{"id":"https://openalex.org/W7225344435","doi":"https://doi.org/10.1186/s13049-026-01723-0","title":"Is prehospital opioid administration safe in children? A register-based study","display_name":"Is prehospital opioid administration safe in children? A register-based study","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225344435","doi":"https://doi.org/10.1186/s13049-026-01723-0"},"language":"en","primary_location":{"id":"doi:10.1186/s13049-026-01723-0","doi":"https://doi.org/10.1186/s13049-026-01723-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13049-026-01723-0","pdf_url":null,"source":{"id":"https://openalex.org/S108358066","display_name":"Scandinavian Journal of Trauma Resuscitation and Emergency Medicine","issn_l":"1757-7241","issn":["1757-7241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13049-026-01723-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160733504","display_name":"Vibe Nyrop Sk\u00f8tt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I4210115306","display_name":"Region of Southern Denmark","ror":"https://ror.org/0290a6k23","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210115306"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Vibe Nyrop Sk\u00f8tt","raw_affiliation_strings":["The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490","https://openalex.org/I4210115306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120094431","display_name":"Nikolaj Nedahl Oldin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I4210115306","display_name":"Region of Southern Denmark","ror":"https://ror.org/0290a6k23","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210115306"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nikolaj Nedahl Oldin","raw_affiliation_strings":["The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490","https://openalex.org/I4210115306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104423692","display_name":"Josefine Tvede Colding-J\u00f8rgensen","orcid":"https://orcid.org/0009-0005-8240-6585","observed_orcids":["https://orcid.org/0009-0005-8240-6585"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I4210115306","display_name":"Region of Southern Denmark","ror":"https://ror.org/0290a6k23","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210115306"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Josefine Tvede Colding-J\u00f8rgensen","raw_affiliation_strings":["The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0009-0005-8240-6585","affiliations":[{"raw_affiliation_string":"The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490","https://openalex.org/I4210115306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116153714","display_name":"Gina Maj Graven Brandstrup","orcid":"https://orcid.org/0009-0004-7990-1895","observed_orcids":["https://orcid.org/0009-0004-7990-1895"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I4210115306","display_name":"Region of Southern Denmark","ror":"https://ror.org/0290a6k23","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210115306"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Gina Maj Graven Brandstrup","raw_affiliation_strings":["The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0009-0004-7990-1895","affiliations":[{"raw_affiliation_string":"The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490","https://openalex.org/I4210115306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074751364","display_name":"Signe Amalie Wolthers","orcid":"https://orcid.org/0000-0001-6325-2449","observed_orcids":["https://orcid.org/0000-0001-6325-2449"]},"institutions":[{"id":"https://openalex.org/I2799668677","display_name":"Region Zealand","ror":"https://ror.org/01dtyv127","country_code":"DK","type":"government","lineage":["https://openalex.org/I2799668677"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Signe Amalie Wolthers","raw_affiliation_strings":["Emergency Medical Services, Prehospital Center, N\u00e6stved, Region Zealand, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-6325-2449","affiliations":[{"raw_affiliation_string":"Emergency Medical Services, Prehospital Center, N\u00e6stved, Region Zealand, Denmark","institution_ids":["https://openalex.org/I2799668677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039671772","display_name":"Josefine Gradman","orcid":"https://orcid.org/0000-0002-3196-6655","observed_orcids":["https://orcid.org/0000-0002-3196-6655"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Josefine Gradman","raw_affiliation_strings":["Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-3196-6655","affiliations":[{"raw_affiliation_string":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116153715","display_name":"Line Anker Bang Thybo","orcid":"https://orcid.org/0009-0007-0089-3207","observed_orcids":["https://orcid.org/0009-0007-0089-3207"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Line Anker Bang Thybo","raw_affiliation_strings":["Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital, Odense, Denmark"],"raw_orcid":"https://orcid.org/0009-0007-0089-3207","affiliations":[{"raw_affiliation_string":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045472566","display_name":"S\u00f8ren S\u00f8ndergaard Mikkelsen","orcid":"https://orcid.org/0000-0002-5187-7027","observed_orcids":["https://orcid.org/0000-0002-5187-7027"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]},{"id":"https://openalex.org/I4210115306","display_name":"Region of Southern Denmark","ror":"https://ror.org/0290a6k23","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210115306"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"S\u00f8ren Mikkelsen","raw_affiliation_strings":["The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5187-7027","affiliations":[{"raw_affiliation_string":"The Prehospital Research Unit, Region of Southern Denmark, Prehospital South - EMS, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490","https://openalex.org/I4210115306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045472566"],"corresponding_institution_ids":["https://openalex.org/I177969490","https://openalex.org/I4210115306"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.3246999979019165,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.3246999979019165,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.15389999747276306,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11292","display_name":"Pediatric Pain Management Techniques","score":0.15119999647140503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6019999980926514},{"id":"https://openalex.org/keywords/opioid-side-effects","display_name":"opioid side effects","score":0.7360000014305115},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pediatric-pain-management","display_name":"pediatric pain management","score":0.6890000104904175},{"id":"https://openalex.org/keywords/respiratory-depression","display_name":"respiratory depression","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nausea-and-vomiting","display_name":"nausea and vomiting","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.978600025177002},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7210000157356262},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6952999830245972},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.6820999979972839},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.6435999870300293},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5985999703407288},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.590499997138977},{"id":"https://openalex.org/C2776890885","wikidata":"https://www.wikidata.org/wiki/Q1067560","display_name":"Vital signs","level":2,"score":0.5849999785423279},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.5843999981880188},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.41510000824928284},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3880000114440918},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.38749998807907104},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.37689998745918274},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.3617999851703644},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.3517000079154968},{"id":"https://openalex.org/C2780457178","wikidata":"https://www.wikidata.org/wiki/Q3774744","display_name":"Respiratory arrest","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3086000084877014},{"id":"https://openalex.org/C545288138","wikidata":"https://www.wikidata.org/wiki/Q860447","display_name":"Emergency medical services","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2831999957561493},{"id":"https://openalex.org/C2776093070","wikidata":"https://www.wikidata.org/wiki/Q621636","display_name":"Route of administration","level":2,"score":0.2648000121116638},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C8213797","wikidata":"https://www.wikidata.org/wiki/Q754250","display_name":"Respiratory rate","level":4,"score":0.2542000114917755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13049-026-01723-0","doi":"https://doi.org/10.1186/s13049-026-01723-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13049-026-01723-0","pdf_url":null,"source":{"id":"https://openalex.org/S108358066","display_name":"Scandinavian Journal of Trauma Resuscitation and Emergency Medicine","issn_l":"1757-7241","issn":["1757-7241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13049-026-01723-0","doi":"https://doi.org/10.1186/s13049-026-01723-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13049-026-01723-0","pdf_url":null,"source":{"id":"https://openalex.org/S108358066","display_name":"Scandinavian Journal of Trauma Resuscitation and Emergency Medicine","issn_l":"1757-7241","issn":["1757-7241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323799","display_name":"Syddansk Universitet","ror":"https://ror.org/03yrrjy16"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407152978","https://openalex.org/W2232664922","https://openalex.org/W2988791591","https://openalex.org/W4200386413","https://openalex.org/W2301715586","https://openalex.org/W3025261598","https://openalex.org/W2467836576","https://openalex.org/W3196588383","https://openalex.org/W4415434957","https://openalex.org/W7221124778"],"abstract_inverted_index":{"Pain":[0],"in":[1,31,41,44,66,130,178,184,198,205,224,337],"prehospital":[2,37,64,291,306,314,334],"paediatric":[3],"patients":[4],"is":[5],"often":[6],"poorly":[7],"managed.":[8],"Prehospital":[9],"opioid":[10,210,307,335],"doses":[11],"generally":[12],"stay":[13],"below":[14],"the":[15,23,67,138,145,170,215,273,284,322],"upper":[16],"limits":[17],"recommended":[18,146],"by":[19],"guidelines.":[20],"Concerns":[21],"about":[22],"risk":[24],"of":[25,39,47,69,83,137,246,305,313,327],"overdosing":[26],"may":[27,264,278],"affect":[28],"analgesic":[29,262],"administration":[30,38,336],"children.":[32,139,338],"This":[33,53],"study":[34,56],"investigated":[35],"whether":[36],"opioids":[40,65,143],"children":[42,58,122,247],"resulted":[43],"clinical":[45,81,102,155,190],"signs":[46,82,172,191,234],"adverse":[48,85,160,239,328],"effects":[49,88,240,329],"at":[50,152,214,251,272],"hospital":[51,218,252,276],"admission.":[52,260],"retrospective,":[54],"register-based":[55],"included":[57],"aged":[59],"0\u201314":[60],"years":[61],"who":[62],"received":[63,142,229,255],"Region":[68],"Southern":[70],"Denmark":[71],"between":[72],"2017":[73],"and":[74,97,99,106,114,182,202,254,325,330],"2022.":[75],"Medical":[76],"records":[77],"were":[78,89,123,192,212,223,241],"reviewed":[79],"for":[80,169],"opioid-related":[84,159,238],"effects.":[86,161],"The":[87,261],"categorised":[90],"as":[91,303,310],"nonspecific":[92],"signs,":[93,103],"including":[94],"nausea/vomiting,":[95],"drowsiness":[96,183],"sedation":[98],"more":[100],"serious":[101,189],"comprising":[104],"bradycardia":[105,196],"respiratory":[107,203],"depression.":[108],"We":[109],"assessed":[110],"diagnoses,":[111],"antidote":[112],"use,":[113],"vasopressor":[115],"administration.":[116],"In-hospital":[117],"analgesia":[118,257],"was":[119,126,173,176],"recorded.":[120],"1,531":[121],"included.":[124],"Fentanyl":[125],"administered":[127,213],"alone":[128],"or":[129,293,309],"combination":[131],"with":[132,158,195,237],"other":[133,167],"analgesics":[134],"to":[135,275,320],"99.7%":[136],"Although":[140],"97.0%":[141],"within":[144],"dosage":[147],"range,15.1%":[148],"(231":[149],"children)":[150,181,201,222,228],"exhibited":[151],"least":[153],"one":[154],"sign":[156],"compatible":[157,236],"In":[162],"9.2%":[163],"(141":[164],"children),":[165],"no":[166],"explanation":[168],"observed":[171,197],"identified.":[174],"Nausea":[175],"present":[177],"5.6%":[179],"(86":[180],"2.5%":[185],"(39":[186],"children).":[187,208],"More":[188],"less":[193],"frequent,":[194],"0.7%":[199,206],"(12":[200],"depression":[204],"(10":[207],"No":[209],"antidotes":[211],"hospital.":[216],"At":[217],"arrival,":[219],"63.6%":[220],"(974":[221],"pain.":[225],"51%":[226],"(781":[227],"additional":[230,256],"in-hospital":[231],"analgesia.":[232],"Serious":[233],"potentially":[235],"uncommon.":[242],"A":[243],"substantial":[244],"proportion":[245],"had":[248],"pain":[249,271,281,295,331],"documented":[250],"arrival":[253],"soon":[258],"after":[259,333],"effect":[263],"have":[265],"diminished":[266],"before":[267],"handover;":[268],"however,":[269],"persistent":[270],"transition":[274],"care":[277],"indicate":[279],"insufficient":[280],"management.":[282],"Because":[283],"retrospective":[285],"design":[286],"does":[287],"not":[288,300],"capture":[289],"transient":[290],"events":[292],"standardised":[294],"trajectories,":[296],"these":[297],"findings":[298],"should":[299],"be":[301],"interpreted":[302],"proof":[304],"safety":[308],"direct":[311],"evidence":[312],"undertreatment.":[315],"Prospective":[316],"studies":[317],"are":[318],"needed":[319],"characterise":[321],"timing,":[323],"severity,":[324],"causality":[326],"trajectories":[332]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-06T00:00:00"}