":[83,175],"study,":[84],"forthcoming":[87],"problem":[88],"diabetes":[90],"pharmaceuticals,":[91],"effects":[93],"on":[94,135,181,211],"commercially":[96],"available":[97],"insulin":[98,136],"(Humulin-R)":[100],"glucose-mediated":[102],"glycation":[103,179,193,196,207],"bovine":[105],"serum":[106,112],"albumin":[107],"(BSA,":[108],"model":[111],"protein":[113],"for":[114,146,217],"vitro":[116],"tests)":[117],"were":[118],"investigated":[119],"means":[121],"FFC":[123,224],"experiments.":[126],"1H":[127],"spin\u2013lattice":[128],"relaxation":[129,188],"rate":[130],"dispersion":[131,163],"(NMRD)":[132],"profiles":[133],"obtained":[134],"samples":[137],"treated":[138],"under":[139,174],"three":[140],"stress":[142],"showed":[144],"that,":[145],"sample":[148,242],"agitated":[149],"high":[152],"temperature":[153,194],"(T":[154],"=":[155],"50":[156],"\u00b0C),":[157],"one":[158],"observes":[159],"significant":[161],"low-frequency":[162,186],"associated":[167],"with":[168,192],"rotational/reorientational":[169],"motion":[170],"aggregates":[172],"formed":[173],"condition.":[176],"Regarding":[177],"experiments":[180],"BSA":[183],"solution,":[184],"proton":[187],"rate,":[189],"R1,":[190],"increases":[191],"time,":[197],"which":[198],"is":[199,227],"related":[200],"induced":[204],"advanced":[206],"end-product":[208],"(AGEs)":[209],"formation":[210],"surface":[213],"BSA.":[215],"Overall,":[216],"issues,":[223],"promising":[228],"noninvasive":[231],"relatively":[233],"low-cost":[234],"technique":[235],"does":[237],"not":[238],"involve":[239],"additional":[241],"preparation":[243],"procedures":[244],"use":[246],"chemicals.":[248]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-06T00:00:00"}
