{"id":"https://openalex.org/W7225344113","doi":"https://doi.org/10.21203/rs.3.rs-11351682/v1","title":"Efficacy of early postoperative ON101 application for lower- extremity fracture incisions: a prospective evaluator-blinded controlled study of scar quality and digital-clinical concordance","display_name":"Efficacy of early postoperative ON101 application for lower- extremity fracture incisions: a prospective evaluator-blinded controlled study of scar quality and digital-clinical concordance","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225344113","doi":"https://doi.org/10.21203/rs.3.rs-11351682/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11351682/v1","doi":"https://doi.org/10.21203/rs.3.rs-11351682/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11351682/v1","pdf_url":"https://www.researchsquare.com/article/rs-11351682/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11351682/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160877993","display_name":"Shao-Cheng Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shao-Cheng Liu","raw_affiliation_strings":["National Defense Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Defense Medical Center","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072761707","display_name":"Jui-Ching Chen","orcid":"https://orcid.org/0000-0002-5474-2371","observed_orcids":["https://orcid.org/0000-0002-5474-2371"]},"institutions":[{"id":"https://openalex.org/I4405267120","display_name":"Oneness Biotech Co., Ltd. (Taiwan)","ror":"https://ror.org/019z49298","country_code":"TW","type":"company","lineage":["https://openalex.org/I4405267120"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jui-Ching Chen","raw_affiliation_strings":["Oneness Biotech Co, Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oneness Biotech Co, Ltd","institution_ids":["https://openalex.org/I4405267120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101711555","display_name":"Kai Cheng Lin","orcid":"https://orcid.org/0000-0003-3408-7581","observed_orcids":["https://orcid.org/0000-0003-3408-7581"]},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai Cheng Lin","raw_affiliation_strings":["Kaohsiung Veterans General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaohsiung Veterans General Hospital","institution_ids":["https://openalex.org/I4210152230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scar-maturation","display_name":"scar maturation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/postoperative-scar","display_name":"postoperative scar","score":0.6809999942779541},{"id":"https://openalex.org/keywords/lower-limb-fractures","display_name":"lower limb fractures","score":0.9539999961853027},{"id":"https://openalex.org/keywords/open-reduction-and-internal-fixation","display_name":"open reduction and internal fixation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/vancouver-scar-scale","display_name":"Vancouver Scar Scale","score":0.7149999737739563},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.5619999766349792},{"id":"https://openalex.org/keywords/cielab-color-space","display_name":"CIELAB color space","score":0.5509999990463257},{"id":"https://openalex.org/keywords/gray-level-co-occurrence-matrix-texture-features","display_name":"gray-level co-occurrence matrix texture features","score":0.8690000176429749},{"id":"https://openalex.org/keywords/scar-vascularity","display_name":"scar vascularity","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9627000093460083},{"id":"https://openalex.org/C2777642821","wikidata":"https://www.wikidata.org/wiki/Q206060","display_name":"Scars","level":2,"score":0.776199996471405},{"id":"https://openalex.org/C178596483","wikidata":"https://www.wikidata.org/wiki/Q7916472","display_name":"Vascularity","level":2,"score":0.7423999905586243},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6974999904632568},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.5174000263214111},{"id":"https://openalex.org/C2993807428","wikidata":"https://www.wikidata.org/wiki/Q25324087","display_name":"Wound care","level":2,"score":0.477400004863739},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.46160000562667847},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4189000129699707},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4083999991416931},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.40549999475479126},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3799000084400177},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.37279999256134033},{"id":"https://openalex.org/C2780660378","wikidata":"https://www.wikidata.org/wiki/Q1667915","display_name":"Internal fixation","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.34130001068115234},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.33390000462532043},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2802000045776367},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.25440001487731934}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11351682/v1","doi":"https://doi.org/10.21203/rs.3.rs-11351682/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11351682/v1","pdf_url":"https://www.researchsquare.com/article/rs-11351682/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11351682/v1","doi":"https://doi.org/10.21203/rs.3.rs-11351682/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11351682/v1","pdf_url":"https://www.researchsquare.com/article/rs-11351682/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320327359","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225344113.pdf","grobid_xml":"https://content.openalex.org/works/W7225344113.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2972195121","https://openalex.org/W4313656136","https://openalex.org/W4414145663"],"related_works":["https://openalex.org/W4252447288","https://openalex.org/W2529364088","https://openalex.org/W4283576283","https://openalex.org/W4394935760","https://openalex.org/W3181642997","https://openalex.org/W2800012567","https://openalex.org/W2047114119","https://openalex.org/W2059684261","https://openalex.org/W2972515642","https://openalex.org/W3009584875"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Postoperative":[2],"scars":[3],"after":[4],"lower-extremity":[5,104],"fracture":[6],"fixation":[7,102],"endure":[8],"high":[9],"tension,":[10],"where":[11],"excessive":[12],"scarring":[13],"can":[14],"restrict":[15],"periarticular":[16],"mobility.":[17],"While":[18,277],"the":[19,49,54,76,139,165,179],"2002":[20],"International":[21],"Clinical":[22],"Recommendations":[23],"on":[24,304],"Scar":[25,141],"Management":[26],"emphasize":[27],"early":[28,77,253,282],"prevention,":[29],"conventional":[30],"silicone":[31],"products":[32],"require":[33],"complete":[34,126],"epithelialization":[35,256],"before":[36,125,255],"use.":[37],"Conversely,":[38],"ON101":[39,74,110,169,194],"is":[40,58,263],"a":[41],"topical":[42,109],"formulation.":[43],"The":[44,168],"formulation":[45],"helps":[46],"to":[47,183,290],"maintain":[48],"wound":[50,56,61,83,245,260],"moist":[51,55],"environment,":[52],"and":[53,85,100,128,153,215,231,273,301],"environment":[57],"conducive":[59],"for":[60,67,103,130,261],"healing.":[62],"This":[63,89],"profile":[64],"suggests":[65],"potential":[66],"earlier":[68],"intervention.":[69],"We":[70],"evaluated":[71],"whether":[72],"initiating":[73],"during":[75],"postoperative":[78],"repair":[79],"phase":[80],"improves":[81],"subsequent":[82],"healing":[84],"scar":[86,136,268,283],"maturation.":[87],"Methods":[88],"prospective,":[90],"evaluator-blinded,":[91],"controlled":[92],"study":[93],"enrolled":[94],"30":[95,162],"adults":[96],"undergoing":[97],"open":[98],"reduction":[99],"internal":[101],"fractures.":[105],"Patients":[106],"received":[107],"once-daily":[108],"(n":[111,117],"=":[112,118,213],"20)":[113],"or":[114,244],"standard":[115],"care":[116],"10),":[119],"initiated":[120],"within":[121],"3":[122],"days":[123],"postoperatively":[124],"epithelialization,":[127],"continued":[129],"16":[131,185],"weeks.":[132],"Blinded":[133],"clinicians":[134],"assessed":[135],"maturation":[137,269],"using":[138,149],"Vancouver":[140],"Scale":[142],"(VSS).":[143],"Standardized":[144],"photographs":[145],"were":[146,247],"quantitatively":[147],"analyzed":[148],"CIELab":[150],"color":[151,230],"parameters":[152],"gray-level":[154],"co-occurrence":[155],"matrix":[156],"(GLCM)":[157],"texture":[158,232],"features.":[159],"Results":[160],"All":[161],"participants":[163],"completed":[164],"16-week":[166],"treatment.":[167],"group":[170],"demonstrated":[171],"greater":[172,198],"improvement":[173],"in":[174,200,229,270,281],"total":[175],"VSS":[176,238],"scores":[177],"from":[178],"initial":[180],"evaluable":[181],"assessment":[182],"Week":[184],"than":[186],"controls":[187],"(51.22%":[188],"vs.":[189,203,210,218],"15.10%,":[190],"p":[191,205,212,220],"<":[192,206,221],"0.001).":[193,222],"also":[195],"yielded":[196],"significantly":[197],"improvements":[199,280],"vascularity":[201],"(64.98%":[202],"28.33%,":[204],"0.001),":[207,214],"pliability":[208],"(49.35%":[209],"-2.08%,":[211],"height":[216],"(44.32%":[217],"-16.67%,":[219],"Objective":[223],"image":[224],"analysis":[225],"detected":[226],"treatment-associated":[227],"differences":[228],"by":[233],"Weeks":[234],"2\u201316,":[235],"preceding":[236],"clinical":[237],"divergence.":[239],"No":[240],"treatment-related":[241],"adverse":[242],"events":[243],"complications":[246],"observed.":[248],"Conclusions":[249],"From":[250],"our":[251],"study,":[252],"intervention":[254],"of":[257],"orthopedic":[258],"surgical":[259],"trauma":[262],"associated":[264],"with":[265],"more":[266],"favorable":[267],"both":[271],"subjective":[272],"objective":[274],"evaluation":[275],"tools.":[276],"establishing":[278],"robust":[279],"morphology,":[284],"larger":[285],"randomized":[286],"trials":[287],"are":[288],"warranted":[289],"confirm":[291],"definitive":[292],"functional":[293],"benefits.":[294],"Trial":[295],"registration":[296],"ClinicalTrials.gov,":[297],"NCT07854470.":[298],"Retrospectively":[299],"registered":[300],"publicly":[302],"posted":[303],"2":[305],"October":[306],"2026.":[307]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-06T00:00:00"}
