{"id":"https://openalex.org/W7225341302","doi":"https://doi.org/10.1080/13880209.2026.2757313","title":"Euonymus alatus extract ameliorates DSS-induced experimental colitis and attenuates NLRP3 inflammasome-associated pyroptosis in macrophages","display_name":"Euonymus alatus extract ameliorates DSS-induced experimental colitis and attenuates NLRP3 inflammasome-associated pyroptosis in macrophages","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225341302","doi":"https://doi.org/10.1080/13880209.2026.2757313"},"language":"en","primary_location":{"id":"doi:10.1080/13880209.2026.2757313","doi":"https://doi.org/10.1080/13880209.2026.2757313","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13880209.2026.2757313","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13880209.2026.2757313?needAccess=true","source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/13880209.2026.2757313?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004978664","display_name":"Doeun Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Doeun Jeon","raw_affiliation_strings":["KM Convergence Research Division, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Convergence Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007555550","display_name":"Ami Lee","orcid":"https://orcid.org/0009-0002-7646-375X","observed_orcids":["https://orcid.org/0009-0002-7646-375X"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ami Lee","raw_affiliation_strings":["KM Convergence Research Division, Korea Institute of Oriental Medicine","Korean Convergence Medical Science Major, KIOM School, University of Science & Technology (UST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Convergence Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]},{"raw_affiliation_string":"Korean Convergence Medical Science Major, KIOM School, University of Science & Technology (UST)","institution_ids":["https://openalex.org/I88761825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158892949","display_name":"Seong Eun Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Eun Jin","raw_affiliation_strings":["NeuroGlymph Imaging and Modulation Center, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NeuroGlymph Imaging and Modulation Center, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025382550","display_name":"Hyunil Ha","orcid":"https://orcid.org/0000-0001-5947-9982","observed_orcids":["https://orcid.org/0000-0001-5947-9982"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunil Ha","raw_affiliation_strings":["KM Convergence Research Division, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Convergence Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160803694","display_name":"Han Na Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Han Na Kang","raw_affiliation_strings":["KM Convergence Research Division, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Convergence Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139281679","display_name":"Jihee Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihee Choi","raw_affiliation_strings":["KM Convergence Research Division, Korea Institute of Oriental Medicine","Korean Convergence Medical Science Major, KIOM School, University of Science & Technology (UST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Convergence Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]},{"raw_affiliation_string":"Korean Convergence Medical Science Major, KIOM School, University of Science & Technology (UST)","institution_ids":["https://openalex.org/I88761825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083544434","display_name":"Jin Ah Ryuk","orcid":"https://orcid.org/0000-0002-1811-2815","observed_orcids":["https://orcid.org/0000-0002-1811-2815"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin Ah Ryuk","raw_affiliation_strings":["KM Convergence Research Division, Korea Institute of Oriental Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KM Convergence Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016137020","display_name":"Youn\u2010Hwan Hwang","orcid":"https://orcid.org/0000-0002-4959-2436","observed_orcids":["https://orcid.org/0000-0002-4959-2436"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Youn-Hwan Hwang","raw_affiliation_strings":["KM Convergence Research Division, Korea Institute of Oriental Medicine","Korean Convergence Medical Science Major, KIOM School, University of Science & Technology (UST)"],"raw_orcid":"https://orcid.org/0000-0002-4959-2436","affiliations":[{"raw_affiliation_string":"KM Convergence Research Division, Korea Institute of Oriental Medicine","institution_ids":["https://openalex.org/I4210087584"]},{"raw_affiliation_string":"Korean Convergence Medical Science Major, KIOM School, University of Science & Technology (UST)","institution_ids":["https://openalex.org/I88761825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016137020","https://openalex.org/A5083544434"],"corresponding_institution_ids":["https://openalex.org/I4210087584","https://openalex.org/I88761825"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":{"value":2085,"currency":"GBP","value_usd":2557},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"64","issue":"1","first_page":"1203","last_page":"1221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/euonymus-alatus","display_name":"Euonymus alatus","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7879999876022339},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":1.0},{"id":"https://openalex.org/keywords/intestinal-epithelial-barrier","display_name":"intestinal epithelial barrier","score":0.8270000219345093},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9049999713897705},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7910000085830688},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7670000195503235},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7979999780654907},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9800000190734863},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.9340000152587891},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.7020000219345093},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.46399998664855957},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7912999987602234},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.7671999931335449},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.7634000182151794},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6251000165939331},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5289999842643738},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5238000154495239},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5041000247001648},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.49810001254081726},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4869000017642975},{"id":"https://openalex.org/C2779028967","wikidata":"https://www.wikidata.org/wiki/Q161113","display_name":"Euonymus","level":2,"score":0.4580000042915344},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.43849998712539673},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4223000109195709},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.3799999952316284},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.34700000286102295},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33640000224113464},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.3353999853134155},{"id":"https://openalex.org/C2779655422","wikidata":"https://www.wikidata.org/wiki/Q1196166","display_name":"Glycyrrhiza uralensis","level":3,"score":0.33320000767707825},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.32089999318122864},{"id":"https://openalex.org/C2776848411","wikidata":"https://www.wikidata.org/wiki/Q418374","display_name":"Naringenin","level":4,"score":0.31209999322891235},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C2780941987","wikidata":"https://www.wikidata.org/wiki/Q3796380","display_name":"Ileitis","level":4,"score":0.304500013589859},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.29319998621940613},{"id":"https://openalex.org/C2776148510","wikidata":"https://www.wikidata.org/wiki/Q6468907","display_name":"Lactacystin","level":4,"score":0.28700000047683716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2721000015735626},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.26649999618530273},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2630999982357025},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.25999999046325684}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/13880209.2026.2757313","doi":"https://doi.org/10.1080/13880209.2026.2757313","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13880209.2026.2757313","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13880209.2026.2757313?needAccess=true","source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:9be09e125da442b194b9b7a0ce9f9bc9","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9be09e125da442b194b9b7a0ce9f9bc9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutical Biology, Vol 64, Iss 1, Pp 1203-1221 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/13880209.2026.2757313","doi":"https://doi.org/10.1080/13880209.2026.2757313","is_oa":true,"landing_page_url":"https://doi.org/10.1080/13880209.2026.2757313","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/13880209.2026.2757313?needAccess=true","source":{"id":"https://openalex.org/S130009153","display_name":"Pharmaceutical Biology","issn_l":"0925-1618","issn":["0925-1618","1388-0209","1744-5116"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7442577407","display_name":null,"funder_award_id":"KSN2225021","funder_id":"https://openalex.org/F4320322113","funder_display_name":"Korea Institute of Oriental Medicine"}],"funders":[{"id":"https://openalex.org/F4320322113","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225341302.pdf","grobid_xml":"https://content.openalex.org/works/W7225341302.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1184016030","https://openalex.org/W1864325817","https://openalex.org/W1970930356","https://openalex.org/W1973548938","https://openalex.org/W1976327936","https://openalex.org/W1990296143","https://openalex.org/W2005001748","https://openalex.org/W2032370476","https://openalex.org/W2035414622","https://openalex.org/W2051006249","https://openalex.org/W2082451081","https://openalex.org/W2131632358","https://openalex.org/W2164675156","https://openalex.org/W2175794645","https://openalex.org/W2194307286","https://openalex.org/W2431987552","https://openalex.org/W2510144363","https://openalex.org/W2919321004","https://openalex.org/W2946537104","https://openalex.org/W3022073735","https://openalex.org/W3022724484","https://openalex.org/W3131893289","https://openalex.org/W3213927789","https://openalex.org/W4313244299","https://openalex.org/W4381337091","https://openalex.org/W4385728359","https://openalex.org/W4387343981","https://openalex.org/W4392481323","https://openalex.org/W4398783841","https://openalex.org/W4402984212","https://openalex.org/W4410019431","https://openalex.org/W4414422465"],"related_works":["https://openalex.org/W4400294790","https://openalex.org/W2897687536","https://openalex.org/W4224983009","https://openalex.org/W2805097160","https://openalex.org/W2792299707","https://openalex.org/W2802589349","https://openalex.org/W4406713764","https://openalex.org/W4385786399","https://openalex.org/W2609027890","https://openalex.org/W2186873815"],"abstract_inverted_index":{"Context":[0],"Euonymus":[1],"alatus":[2,32],"(Thunb.)":[3],"Siebold":[4],"has":[5],"been":[6],"traditionally":[7],"used":[8],"in":[9,35,64,79,231],"East":[10],"Asian":[11],"medicine":[12],"for":[13],"dysentery":[14],"and":[15,24,41,46,50,83,99,108,115,124,126,132,157,160,170,173,185,190,196,205,210,213,220,226],"inflammatory":[16,209],"disorders.":[17],"However,":[18],"its":[19,239],"effects":[20],"on":[21],"intestinal":[22],"inflammation":[23],"barrier":[25,48,111,168],"injury":[26],"remain":[27],"unclear.Objective":[28],"To":[29],"evaluate":[30],"E.":[31],"extract":[33],"(EEA)":[34],"dextran":[36],"sulfate":[37],"sodium":[38],"(DSS)-induced":[39],"colitis":[40,219],"examine":[42],"inflammatory,":[43,222],"inflammasome-related,":[44,223],"pyroptosis-associated,":[45],"epithelial":[47,97,224],"responses.Materials":[49],"methods":[51],"EEA":[52,121,136,154,166,179,215],"was":[53,62],"profiled":[54],"using":[55,73],"ultra-high-performance":[56],"liquid":[57],"chromatography\u2013tandem":[58],"mass":[59],"spectrometry.":[60],"Colitis":[61],"induced":[63],"male":[65],"C57BL/6":[66],"mice":[67],"(five":[68],"groups,":[69],"n":[70],"=":[71,150],"8/group)":[72],"two":[74],"cycles":[75],"of":[76,86],"2.0%":[77],"DSS":[78,87],"drinking":[80],"water":[81],"(6":[82],"5":[84],"days":[85],"exposure":[88],"separated":[89],"by":[90],"a":[91],"7-day":[92],"DSS-free":[93],"interval).":[94],"Cytokine-stimulated":[95],"Caco-2":[96,164],"cells":[98],"lipopolysaccharide/adenosine":[100],"triphosphate-stimulated":[101],"J774A.1":[102,177],"macrophages":[103],"were":[104,119],"also":[105],"used.":[106],"Histological":[107],"molecular":[109],"assessments,":[110],"assays,":[112],"RNA":[113],"sequencing,":[114],"network":[116,206],"pharmacology":[117],"analyses":[118,207],"performed.Results":[120],"contained":[122],"flavonoids":[123],"phenolic":[125],"reduced":[127,180],"weight":[128],"loss,":[129],"disease":[130],"activity,":[131],"histological":[133],"injury;":[134],"high-dose":[135],"increased":[137,171],"colon":[138],"length":[139],"from":[140],"6.67":[141],"\u00b1":[142,146],"0.18":[143],"to":[144,237,242],"7.58":[145],"0.13":[147],"cm":[148],"(p":[149],"0.003":[151],"vs.":[152],"N.C.).":[153],"decreased":[155],"MPO-":[156],"F4/80-positive":[158],"infiltration":[159],"inflammatory/inflammasome-related":[161],"transcripts.":[162],"In":[163,176],"cells,":[165],"improved":[167],"function":[169],"ZO-1":[172],"occludin":[174],"expression.":[175],"macrophages,":[178],"pyroptotic":[181],"cell":[182],"death,":[183],"IL-1\u03b2":[184],"IL-18":[186],"release,":[187],"ASC":[188],"oligomerization":[189],"specks,":[191],"cleaved":[192],"caspase-1,":[193],"mature":[194],"IL-1\u03b2,":[195],"GSDMD-NT.":[197],"Selected":[198],"phytochemicals":[199],"partly":[200],"reproduced":[201],"these":[202],"effects.":[203],"Transcriptomic":[204],"implicated":[208],"barrier-related":[211],"pathways.Discussion":[212],"conclusions":[214],"attenuated":[216],"DSS-induced":[217],"experimental":[218,233],"modulated":[221],"barrier,":[225],"pyroptosis-associated":[227],"responses.":[228],"Further":[229],"validation":[230],"other":[232],"models":[234],"is":[235],"needed":[236],"establish":[238],"broader":[240],"relevance":[241],"IBD.":[243]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}
